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Roni Koneri
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Jurnal Bios Logos
Published by Universitas Sam Ratulangi
ISSN : 20889569     EISSN : 26563282     DOI : https://doi.org/10.35799/jbl.11.2.2020.28153
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology
JURNAL BIOS LOGOS is the journal published by Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University. The aims of the journal are to publish original research papers and article review in biology science i.e. botany, zoology, molecular biology, microbiology, ecology, diversity and conservation, taxonomy and biogeography. BIOS LOGOS is published two times per year (February and August)
Arjuna Subject : Ilmu Pertanian dan Biologi (Semua) - Ilmu Pertanian dan Biologi (Lain-Lain)
Articles 15 Documents
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Search results for , issue "Vol. 15 No. 1 (2025): JURNAL BIOS LOGOS" : 15 Documents clear
In Silico Study of Quercetin and Its Derivatives as Potential Antituberculosis Angelina Stevany Regina Masengi; Greachylia Chelzy; Jimmy Posangi; Trina Ekawati Tallei; Fatimawali; Christi Diana Mambo; Dian Augina Rintibulawan Rambulangi
JURNAL BIOS LOGOS Vol. 15 No. 1 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i1.60150

Abstract

Tuberculosis (TB) remains the second leading cause of death in the world, with the resistance of Mycobacterium tuberculosis to first-line drugs, such as isoniazid (INH), contributing to the emergence of multi-drug resistant TB (MDR-TB). This study aims to evaluate the potential of quercetin and its derivatives as InhA enzyme inhibitors through an in silico approach to offer innovative therapeutic alternatives to improve the effectiveness of TB treatment. The analysis includes physicochemical properties, ADMET profiles, molecular interactions, and affinity of compounds to the InhA enzyme as an antituberculosis target. The study workflow included ligand and receptor preparation, prediction of biological activity, physicochemical and ADMET analysis, docking validation, molecular docking, and visualization of molecular interactions. Molecular docking was performed using Gnina software, showing that rutin has the lowest binding energy (ΔG) of -12.22 kcal/mol, indicating strong interaction affinity. In addition, ADMET and toxicity analysis showed good pharmacokinetic potential for the test compounds Docking validation confirmed the reliability of the employed methodology, further supporting the potential of quercetin and its derivatives as antituberculosis candidates. However, although quercetin and its derivatives showed promising biological activity, the ADMET profile results were variable, requiring further optimization to develop effective and safe TB therapies.
Novel Innovations in Herbal Wine and Pharmacological Potential Dwi Rahayu Pujiastuti; Mario Nikolaus Dalengkade
JURNAL BIOS LOGOS Vol. 15 No. 1 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i1.62572

Abstract

In recent years, the wine industry has undertaken various innovations to support the development of functional foods, as evidenced by numerous wine products formulated with herbal plants. These combinations have resulted in a diversity of secondary metabolites, which are of significant interest to the pharmaceutical industry. Nevertheless, further breakthroughs are needed to introduce novelty in herbal wine products. One such innovation involves the utilization of Cymbopogon citratus, Zingiber officinale, Citrus hystrix, Elettaria cardamomum, Cinnamomum verum, Syzygium aromaticum, and Caesalpinia sappan L. This study identified 85 compounds, demonstrating distinct differences in the chemical of bioactive compounds between the raw herbal plants and the fermented product. These differences are attributed to substitution reactions occurring in the carbon framework, resulting in the formation of derivative compounds in the herbal wine. Additionally, enzymatic reactions mediated by Saccharomyces cerevisiae during fermentation led to the formation of biologically important precursors, such as N-Acetylmannosamine, which plays a role in the regulation of GNE gene mutations. Therefore, the herbal wine produced in this study presents potential as a functional food with promising pharmacological applications.
Uji Aktivitas Hepatoprotektor pada Tikus Model Kanker Payudara yang Diinduksi Benzo(A)Piren Setelah Pemberian Ekstrak Metanol Daun Biwa (Eriobotrya japonica Lindl) Fitri Elizabrth Hasibuan; Widya Syahfitri; Salomo Hutahaean; Syafruddin Ilyas; Febry Rahmadani Hasibuan
JURNAL BIOS LOGOS Vol. 15 No. 1 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i1.63461

