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Jurnal Farmasi Sains dan Komunitas

JFSK
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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 8 Documents

Search results for , issue "Vol 10, No 2 (2013)" : 8 Documents clear

EFEK PEMBERIAN JUS BUAH PISANG KEPOK (Musa paradisiaca forma typica) TERHADAP KADAR GLUKOSA DARAH TIKUS JANTAN GALUR WISTAR YANG TERBEBANI GLUKOSA F. Eki Supra Bawati; Yunita Linawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Abstract: This research aimed to determine the effects of administration of Musa paradisiacaforma typica juice on blood glucose levels and determine what dose of Musa paradisiaca formatypica juice which is most effective for lowering blood glucose levels in rats burdened glucose.This research was experimental with study with one way complete design using 25 male rats weredivided into five groups. Group I (negative control) was given CMC 1%, group II (positivecontrol) was given Glibenclamide dose of 0,64 mg/kgBW and group III, IV, V the rats were given5; 10; 20 mL/kgBW dose of Musa paradisiaca forma typica juice, all of the processes were giventhrough the oral method. Hypoglycemic effect of Musa paradisiaca forma typica juice was testedby following the Oral Glucose Tolerance Test (OGTT) method. The blood-glucose contents weretaken, at the 0 minutes before the OGTT and also taken at minutes of 15, 30, 60, 90, 120, 180, and240 after the OGTT, from the tested animal that had been gotten the pre-treatment of the negativecontrol, positive control and Musa paradisiaca forma typica juice before. Data of blood glucoselevels was statistically analyzed using one way ANOVA and Scheffe test with 95% convidencelevel. The result of this research showed that Musa paradisiaca forma typica juice can loweringblood glucose levels on rats in burdened glucose. Dose Musa paradisiaca forma typica juice aremost effective in lowering blood glucose levels in a dose was 10 mL/kgBW.Key words: Musa paradisiaca forma typica, blood glucose levels, OGTT

POTENSI TAPE SEBAGAI PANGANAN TRADISIONAL TERHADAP EFEK HEPATOTOKSIK TIKUS TERINDUKSI KARBON-TETRAKLORIDA Gidion Krisnadi Yoseph; Christiana Destia Anggraeni; Ni Luh Putu Dian Prawita Putri; Phebe Hendra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Abstract: The purpose of this study was to determine the effect of Tape that has an alcoholiccompound, to the hepatotoxic effect in the rat induced Carbon Tetrachloride. And also determinewhich fermentation time of the Tape can give effect to the hepatotoxic in the rat induced Carbontetrachloride. Healthy rats were randomly divided into 7 groups of 5 animals in each. Group 1received carbon tetrachloride 2ml/kgBW treated intraperitoneal. Group 2-4 were given Tapesuspension 18g/kgBW once daily for 6 days with different fermentation time (3, 5, 7 days). Group5-7 were given Tape suspension 18g/KgBW once daily for 6 days with different fermentationtime and carbon tetrachloride was given on the 7th day. Blood sample from all groups wasobtained by sinus orbitalis after 24 hours application for estimation the serum level oftransaminase. The result showed that Tape suspension had a potential effect to reduce thehepatotoxicity induced by carbon tetrachloride. Tape suspension with 5 days fermentationwas significantly decreased serum level of transaminase (P0,05) upon carbon tetrachlorideinduced hepatic damage in rats.Keywords: hepatotoxicity, tape, fermentation time,carbon tetrachloride

