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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
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Articles 5 Documents
 1 
Search results for , issue "Vol. 9 No. 2 (2021)" : 5 Documents clear
Evaluation of analgesic, antioxidant and cytotoxic activities of ethanol extract of Clerodendrum viscosum Vent Das, Sujan Chandra; Kuddus, Md. Ruhul; Qais, Nazmul; Hasan, Choudhury M.
Journal of Applied Pharmaceutical Research Vol. 9 No. 2 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.10.14

Abstract

Clerodendrum viscosum Vent. is a very common plant in Bangladesh which is locally familiar as “Bhat” or “Ghetu”. Here, the ethanol extract of whole plant part of C. viscosum and its various solvent (petroleum-ether, chloroform and ethyl acetate) fractions were subjected for the appraisal of analgesic, antioxidant and cytotoxic activities. Analgesic activity was tested by acetic acid-induced writhing model in Swiss albino mice. All the plant samples at the oral doses of 100- and 200 mg/kg body weight were found to exhibit significant (p<0.05) pain reducing activity in test animals. Highest inhibition of writhing was 62.38% by the ethyl acetate soluble fraction at dose of 200 mg/kg body weight while the standard drug diclofenac sodium (50 mg/kg) produces 76.14% reduction of abdominal writhing. DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical quenching assay was employed to determine the antioxidant potential of the plant samples while cytotoxic activity was checked by brine shrimp lethality bioassay. In DPPH radical scavenging assay, the plant samples showed prominent antioxidant activity. Among all, the ethyl acetate fraction showed maximum antioxidant potential with IC50 value of 28.02±0.53 μg/ml. In cytotoxic assay, the petroleum-ether fraction demonstrated strong cytotoxicity with LC50 value of 1.42±1.12 μg/ml. In summary, C. viscosum extracts possess significant analgesic, antioxidant and cytotoxic activities which rationalize its traditional use in folk medicine.
In India, diabetes mellitus is on the rise at an alarming rate: A review Bagchi, Arnab; Pal, Prosanta
Journal of Applied Pharmaceutical Research Vol. 9 No. 2 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.01.05

Abstract

The aim of the current review is to acquaint all the covering aspect of dibetes mellitus which can provide awareness to the diabetes patients in india as well as all over the world. The number of diabetic patients in india is increasing at an alarming rate and is therefore a major area for concern. As per the WHO, the diabetes is expected to reach 79.4 million by 2030. The studies have shown that the type II diabetes is 4-6 times higher in urban than in rural areas in india. Development of  diabetes among indians is due to several factors such as age ( Based on NHANES data),waist circumference, hypertention, BMI, smoking habit and total cholestero these variables are important for comparing diabetic and non-diabetic patients
Combined effect of bromelain and turmeric against acetic acid induced ulcerative colitis in wistar rats reddi, Padmavathi; Keerthana, K. B; Lalitha Devi, A.; Sree Hari, Y.; Samad, Abdul
Journal of Applied Pharmaceutical Research Vol. 9 No. 2 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.15.24

Abstract

Objective: The present study planned to study the combined effect of Bromelain and Turmeric in acetic acid induced ulcerative colitis in Wistar rats. Methodology: Wistar rats of either sex (n = 30) were divided into 5 groups. Group – I, Sham control, administered single dose of vehicle rectally; Group –II, colitis control, colitis was induced by rectal administration of single dose of 2 ml of 3%, v/v of acetic acid in 0.9% saline; Group–III, treated with Turmeric (50 mg/kg/p.o); Group–IV, treated with Bromelain (100 mg/kg/p.o) and Group –V, treated with both Turmeric (50 mg/kg/p.o) and Bromelain (100 mg /kg/p.o). Colitis was induced in all the treatment groups on first day and drug treatment was continued for 7 days. During the treatment period, Disease Activity Index (DAI) was assessed daily and on 8th day White Blood Cell (WBC) Count and Differential Leucocyte Count (DLC) was performed and on 9th day all the rats were sacrificed for the assessment of intestinal inflammation, colon myeloperoxidase (MPO) levels and Histopathology. Results obtained were analysed by one-way analysis of variance followed by Tukey’s multiple comparison test. Results: Overall changes in DAI, Inflammatory scores, WBC, DLC and MPO has shown significant improvement with Turmeric and Bromelain compared to Colitis control. However, the combined therapy has shown to be more effective in alleviating ulcerative colitis compared to individual therapies. Conclusion: The present study recommends that the combination of Turmeric and Bromelain has synergistic effect in treating ulcerative colitis.
Recent advancement in the method of transdermal drug delivery system: A review Halder, Sudip; Chakraborty, Prodipta; Pradhan, Darshan; Bagchi, Arnab
Journal of Applied Pharmaceutical Research Vol. 9 No. 2 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.06.09

Abstract

A transdermal patch is a medicated adhesive patch that is applied to the skin and used to deliver a particular amount of medication into the bloodstream through the skin. It aids in the recovery of an injured bodily part. The transdermal drug delivery system (TDDS) provides an alternative safe means of drug delivery to previous intrusive techniques. In the past, topically applied lotions and ointments were the most commonly utilised systems for dermatological issues. The fact that some of these formulations cause systemic side effects indicates that they are absorbed through the skin. All topically applied medication formulations intended to transport the active ingredient into the general circulation are included in the transdermal delivery system. To overcome the skin's formidable barrier to topical medication administration, several substances have been utilised. Because of their unique qualities, such as improved bioavailability, regulated pharmaceutical release, and improved patient compliance, TDDS have recently gained increased attention. The current review focuses on the various advancements in transdermal drug delivery, as well as the various available methods for preparing transdermal patches, characterization and assessment tools for transdermal patch preparation, patents, transdermal compound clinical trials, and drug approved and future applications of transdermal drug delivery systems. As a result, in recent years, the Transdermal Drug Delivery System has received a lot of attention.
Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate Shoaeba, Shaikh; Sharav, Desai; Jain, Hitesh; Sahu, Asit; Meshram, D. B.
Journal of Applied Pharmaceutical Research Vol. 9 No. 2 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.25.29

Abstract

The aim of present study was to prepared ocular in-situ gel to increase the residence time of drug in cornea for improvement of ocular bioavailability of drug. In situ gel of Loteprednol etabonate was prepared by using carobopol 940 and different grades of HPMC in different ratios by pH triggered method. The prepared in situ gels were evaluated for pH, drug content, viscosity, gelling time, gelling strength spreadability and sterility testing. In vitro drug release study was carried by using diffusion cell with dialysis membrane. The drug content and pH of the formulation were found to be satisfactory. The gelling strength was found to be in the range of 34 seconds to 91 seconds. The viscosity and spredability of the formulations were found to be satisfactory. Formulation F5 containing 0.3 % carobopol 940 and 0.6 % HPMC K4M showed highest drug release of 80.30 %. The developed formulations showed sustained release of drug up to 8 hrs. From in-vitro drug release studies, it could be concluded that the developed in-situ gelling systems were thus a better alternative to conventional eye drops.

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