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Journal of General Procedural Dermatology and Venereology Indonesia
Published by Universitas Indonesia
ISSN : 24607991     EISSN : 24607991     DOI : 10.191
Core Subject : Health,
Medicine & Pharmacology
The initiation of JDVI (Journal of General - Procedural Dermatology & Venereology Indonesia) was done by leading dermatologists and venereologists from Indonesia who aspired to contribute in the field of scientific publication and research. Knowledge and science continue to evolve in the field of dermatology and venereology, especially with new diagnostic methods, therapeutic and procedural approaches, and new emerging diseases.
Arjuna Subject : -
Articles 106 Documents
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The relationship between increased body mass index with transepidermal water loss: a comparative study
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 6, No 1 (2022): June 2022
Publisher : Universitas Indonesia

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Abstract

Background: Obesity affect significant populations on all ages. The relationship between obesity and metabolic diseases is known but a dermatological link is rarely explained. Transepidermal water loss (TEWL) is one of the measurement tools used to define the skin&rsquo;s barrier function by measuring the amount of water that evaporates through the skin in aspecific amount of time. Although several studies on TEWL are available but discussion about the correlation between TEWL and body mass index (BMI) is still limited. This study aims to evaluate the correlation between TEWL and BMI.Methods: This research is a single-center study with analytical cross-sectional design that includes healthy subjects among medical students aged 18 to 23 years old in Universitas Sebelas Maret. A questionnaire was used to ensure that all subjects met the criteria. Chi-square and Pearson were used to analyze the observed variables.Results: The total sample in this study was 62 participants, with a majority of female (59.7%) and ranged from 21 to 23 years (74.2%). The ratio of normoweight and overweight/obese was 1:1. The results demonstrated significant difference and positive correlation between increased BMI with TEWL (p<0.05; r=0.510).Conclusion: This study showed a significant correlation between increased body mass index and transepidermal water loss. Overweight participants tend to develop high values of TEWL which reflect a disruption of skin barrier. Further research on other influencing factors with larger samples and more study centers are needed. Keywords: BMI; skin barrier; TEWL
Cutaneous manifestation of thyroid carcinoma in a 64-year-old Filipino woman: a case report
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 6, No 1 (2022): June 2022
Publisher : Universitas Indonesia

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Abstract

Background: Cutaneous metastasis is a rare phenomenon of thyroid carcinoma. Several mechanisms regarding cutaneous metastasis from internal malignancies have been proposed. Various treatment options are available, including surgical procedures, radioiodine therapy, thyroid hormone therapy, and other possible therapies. The prognosis of thyroid carcinoma with cutaneous manifestation is poor.Case Illustration: We presented a case of 64-year-old female patient with previously diagnosed thyroid carcinoma admitted with enlarged and tender nodules on the right side of the anterior neck. No surgical intervention was done and patient was treated with chemotherapy using doxorubicin 80 mg as the agent of choice. Levothyroxine 100 mcg was also administered every 24 hours. Chemotherapy was given, however the patient eventually died due to respiratory failure.Discussion: The patient initially presented with a slow-growing neck mass, which rapidly developed into larger mass with multiple erythematous to violaceous papules, firm tender nodules, and patches on the thoracic area, indicating slow and rapid progression of the disease. According to histopathologic examination, the patient had papillary thyroid carcinoma. However, the patient poorly responded to the chemotherapy regimen with doxorubicin, which indicated that this malignancy is associated with poor prognosis.Conclusion: Cutaneous metastasis is a rare complication of thyroid carcinoma. Typically, it initially develops as a slow-growing tumor that subsequently progresses into multiple malignant lesions. It is an indicator of poor prognosis in thyroid carcinoma, and further studies are warranted to improve the prognosis of this disease. Keywords: cutaneous manifestation, thyroid carcinoma, metastasis
Combined use of CROSS TCA and modified subcision with PRP administration for acne scars
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 6, No 1 (2022): June 2022
Publisher : Universitas Indonesia

