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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
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Articles 2 Documents
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Search results for , issue "Vol. 4 No. 2 (2016)" : 2 Documents clear
Phytochemical and antipyretic potential of ethanolic leaf extract of Heliotropium indicum l. Basak, Mrinmoy; Dey, Biplab Kumar
Journal of Applied Pharmaceutical Research Vol. 4 No. 2 (2016)
Publisher : Creative Pharma Assent

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Abstract

In the present study, the ethanolic leaf extract of Heliotropium indicum L (H. indicum L) was investigated for phytochemical screening and antipyretic activity in rats using Brewer's yeast induced Pyrexia. The leaves of H. indicum were collected from different part of Assam and cut into small pieces and shade dried. The dried powdered leaves (100 gm) were extracted in a Soxhlet apparatus by using 95% ethanol. Phytochemical screening has been done by standard procedure and showed the presence of alkaloids, glycoside, carbohydrate, phytosterol, flavonoids and saponins and absence of fixed oil and gums-mucilage. Albino rats weighing (200-250g) were taken for the experiment divided into four groups of six animals each. Group 1 received 3% aqueous suspension of gum Acacia (1ml/200g) as vehicle orally, group 2 and group 3 received ethanolic leaf extract of H. indicum 250 and 500 mg/kg with 3% aqueous suspension of gum Acacia orally and the group 4 served as standard received paracetamol 25 mg/kg with 3% aqueous suspension of gum Acacia orally. The subcutaneous injection of yeast suspension markedly elevated the rectal temperature after 18h of administration. Treatment with H. indicum extract at a dose of 250, 500 mg/kg decreased the rectal temperature of the rats in dose dependent manner. This effect was maximal at dose of 500 mg/kg and it caused significant lowering of body temperature (P< 0.01) up to 4 hour after its administration. The antipyretic effect started as early as 1h and the effect was maintained for 4h, after its administration. Both the standard drug paracetamol 25mg/kg and tested drug H. indicum extract were significantly reduced the yeast elevated rectal temperature, at 2nd, 3rd and 4th hour compared to control group.
A critical review on keeta visha: an ayurvedic approach Kumar, Parvesh; Goswami, Ashish B.
Journal of Applied Pharmaceutical Research Vol. 4 No. 2 (2016)
Publisher : Creative Pharma Assent

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Abstract

Indian system of medicine plays an important part in health care system all over India. Ayurveda is an ancient Indian system of medicine having eight important branches. Agad tantra is among one of them which deals with toxicological conditions and their management. Sage Susruta in Kalpasthaana of his work Susruta Samhita, and Sage Vaagbhata in Uttaratantra of his work Ashtaanga Hrdaya, and in other classics and regional texts have narrated regarding the origin of Visha and Keeta Visha. There are several types of Keeta Visha described. Among animal poisoning, Acharayas have described different creatures (Sarpa, Keeta, and Luta) responsible for life threatening situations. The importance of Keeta Visha is more because it causes severe manifestations in the human being, even death also. Acharya Suhsruta described Keeta Visha under Jangama Visha and explained 67 varieties of Keeta under 4 groups. According to its variety diagnosis and treatment of Keeta Visha is found to be very difficult because these varieties are not yet correctly identified and besides, regional variations of these Keetas manifests very differently.

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