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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 14 Documents
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Search results for , issue "Vol. 42 No. 3 (2023)" : 14 Documents clear
Profile of multidrug-resistant bacteria causing urinary tract infections in inpatients and outpatients in Jakarta and Tangerang Rosana, Yeva; Herliyana, Lina; Krisandi, Grady; Anggraini Suwarsono, Erike
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.303-313

Abstract

Background Urinary tract infections (UTIs) caused by bacteria occupy the second highest rank of common infectious diseases in the world. Empirical use of antibiotics may give rise to multidrug-resistant (MDR) bacteria because of irrational prescription. Choice of antibiotics to treat UTIs is limited because of MDR bacteria. Thus, this study was conducted to investigate the bacterial antibiotic susceptibility patterns in inpatients and outpatients in Jakarta and Tangerang. Methods Bacterial isolates were obtained from midstream urine specimens from 43 inpatients and 43 outpatients with UTIs in Jakarta and Tangerang. Bacteria were isolated on blood and MacConkey agar media using colony count method. Isolate identification and their susceptibility patterns were performed using VITEK2 compact system according to manufacturers’ instructions. Data were analyzed using Chi-square test. Results A total of 89 bacterial isolates consisting of 15 bacterial species were successfully isolated from 86 specimens. Gram-negative bacteria were the most common etiology of UTIs in inpatients and outpatients. MDR bacteria were found in 52 of the 89 isolates. ESBL-producing E. coli was the most common MDR bacteria. ESBL-producing E. coli and other MDR bacteria showed good susceptibility to ertapenem, meropenem, amikacin, and tigecycline. There were no significant differences regarding the MDR bacterial count in inpatients and outpatients (p=0.521). Conclusion E. coli was found to be the most common MDR bacteria causing UTIs in inpatients and outpatients in Jakarta and Tangerang. Higher resistance to many antibiotics was found in MDR bacterial isolates in inpatients compared to outpatients. MDR bacteria in outpatient UTIs were highly resistant to commonly used antibiotics.
Protective role of melatonin in ultraviolet radiation- induced oxidative stress in human skin photoaging Suyanto, Maria Veronica Putri; Widianti, I Gusti Ayu
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.346-359

Abstract

The ultraviolet radiation of the sun that reaches the earth is made up of ultraviolet A (95%) and ultraviolet B (5%). Exposure to ultraviolet radiation (UVR) is the main factor in photoaging. Chronic exposure to sunlight acts as an environmental stressor, leading to oxidative damage or stress. Oxidative damage stimulates the accumulation of free radicals, such as reactive oxygen species (ROS) or reactive nitrogen species (RNS) that are responsible for premature skin aging. Photoaged skin is characterized externally by irregular pigmentation, wrinkles, and reduced skin elasticity, and internally by the breakdown of dermal collagen and elastin. Free radicals can be scavenged and the skin can be protected from further oxidative damage by antioxidants. Melatonin is a hormone produced mainly by the pineal gland, as well as many other organs, including the skin. One of the functions of melatonin is exerted by the antioxidative melatoninergic system to prevent ultraviolet (UV)-induced skin photoaging. The aim of this review was to study the protective effect of melatonin on skin photoaging resulting from UVR exposure. The references were tracked using various databases, such as Google Scholar and PubMed with regard to publications in English for the last 5 years (2019-2023). Melatonin inhibits UVR-induced aging in multiple ways, such as protecting skin cells, binding free radicals, accelerating the activity of antioxidant enzymes, preventing increased mitochondrial membrane permeability, and assisting electron transport efficiency in the mitochondrial respiratory chain. Exogenous application of melatonin is usually by the oral route, but for localized effects on the skin, topical administration is recommended, with consideration of preparations with a better half-life and bioavailability. Understanding the protective antioxidant function of melatonin in UV-induced skin photoaging helps to optimize its application. The protective properties of melatonin against UVR-oxidative stress-induced photoaging will be further explored in this review.
Correlation of angle kappa with biometry and higher-order aberrations of cataract patients at Prof. Ngoerah Hospital Ophthalmology Clinic Siska, Siska; Suryaningrum, I Gusti Ayu Ratna; Evani, Saphira
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.314-319

Abstract

Background Advancements in ophthalmic surgery now hinge on intricate interplays among ocular parameters. Angle kappa, measuring deviation between visual and pupillary axes, is crucial, especially in refractive procedures with multifocal intraocular lens implants. The research aimed to correlate angle kappa with biometry and higher-order aberrations (HOA) to enhance surgical outcomes among adult cataract patients at Prof. Ngoerah Hospital Ophthalmology Clinic, Denpasar, Bali. MethodsThis cross-sectional study included 29 male and female cataract patients aged 18-80 years, without prior treatment. All patients had a basic examination that included testing of visual acuity using Snellen chart, autorefractometer, measurement of ocular pressure using non-contact tonometry, and slit-lamp examination for cataract grading. Patients who met the inclusion criteria were then examined for biometry (axial length, spherical equivalent, white-to-white distance, anterior chamber depth) using Nidek AL Scan and for angle kappa and HOA using OPD scan III. ResultsData from 50 eyes of 29 subjects (15 females and 14 males) were analyzed. The mean age of the subjects was 60.6 ± 12.5 years. Age and spherical equivalent had positive correlation with angle kappa (r =0.104, r=0.213), but the correlation was not statistically significant. In this study, interestingly angle kappa was not significantly correlated with HOA, AXL, WTW, and ACD (r = -0.050, r = -0.192, r = -0.104, r = -0.195, p >0.05). ConclusionIn conclusion, angle kappa may increase with age and spherical equivalent. Further study with larger sample size is required.
Time to treat the climate and nature crisis as one indivisible global health emergency Abbasi, Kamran; Ali, Parveen; Barbour, Virginia; Benfield, Thomas; Bibbins Domingo, Kirsten; Hancocks, Stephen; Horton, Richard; Laybourn Langton, Laurie; Mash, Robert; Sahni, Peush; Sharief, Wadeia Mohammad; Yonga, Paul; Zielinski, Chris
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.251-254

Abstract

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