<![CDATA[Objective: To investigate that curcumin can decreasing proliferation
index and increasing apoptosis index.
Method: This is an experimental non-blinded study with post test
control group design, at Cell/Tissue Culture Laboratory at Medical
Faculty of Brawijaya University. This study using CHM trophoblastic
cell culture from CHM curettage patient, exposed by several doses of
curcumin, 0, 50, 100, 200, 400 and 800 μM, then examined by the
method of MTT proliferation index and apoptosis index by the
method of labeling DNA fragmentation TUNEL system. Data analyzed
by one-way ANOVA.
Result: In this study, the mean values obtained decrease in proliferation
index with increasing doses of curcumin. Giving a dose of
200 μM curcumin, 400 μM and 800 μM proved highly significant
(p = 0.001) reduced proliferation index compared with the control
and curcumin dose of 50 μM and 100 μM. From this research shows
that there are significant differences in the increase of apoptosis index
(p = 0.001) between the control group with curcumin dose
group 200 μM, 400 μM and 800 μM. But there was no significant
difference in the mean of apoptosis index among the three dose
groups.
Conclusion: Giving curcumin dose of 200 μM can decreasing the
proliferation index and increasing the apoptosis index increases in
CHM trophoblastic cell culture.
[Indones J Obstet Gynecol 2016; 1: 37-41]
Keywords: apoptosis index, curcumin, proliferation index]]>
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