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Siwi Hastuti
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Evaluasi Mutu Fisik Tablet Antalgin Dengan Bahan Penghancur Amilum Kulit Pisang (Musa paradisiacal) Metode Granulasi Basah Sri Saptuti Wahyuningsih; Siwi Hastuti
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (491.823 KB) | DOI: 10.31001/jfi.v14i2.368

Abstract

Tablets are solid preparations taken by oral. Some people consider banana peel as a waste, whereas banana peel contains amylum which can be used as additional material. This study aims to determine the ability of banana peel as a crushing material and its effect on the physical character of antalgin tablets.This research was done by making the formula using variation of banana peel concentration (5%, 10%, 15%). The research begins with granule preparation with wet granulation method, then continued compressing of tablets. Tests include physical character of granules and physical character of antalgin tablets (uniformity of size and weight, hardness, distegration test, friability) for each formula.The results showed that the difference in thickness of the tablets due to differences in pressure at the time of printing, granule quality and the number of fines on the granule. Uniformity of weight is affected granule quality including granule flow character. The increasing concentration of disintegrant causes the tablet to have a decreasing hardness and decay time, while the friability of the tablet increases. The result of ANOVA test shows that there is a significant influence between the variation of disintegrant concentration on the physical character of antalgin tablets. Conclusion. Banana peel can be used as an antalgin tablet crusher. The increased variation of banana peel concentration as a disintegrant resulted in decreased hardness and disintegration time of tablets as well as an increase in tablet friability
Pengaruh Ekstrak Etanol Dan Dekokta Kulit Manggis (Garcinia Mangostana L.) Sebagai Pewarna Terhadap Kualitas Sabun Organik Transparan Berbasis Minyak Jelantah Yang Dimurnikan Dengan Ekstrak Mengkudu Dengan Pengaroma Minyak Atsiri Kulit Jeruk Purut (Citr Wiji Sri Kusumaningsih; Siwi Hastuti
Indonesian Journal on Medical Science Vol 1 No 2 (2014): IJMS - 2014
Publisher : Unit Penelitian dan Pengabdian Masyarakat Politeknik Kesehatan Bhakti Mulial

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (118.442 KB)

