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INDONESIA
Jurnal Fitofarmaka Indonesia
Published by Universitas Muslim Indonesia
ISSN : 23560398     EISSN : 25412329     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
Jurnal Fitofarmaka Indonesia merupakan salah satu jurnal yang dikelola oleh Laboratorium Farmakognosi-Fitomikia Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Januari 2014. Jurnal Fitofarmaka Indonesia merupakan jurnal ilmiah yang terbit secara on-line dan cetakan serta menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 7, No 2 (2020): JURNAL FITOFARMAKA INDONESIA" : 5 Documents clear
UJI AKTIVITAS EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) SEBAGAI INHIBITOR ENZIM α-GLUKOSIDASE DENGAN MENGGUNAKAN ELISA READER Sukmawati Syarif; Nurnaningsih Nurnaningsih; Mamat Pratama
Jurnal Fitofarmaka Indonesia Vol 7, No 2 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v7i2.506

Abstract

Kersen leaves (Muntingia calabura L) contain metabolites such as alkaloids, anthrax, polyphenols, tannins, saponins and are rich in flavonoid components such as flavones, flavonones, flavan and biflavan which have antidiabetic activity. According to a study conducted by Apriyanti (2016), the ethanol extract of kersen (Muntingia calabura L) at a dose of 250 mg / kg BB significantly reduced blood glucose levels in male wistar rats. In this study aimed at determining IC50 ethanol extract of Muntingia calabura L as an inhibitor of α-glucosidase enzymes using ELISA reader. The method was divided into 3 category is 1 (sample extract), 2 (blank) and 3 (akarbose). Each group added 25 µL α-glucosidase solution (0.25 units / mL then measured using ELISA reader 405 nm. The results showed that the ethanol extract of kersen (Muntingia calabura L) had activity as an inhibitor of α-glucosidase enzyme with IC50 34,197 µg / mL and can be categorized as active.
ISOLASI SENYAWA KIMIA FRAKSI n-HEKSANA DAUN BILARAN TAPAH (Argyreia nervosa (Burm. F.) ASAL KALIMANTAN SELATAN Sutomo Sutomo; Putri Helena Junjung Buih; Arnida Arnida
Jurnal Fitofarmaka Indonesia Vol 7, No 2 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v7i2.527

Abstract

ABSTRACTOne of the plants that is used empirically by people in South Kalimantan as a traditional medicine is bilaran tapah (Argyreia nervosa (Burm. F.). This plants that has purposed antiinflamation, antimicroba, antidiabetic, diuretic, and aphrodisiac. This research aims to isolate and explore the chemical compounds of n-hexana fraction of A. nervosa leaves. Extraction is conducted by using maceration method. Isolation is conducted by using Vacumn Liquid Chromatography and gravity chromatography column. Identification qualitative assay of compound used TLC test, UV-Vis and FTIR spectrophotometry. The extraction of 500 grams A. nervosa leaves rough powder with 96% ethanol extracts produces 16,92% of rendement. The fractionation of 30 grams ethanol extracts with n-hexane produces 23,60% of rendement. N-hexane fraction by using VLC with n-hexane : ethyl acetate eluent 25:1; 20:1; 15:1; 10:1; 9:1; 8:2; 7:3 ; 6:4) v/v and methanol : etyl acetate (1:4) v/v produces fractions A, B, C, D, E, F, G, H, and I. Fraction F was chosen for isolation using PTLC with n-hexane :etyl acetate eluent (8:2) v/v. Fraction C is chosen to be isolated by using gravity chromatography column with n-hexane : ethyl acetate eluent (25:1) v/v. TLC qualitative test with H2SO4 10% and Liebermann-Burchard reagent shows that C-4 isolates contains terpenoid compounds. Analysis of C-4 isolates by using UV-Vis spectrophotometry reach peak at λ 245 nm. Analysis FTIR spectra shows that the functional groups of C-4 isolates are -OH (3309.85 cm-1), -CH aliphatic (2939.52 cm -1 and 2870.08 cm-1), C = C (1635.64 cm- 1) and C-O (1033,85 cm-1).
PERBANDINGAN AKTIVITAS EKSTRAK DAUN KELOR DAN TEH HIJAU SERTA KOMBINASI SEBAGAI ANTIBAKTERI PENYEBAB JERAWAT Asri Wulandari; Yunahara Farida; Shelly Taurhesia
Jurnal Fitofarmaka Indonesia Vol 7, No 2 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v7i2.535

