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ALCHEMY Jurnal Penelitian Kimia
Published by Universitas Sebelas Maret
ISSN : 14124092     EISSN : 24434183     DOI : -
Core Subject : Science, Social, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology
ALCHEMY Jurnal Penelitian Kimia is a chemistry journal published by Sebelas Maret University, Surakarta. ALCHEMY Jurnal Penelitian Kimia publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
Arjuna Subject : -
Articles 12 Documents
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Search results for , issue "Vol 16, No 2 (2020): September" : 12 Documents clear
Prakonsentrasi Ion Cd(II) dalam Sampel Pupuk Nitrogen, Fosfor dan Kalium (NPK) Menggunakan Alumina Teraktivasi sebagai Material Pengisi Kolom Lossi Hotmaida Simanjuntak; Erwin Erwin; Aman Sentosa Panggabean
ALCHEMY Jurnal Penelitian Kimia Vol 16, No 2 (2020): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.16.2.39363.152-162

Abstract

Prakonsentrasi ion Cd(II) dalam sampel pupuk nitrogen, fosfor dan kalium (NPK) menggunakan alumina teraktivasi sebagai material pengisi kolom telah dilakukan. Alumina terlebih dahulu diaktivasi dengan NaOH pada pH 8 sebelum dimasukkan ke dalam kolom. Beberapa parameter penting dalam tahapan prakonsentrasi yang dapat meningkatkan kinerja analitik pengukuran telah ditentukan menggunakan instrumen spektrofotometer serapan atom (SSA). Hasil penelitian menunjukkan kondisi optimum tahapan prakonsentrasi ion Cd(II), adalah pada volume sampel 10 mL, volume HNO3 adalah 4 mL pada konsentrasi 0,5 M, dengan nilai kapasitas retensi adalah 1,4113 mg Cd(II)/g alumina. Kinerja analitik pengukuran metode sangat baik, ditunjukkan dengan nilai batas deteksi metode adalah 2,7997 μg/L. Presisi metode dinyatakan sebagai persentase koefisien variansi adalah 4,03%. Penggunaan alumina sebagai bahan pengisi kolom dapat meningkatkan signal sebesar 2,5 kali dibandingkan dengan pengukuran ion Cd(II) secara langsung. Akurasi metode ini sangat baik, dengan nilai persen perolehan kembali adalah 91,67 – 103,49%, menunjukkan bahwa matriks sampel tidak  mempengaruhi hasil pengukuran, sehingga metode ini dapat digunakan untuk analisis ion Cd(II) dalam sampel pupuk NPK. Estimasi ketidakpastian metode ini juga telah dihitung dan ditunjukkan dengan nilai persen ketidakpastian adalah 14,16%.Preconcentration of Cd(II) Ion in Nitrogen, Phosphor, and Kalium (NPK) Fertilizer Sample Using Activated Alumina as a Column Filler Material. The research about preconcentration of Cd(II) in NPK fertilizer using activated alumina as a column filler material was done. The column used a filler material of alumina previously activated using NaOH at pH 8. Some important parameters in the preconcentration stage are able to increase the analytical performance, determined using atomic absorption spectrophotometer (AAS). The result of the research shows the optimum condition of preconcentration stage Cd(II) ion are volume of the sample was 10 mL, the volume of eluent HNO3 was 4 mL with a concentration of 0.5 M, with the retention of capacity value was 1.4113 mg Cd(II)/g alumina. The analytical performance of this method is good, shown with the limit of detection value was 2.7997 μg/L. The precision of this method was indicated by the percentage of the coefficient variance of 4.03%. Alumina used as a filler column can increase the signal up to 2.5 times for direct Cd(II) ions measurement. The accuracy of this method is excellent, with the recovery percentage value was 91.67 – 103.49%, indicating that the matrices of NPK fertilizer give no effect on the results of measurements, and this method was capable of analyzing Cd(II) ions in NPK fertilizer. The uncertainty of this method was estimated as the percentage of the uncertainty of 14.16%.
Virtual Screening Kandungan Senyawa Kipas Laut (Gorgonia mariae) sebagai Antiasma Faruk Jayanto Kelutur; Resmi Mustarichie; Abdul Kakhar Umar
ALCHEMY Jurnal Penelitian Kimia Vol 16, No 2 (2020): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.16.2.39965.199-210

