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Journal of Medicine and Health

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Published by Universitas Kristen Maranatha

ISSN : 24425227 EISSN : - DOI : -

Core Subject : Health, Science,

Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Journal of Medicine and Health (JMH) is an open access journal (OAJ), a periodic scientific publication biannually online published on February and August; using review and screening system by peer group reviewer. JMH receives original research articles which related to medicine, health, new developing therapy from traditional medicine or herbs and developing clinical therapy. JMH also receives otiginal review articles, case report, continuing medicine and health study. Articles should be written in good English or Indonesian language.

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Articles 11 Documents

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Search results for , issue "Vol. 2 No. 5 (2020)" : 11 Documents clear

Potensi Kombinasi Mikrosfer Fukoidan dan MiRNA-200b sebagai Terapi pada Kanker Payudara Kemoresisten Sinta Wiranata; Made VW Yani; Agung Bagus S Satyarsa; I Ketut R Ardiana; Putu AT Adiputra
Journal of Medicine and Health Vol. 2 No. 5 (2020)
Publisher : Universitas Kristen Maranatha

Breast cancer still become a major health problem in Indonesia and worldwide until today. Based on WHO 2012, breast cancer incidence is reported as 1.67 million cases with 90% of mortality rate in the metastasis stage. Chemoresistant is one cause of this increased mortality and morbidity. Nowadays, there are many treatment choices for cancer, but 90% incident of chemoresistant breast cancer occur even with prior chemotherapy. This review aimed to describe the potential of microsphere combinations fucoidan and miRNA-200b as a treatment for chemoresistant in breast cancer. Literature review were derived from scientific journals using www.pubmed.com and scholar.google.com database with “chemoresistant breast cancer, Fucoidan, microRNA-200b” as keyword. Fucoidan can induce apoptosis through the extrinsic pathway involving apoptotic receptor, or intrinsic pathway involving changes in mitochondrial membrane potential (MMP) to release cytochrome C and activating the apoptotic signal. Meanwhile, miRNA-200b expression, will decrease Sp1 expression and decrease histone-3 acetylation level in a miRNA-200b promoter, resulting in decreased cancer cell migration and invasion. However, no studies have evaluated this combination clinically. So, further studies are needed to confirm the potential of microsphere combination fucoidan and miRNA-200b in chemoresistant breast cancer. Keywords: chemoresistant breast cancer; Fucoidan; miRNA-200b.

Gambaran Penderita Diabetes Mellitus tipe 2 dengan Obat Antidiabetik Oral Grace Y Irene; Kuswinarti Kuswinarti; Maya Kusumawati
Journal of Medicine and Health Vol. 2 No. 5 (2020)
Publisher : Universitas Kristen Maranatha

Uncontrolled hyperglycemia in people with diabetes mellitus can increase the risk of diabetes complications and comorbidities. This study aimed to determine the demographic, clinical, history, complications, and comorbid characteristics of diabetes. The study was conducted with a descriptive method and cross-sectional research design. Data were collected retrospectively using medical record data and using the Finite Population Correction formula with a sample of 115. The results showed the majority of patients were female (67.8%), aged ? 65 years (40.0%), residing in urban (87.6%), high school graduates (35.2%), and unemployed (63.6%). Patients generally have a normal BMI (45.9%) and have several variables that reach the target, namely fasting blood glucose (50.4%), triglycerides (55.3%), and creatinine (69.6%). Patients also had several variables that did not reach the target, namely postprandial 2 hour blood glucose (51.3%), blood pressure (65.8%), total cholesterol (55.6%), HDL cholesterol (54.5%), LDL cholesterol (80.0%), and urea (56.0%). Patients who use oral anti-diabetes generally have used it <5 years (76.3%) and used monotherapy (63.5%). Neuropathy (42.6%) and hypertension (85.9%) were the most common complications and comorbidities of diabetes in this study. Strict glycemic control is an important management for people with diabetes mellitus. Keywords: oral antidiabetic drugs; diabetes mellitus; comorbid

