UJI IN VITRO DAN IN SILICO SENYAWA 5,7,2’,5’-TETRAHYDROXY FLAVAN-3-OL TERHADAP ENZIM ALPHA GLUCOSIDASE

Frengki Frengki (Biomedik Fakultas Kedokteran Universitas Andalas-Padang FKH Universitas Syiah Kuala-Banda Aceh)
Deddi Prima (Fakultas Farmasi, Universitas Andalas)
Fatma Sri Wahyuni (Fakultas Farmasi, Universitas Andalas)
Daan Khambri (Fakultas Farmasi, Universitas Andalas)
Henny Vanda (Biomedik Fakultas Kedokteran, Universitas Andalas-Padang)
Noni Zakiah (Akademi Farmasi-Aceh Besar)
Jamilah Abbas (LIPI-Kimia Puspitek-Serpong)
Berna Elya (Fakultas Farmasi Universitas Indonesia)

Jurnal Fitofarmaka Indonesia
Vol 5, No 2 (2018): JURNAL FITOFARMAKA INDONESIA

Several of Calophyllums genus have been searched and proven as medicinal plants and Calophyllum macrophyllum is one of its genus. We have been isolated a compound from ethyl acetate fraction of the stem-bark. The compound was flavan-3-ol (5,7,2’,5’-tetrahydroxy flavan-3-ol). This research aimed to determine inhibition antidiabetic activity and affinity of its compound on α-glycosidase enzyme. In vitro antidiabetic effect shown by IC50 9.10 µg/ml and docking by Arguslab 4.01 shown by ΔG -10,24 kkal/mol as in silico test. The inhibition activity of flavan-3-ol against the α-glucosidase enzyme that is very strong shows its promising potential as a candidate for antidiabetic drugs.