Jurnal Farmasi Indonesia
Vol 14 No 2 (2017): Jurnal Farmasi Indonesia

Evaluasi Mutu Fisik Tablet Antalgin Dengan Bahan Penghancur Amilum Kulit Pisang (Musa paradisiacal) Metode Granulasi Basah

Sri Saptuti Wahyuningsih (Unknown)
Siwi Hastuti (Unknown)



Article Info

Publish Date
31 Jan 2019

Abstract

Tablets are solid preparations taken by oral. Some people consider banana peel as a waste, whereas banana peel contains amylum which can be used as additional material. This study aims to determine the ability of banana peel as a crushing material and its effect on the physical character of antalgin tablets.This research was done by making the formula using variation of banana peel concentration (5%, 10%, 15%). The research begins with granule preparation with wet granulation method, then continued compressing of tablets. Tests include physical character of granules and physical character of antalgin tablets (uniformity of size and weight, hardness, distegration test, friability) for each formula.The results showed that the difference in thickness of the tablets due to differences in pressure at the time of printing, granule quality and the number of fines on the granule. Uniformity of weight is affected granule quality including granule flow character. The increasing concentration of disintegrant causes the tablet to have a decreasing hardness and decay time, while the friability of the tablet increases. The result of ANOVA test shows that there is a significant influence between the variation of disintegrant concentration on the physical character of antalgin tablets. Conclusion. Banana peel can be used as an antalgin tablet crusher. The increased variation of banana peel concentration as a disintegrant resulted in decreased hardness and disintegration time of tablets as well as an increase in tablet friability

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Journal Info

Abbrev

farmasi-indonesia

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

Description

Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang ...