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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
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Articles 5 Documents
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Search results for , issue "Vol 31, No 1 (2012)" : 5 Documents clear
Prevalence of osteoporosis increased in postmenopausal women with postural scoliosis Rachmawati, Maria Regina; Sidarta, Nuryani; Bastian, Yefta D.
Universa Medicina Vol 31, No 1 (2012)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.63-70

Abstract

BackgroundMenopause is an aging process of the female reproductive system characterized by reduced estrogen levels. This results in increased osteoclastic activity, causing increased bone resorption and thus reduced bone mineral density (BMD). In addition to being influenced by osteoclastic activity, BMD of the lumbar vertebrae is also affected by the erector spinae muscle. The purpose of this study was to determine an association between postural scoliosis and erector spinae muscle endurance and its relation to BMD in postmenopausal women. MethodsThis was a cross-sectional study conducted on postmenopausal women, who were selected by simple random sampling among residents of Mampang Prapatan subdistrict. The postural abnormality of scoliosis was determined by physical examnation, while erector spinae muscle endurance time was assessed using a modified Biering-Sorensen technique, and BMD was measured by bone mineral densitometry, to categorize into normal, osteopenia, and osteoporosis.ResultsA total of 213 postmenopausal women with mean age of 53.52 ± 3.64 years participated in the study. The prevalence of scoliosis was 54.0%, and osteoporosis was 38.1%. The prevalence of osteoporosis was higher in women with scoliosis (48.7%) in comparison with those without scoliosis (31.6%) (p=0.411). In postmenopausal women with strong erector spinae muscle endurance the risk of of scoliosis was lower (0.76;95% Confidence Interval = 0.58 - 0.99) ConclusionsIn post menopausal women with postural scoliosis found a higher incidence of osteoporosis. High endurance of erector spinae muscle lowers the risk of scoliosis. Exercise to improve posture and increase endurance of erector spinae muscle need to be done to prevent decline of BMD.
Safety of cerebral digital subtraction angiography : complication rate analysis Usman, Fritz Sumantri; Sani, Achmad Firdaus; Husain, Shakir
Universa Medicina Vol 31, No 1 (2012)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.27-33

Abstract

Background Cerebral digital subtraction angiography (DSA) continues to be used for the examination of patients with cerebrovascular diseases. In the past decade, safer contrast agents have been used and there have been important technical advances including smaller catheters, hydrophylic guide wires, and digital imaging systems. The objective of this study was to determine the neurological complication rates of cerebral angiography performed for inpatients. MethodsA prospective study was conducted from January 2009 until December 2011. The patient’s demographic characteristics, the procedural details as well as complications appearing during and after the procedure were documented. Neurological complications are classified based on the international classification: (a) transient, disappearing within 24 hours; (b) reversible, lasting more than 24 hours but less than 7 days; (c) permanent, if the complication last for more than 7 days. The complications were examined by a neurologist.ResultsThe patients comprised 82 (41%) women and 118 (59%) men, ranging from 11 to 86 years of age. From 200 patients who underwent the procedure, permanent neurological complications were found in 1 (0.50 %) patient. Neither reversible nor transient neurological complications were found. ConclusionThe cerebral digital subtraction angiography procedure, when conducted by a neuro interventionist, is relatively save, both from the aspect of neurological and non-neurological complications, and from the number of deaths. The overall neurological complication rate fell within the limits recommended by quality improvement and safe practice guidelines.
Topiramate sprinkle is effective in the treatment of childhood epilepsy Gunawan, Prastiya Indra; Suharso, Darto
Universa Medicina Vol 31, No 1 (2012)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.34-42