Abstract

Kipas laut (Gorgonia mariae) telah digunakan masyarakat Maluku secara turun temurun sebagai obat asma. Kandungan metabolit sekunder yang paling dominan dalam kipas laut adalah sterol, dimana memiliki aktivitas terapi melalui efek sinergisme antara senyawa metabolit dengan polivalent activity. Pengujian kipas laut sebagai anti-asma belum pernah dilaporkan sebelumnya. Oleh karena itu, perlu dilakukan virtual screening menggunakan metode in silico pada komponen sterol kipas laut sebagai tahap awal dalam menentukan efektivitas terapi anti-asma dengan memprediksi nilai ikatan energi bebas (ΔG), konstanta inhibisi (Ki), dan interaksi residu asam amino menggunakan Autodock Tools 4.2 dan Discovery Studio 2016 Client®. Keamanan dan efektivitas kandidat obat dievaluasi menggunakan parameter dari Lipinski Rule of Five dan pre-ADMET. Hasil penelitian menunjukkan bahwa konstanta inhibisi dan ikatan energi bebas (Ki; ΔG) dari komponen senyawa kipas laut dapat diurutkan secara potensial yaitu 4,24-dimetil kolestanol  (0,809; -12,40) > 24-metil-22-dehidrokolesterol (0,864; -12,36) > 23-demetil gorgosterol (1,74; -11,95) > 4,24-dimetil-22-dehidrokolestanol (1,89; -11,90). Residu asam amino yang berperan penting dalam aktivitas inhibisi hCHIT1 adalah 213-ASP. Semua komponen senyawa uji memiliki nilai log P lebih dari 5 yang menunjukkan bahwa kelarutan dan toksisitas perlu diperhatikan. Evaluasi distribusi pre-ADMET berdasarkan nilai dari pengikatan protein plasma menunjukan bahwa senyawa uji dapat berdifusi menembus membran plasma dan berinteraksi sesuai target farmakologi. Selain itu, hasil parameter uji toksisitas menunjukkan bahwa senyawa 23-demetil gorgosterol dan 4,24-dimetil-22-dehidrokolestanol memiliki potensi sebagai anti-asma.Virtual Screening of the Compounds in Gorgonians (Gorgonia mariae) as anti-asthma. The people of Maluku have used Kipas laut (G. mariae) for generations as an asthma medicine. The secondary metabolite that is most dominant in kipas laut is sterols, which have therapeutic activity through the synergistic effect between metabolite compounds and polyvalent activity. Anti-asthma activity of kipas laut has never been reported. Therefore, it is necessary to do virtual screening using the in silico method on the sterol component of kipas laut as a first step in determining the effectiveness of anti-asthma therapy by predicting the value of free energy bonds (ΔG), constant inhibition (Ki), and interactions of amino acid residues using Autodock Tools 4.2 and Discovery Studio 2016 Client®. The effectiveness and safety of prospective drugs are evaluated using the Lipinski Rule of Five and pre-ADMET. The results showed that the value of inhibition constants and free energy bonds (Ki; ΔG) on the compound of kipas laut that was potentially sorted was 4.24-dimethyl cholestanol (0.809; -12.40) > 24-methyl-22-dehydrocholesterol (0.864; -12.36) > 23-demethyl gorgosterol (1.74; -11.95) > 4.24-dimethyl-22-dehidrokolestanol (1.89; -11.90). The crucial residues of amino acids is 213-ASP, which play a significant role in hCHIT1 inhibitory activity. All components of the test compound have a log P value of more than five, which indicates that solubility and toxicity need to be considered. Evaluation of the pre-ADMET based on the value of plasma protein binding shows that the test compound can diffuse through the plasma membrane and interact according to pharmacological targets. In addition, the results of the toxicity test showed that 23-demethyl gorgosterol and 4.24-dimethyl-22-dehidrokolestanol compounds have potential as anti-asthma.

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