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All Journal SALAM: Jurnal Sosial dan Budaya Syar-i Universa Medicina
Herman Setiawan, Herman
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Religion Humanities Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Isoflavone supplementation reduced serum sex hormone-binding globulin concentration in postmenopausal women Parwanto, ML. Edy; Indrawati, Yanti; Setiawan, Herman
Universa Medicina Vol 31, No 1 (2012)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.52-62

Abstract

IntroductionThe bone loss that occurs with ageng in postmenopausal women is related to a decrease in serum levels of bioavailable estrogen and testosterone, which are mainly bound to sex hormone-binding globulin (SHBG) and albumin. Phytoestrogens are thought to exert hormonal effects in the body due to their structural resemblance to 17â-estradiol. The objective of this study was to evaluate the effect of isoflavone supplementation on levels of SHBG in postmenopausal women aged 47- 60 years. Methods A study of pre and post test design with controls was conducted in 70 women aged 47- 60 years. Subjects were randomly divided into 2 groups, the isoflavone group received 100 mg isoflavones/day + calcium 500 mg/day and the control group calcium 500 mg/day for 6 months. Measurement of bone mineral density was performed prior to supplementation, and serum SHBG levels before and after supplementation. Results Supplementation of isoflavones for 6 months reduced the SHBG levels by 31.1% in the isoflavone group (p=0.000), whereas supplementation of calcium for 6 months did not affect the levels of SHBG in the control group (p=0.359). Supplementation of isoflavones for 6 months reduced SHBG levels of postmenopausal women in the isoflavone group with either osteopenia (p=0.028) or osteoporosis (p=0.008).Conclusion Supplementation of isoflavones for 6 months decreased the SHBG levels of postmenopausal women in the isoflavone group with osteopenia and osteoporosis. Our findings suggest that phytoestrogens may significantly decreased SHBG levels in postmenopausal women.
Legal Analysis of the Rehabilitation Decision for Narcotics Abusers in District Court Decision Number 43/Pid.Sus/2022/PN Jkt.Brt Rochman, Arif; Setiawan, Herman
SALAM: Jurnal Sosial dan Budaya Syar-i Vol 11, No 1 (2024): Spring Edition
Publisher : Faculty of Sharia and Law UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/sjsbs.v12i1.45685

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Drug abuse has a disturbing impact on society and is a serious concern in efforts to combat illicit drug trafficking in Indonesia. Drug addicts are victims who require special treatment through rehabilitation, as regulated in laws and regulations. In this context, the authority of judges to decide on rehabilitation for drug addicts is interesting to study.This study aims to analyze the legal regulations on rehabilitation for drug addicts and the basis for the considerations of the Panel of Judges in issuing a rehabilitation decision in the District Court Decision Number 43/Pid.Sus/2022/PN Jkt.Brt. The research method used is normative juridical, with a focus on the application of positive legal norms in the case.The results of the study show that the legal regulations on rehabilitation for drug addicts are regulated in Article 1, number 16 of Law No. 35 of 2009 concerning Narcotics. Medical rehabilitation is carried out in hospitals appointed by the government or private hospitals that have obtained permission from the Minister of Health. The Panel of Judges in Decision Number 43/Pid.Sus/2022/PN Jkt.Brt based its considerations on TAT Recommendation Number R/64/X/TAT/2021/BNNP dated October 21, 2021, on behalf of the defendant Thomas Sondegau, ST, which stipulated four months of outpatient rehabilitation at the BNNP DKI Jakarta. This consideration also refers to Article 54 of the Law of the Republic of Indonesia Number 35 of 2009 concerning Narcotics, which requires drug addicts to undergo medical and social rehabilitation.Keywords: Rehabilitation, Drug Addicts, Narcotics
Co-Authors ML Edy Parwanto Rochman, Arif Yanti Indrawati, Yanti