Abstract

Daun kelor dan daun teh hijau telah terbukti berkhasiat sebagai antibakteri penyebab jerawat terhadap  S. aureus dan P. acne. Kandungan yang berkhasiat sebagai antibakteri penyebab jerawat pada daun kelor adalah kuersetin dan pada daun teh hijau adalah katekin. Tujuan penelitian ini untuk mengetahui aktivitas antibakteri terhadap S. aureus dan P. acne pada berbagai konsentrasi ekstrak daun kelor dan teh hijau serta kombinasi ekstrak daun teh hijau dan kelor dengan rasio 1:2, 1:1 dan 2:1. Ekstraksi dilakukan dengan maserasi kinetic menggunakan etanol 70%. Uji aktivitas antibakteri menggunakan metode difusi agar sumuran. Hasil uji aktivitas antibakteri terhadap S. aureus menunjukan bahwa KHM ekstrak daun kelor dan daun teh hijau berturut-turut adalah 2.5% dan 1.25% dengan zona hambat 8 mm dan 7 mm dan KHM ekstrak daun kelor dan daun teh hijau berturut-turut 2.5% dan 1.25% terhadap P. acne adalah dengan zona hambat 9 mm dan 5 mm. Aktivitas antibakteri terbaik kombinasi ekstrak daun teh hijau dan kelor pada rasio 1:2 terhadap bakteri S. aureus dan P. acne dengan zona hambat berturut-turut 16 ±  0,471 mm dan 16 ± 0,942 mm. Kontrol positive yang digunakan Mediklin® dengan zona hambat 50 mm.
Isolasi Dan Karakterisasi Senyawa Steroid Dari Ekstrak Biji Mahoni (Swietenia mahagoni Jacq.) Fadillah Maryam; Subehan Subehan; Lilis Musthainah
Jurnal Fitofarmaka Indonesia Vol 7, No 2 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v7i2.647

Abstract

Mahogany seeds (Swietenia mahagoni Jacq.) Have many benefits as drugs such as febrifuge, diabetes (Diabetes Mellitus), high blood pressure, fat decay, colds, colitis, diarrhea, wounds, and ulcers. Swietenia mahagoni Jacq Contain steroid compounds. This study aims to determine the characterization of steroid compounds isolated from mahogany seed extract (Swietenia mahagoni Jacq.). Extracts were obtained from maceration processes using n-hexane, ethyl acetate, and ethanol 70% solvents with percent of rendament of 6.34%, 7.34%, and 8% respectively. The test results for the chemical content of ethyl acetate extract positively contained steroids. 5 grams of extract was carried out using conventional column chromatography to produce 6 fractions. Fraction 6 were selected and continued with preparative thin layer chromotography and produced 2 isolates. Isolates P2b which showed one tonggal stain on the TLC profile with a value of Rf 0.50 were continued to be analyzed by UV-Vis and FT-IR spectrophotometry.The results of UV-Vis spectrophotometric isolates P2b had maximal absorption at a wavelength of 253.50 nm. FT-IR data shows the presence of functional groups C-H, C-O, C = O, C = C, and O-H whichare thought to be steroid compounds.
POTENSI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAN FRAKSI N-HEKSAN BUAH JERUK PAMELO (Citrus maxima (Burm) Merr) ASAL KABUPATEN PANGKEP Masdiana Tahir; Asriani Suhaenah; Yulinda Rahim
Jurnal Fitofarmaka Indonesia Vol 7, No 2 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v7i2.488

Abstract

Pomelo citrus (Citrus maxima (Burm) Merr) is a fruit plant that has the potential to be developed for health. Pomelo fruit contains lycopene, flavonoids and vitamin C which can provide antioxidant activity. The purpose of this study was to determine the potential antioxidant activity of ethanol extract and fraction of n-hexane of pomelo citrus using quercetin as a comparison. Extraction of pomelo citrus fruit using the maceration method with liquid-liquid fractionation using water and n-hexane (1: 3 v / v). Testing of antioxidant activity using the DPPH (1,1-Diphenyl-2-picrylhidrazil) method is based on the ability of the sample to capture DPPH free radicals which are characterized by purple to yellow discoloration and a decrease in the absorbance value of DPPH which has reacted with samples in certain concentrations. Absorbance measurements using a UV-Vis spectrophotometer at a wavelength of 514,942 nm. The results showed that the IC50 value of quercetin was 6.55 µg / mL which was a strong antioxidant, while the IC50 value of the ethanol extract of pomelo citrus fruit was 2882.26 µg / mL and IC50 value of the n-hexane fraction of pomelo orange was 3668,44 µg / mL which is a weak antioxidant category. Kata kunci : Antioxidants, Ethanol Extract, n-Hexane Fraction, Pomelo citrus (Citrus maxima (Burm) Merr

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