Kombinasi Nanopartikel Cisplatin-Withaferin Berbasis PEGylated Liposome Sebagai Terapi Alternatif Kanker Ovarium Made VW Yani; Ida Ayu W Anjani; I Gede S Narayana; Desak M Wihandani; I Gede P Supadmanaba
Journal of Medicine and Health Vol. 2 No. 5 (2020)
Publisher : Universitas Kristen Maranatha

Ovarian cancer is one of the major health problems in gynecology worldwide. Globocan 2012 data shows that ovarian cancer occurs in 239.000 cases, and is placed fourth as the most malignancy occurred in Indonesia. So far, cisplatin is the most effective therapeutic agent, but the high dosage of administration often caused side effects. A new alternative therapy to overcome the problems by using withaferin-A and nanoparticle PEGylated liposome. WFA has the potential effect to reduce cisplatin resistance but has low bioavailability thus, it needs to be encapsulated. This review’s goal is to depict the potency of withaferin-A, cisplatin, and PEGylated liposome combination as a therapeutic agent to treat ovarian cancer. The combination of Cisplatin-Withaferin PEGylated Liposome is constructed by the modified thin lipid film hydration method then administered orally. This combination suppresses 70-80% of the ovarian cancer cell growth in vivo and inhibits NGFR from binding to TRKA, prevents cell migration as much as 50%. Nano-Cisferin-Liposome, inhibits migration of ovarian cancer cell significantly through ?-catenin signaling through ALDH1 that disturb the spheroid formation, and increase apoptosis event as much 70-80% by increasing ROS production up to 2,5 times. Thus, Nano-Cisferin-Liposome (NCL) has potential as a therapeutic agent for treating ovarian cancer. Keywords: Cisplatin; Ovarian Cancer; PEGylated Liposome; Withaferin A

Efek Kinesio Taping pada Latihan Penguatan Otot Kuadriseps terhadap Kekuatan Otot Kuadriseps san Status Fungsional Penderita Osteoarthritis Lutut Anggia P Nayanti; Tertianto Prabowo; Dian M Sari
Journal of Medicine and Health Vol. 2 No. 5 (2020)
Publisher : Universitas Kristen Maranatha

Knee Osteoarthritis (KOA) is characterized by knee cartilage degradation. Knee Osteoarthritis symptoms are joint pain, stiffness, quadriceps muscle weakness and daily activities difficulties. The use of Kinesio Taping (KT) in Quadriceps muscle strengthening exercises (QSE) is known to increase quadriceps muscle strength, reduce pain and improve functional abilities in KOA. This study aimed to determine the effect of KT with QSE on quadriceps muscle strength and functional status in KOA. This is a double-blind randomized controlled trial, involving twenty-six KOA women that were divided equally into treatment and control groups. The treatment group was given KT and QSE, the control group received sham taping and QSE. Quadriceps muscle strength and WOMAC scores were measured before and after treatment at 4, 6 and 8 weeks. There was a significant difference in quadriceps muscle strength at the 6th week (p = 0.019) between treatment and control groups and no significant differences (p> 0.05) in the strength of quadriceps muscle at 4th and 8th weeks and WOMAC values ??at 4th, 6th and 8th weeks. We concluded that a combination of KT with QSE offers advantages for improvement of quadriceps muscle strength at 6th week but not for functional status in KOA. Keywords: Kinesio taping, Osteoarthritis, Strengthening exercises, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

Kasus Lupus Vulgaris yang Didiagnosis Tanpa Biopsi Kulit Dian Puspitasari; Feilicia Henrica
Journal of Medicine and Health Vol. 2 No. 5 (2020)
Publisher : Universitas Kristen Maranatha