Abstract

BackgroundEpilepsy remains one of the most frequently occurring pediatric problems. Approximately 10-15% patients do not respond to conventional therapy. Topiramate as a novel antiepileptic drug has a broad spectrum activity, presumably indicative of multiple anti-seizure mechanisms. Previous studies of topiramate as adjunctive and monotherapy in adults have shown beneficial effects. The objective of this research was to evaluate the efficacy and tolerability of topiramate sprinkle monotherapy in pediatric epilepsy.MethodsThis experimental research was conducted in the Pediatric Neurology outpatient clinic department, Soetomo hospital, Surabaya, involving 18 consecutive subjects. Subjects meeting the inclusion criteria were treated with topiramate sprinkle adjusted dose. Seizure frequency and side effects were observed in weeks 1, 4, 8, 12, 16, 20 and 24, respectively. Electro encephalogram (EEG) and laboratory examinations were performed prior to and after 6 months of treatment. The t-test for related samples and McNemar test were utilized for statistical analysis. ResultsA total of 15 subjects completed the study. Topiramate-treated patients showed a statistically significant difference of seizure frequency reduction from 2.7 ± 1.16 to 0.13 ± 0.51 (p=0.000) with 93.7% patients being seizure free in 20 weeks. EEG recordings did not differ statistically in decrement of epileptiform activity in 20% subjects. About 7% subjects developed drowsiness and 33.3% subjects suffered from appetite suppression in the initial treatment. Laboratory results showed no abnormalities. ConclusionsThere was reduction of seizure frequency and no EEG recording alterations after topiramate sprinkle monotherapy. Topiramate as a monotherapy is highly effcicacious in childhood epilepsy.
Serum 8-isoprostane increased in pre-eclampsia Pramono, Besari Adi; Kristanto, Herman
Universa Medicina Vol 31, No 1 (2012)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.43-51

Abstract

Background The main causes of maternal mortality in Indonesia are pre-eclampsia, hemorrhage, and infection. Oxidative stress has a primary role in pre-eclampsia and one of its parameters is 8-isoprostane serum level. The objective of this study is to measure 8-isoprostane and to analyze the relationship between 8-isoprostane level and birth weight in pre-eclampsia.Methods A cross-sectional study involving 23 pre-eclampsia and 29 normotensive pregnant women with normal or cesarean delivery at Dr. Kariadi Hospital Semarang from January to May 2011. Collected maternal blood samples were assessed for 8-Isoprostane levels by means of a specific ELISA kit. Neonatal birth weight was measured immediately after delivery by means of calibrated baby scales. Differences in 8-isoprostane levels between pre-eclampsia and normotensive women were assessed using independent t-test for normal distributed data, and the Mann-Whitney test for non-normally distributed data. ResultsMean 8-isoprostane level was significantly higher in women with pre-eclampsia than in normotensive women (62.52 ± 12.19 pg/mL vs 28.64 ± 8.81 pg/mL) (p<0.05). Low birth weight was twice as frequent in pre-eclampsia than in normotensives. There was no correlation between 8-isoprostane serum level and neonatal birth weight in pre-eclampsia.Conclusion The level of 8-isoprostane was higher in pre-eclampsia than in normotensives. It is recommended to conduct further studies to determine whether 8-isoprostane may be used as a predictive marker of pre-eclampsia.
Isoflavone supplementation reduced serum sex hormone-binding globulin concentration in postmenopausal women Parwanto, ML. Edy; Indrawati, Yanti; Setiawan, Herman
Universa Medicina Vol 31, No 1 (2012)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.52-62

Abstract

IntroductionThe bone loss that occurs with ageng in postmenopausal women is related to a decrease in serum levels of bioavailable estrogen and testosterone, which are mainly bound to sex hormone-binding globulin (SHBG) and albumin. Phytoestrogens are thought to exert hormonal effects in the body due to their structural resemblance to 17â-estradiol. The objective of this study was to evaluate the effect of isoflavone supplementation on levels of SHBG in postmenopausal women aged 47- 60 years. Methods A study of pre and post test design with controls was conducted in 70 women aged 47- 60 years. Subjects were randomly divided into 2 groups, the isoflavone group received 100 mg isoflavones/day + calcium 500 mg/day and the control group calcium 500 mg/day for 6 months. Measurement of bone mineral density was performed prior to supplementation, and serum SHBG levels before and after supplementation. Results Supplementation of isoflavones for 6 months reduced the SHBG levels by 31.1% in the isoflavone group (p=0.000), whereas supplementation of calcium for 6 months did not affect the levels of SHBG in the control group (p=0.359). Supplementation of isoflavones for 6 months reduced SHBG levels of postmenopausal women in the isoflavone group with either osteopenia (p=0.028) or osteoporosis (p=0.008).Conclusion Supplementation of isoflavones for 6 months decreased the SHBG levels of postmenopausal women in the isoflavone group with osteopenia and osteoporosis. Our findings suggest that phytoestrogens may significantly decreased SHBG levels in postmenopausal women.

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