Abstract

ABSTRACT: Background : Soap is a main requirement to keep cleaning. The dye used are usually synthetic dyes which have side effects. Mangos teen peel contains anthocyanins which can  be used for colouring. Lime skin contain of oil that can be used as perfume .Objective:To examine the effect of mangosteen peel extracts were isolated with water and ethanol 96 % to the transparent quality organic soap based cooking oil with odour lime peel essential oil.Methods: Refine cooking oil, mangos teen  peel is isolated by maceration and dekokta,  the lime skin is  isolated by distillation. Later made into a soap formulation and evaluation test then observed the effect of mangos teen peel extract against the results of an evaluation test that determines the quality of the soap . This research is an experimental study conducted in the laboratory by the method of saponification. The data analysis use SPSS 18 to the formality test(Kolmogorov Smirnov test) followed by a test of independent samples test.Results : Quality soap dekokta and ethanol extract of mangos teen peel has a value of p>0.05 (Ho is accepted, there is no difference).except of rendemen and the length of the soap foam.soapdekokta and ethanol extract of mangoes teen peel,compared with ISO soap standar has a value p> 0,05 ( Ho is accepted, thereis no difference)exceptt of dekokta soap rendemen.Conclusion : There is no significant difference etanol extract soap and dekokta mangoes teen peel except rendemen and the length of soap foam.Ethanol extract and dekokta mangoes teen peel has an effect on the yield parameters of soap. Ethanol extract soap and dekokta mangoes teen peel reach the standards of ISO 06-3532 1994 in randemen and organoleptic parameters, pH, length of foam, stability test, a test of homogeneity, transparency test, inhibition against Staphylococcus aureus and determination of the saponification numbering except of dekokta soap mangoes teen peel.Keywords : The quality of transparant organic soap , cooking oil , extracts ethanol of mangos teen peel , dekokta of mangoes teen peel, lime peel , ISO standard 06-3532 1994 ABSTRAK: Latar belakang : Sabun merupakan kebutuhan pokok untuk menjaga kebersihan. Pewarna yang digunakan biasanya adalah pewarna sintetis yang mempunyai efek samping. Kulit manggis mengandung antosianin yang bisa digunakan untuk pewarna. Kulit jeruk purut memiliki kandungan minyak atsiri yang bisa dijadikan untuk parfum.Tujuan : Untuk meneliti pengaruh ekstrak kulit manggis yang diisolasi dengan air dan etanol 96% terhadap kualitas sabun organik transparan berbasis minyak jelantah dengan pengaroma minyak atsiri kulit jeruk purut.Metode : Minyak jelantah dimurnikan dengan ekstrak mengkudu, kulit manggis diekstraksi dengan maserasi dan dekok, kulit jeruk purut diisolasi dengan destilasi. Kemudian dibuat formulasi menjadi sabun  dan dilakukan uji evaluasi kemudian diamati pengaruh ekstrak kulit manggis terhadap hasil uji evaluasi sabun yang menentukan kualitas sabun. Jenis penelitian ini adalah penelitian  eksperimental yang dilakukan di laboratorium dengan metode saponifikasi.  Analisa data menggunakan SPSS 18 dengan uji normalitas (kolmogorov Smirnov) dilanjutkan dengan uji independent samples test.Hasil:  Parameter  sabun ekstrak etanol dan dekokta kulit manggis dengan sabun standar SNI  memiliki nilai P>0,05(Ho diterima, tidak ada beda) kecuali rendemen dan panjang busa sabun. Sabun ekstrak etanol dan dekokta kulit manggis dengan sabun standar SNI memiliki nilai P>0,05 (Ho diterima, tidak ada beda) kecuali pada rendemen sabun dekokta.Kesimpulan: Tidak ada perbedaan yang signifikan sabun ekstrak etanol dan dekokta kulit manggis kecuali rendemen dan panjang busa sabun. Ekstrak etanol dan dekokta kulit manggis mempunyai pengaruh terhadap rendemen dan parameter sabun. Sabun ekstrak etanol dan dekokta kulit manggis memenuhi standar SNI dalam rendemen dan parameter organoleptis, pH, panjang busa, uji stabilitas, uji homogenitas, uji transparansi, daya hambat terhadap bakteri Staphylococcus aureus dan angka penyabunan kecuali pada rendemen sabun dekokta kulit manggis.Kata Kunci : Sabun organik transparan, minyak jelantah, ekstrak etanol, dekokta, kulit manggis, kulit jeruk purut, standar SNI 06-35321994.
Pengaruh Fraksi Tak Larut N-Heksana dari Ekstrak Etanol Daun Seligi (Phyllanthus buxifolius Muell.Arg) terhadap Daya Antiinflamasi pada Mencit yang terinduksi Karagenin Siwi Putri Handayani; Siwi Hastuti
Indonesian Journal on Medical Science Vol 10 No 1 (2023): IJMS 2023
Publisher : Unit Penelitian dan Pengabdian Masyarakat Politeknik Kesehatan Bhakti Mulial

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55181/ijms.v10i1.412

Abstract

Seligi (Phyllanthus buxifolius Muell. Arg) has been used empirically as a painkiller and anti-inflammatory. The purpose of this study was to determine the anti-inflammatory power of the n-hexane insoluble fraction from the ethanol extract of Seligi leaves in carrageenin-induced mice. The isolation method was carried out by maceration and fractionation. Mice were given the test preparation orally and then induced using a 0.1% carrageenin solution intraplantarly. The length of the edema was observed by measuring the diameter of the soles of the mice's feet. Udem length to determine the percentage of anti-inflammatory power (% DAI). One way ANOVA test as statistical analysis and post hoc test. The percentage of anti-inflammatory power in a row the insoluble fraction of the ethanol extract of Seligi leaves doses of 200, 400 and 800 mg/kg BW were (49.24 ± 0.65)%, (56.01 ± 1.58)% and (65.03 ±1.16)%, while diclofenac sodium 6.5 mg/kgBW has a %DAI of (66.16±1.96)%. There is a significant difference shown from the results of the one way ANOVA test. In the post hoc test, there were significant differences between the treatments, except for the highest dose fraction, which was 800 mg/kgBW with diclofenac sodium at a dose of 6.5 mg/kgBW. The content of flavonoids in the fraction can reduce inflammation in mice. Seligi leaf fraction preparations have the potential for local wisdom as an anti-inflammatory.
Co-Authors Siwi Putri Handayani Sri Saptuti Wahyuningsih Wiji Sri Kusumaningsih