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Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya
Published by Universitas Muhammadiyah Surabaya
ISSN : 25412272     EISSN : 25489526     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Arjuna Subject : -
Articles 16 Documents
 1   2 
Search results for , issue "Vol 4, No 2 (2020)" : 16 Documents clear
Relationship of Prostate-Specific Antigen (PSA) and Prostate Volume in Patients with Biopsy Proven Benign Prostatic Hyperplasia (BPH) Aulia Nur Fadila; Anny Setijo Rahaju; Tarmono Tarmono
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.3426

Abstract

Abstract  Benign prostatic hyperplasia (BPH) is one of the most common benign tumors in men with prevalence ranging from 50% for men in their 60s to 90% for men in their 80s. The researcher sought to determine the relationship of prostate-specific antigen (PSA) and prostate volume in patients with benign prostatic hyperplasia. This study was based on 33 cases of benign prostatic hyperplasia in the Department of Urology, RSUD Dr. Soetomo Surabaya that diagnosed by histopathology examination. Cases with malignancy, acute urinary retention and prostatitis were excluded. The variables of prostate-specific antigen and prostate volume were examined. The results of this study found that 33 men were enrolled with mean PSA 16,04 ng/ml and a mean prostate volume of 49,13 ml. Overall, 84,8% had PSA level >4 ng/ml and 90,9% had prostate volume >25 ml. Prostate-specific antigen has significant correlation with prostate volume (p=0,019; r=0,362). This study concluded that prostate-specific antigen and prostate volume showed a significant correlation. Keywords             : benign prostatic hyperplasia, prostate specific antigen, prostate volumeCorrespondence   : anny_sr@fk.unair.ac.id
Effects of Prebiotics, Probiotics, and Synbiotics on the Bodyweight, Blood Glucose, Triglyceride and TNF-α of Diet-induced Obesity Rats Lenny Octavia; Soebagijo Adi Soelistijo; Agung Dwi Wahyu Widodo
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4206

Abstract

Abstract  High-fat diet leads to obesity-associated chronic low-grade inflammation. Prebiotics, probiotics, and synbiotics produced short-chain fatty acids (SCFA), bonded to G protein-coupled receptors (GPR)-41 and GPR-43 decreased triglyceride deposits in adipocytes and liver, decreased fatty acid oxidation, increased glucose regulation and insulin sensitivity thus reduced the risk of obesity and metabolic syndrome. This study conducted in order to evaluate the effects of prebiotics, probiotics, and synbiotics on the body weight, blood glucose, triglyceride, and TNF-α used rats model, which were fed by a high-fat diet. Thirty-eight 6-8 weeks old male rats were fed by high-fat diet for three weeks, then rats were randomly divided into four groups, high-fat diet (HFD), a high fat diet with prebiotics supplementation (HFD+ PRE), a high fat diet with probiotics supplementation (HFD+PRO), and high-fat diet with synbiotics supplementation (HFD+SYN) for three weeks. Blood samples and body weight were measured at the third and sixth week. There was no effect of prebiotics, probiotics, and synbiotics on body weight, triglyceride levels, blood glucose, and TNF-α in rats fed a high-fat diet compared to control. These results suggested that supplementations gave inconsistent results with other studies and needed further researches.Keywords             : high fat diet, prebiotics, probiotics, synbiotics, meta-inflammationCorrespondence   : soebagijo@yahoo.com
IN VITRO TEST: Antimicrobial Activity Potential From Ciplukan Fruit (Physalis minima L.) Extract in Methicillin-resistant Staphylococcus aureus (MRSA) Muhammad Hanun Mahyuddin; Arifa Mustika; Gwenny Ichsan Prabowo; Deby Kusumaningrum
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.3645

Abstract

In Indonesia, in 2006 the prevalence of infections due to MRSA was 23.5%. Physalis minima L. plants are known to have antimicrobial activity because they contain compounds withaferin A which can induce programmed cell death. This research was to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Ciplukan (Physalis minima L.) extract in Methicillin-resistant Staphylococcus aureus (MRSA) bacteria. Dilution test with Mueller-Hinton broth medium used for measuring the minimum inhibitory concentration (MIC). Ciplukan  fruit extract was dissolved in distilled water, and poured into a test tube with a certain concentration (0.9 g/mL (90%); 0.3 g/mL (45%); 0.15 g/mL (22.5%); 0.075 g/mL (11.25%) and 0.0375 g/mL (5.625%). After being incubated for 24 hours, the bacteria in the test tube were plated on nutrient agar plates, to determine the MBC. The MIC cannot be determined, because the solution in the dilution test tube is disturbed by the color of the extract so that turbidity cannot be observed. From the observations of the minimum bactericidal concentration MBC of the Ciplukan (Physalis minima  L.) fruit extract against MRSA was in the P1 tube or equivalent to 0.9 g / ml (90%).
Quality of life of cervical cancer patients Mayang Wulan; Yuzana Binti Mohd Yusop; Harmy Bin Mohamed Yusoff
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4593

