Indonesian Journal of Chemistry
Vol 17, No 1 (2017)

Cinnamic Acid Derivatives as α-Glucosidase Inhibitor Agents

Teni Ernawati (Research Center for Chemistry – Indonesian Institute of Sciences (LIPI), Kawasan Puspiptek, Serpong Tangerang Selatan, Banten 15314)
Maksum Radji (Faculty of Pharmacy, Universitas Indonesia, Depok 16242)
Muhammad Hanafi (Research Center for Chemistry – Indonesian Institute of Sciences (LIPI), Kawasan Puspiptek, Serpong Tangerang Selatan, Banten 15314)
Abdul Mun’im (Faculty of Pharmacy, Universitas Indonesia, Depok 16242)
Arry Yanuar (Faculty of Pharmacy, Universitas Indonesia, Depok 16242)



Article Info

Publish Date
01 Apr 2017

Abstract

This paper reviews biological activity of some cinnamic acid derivative compounds which are isolated from natural materials and synthesized from the chemical compounds as an agent of α-glucosidase inhibitors for the antidiabetic drug. Aegeline, anhydroaegeline and aeglinoside B are natural products isolated compounds that have potential as an α-glucosidase inhibitor. Meanwhile, α-glucosidase inhibitor class of derivatives of cinnamic acid synthesized compounds are p-methoxy cinnamic acid and p-methoxyethyl cinnamate. Chemically, cinnamic acid has three main functional groups: first is the substitution of the phenyl group, second is the additive reaction into the α-β unsaturated, and third is the chemical reaction with carboxylic acid functional groups. The synthesis and modification of the structure of cinnamic acid are very influential in inhibitory activity against α-glucosidase.

Copyrights © 2017






Journal Info

Abbrev

ijc

Publisher

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry

Description

Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology ...