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All Journal International Journal of Public Health Science (IJPHS) Medical Journal of Indonesia Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Medica Arteriana (Med-Art) Majalah Biomorfologi (Biomorphology Journal) Cardiovascular and Cardiometabolic Journal (CCJ) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Global Pharma Technology Jurnal Penyakit Dalam Indonesia Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD) Folia Medica Indonesiana
Soelistijo, Soebagijo Adi
Departemen Ilmu Penyakit Dalam RSUD Dr. Soetomo – Fakultas Kedokteran Universitas Airlangga, Surabaya
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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A Prediction Model of Mortality in Patients Hospitalized with Diabetic Ketoacidosis in a Tertiary Referral Hospital in Surabaya, Indonesia Hermina Novida; Fajar Setiyawan; Soebagijo Adi Soelistijo
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14751

Abstract

Background: The mortality rate of diabetic ketoacidosis (DKA) remains high in Indonesia. Differentpatterns were contributing to DKA mortality from previous studies. We aim to identify clinical and laboratoryfindings as mortality predictors of DKA.Methods: This retrospective study was conducted in a tertiary referral hospital in Surabaya. Medical recordsof DKA patients from January 2016 to December 2018 were analyzed. Clinical and laboratory data wereobtained from medical records for three years period. Clinical outcome was defined as either dischargedhome or death.Results: Fifty-six among 116 DKA patients did not survive during hospitalized. Age of 60 or older, thedepressed mental state with GCS below 13, potassium serum less than 3.5 mmol/L, and bicarbonate serumless than 15 mmol/L are found to be significant as independent factors of mortality in DKA patients.Conclusion: The mortality rate of DKA patients in this study is still high. It independently associatedwith the age of 60 years or older, depressed mental state, hypokalemia, and low bicarbonate level. Earlystratification of these predictors would help to treat patients accordingly.
Moderate Intensity Exercise is Most Influential in The Expression of UCP-1 in Mice Male ------ (RETRACTED) Chabib Fachry Albab; Purwo Sri Rejeki; Muhammad Miftahussurur; Soebagijo Adi Soelistijo
Health Notions Vol 3, No 12 (2019): December
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn31207

Abstract

This article has been retracted at the request of the authors
Effects of Prebiotics, Probiotics, and Synbiotics on the Bodyweight, Blood Glucose, Triglyceride and TNF-α of Diet-induced Obesity Rats Lenny Octavia; Soebagijo Adi Soelistijo; Agung Dwi Wahyu Widodo
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4206

Abstract

Abstract  High-fat diet leads to obesity-associated chronic low-grade inflammation. Prebiotics, probiotics, and synbiotics produced short-chain fatty acids (SCFA), bonded to G protein-coupled receptors (GPR)-41 and GPR-43 decreased triglyceride deposits in adipocytes and liver, decreased fatty acid oxidation, increased glucose regulation and insulin sensitivity thus reduced the risk of obesity and metabolic syndrome. This study conducted in order to evaluate the effects of prebiotics, probiotics, and synbiotics on the body weight, blood glucose, triglyceride, and TNF-α used rats model, which were fed by a high-fat diet. Thirty-eight 6-8 weeks old male rats were fed by high-fat diet for three weeks, then rats were randomly divided into four groups, high-fat diet (HFD), a high fat diet with prebiotics supplementation (HFD+ PRE), a high fat diet with probiotics supplementation (HFD+PRO), and high-fat diet with synbiotics supplementation (HFD+SYN) for three weeks. Blood samples and body weight were measured at the third and sixth week. There was no effect of prebiotics, probiotics, and synbiotics on body weight, triglyceride levels, blood glucose, and TNF-α in rats fed a high-fat diet compared to control. These results suggested that supplementations gave inconsistent results with other studies and needed further researches.Keywords             : high fat diet, prebiotics, probiotics, synbiotics, meta-inflammationCorrespondence   : soebagijo@yahoo.com
The Combination Effect of Simvastatin and Virgin Coconut Oil on Total Cholesterol Levels in Dislipidemic Male Albino Rats (Rattus norvegicus) Lutfi Dewanda Nugroho; Soebagijo Adi Soelistijo; Jusak Nugraha
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 12 No. 2 (2021): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V12I22021.72-76

Abstract

Introduction: Simvastatin is a primary pharmacological therapy for dyslipidemia (hypercholesterolemia). Virgin coconut oil (VCO) is a companion intake of statin drugs considered capable of lowering blood cholesterol levels. This study aimed to determine the combination effect of statin drug groups with VCO on total cholesterol.Methods: The stages of this study started with the adaptation process of animals, giving a high-fat diet (HFD), and treatment with simvastatin and VCO. The adaptation process was conducted where the experimental animals were fed pellets and drank clean water in a container. A HFD was given by mixing pork brains with distilled water with a ratio of 1:3 as much as 2 ml per day for 21 days. In simvastatin and VCO treatment for 7 days, the experimental animals were divided into 4 groups; group I was given aquades, group II was given VCO, group III was given simvastatin, and group IV was given simvastatin and VCO. The total cholesterol levels in the blood of albino rats were examined by employing a BS-300 Chemistry Analyzer through a spectrophotometric method. The total cholesterol levels data obtained were then examined for normality (Shapiro-Wilk test) and analyzed parametrically by utilizing One-way ANOVA.Results: The average total cholesterol level in the negative control group (being given a standard diet) was 45.57 mg/dL. The averages of blood total cholesterol levels were 47.28 mg/dL, 45.00 mg/dL, 46.85 mg/dL, 41.42 mg/dL, and 44.28 mg/dL in the positive control group (given an HFD), in the treatment group I, in the treatment group II, in the treatment group III, and in the treatment group IV, respectively. There were no significant distinctions in the statistical test on decreasing blood total cholesterol among the negative control group, positive controls I, II, III, and IV.Conclusion: Combination of simvastatin and VCO tends to reduce the total cholesterol level in albino rats. This is better than just giving VCO simvastatin alone.
CORRELATION BETWEEN METABOLIC SYNDROME AND URIC ACID LEVEL IN THE OFFICE WORKERS OF A BUMN COMPANY IN SURABAYA Jihan Jauza Fairuz; Dewi Ratna Sari; Soebagijo Adi Soelistijo
Majalah Biomorfologi Vol. 31 No. 1 (2021): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v31i1.2021.11-17

Abstract

Background: Metabolic syndrome is a cluster of risk factor which consists of central obesity, hypertriglyceride, low High Density Lipoprotein (HDL) level, hypertension, and hyperglycemia. Its incidence among the office workers is increasing. Uric acid is often associated with cardiovascular disease while risk factor of cardiovascular disease is associated with metabolic syndrome. Objective: To analyze the correlation between metabolic syndrome and uric acid level in office workers. Materials and Methods: This study used medical record of health examination of PT Wijaya Karya Divisi IV male office workers aged of 20 – 60 years. The data taken consisted of abdominal circumference, blood pressure, triglyceride, HDL, fasting blood glucose, and uric acid levels. The diagnostic criterion of metabolic syndrome used in this study was National Cholesterol Education Program’s Adult Treatment Panel III (NCEP ATP III) that had been modified for Asians. The correlation of metabolic syndrome and serum uric acid level was analyzed by chi-square test with IBM SPSS Statistic 20 application. Results: There was no significant correlation (p=0.598) between metabolic syndrome and uric acid level in male office workers of PT Wijaya Karya Divisi IV. Conclusion: Metabolic syndrome and uric acid level among male office workers of PT Wijaya Karya Division IV had no correlation.
CORRELATION BETWEEN HCV RNA VIRAL LOAD AND HOMA-IR IN CHRONIC HEPATITIS C PATIENTS Nadhya Allia; Poernomo Boedi Setiawan; Soebagijo Adi Soelistijo
Current Internal Medicine Research and Practice Surabaya Journal Vol. 2 No. 2 (2021): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v2i2.26537

Abstract

Background: Insulin resistance (IR) is one of the extrahepatic complications of hepatitis C virus (HCV) infection that needs to be recognized early. HOMA-IR is an effective way to measure insulin resistancy. Core proteins, NS-3, and NS-5 are the main components of HCV RNA proteins which are involved in the incidence of IR. Seeing this, a hypothesis was developed that the level of HCV RNA viral load was related to the HOMA-IR. This study was designed to identify the correlation between HCV RNA viral load with HOMA-IR in chronic hepatitis C patients.Method: We conducted a cross-sectional approach from the medical record of chronic hepatitis C patients at the outpatient clinic dr. Soetomo Hospital, Surabaya. A total of 30 patients aged >19 years old with complete medical records were included. Clinical and laboratory (including HCV RNA viral load level and HOMA-IR) data were obtained from the availability of medical records.Result: A total of 30 chronic hepatitis C patients, 17 (56.7%) were women and 13 (43.3%) were men, with mean age was 50.90 ± 7.17 years. The median of HCV RNA viral load level was 3,14 x106 IU/ml and the median of HOMA-IR was 4.50. The result of the Spearman correlation test showed a moderate positive association between HCV RNA viral load and HOMA-IR (r=0.537 ; p=0.002).Conclusion: A positive moderate correlation was obtained between HCV RNA viral load with HOMA-IR in chronic hepatitis C patients.
Pengaruh Senam PERSADIA 1 terhadap Lingkar Pinggang dan Rasio HDL-c LDL-c pada Wanita Hafizha Firdaus Al-Fuady; Bambang Purwanto; Soebagijo Adi Soelistijo
Medica Arteriana (Med-Art) Vol 2, No 2 (2020): Desember 2020
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/medart.2.2.2020.94-101

Abstract

AbstrakLatar Belakang: Diabetes melitus tipe 2 menjadi penyebab kematian nomer 3 di Indonesia. Kelebihan berat badan atau lingkar pinggang diatas normal dan kadar HDL-c rendah merupakan faktor risiko diabetes melitus tipe 2. Faktor risiko tersebut dapat diatasi salah satunya dengan olahraga. Senam PERSADIA 1 dirancang khusus untuk pencegahan diabetes. Namun, efek dari senam ini dalam menurunkan lingkar pinggang dan meningkatkan rasio HDL-c LDL-c belum pernah diteliti.Metode: Desain penelitian ini adalah eksperimen lapangan. Pengaruh Senam PERSADIA 1 terhadap lingkar pinggang dan rasio HDL-c LDL-c dianalisis dengan uji statistik deskriptif, uji normalitas saphiro wilk-test, uji beda berpasangan paired t-test / Wilcoxon-test.Hasil: Penelitian ini melibatkan 12 ibu-ibu PKK Lidah Wetan Gang V RW 2 Surabaya. Dari hasil analisis, terdapat penurunan rerata lingkar pinggang dan bermakna namun sedikit (p= 0,032), tidak ada peningkatan kadar HDL-c yang bermakna (p= 0,301), terdapat penurunan rerata LDL-c namun belum bermakna (p= 0,755), terdapat peningkatan rerata rasio HDL-c LDL-c namun belum bermakna (p= 0,303).Kesimpulan: Senam PERSADIA 1 dapat menurunkan lingkar pinggang namun sedikit dan belum dapat meningkatkan rasio HDL-c/LDL-c pada wanita secara bermakna menurut statistika. Diperlukan penelitian lebih lanjut dengan menambah waktu pelaksaan senam dan mengontrol energy intake subjek penelitian. Kata Kunci:. Diabetes melitus, Senam PERSADIA 1, lingkar pinggang, rasio HDL-c LDL-c, wanita AbstractBackground: Type 2 diabetes mellitus is the third causes of death in Indonesia. Overweight or waist circumference above normal and low HDL-c levels are risk factors for type 2 diabetes mellitus. One of the risk factors can be resolve with exercise. First series PERSADIA exercise is specifically designed for the prevention of diabetes. Howefer, the effect of this exercise in reducing waist circumference and increase ratio HDL-c LDL-c had never been proven.Method: The design of this study was a field experiment. The effect of first series PERSADIA exercise on waist circumference and HDL-c LDL-c ratio was analyzed by descriptive statistical test, saphiro wilk-test for normality test, paired t-test / Wilcoxon-test for different paired test.Result: This study involved 12 Women lived in Lidah Wetan Gang V RW 2 Surabaya. From the analysis, there was a decrease in mean waist circumference and significant but slightly (p = 0.032), there was no significant increase in HDL-c levels (p = 0.301), there was a decrease in LDL-c mean but it was not significant (p = 0.755), there was an increase in the mean HDL-c LDL-c ratio but it was not significant (p = 0.303).Conclusion: First series PERSADIA exercise has been able to reduce waist circumference but slightly and not able to increase HDL-c / LDL-c ratio significantly in women according to statistics. Further research is needed by increasing the exercise time and controlling the energy intake of subjects. Keywords: diabetes mellitus, first series PERSADIA exercise, waist circumference, HDL-c LDL-c ratio, women 
The Effect of Fetuin-A and Palmitate on the Translocation of Glucose Transporter-4 Through the Activation of Toll-Like Receptor 4 in Skeletal Muscle Cells Soebagijo Adi Soelistijo
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (452.771 KB)