Abstract

This study aimed to evaluate the hepatoprotective activity of methanolic extract of loquat (Eriobotrya japonica Lindl) leaves in breast cancer model rats induced by benzo(α)pyrene. This study used a completely randomized design with five groups: Group I as the negative control, Group II as the positive control (administered BaP 50mg/KgBW), and three treatment groups receiving methanolic extract of loquat leaves at doses of 200 mg/kg BW, 300 mg/kg BW, and 400 mg/kg BW for 30 days. Blood serum samples from the breast cancer model rats were analyzed to determine SGPT and SGOT levels using the IFCC method. Data were statistically analyzed using Analysis of Variance (ANOVA) followed by Tukey’s HSD post-hoc test. The results showed no significant differences between the treatment and control groups for SGOT (F(4,20) = 0.7123, P = 0.593) and SGPT (F(4,20) = 0.4460, P = 0.774) levels. Based on these findings, it can be concluded that administration of methanolic extract of loquat leaves did not cause liver function impairment in the breast cancer model rats. These results support the potential of loquat leaf extract as a hepatoprotective agent, particularly in maintaining stable SGPT and SGOT levels in breast cancer conditions.
Anatomical Study of Pigmented Rice Leaves (Oryza sativa L.) Resistant to Blast (Pyricularia grisea Sacc.) Disease Pingkan Krista Mantiri; Fione Yukita Yalindua
JURNAL BIOS LOGOS Vol. 15 No. 1 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i1.63500

Abstract

Pigmented Rice (Oryza sativa L.) is one of Indonesia’s local crops with potential to be developed as a source of healthy food. A major constraint in pigmented rice cultivation is the emergence of the fungus Pyricularia grisea (Sacc.), which causes blast disease. This pathogen attacks the leaves, leading to growth damage and even plant death. All plants inherently possess defense mechanisms against external threats, whether biotic (insects, fungi, bacteria, viruses) or abiotic (environmental stress). These mechanisms involve anatomical response. Previous research identified a pigmented rice variety, Cempo Ireng, that exhibits resistance to blast disease caused by P. grisea. Pigmented rice is also known to contain high levels of phenolic compounds and flavonoids, which contribute to plant defense and coloration. This study aims to determine the total phenolic and flavonoid content in the leaves of blast-resistant and susceptible pigmented rice varieties infected by P. grisea (Sacc.). Two pigmented rice varieties were tested: Cempo Ireng (resistant) and Indmira Hitam (moderately resistant). Control Varieties: Asahan (blast-resistant) and Kencana Bali (susceptible). Based on the results of this study, Cempo Ireng and Asahan showed strong resistance to blast disease, Indmira Hitam exhibited moderate resistance and Kencana Bali was highly susceptible to P. grisea infection. Anatomical observations of leaves using leaf surface section showed differences in structural modification of epidermal thickness, mesophyll thickness and the diameter of vascular bundle, where Cempo Ireng varieties were able to form good epidermal thickness as the initial barrier of defense. The anatomical observations of leaves using SEM showed anatomical differences in trichome density in Cempo Ireng and Asahan leaves which had the highest density compared to other varieties in response to the attack of fungal pathogens.
Isolation, Screening, and Optimization of Amylase-Producing Endophytic Bacteria from Rhizophora apiculata Agustina Monalisa Tangapo; Susan Marlein Mambu; Pience Veralyn Maabuat; Dwina Kristianti; Williando Ering; Lalu Wahyudi
JURNAL BIOS LOGOS Vol. 15 No. 1 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i1.63548

Abstract

High amylase enzyme production requires optimal supporting factors for enzyme production. The purpose of this study was to determine the optimum conditions for endophytic bacterial fermentation, including substrate concentration, pH, and fermentation temperature, for the production of amylase from endophytic bacteria of mangrove plants Rhizophora apiculata. Analysis of amylase enzyme activity was carried out using the 3,5-dinitrosalicylic acid (DNS) assay. The results obtained from this research were from a total of 18 endophytic bacteria R. apiculata that were successfully isolated, 6 bacterial isolates were obtained which showed the ability to produce extracellular amylase. The potential of bacteria for amylase production grown on 0.5% starch media was determined based on the ratio between the diameter of the halo zone and the diameter of the bacterial colony. Three isolates were selected, EB.5, EB.10, and EB.12 for further optimization of the fermentation conditions for amylase production. Based on the results obtained, it was shown that the fermentation conditions for amylase enzyme from the three isolates of endophytic bacteria were optimum in media with a concentration of 1.5% starch, in media with a pH of 6, and optimum in the temperature range of 30oC.

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