PENETAPAN KANDUNGAN FENOLAT TOTAL DAN UJI AKTIVITAS ANTIOKSIDAN MENGGUNAKAN RADIKAL DPPH FRAKSI ETIL ASETAT SARI BUAH APEL BELUDRU (Diospyros blancoi A. DC.) Johannes Baptista Yunio Rahmawan; Yohanes Dwiatmaka
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Abstract: Antioxidant plays a role in inhibiting oxidation by binding to free radicals. As a result,the cell damage that leads to degenerative diseases can be inhibited. This research wasconducted to determine the antioxidant activity and total phenolic content of ethyl acetatefraction of velvet aple (Diospyros blancoi A.DC.) juice. Previously known that other plants fromgenus Diospyros contain phenolic compounds such as quercetin. Antioxidant activity testperformed qualitatively and quantitatively using radical of 1,1-diphenyl-2 pikrilhidrazil(DPPH) and expressed as the value Inhibition Concentration 50 (IC50). Determination of totalphenolic using Folin-Ciocalteu method expressed as equivalent mass of gallic acid. Phenoliccompounds will be oxidized by the Folin-Ciocalteu under alkaline conditions, forming a bluesolution. The results showed that the ethyl acetate fraction of velvet apple juice has very strongantioxidant activity with IC50 of (30.0 0.09) mg / mL. Total phenolic content of (393.5 0.35) mggallic acid equivalents per gram of ethyl acetate fraction.Keywords: antioxidant, velvet apple (Diospyros blancoi A. DC), ethyl acetate fraction, DPPH,total phenolic content.

PENGETAHUAN MENGENAI ANTIBIOTIKA DI KALANGAN MAHASISWA ILMU ILMU KESEHATAN UNIVERSITAS GADJAH MADA YOGYAKARTA Rizky Indah Pratiwi; Rustamadji Rustamadji; Aris Widayati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Abstract: Inappropriate use of antibiotics, both prescribed and non-prescribed, is a globalpublic health problem. In Indonesia, there is an increase of self-medication with antibiotics in thecommunity in the last decade. Health practitioners are the main source of information and adviceon self-medication with antibiotics in the community. Therefore, it is important to investigateknowledge of antibiotics among students of health sciences because they are candidates forfuture health practitioners. This study is an observational cross-sectional survey using avalidated questionnaire. Respondents were 150 students of health sciences faculties at GadjahMada University Yogyakarta who were selected using a non-random convenience samplingtechnique. Of the 150 respondents, 79%(119) were familiar with antibiotics. Only these data (n=119) were subsequently analysed. Overall, they had appropriate knowledge about efficacy ofantibiotics for bacterial infections and risks of antibiotic use, i.e. allergic reactions and antibioticresistance. However, their knowledge about efficacy of antibiotics for viral infections and the useof antibiotics immediately for fever were not appropriate. In general, 34% of respondents hadhigh level of knowledge about antibiotics, 54% in the moderate level and 12% in the low level.Keywords: knowledge of antibiotics, health sciences students

UJI AKTIVITAS ANTIOKSIDAN MENGGUNAKAN RADIKAL 1,1-DIFENIL-2- PIKRILHIDRAZIL DAN PENETAPAN KANDUNGAN FENOLIK TOTAL FRAKSI ETIL ASETAT EKSTRAK ETANOL BUAH ANGGUR BALI (Vitis vinifera L.) Mikhael Gustandy; C.J. Soegihardjo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Abstract: This research was conducted to determine the antioxidant activity of ethyl acetatfraction of extract of Balinesse grape (Vitis vinifera L.) using free radical and determine the totalphenolic content. Balinesse grape was extracted with ethanol and then fractionated using ethylacetate. Free radical scavenging activity was tested by measuring the DPPH radical scavengingactivity. Total phenolic content was determined using the Folin-Ciocalteau method measured theconcentration of phenolic content in gallic acid total equivalents using unit's mg/g. The mean IC50value for DPPH radical scavenging activity of the ethyl acetat fraction of ethanolic extract ofBalinesse grape was found to be 36.55 0.09 g/mL. The phenolic content was ranging from 3.23 0.02 mg gallic acid equivalents per gram of ethyl acetat fraction of ethanolic extract ofBalinesse grape.Keywords: antioxidants, Balinesse grape (Vitis vinifera L.), fraction of ethyl acetat, DPPH, totalphenolic content.

