This study aims to analyze factors related to the incidence of Loss To Follow Up (LTFU) in TB patients at the Bintuni Health Center, Teluk Bintuni Regency. The study used an analytical observational design with a cross-sectional design based on secondary data recorded in the TB 03 register. The study population is all TB patients who started treatment in the period from January 2024 to August 2025, with a total of 245 patients sampled. The results showed that the relationship between age (p=0.260), sex (p=0.998), distance traveled (p=0.967), PMO (p=0.536), and ethnicity (p=0.141) was not significant with the incidence of LTFU. Meanwhile, the variables of education (p=0.000), employment (p=0.000), and drug side effects (p=0.000) were significantly related to the incidence of LTFU. Drug side effect variables are the most dominant factor in the incidence of LTFU
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