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ALCHEMY Jurnal Penelitian Kimia
Published by Universitas Sebelas Maret
ISSN : 14124092     EISSN : 24434183     DOI : -
Core Subject : Science, Social, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology
ALCHEMY Jurnal Penelitian Kimia is a chemistry journal published by Sebelas Maret University, Surakarta. ALCHEMY Jurnal Penelitian Kimia publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
Arjuna Subject : -
Articles 13 Documents
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Search results for , issue "Vol 19, No 2 (2023): September" : 13 Documents clear
Antibacterial Activity of Streptococcus mutans from Saga Herbaceous Plant (Abrus precatorius): In Silico Study Richa Mardianingrum; Neta Ekayanti Suganda; Srie Rezeki Nur Endah; Ruswanto Ruswanto
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 2 (2023): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.2.67780.177-189

Abstract

Antibacterial is a substance that can inhibit growth or can even kill bacteria that cause infection. One of them is infection with Streptococcus mutans bacteria that cause damage to teeth, such as dental caries. Dental caries is a disease that affects many adults and children, permanently damaging the tooth layer and forming small holes in the teeth. The purpose of this study was to find active compounds from the herb Saga plant (Abrus precatorius), which has the potential to be antibacterial of S. mutans in silico. The methods used are pharmacokinetics and toxicity screening, Lipinski's Rule of Five, as well as simulations of molecular docking and molecular dynamics. The Abruquinone D (-6.43) and Abruquinone F (-7.08) were predicted to have stable interactions and be similar to amoxicillin (-7.69) and native ligand (-8.56 kcal/mol) based on the results of screening and molecular docking simulations of active compounds from Saga herbaceous (Abrus precatorius) against deoxycytidylate deaminase receptors. Molecular dynamics findings confirmed by MMGBSA methods that Abruquinone D (-41.3876 kcal/mol) had a lower energy value than Abruquinone F (-24.8521 kcal/mol). It can be inferred that Abruquinone D has a higher potential as an antibiotic (S. mutans) than Abruquinone F.
Molecular Docking and Pharmacophore Analysis of Compounds from Ginger (Zingiber officinale) as Inhibitor for Dengue DEN2 NS2B/NS3 Serine Protease Neni Frimayanti; Enda Mora; Rindiyani Rindiyani
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 2 (2023): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.2.75234.190-196

Abstract

Dengue hemorrhagic fever (DHF) is a disease caused by the dengue virus (DENV). Dengue virus can enter the human body through the Aedes aegypti and Aedes albopictus mosquitoes. According to the Indonesian Ministry of Health, dengue hemorrhagic fever (DHF) is still a serious health problem in Indonesia. The type of dengue virus serotype most commonly found to cause infection in the human body is the DENV-2 serotype. This study aims to determine whether Ginger (Zingiber officinale) isolate compounds have potential as dengue DEN-2 NS2B/NS3 inhibitors. Samples used are compounds with IUPAC names (S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl) octan-3-one (4-gingerol) and (S)-5-hydroxy-1-(3-methoxy-4-methylphenyl) decan-3-one. The method used is molecular docking and Pharmacophore using the MOE (Molecular Operating Environment) 2022.0901 software package. The results obtained based on the observed parameters of the two compounds isolated from ginger (Zingiber officinale) could be estimated as potential dengue DEN2 NS2B/NS3 inhibitors.
Efek Perbedaan Komposisi Komposit Na2FeSiO4/C Berbasis Silika Sekam Padi Terhadap Fasa dan Sifat Listriknya Agus Riyanto; Sutiarno Sutiarno; Nindya Aisah Indriyani; Wulan Warohmah; Silvi Indah Kusuma Wardani; Syafriadi Syafriadi; Pulung Karo Karo; Sri Wahyu Suciati
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 2 (2023): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.2.65707.140-148

Abstract

Salah satu teknik yang digunakan untukmengoptimasi sifat listrik dari Na2FeSiO4 ialah menambahkan grafit (C) sehingga menjadi komposit. Studi ini dilakukan untuk meninjau karakteristik fasa dan sifat listrik dari komposit Na2FeSiO4/C yang komposisinya bervariasi. Preparasi sampel diawali dari penyiapan Na2FeSiO4 dan dilanjutkan dengan pembuatan Na2FeSiO4/C. Na2FeSiO4 dipreparasi dari silika sekam padi, NaOH, Fe(NO3)3.H2O, dan C6H8O7.H2O menggunakan metode sol-gel diikuti dengan proses sinter pada suhu 800 ℃ selama 10 jam. Bahan baku Na2FeSiO4, grafit, dan Carboxy Methyl Cellulose (CMC) dengan variasi perbandingan massa dicampurkan dengan menambahkan n-metilpirrolidin hingga menjadi slurry, kemudian dikeringkan pada suhu 120 ℃ selama 1 jam dan menghasilkan komposit Na2FeSiO4/C. Spektrum FTIR mengindikasikan keberadaan gugus Na‒O, Fe‒O, Si‒O, dan C=C. Difraktogram mendeteksi keberadaan 4 fasa di dalam setiap sampel yaitu Na2FeSiO4, Na2SiO3, SiO2, dan grafit (C). Fasa Na2FeSiO4 memiliki puncak difraksi dengan intensitas tertinggi dibanding dengan fasa yang lainya sehingga terindikasi kuat bahwa fasa tersebut ialah fasa utama. Fasa grafit semakin meningkat seiring dengan meningkatnya komposisi grafit di dalam sampel sebagaimana terkonfirmasi dari naiknya intensitas puncak difraksi dari fasa tersebut, serta ditandai dengan menurunnya nilai transmitansi pada bilangan gelombang yang berkaitan dengan gugus C=C. Meningkatnya fasa grafit dalam Na2FeSiO4/C berpengaruh terhadap nilai penurunanenergi celah pita dan berpengaruh signifikan terhadap peningkatan konduktivitas listrik.

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