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Abstract

Background: Acne vulgaris is a skin disease that can cause permanent scarring. Various therapeutic options are available to treat atrophic scars, but combination therapy is still the best choice according to different types of scars in a single patient. Chemical reconstruction of skin scars (CROSS) trichloroacetic acid (TCA), modified subcutaneous incisionless (subcision), and platelet-rich plasma (PRP) can be used as a combination therapy to treat acne scars.Case Illustration: A 25-year-old man complained of acne scars on both sides of his face. Dermatologic findings were blackheads, icepick, boxcar, and rolling scars. Clinically he had moderate to severe acne scores. He was treated with a combination of CROSS TCA for icepick-type acne scars, modified subcision, and PRP injection for rolling and boxcar-type acne scars on both sides of the face. During treatment, the patient was given oral and topical antibiotics. The patient was followed-up after one month. It resulted in a good therapeutic response, which showed 25%-49% of Goodman and Baron&rsquo;s classification, and a visual analog scale of 6.Discussion: CROSS TCA is a therapeutic choice for icepick-type acne scars with a simple, practical technique and provides a significant effect. Modified subcision is modified therapies from the previous Khunger subcision technique and a new alternative that can be applied to damaged tissue. This can maximally repair scarring, facilitate surgeon, provide avenues, and increase maximum PRP penetration.Conclusion: CROSS TCA with subcision and PRP are simple procedures that can be applied as an alternative therapy to acne scars with good therapeutic response. Keywords: CROSS TCA, PRP, scars, subcision
Microneedling and platelet-rich plasma (PRP) treatment for mixed melasma
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 6, No 1 (2022): June 2022
Publisher : Universitas Indonesia

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Abstract

Background: Melasma, or chloasma, is an acquired pigmentary disorder caused by increased melanin in the epidermal and dermal layers, characterized by brown or gray patches on the face and neck. There are many treatment options available; however, the difficulties in treating melasma are frequent recalcitrants, high recurrence rate, irregularity in treatment, and the tendency of the patients to self-medicate.Case Ilustration: We report a case of mixed melasma treated by microneedling and topical PRP administration. Thirteen weeks following the therapy, the patient showed a favorable response brighter skin and substantial disappearance of brown patches.Discussion: Studies assessing the efficacy of microneedling and platelet-rich plasma (PRP) treatment for melasma are still lacking. However, melasma improvement has been reported in patients treated with microneedling and PRP. In this study, we provided a study of a patient with mixed melasma treated by microneedling and PRP, which showed a favorable improvement.Conclusion: Microneedling and PRP treatment showed a favorable response in a patient with melasma, with substantial disappearance of brown patches and a decrease in MASI (Melasma Area and Severity Index) score. Keywords: microneedling, mixed melasma, platelet-rich plasma
The vaginal microbiota
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 6, No 1 (2022): June 2022
Publisher : Universitas Indonesia

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Abstract

The vagina is an ecosystem consisting of various species of microorganisms (microbiota) that play important role in maintaining vaginal health. The vaginal ecosystem includes a variety of species classified into aerobic and anaerobic microorganisms which are vaginal microbiota (VMB). In the vagina of a healthy woman, 70% of normal microbiota is dominated by the Lactobacillus species. Lactobacillus is a Gram-positive, anaerobic bacterium, and belongs to the group of lactic acid bacteria (LAB). LAB produces lactic acid which plays a role in maintaining vaginal acidity at pH <4, producing H2O2 and bacteriocin, modulating non-specific immune responses, and preventing colonization of microorganisms through competitive adhesion in the vaginal epithelium. The composition of the VMB can vary between women and can change dramatically in a short time in the same individual. Over the past several decades, it has been known that a significant shift from the normal number of VMB colonies affects the integrity of the mucosal surface protective layer. The imbalance of VMB colonies and their effects on the vagina can cause an increased risk of sexually transmitted infections (STI) including bacterial vaginosis, vulvovaginal candidiasis, gonorrhea, trichomoniasis, Chlamydia trachomatis infection, herpes simplex virus (HSV) infection, bacterial vaginosis infection, vulvovaginal candidiasis, gonorrhea, trichomoniasis, Chlamydia trachomatis infection, herpes simplex virus (HSV) infection, human papillomavirus infection (HPV), and human immunodeficiency virus (HIV) infection. Keywords: Lactobacillus, STI, vaginal microbiota
Recent progress in immunotherapy for skin cancer
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 6, No 1 (2022): June 2022
Publisher : Universitas Indonesia

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Abstract

Skin cancer is a global health concern due to its growing incidence and high mortality rate. The most common therapeutic modalities in skin cancer include surgery, radiotherapy, and chemotherapy. However, those therapies do not specifically target cancer cells and may damage healthy tissues. Cancer induces immune response by releasing soluble antigens and danger signals caused by tumor cellular stress or death, while the immune system continuously monitor and control malignant proliferation through cancer immunoediting. Therefore, targeting this mechanism is a promising approach to manage cancer, especially those unresponsive to conventional therapies. Immunotherapy is a specific therapy that manipulates the immune system to fight the disease. Previous studies have shown promising results in its clinical use in melanoma and non-melanoma skin cancer (NMSC). However, its potential toxicity and tolerability may pose significant obstacles in developing effective cancer immunotherapy. Biomedical, immunological, and clinical research in skin cancer is still needed to elaborate further on its pathogenesis and design safe and effective therapy for each skin cancer. Keywords: immunotherapy, melanoma, NMSC, toxicity

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