ANALISIS FARMAKOEKONOMI PERESEPAN ANTIBIOTIKA CEFTRIAXONE DAN CEFTAZIDIME PADA PASIEN BEDAH SESAR DI RUMAH SAKIT PANTI RINI YOGYAKARTA Maria Wisnu Donowati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Abstract: The raising of cesarean section had leaded the abuse of antibiotic prescribing in orderto minimize the wound or urethra infection that came in the caesarean surgery. Pharmaceuticalcare oriented had push pharmacist to care more about patients drug use to increase quality oflive. The aim of this research is to identify the total hospital service cost and calculate totalantibiotic cost, total drug and prescribtion. The data are collected through medical records andhospital service cost of 145 Panti Rini hospital cesarean section patients in 2003. Normality andhomogenity test are using computer programme, ? 95%. The most patient were 25-30 years old,first gestational fist partum and non aborts, cephalopelvic disproportion indication and havingthird class in hospital services. Ceftazidime in Pharodime and Ceftriaxone in Tricefin are themost cephalosphorin third generation that had been used among other antibiotics. Total hospitalcost that must be paid by the third class cesarean section patients are same, Rp. 820,974 in a day.The average of total drug and medical equipment cost and total antibiotics cost are different.Total drug and medical equipment cost in a day by using Pharodime is cheaper Rp. 33,903 thanTricefin. Total antibiotics cost in a day by using Pharodime is cheaper Rp. 34,663 thanTricefin.Keywords: pharmacoeconomic, antibiotic, prescription.

SUATU KAJIAN MOLEKULER KETERGANTUNGAN NIKOTIN Agustina Setiawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Abstract: Nicotine, a simple chemical substance from tobacco, stimulates addiction byneuroadaptation inducing rewards system in human brain. Molecular mechanism of nicotineaddiction in rewards system are mediated by nicotinic acetylcholine receptor (nAChR) andactivate dopaminergic neuron. Thus, nicotine addiction are also induce other neurottransmitterand hormone release: norephinefrin, serotonin, opioid, glutamat and mono amine oxidase.Keywords: nicotine, addiction, rewards system.

PENGARUH PENGGUNAAN PARASETAMOL SELAMA KEHAMILAN TERHADAP PREEKLAMPSIA Dita Maria Virginia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Abstract: Preeclampsia is one of the causes of maternal death. The important factor ofpreeclampsia's pathophysiology is reduction of PGI2 as vasodilator. It causes vasoconstrictionwhich influences the formation of desidua. Paracetamol is the most widely used antipyretic in theworld. Mechanism of action of paracetamol may lead to preeclampsia. The aim of this researchwas to determine the relation between paracetamol used during pregnancy and preeclampsia inRS X Yogyakarta. The research was an analytical epidemiology with case control study design.Data were obtained from medical record and interview. Sample size was 137 maternal patients inOctober-December 2013 and 72 maternal have been followed up. Data were analyzed usingdescriptive statistics, Chi-square tests, and logistic regression. Preeclampsia patients weretaking paracetamol during pregnancy (71.8%), aged 30-40 years (84.6%), and hadpreeclampsia family history (28.2) than non preeclampsia patient. Chi-square test showed therelation between paracetamol used (p=0.010, OR= 3.46 (95%CI= 1.30 9.22), dose a day(p=0.010, OR= 3.18 (95%CI= 1.12 9.06), duration of paracetamol used (p=0.005, OR= 7.75(95%CI= 1.60 37.53), and used within first trimester (p=0.878, OR= 0.91 (95%CI= 0.26 3.12) to preeclampsia. Logistic regression analyses showed no correlation between variables topreeclampsia. Women who used paracetamol during pregnancy had an increased risk ofpreeclampsia.Key words: preeclampsia, paracetamol, pregnancy.

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Florentinus Dika Octa Riswanto

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

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Contact Name Florentinus Dika Octa Riswanto

Contact Email editorial.jpsc@usd.ac.id

Phone -

Journal Mail Official editorial.jpsc@usd.ac.id

Editorial Address Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

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Abstract

Abstract

Contact Name
Florentinus Dika Octa Riswanto

Contact Email
editorial.jpsc@usd.ac.id

Phone
-

Journal Mail Official
editorial.jpsc@usd.ac.id

Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA