The purpose of the study was to analyze the determinants of treatment failure in RO tuberculosis patients in Papua Province. Types of analytical observational research with a cross-sectional approach. The population is 471 people, and the sampling is saturated. Data were obtained using secondary data using univariate analysis, bivariate analysis using the Chi-square test, and multivariate analysis using binary logistic regression. The results of the study were found to be 55.4% failed in the treatment of Drug-Resistant TB. Chi-square test results with a p-value of < 0.05 were occupation, OAT side effects, treatment combinations, and adherence to OAT intake. The insignificant variables were age, sex, ethnicity, comorbid DM, comorbid HIV/AIDS, and TB treatment history. Comorbid HIV AIDS is the most dominant factor for treatment failure in RO TB patients
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