Abstract

ABSTRACT Cervical cancer is known as the highest cause of death after breast cancer. It is gynecological cancer contributing to the top cause of death in women. Sexual and reproductive issues can reduce the quality of life of women with cervical cancer. WHO defines the quality of life as an individual's perception in the cultural context and value system in which the individual experiences and is related to their goals, expectations, standards, and affairs. It gives the concept of an individual's physical health, psychological conditions, one's beliefs, social relationships, and one's involvement with something meaningful in their environment. This article will explain the definition, symptoms, and staging of cervical cancer, the definition of the quality of life, the meaning of excellence for the cervical cancer patient, and the facts that affect the quality of life.  Keywords           : quality of life, cervical cancer, reproductive organ cancerCorrespondence  : mayangwulan8@gmail.com 
Sequestration of erythrocytes infected with Plasmodium berghei ANKA in BALB/c mice treated with goat bile Kartika Arum Wardani; Kholida Nur Aini; Heny Arwati; Willy Sandhika
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.3539

Abstract

Abstract Sequestration of Plasmodium berghei ANKA-infected erythrocytes occurs in BALB/c mice as characteristic of  Plasmodium falciparum infection in humans. Animals’ bile has been widely used for centuries in Traditional Chinese Medicine. Goat bile has been used in healing infectious and non-infectious diseases; however, no report on the use of goat bile against malaria infection and sequestration. The purpose of this study was to analyze the correlation between parasitemia and sequestration in the liver of P.berghei ANKA-infected BALB/c mice treated with goat bile. This research was an in vivo experimental study using the post-test control group design. The male BALB/c mice aged ± 6 weeks, body weight 20-25 g were used. The mice were divided into five groups where Group 1-3 were mice treated with goat bile 25%, 50%, and 100%, respectively. Group 4-5 were negative (sterile water) and positive controls (DHP). Parasitemia was observed daily from each mouse and the number of sequestered infected erythrocytes on the endothelium of sinusoids. The data were analyzed using t independent test. Antimalarial activity of goat bile was shown by the lower parasitemia in goat bile-treated mice compared with the negative control. The average number of sequestration was goat bile concentration-dependent manner. The higher the concentration, the lower the number of sequestration. Sequestration was correlated with parasitemia (p=0,0001). Sequestration of P.berghei ANKA-infected erythrocytes correlated with parasitemia, and was goat bile concentration-dependent manner. Keywords: Malaria, parasitemia, sequestration, goat bileCorrespondence: arwatiheny@gmail.com
Pneumonia Degree Correlation in Children with Clean and Healthy Behavior (CHB) Tri Kartika Setyarini; Aisyah Lahdji; Isna Zalwa Noor Fajri
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4269

Abstract

Abstract  Pneumonia is an acute infection that affects the lung with symptoms of cough, shortness of breath, grunting, cyanosis, rhonchi, and infiltrates in thorax imaging. Based on The Integrated Management of Sick Children in handling Acute Respiratory Tract Infection program, pneumonia is classified as severe pneumonia, pneumonia and not pneumonia. One of the risk factors of pneumonia is the low level of Clean and Healthy Behavior (CHB). The purpose of this study was to determine the degree of pneumonia in children with clean and healthy behavior (CHB). The analytic observational study with cross-sectional method. The sample was conducted children under five years old diagnosed with pneumonia in the Children's Ward of Rachma Husada Hospital Bantul with due regard to inclusion and exclusion criteria. Sampling was carried out using consecutive techniques. The data was retrieved using secondary data (medical records) and observing CHB with questionnaire. The data was analyzed using fisher’s exact test. From 32 samples in this study, the majority of samples suffered from severe pneumonia (81.3%) and the most CHB indicators were the Intermediate category (50%). The result of bivariate analysis shows there was a correlation between the degree of pneumonia in children and the family’s CHB (p=0.01). There was a correlation between the degree of pneumonia in children and the clean and healthy behavior (CHB). Keywords             : pneumonia, CHB, childrenCorrespondence   : lahdjiaa@unimus.ac.id

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