Maternal Mortality Rate (MMR) and Infant Mortality Rate (IMR) remain important indicators in assessing the level of public health. In Indonesia, the MMR reaches 305 per 100,000 live births and the IMR is 22 per 1,000 live births. These high rates are influenced by various factors such as hemorrhage, infection, hypertension in pregnancy, and complications during childbirth and postpartum. One effort to reduce MMR and IMR is through continuous midwifery care or Continuity of Care (CoC), which provides comprehensive services from pregnancy to family planning. This study used a descriptive method with a case study approach on Mrs. E, 38 years old, G6P5A0, in the working area of Puskesmas Kota 2, Mappi Regency, South Papua. Midwifery care was provided comprehensively, covering pregnancy, childbirth, postpartum, newborn care, and family planning services using a midwifery management approach. The results showed that the implementation of Continuity of Care midwifery services was carried out well according to service standards. The condition of the mother and baby during pregnancy, childbirth, postpartum, and the newborn period was good without significant complications. The mother also demonstrated understanding of self-care, newborn care, and the importance of contraceptive use. The implementation of comprehensive midwifery care through Continuity of Care is effective in improving the quality of services and supporting efforts to reduce MMR and IMR through early detection and appropriate management. Abstrak Angka Kematian Ibu (AKI) dan Angka Kematian Bayi (AKB) masih menjadi indikator penting dalam menilai derajat kesehatan masyarakat. Di Indonesia, AKI mencapai 305 per 100.000 kelahiran hidup dan AKB sebesar 22 per 1.000 kelahiran hidup. Tingginya angka tersebut dipengaruhi oleh berbagai faktor seperti perdarahan, infeksi, hipertensi dalam kehamilan, serta komplikasi persalinan dan nifas. Salah satu upaya untuk menurunkan AKI dan AKB adalah melalui pelayanan kebidanan berkesinambungan atau Continuity of Care (CoC) yang memberikan asuhan secara menyeluruh sejak kehamilan hingga keluarga berencana. Penelitian ini menggunakan metode deskriptif dengan pendekatan studi kasus pada Ny. E usia 38 tahun G6P5A0 di wilayah kerja Puskesmas Kota 2 Kabupaten Mappi Papua Selatan. Asuhan kebidanan diberikan secara komprehensif meliputi masa kehamilan, persalinan, nifas, bayi baru lahir, hingga pelayanan keluarga berencana dengan pendekatan manajemen kebidanan. Hasil menunjukkan bahwa asuhan kebidanan secara Continuity of Care dapat dilaksanakan dengan baik sesuai standar pelayanan. Kondisi ibu dan bayi selama kehamilan, persalinan, nifas, dan bayi baru lahir dalam keadaan baik tanpa komplikasi yang berarti. Ibu juga memahami perawatan diri, perawatan bayi, serta pentingnya penggunaan kontrasepsi. Penerapan asuhan kebidanan komprehensif secara Continuity of Care efektif dalam meningkatkan kualitas pelayanan serta mendukung upaya penurunan AKI dan AKB melalui deteksi dini dan penanganan yang tepat.
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