Jurnal Farmasi Higea
Vol 7, No 1 (2015)

Perbandingan Kemampuan Polimer HPMC dengan Gom Arab dalam Meningkatkan Kecepatan Disolusi Tablet Karbamazepin

Rina Wahyuni (Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang)
Auzal Halim (Fakultas Farmasi Universitas Andalas Padang)
Eka Syuryani (Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang)



Article Info

Publish Date
22 Feb 2017

Abstract

The effect of HPMC and gom arabic to do dissolution ability of carbamazepine tablets made by wet granulation has been. There are 5 formulas of carbamazepine granules, mind each formula was containing 40% w/w of carbamazepine. Carbamazepine wese coated by HPMC polymers and gom arabic by spray drying process. formula 0 countain carbamazepine with coanted HPMC and  gom arabic witle formula 1 and 2 is countain carbamazepine coated by HPMC polymers with  concentration 5% w/w and 10% w/w respectively. Formula 3 and 4 is countain  carbamazepine which counted by gom arabic with  concentration 5% and 10% respectively. The result shows that formula 2 show the highest dissolution rate 134.7133%.

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