Lupus vulgaris is a variant of cutaneous tuberculosis in a previously sensitized individual that has a high degree of delayed-type hypersensitivity to tuberculin. Absolute criteria for the diagnosis of cutaneous tuberculosis is a positive M. tuberculosis culture on guinea pig or polymerase chain reaction (PCR) examination. We reported a case of lupus vulgaris in a 32 years old female. A diagnosis of lupus vulgaris was made by clinical manifestation, therapeutic trial, interferon-gamma release assay (IGRA) test, and other laboratory tests. The patient presented with an erythematous scaly plaque on the face and left hand. Diascopy test was positive, consistent with the “apple jelly” sign. Regression of lesion was observed after 1 month of therapy with anti-tuberculosis drugs. Culture, PCR, and histopathological examination were not established due to patient’s refusal. The patient was allergic to pyrazinamide and ethambutol, therefore she was initially treated with a daily dose of 450 mg Rifampicin, 300 mg isoniazid (INH), and 500 mg levofloxacin for 2 months and continued with maintenance phase, three times weekly of 450 mg Rifampicin and 450 mg INH until one year. Treatment provided a good result. Keywords: tuberculosis; lupus vulgaris; therapeutic trial

Perawatan Komprehensif Rampan Karies pada Anak Usia Delapan Tahun Triana N Yusuf; Jeffrey Jeffrey
Journal of Medicine and Health Vol. 2 No. 5 (2020)
Publisher : Universitas Kristen Maranatha

The prevalence of dental caries in Indonesia primary school is 60-80%. Dental caries is a continuous dynamic process involving repeating periods of demineralization by organic acids of microbial origin and subsequent remineralization by salivary components, but in which the overall environment is imbalanced towards demineralization. Rampant caries is a sign of gross dietary inadequacy, complete absence of oral hygiene practice or systemic illness. Rampant caries is suddenly appearing, widespread, rapidly burrowing type of caries, resulting in early involvement of the pulp and affecting those teeth usually regarded as immune to ordinary decay. This case report presents a case of rampant caries in an 8-year-old boy and the treatment. The cooperative behavior of patients and parents is needed for optimal results. Keywords: Rampant caries; caries in children; caries

Faktor-faktor yang Berhubungan dengan Terjadinya Gangguan Pendengaran pada Pilot Helikopter dan Casa Nurfitriyana, Nurfitriyana; Ivone, July; Adhy, Pramusinto
Journal of Medicine and Health Vol. 2 No. 5 (2020)
Publisher : Universitas Kristen Maranatha

Noise-Induced Hearing Loss (NIHL) is a hearing disorder caused by noise. Noise with the intensity of 85 decibels (dB)or higher may damage the corti hearing receptor. Pilot is one of the riskiest occupations due to frequent noise exposure from aircraft machine. This research aimed to identify the influence of aircraft noise levels on hearing disorder of both helicopter and casa pilots. This is observational analytical research with cross-sectional design, involving 30 helicopter pilots and 30 casa pilots. The diagnosis of hearing disorder was done using secondary data from medical records. The aircraft noise was measured by sound level meter, the other risk factors were observed with questionnaire. Data were analyzed by chi-square with ?=0,05. The results showed that aircraft noise (p=0,009; OR=4,929), duration of working period (p=0,026; OR=8,308), and flight hours (p=0,006; OR=3,222) were related with hearing disorder, but not age (p=0,093; OR=3,222). We concluded aircraft noise, duration of the working period, and flight hours are related to hearing disorder of the pilots. Keywords: hearing disorder; pilot; noise; noise-induced hearing loss

Hubungan Tingkat Kebiasaan Merokok dengan Stadium Katarak Senilis di Poliklinik Katarak dan Bedah Refraktif (KBR) Rumah Sakit Mata Cicendo Bandung
Journal of Medicine and Health Vol. 2 No. 5 (2020)
Publisher : Universitas Kristen Maranatha

