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Muhammad Sulaiman Zubair
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Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)
Published by Universitas Tadulako
ISSN : 24427284     EISSN : 24428744     DOI : https://doi.org/10.22487/j24428744
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (E-ISSN: 2442-8744) (p-ISSN: 2442-7284), is an open access journal (print and e-journal) focusing on the scientific works in the field of Pharmacy and Pharmaceutical Science. The articles of this journal are published every six months, that is March and October (2 issues per year). This journal is developed by Department of Pharmacy, Faculty of Mathematics and Natural Science, Tadulako University and has been identified in Crossref with the DOI Number : 10.22487/j24428744. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) has been accredited by Kemenristekdikti as Sinta 3 starting from Volume 5 No 1 2019.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 12 Documents
 1   2 
Search results for , issue "Vol. 3 No. 2 (2017): (October 2017)" : 12 Documents clear
Aktivitas Anti-inflamasi Ekstrak Etanol Daun Beluntas (Pluchea indica L.) pada Model Inflamasi Terinduksi CFA (Complete Freund's Adjuvant) : Anti-inflammatory Activity of Ethanol Extract of Beluntas Leaves(Pluchea indica L.) on Complete Freund's Adjuvant-induced Inflammatory Model Reza Setiawan Sudirman; Usmar Usmar; Abdul Rahim; Muh. Akbar Bahar
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 3 No. 2 (2017): (October 2017)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.095 KB) | DOI: 10.22487/j24428744.0.v0.i0.8921

Abstract

A research about anti-inflammatory effect of Beluntas leaves extract on CFA (Complete Freund’s Adjuvant) induced inflammatory model has been conducted. The objective of this research was to determine the effect of Beluntas leaves extract in alleviating CFA-induced paw edema in mice (Mus musculus). The number of mice used was 15 and was divided into 5 groups. Group I was treated with NaCMC. Group II, III, and IV were given suspension of Beluntas leaves extract 100 mg/Kg, 300 mg/Kg, and 500 mg/Kg BW, respectively. Group V was a positive control treated with suspension of diclofenac sodium 0.1 ml/10 g orally. The determination of anti-inflammatory potency was based on the average time needed to ameliorate the edema volume. The shortest time period of edema reduction was produced by diclofenac sodium (within 9.33 days), then followed by Beluntas leaves extract with the concentration of 300 mg/Kg (within 12 days), 500 mg/Kg (within 14.33 days), and 100 mg/Kg (within 17.67 days), consecutively. These results are significantly different compared to negative control group which did not reduce the edema volume during 18 days of observation. In conclusion, ethanol extract of Beluntas leaves has an effective anti-inflamatory effect.
Sensor Asam Nukleat Sebagai Aktivator Imunitas Intrinsik Terhadap Patogen Intraseluler: Nucleic Acid Sensors as Activators of Intrinsic Immunity Against Intracellular Pathogens Usmar Usmar; Rudi Arfiansyah; Firzan Nainu
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 3 No. 2 (2017): (October 2017)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (480.173 KB) | DOI: 10.22487/j24428744.0.v0.i0.8922

Abstract

Vertebrata, termasuk manusia, dilengkapi dengan sistem imun alamiah dan sistem imun adaptif yang saling bekerjasama untuk melindungi tubuh dari material berbahaya, termasuk berbagai patogen dan sel-sel kanker. Kedua sistem imun tersebut secara rutin melakukan pengecekan terhadap beragam material yang ada di dalam tubuh. Salah satu cara yang digunakan oleh sistem imun dalam melaksanakan tugasnya adalah melalui pengaktifan sensor asam nukleat yang berfungsi untuk memberikan informasi keberadaan DNA atau RNA asing maupun kemungkinan adanya salinan DNA inang di sitoplasma atau lokasi lain yang tidak semestinya. Ketika genom patogen terdeteksi oleh sensor-sensor tersebut, selanjutnya efektor sistem imun akan diaktivasi melalui serangkaian proses dan berakhir dengan eradikasi asam nukleat target atau bahkan induksi apoptosis sel yang bersangkutan. Beberapa sensor asam nukleat yang telah ditemukan antara lain adalah Toll-like receptor (TLR), RIG-I-like receptors (RLRs), cyclic GMP-AMP synthase (cGAS), dan interferon-γ-inducible protein 16 (IFI16). Namun, sejumlah patogen telah memiliki mekanisme untuk menghindari sensor-sensor tersebut sehingga infeksi tetap dapat terjadi. Dengan demikian, berbagai penelitian untuk meningkatkan pengetahuan tentang bagaimana sensor asam nukleat bekerja sebagai salah satu respon imun intraseluler serta mekanisme terbentuknya resistensi patogen terhadap deteksi sensor tersebut sangat penting untuk didorong. Hal ini akan memberikan wawasan baru dalam pengembangan berbagai sediaan farmasi terkait seperti vaksin dan antimikroba intraseluler.

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