Abstract

Background: Fetuin-A (FetA) is a 63 kD phosphorylated glycoprotein that relates to insulin resistance inhibits autophosphorylation and the activity of insulin receptor tyrosine kinase (IR-TK) at the receptor levels. FetA positively correlates with insulin levels, and homeostasis model of insulin resistance (HOMA-IR). However, the phenomenon is obtained from several studies; a decrease did not always follow the increase of FetA in glucose uptake in the tissue. Aim: To determine the impact of Fetuin-A and Palmitate on TLR4 mediated Glucose Transporter-4 translocation inhibition in normal glucose-tolerance human skeletal muscle cell (h-SkMC). Method: Normal h-SkMC culture were randomly divided into five arms and treated with human- insulin, and deoxy-glucose (GI arm), or human-insulin, deoxy-glucose, and FetuinA (GIF arm), or human-insulin, deoxy-glucose and Palmitate (GIP arm), or human-insulin, deoxyglucose, FetuinA and Palmitate (GIFP arm). The control arm was without any treatment. The effects of insulin, glucose, FetuinA, and Palmitate on the expression of TLR4, Akt, GLUT-4 were evaluated by immunofluorescence microscopy. The expression of TNF- and IL-6 were measured by ELISA assay, and glucose uptake was measured by spectrophotometry assay. The results were obtained and subject to comparative test and pathway analysis. Results: The treatment with glucose+insulin (GI), FetA (GIF), Palmitate (GIP), and Palmitate+FetA (GIFP) increased TLR4 expression significantly compared to control arm (p<0.05) and only treatment with GI and GIF significantly increased the expression of GLUT-4 compared to control arm (p<0.05). All treatment arms and control arms were not significantly different in altering glucose transport. The treatment with Palmitate significantly decreased GLUT-4 expression and independence of TLR4 expression. Conclusion: The treatment with FetA alone or in combination with Palmitate in normal h-SkMC significantly increases the expression of TLR4 but does not alter GLUT-4 translocation and glucose transport. These results provide novel evidence indicating that acute exposure of FetuinA and Palmitate on normal glucose-tolerance h-SkMC does not induce insulin resistance.Keywords: FetA, Palmitate, TLR4, GLUT-4, TNFα, IL-6, Glucose transport.
Exogenous Cushing Syndrome: When do We Get the Benefit of Glucocorticoid Stress Dose? Soelistijo, Soebagijo Adi; Gunawan, Hendra; Primasatya, Chandra Adi Irawan; Ariana, Audy Meutia; Mudjanarko, Sony Wibisono; Pranoto, Agung
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Exogenous cushing syndrome is the most common cushing syndrome found in clinical practice. Its most frequent etiology is the adverse effect of glucocorticoid therapy found in clinical practice or in the form of traditional medicine. The clinical manifestations of exogenous cushing syndrome are similar to the spontaneous counterpart, albeit with the presence of glucocorticoid consumption. We present a case series of exogenous cushing syndrome due to traditional medicine and glucocorticoid consumption with opportunistic infection as its initial manifestation. The first case did not need glucocorticoid supplementation while it was initiated in the second case. Comprehensive management of exogenous cushing syndrome should involve the decision of giving glucocorticoid stress dose, treatment to the underlying disease and education in order to prevent self-glucocorticoid consumption.
Correlation between Serum High-Sensitivity C-Reactive Protein Level and Severity of Albuminuria Measured by Urine Albumin-to-Creatinine Ratio in Type 2 Diabetic Patients Febrianto, Dicky; Soelistijo, Soebagijo Adi; Tjempakasari, Artaria
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 2 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i2.49152