Cataract is the leading cause of blindness in the world, including Indonesia. Senile cataract is the most common type of cataract, caused by the aging process, and involving many factors such as genetic, ultraviolet radiation, dietary factors, dehydration, and smoking. Smoking is one of the causes involved in the maturity of cataract release due to the accumulation of the 3-hydroxykhynurine molecules and chromophores that have roles in changing the color of the lens. This research aimed to find the relationship between smoking levels and senile cataract severity. This is descriptive correlative research with a cross-sectional approach. The subjects were senile cataract patients with smoking habits at the cataract and refractive surgery clinic of Cicendo Eye Hospital Bandung, Indonesia. We recruited 337 patients with purposive sampling technique. Data were collected through interviews and medical record data. Data were analyzed using Chi-square statistical analysis. We found that 61.7% of the patients were light smokers and 66.2% had immature senile cataracts, and the statistical analysis found a significant correlation between smoking level and senile cataract stadium (p=0.000. We concluded that there is a correlation between smoking level and senile cataract severity. Keywords: cataract; senile cataract severity; smoking level

Uji Aktivitas Antibakteri Ekstrak Metanol, Ekstrak Fraksi N-Heksan dan Ekstrak N-Heksan Daun Filicium decipiens terhadap Bakteri Staphylococcus aureus dan Bakteri Bacillus subtilis
Journal of Medicine and Health Vol. 2 No. 5 (2020)
Publisher : Universitas Kristen Maranatha

The previous study shows ethanol extract of Filicium decipiens leaf possesses a strong antibacterial activity against Staphylococcus aureus, but there have been no studies of the antibacterial activity with different solvents. The purpose of this study was to determine the antibacterial activities of methanol, n-hexane fraction of methanol and n-hexane extract of F. decipiens leaves against S. aureus and Bacillus subtilis bacteria. Extraction was carried out by soxletation method using methanol and n-hexane solvent. The antibacterial activity test was done by measuring the minimum inhibitory concentration (MIC) and Zone of Inhibition. The results showed that methanol extract did not have activity either against S. aureus bacteria or against B. subtilis. N-hexane extract which was fractionated from methanol extract had no activity against B. subtilis but showed moderate activity against S. aureus with 9 mm inhibition diameter at an extract concentration of 40%. N-hexane extract has very strong antibacterial activity against S. aureus with inhibition diameter reaching 21 mm at extract concentration of 30% and showing strong activity against B. subtilis bacteria with inhibition diameter of 10 mm at extract concentration of 30%. It can be concluded that n-hexane extract from F. decipiens has a potent as natural antibiotic material. Keywords: Filicium decipiens; Staphylococcus aureus; Bacillus subtilis; n-hexane extract; methanol extract

Peningkatan Fungsi Atensi dan Memori Jangka Pendek pada Wanita Dewasa Muda dengan Ansietas setelah Terapi Mewarnai
Journal of Medicine and Health Vol. 2 No. 5 (2020)
Publisher : Universitas Kristen Maranatha

Attention and memory are influenced by anxiety. This study aimed to analyze the effect of coloring therapy on the improvement of attention and short-term memory function in young adult women with anxiety. The analytic quasi-experimental method was used with pre-test and post-test design. The measured data were attention (Stroop test score) and short-term memory (Scenery Picture Memory Test / SPMT score). The subjects were 25 female university students with anxiety (Depression Anxiety Stress Scale / DASS-42 score ?8). This study showed the mean Stroop test scores of pre-test and post-test were 136.20 and 72.60 seconds subsequently, and the mean SPMT scores of pre-test and post-test were 17.88 and 20.92 subsequently. Wilcoxon's statistical analysis test with ?=0.05 showed a p-value of 0.000 for both the Stroop test and SPMT score (highly significant). We concluded that coloring therapy improved attention and short-term memory function in young adult women with anxiety. Keywords: coloring therapy, attention, short-term memory, cognitive, anxiety

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