Philosophy of science is a fundamental foundation for understanding the nature, structure, and validity of science. This study aims to analyze the role of philosophy of science as an epistemological basis for the development of science. The method used is library research with a descriptive qualitative approach. The results of the study indicate that philosophy of science plays a crucial role in providing a framework for critical, systematic, and reflective thinking regarding the scientific process. Epistemology, as a branch of the philosophy of science, serves as the basis for determining the sources, methods, and validity of scientific knowledge. Thus, the development of science is not solely empirical-positivistic but must also consider rational, methodological, and philosophical aspects. In conclusion, philosophy of science is an important foundation in ensuring that science develops objectively, systematically, and scientifically accountable.
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