Abstract

Introduction: One of complications in type 2 diabetes mellitus (DM) that require high treatment cost is diabetic kidney disease (DKD), which is characterized by the presence of albuminuria, decrease in glomerular filtration rate, or both. Researches show a positive correlation between type 2 DM and serum high-sensitivity C-reactive protein (hs-CRP) level, a sensitive marker of subclinical inflammation. This study aimed to analyze the correlation between serum hs-CRP level and severity of albuminuria measured by urine albumin-to-creatinine ratio (ACR).Methods: The study was conducted at the Endocrinology Outpatient Clinic of Dr. Soetomo General Academic Hospital, Surabaya, on June-July 2020.Results: The study included 50 patients with type 2 DM, consisting of 25 (50%) men and 25 (50%) women, with median age of 58.0 (42-68) years and mean body mass index (BMI) of 21.91 ± 1.310 kg/m2. Median duration of DM was 12.0 (6-22) years, median HbA1c level was 7.20% (5.7%-12.3%), mean serum crEatinine level was 0.83 ± 0.180 mg/dL, and median estimated glomerular filtration rate (eGFR) value was 92.85 (61.6-121.2) mL/minute/1.73 m2. Median serum hs-CRP level was 1.20 (0.1-4.0) mg/L and median urine ACR value was 49.570 (7.78-426.00) mg/g. Normoalbuminuria was detected in 28% of subjects, microalbuminuria in 66% of subjects, and macroalbuminuria in 6% of subjects. This study showed positive and significant correlation between serum hs-CRP level and severity of albuminuria (r = 0.701; p = <0.001).Conclusion: There was positive and significant correlation betweeen serum hs-CRP level and severity of albuminuria in type 2 diabetic patients.
Co-Authors Adhibagio, Aria Damarjiwo Agung Dwi Wahyu Widodo Agung Pranoto AGUNG PRANOTO Alhakiim, Muhammad Valeri Amatlulloh, Hasna Shahida Ardiany, Deasy Ari Sutjahjo, Ari Ariana, Audy Meutia Artaria Tjempakasari, Artaria Audy Meutia Ariana Bambang Purwanto Batari Retno Minanti Chabib Fachry Albab Chandra Adi Irawan Primasatya Dewi Ratna Sari Dwitama Adiwinoto, Robert Fajar Setiyawan Febri Kurniawati Febrianto, Dicky Hadisuwarno, Wiharjo Hafizha Firdaus Al-Fuady Haikal, Vikri Hakim, Arief Rakhman Hasna Shahida Amatlulloh Hendra Gunawan Hermina Novida, Hermina Jayawarsa, A.A. Ketut Jihan Jauza Fairuz Jongky Hendro Prajitno Jusak Nugraha Lefi, Achmad Lenny Octavia Lusida, Michael Austin Pradipta Lutfi Dewanda Nugroho Lutfi, Delfitri Muhammad Miftahussurur Muhammad Valeri Alhakiim Nadhya Allia Nurainy Trias Setyoputri Poernomo Boedi Setiawan Prabowo, Gwenny Ichsan Pradhevi, Lukita Prasmono, Agung Prastyani, Reni Primasatya, Chandra Adi Irawan Puspa Putri, Karina Widya Rejeki, Purwo Sri Robert Dwitama Adiwinoto Ronald Pratama Adiwinoto Saefudin, Rendra Prasetya Sasono, Wimbo Sony Wibisono Thamrin, Husin Titong Sugihartono Ummi Maimunah Vincent, Agustinus Wulansari, Ratih