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Journal of General Procedural Dermatology and Venereology Indonesia
Published by Universitas Indonesia
ISSN : 24607991     EISSN : 24607991     DOI : 10.191
Core Subject : Health,
Medicine & Pharmacology
The initiation of JDVI (Journal of General - Procedural Dermatology & Venereology Indonesia) was done by leading dermatologists and venereologists from Indonesia who aspired to contribute in the field of scientific publication and research. Knowledge and science continue to evolve in the field of dermatology and venereology, especially with new diagnostic methods, therapeutic and procedural approaches, and new emerging diseases.
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Articles 106 Documents
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Prevalence of Cutibacterium acnes and Staph spp. in the lesions of acne vulgaris in Jakarta Melyawati Hermawan; Enty Tjoa; Inneke J. Hidajat; Maria Teressa; Eka B. Layadi; Alegra Wolter
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 5, No 2 (2021): June 2021
Publisher : Universitas Indonesia

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Abstract

Background: Acne vulgaris (AV) is a chronic skin disorder that is commonly seen in young adults. Recent studies have shown that bacteria other than Cuticubacterium acnes found in the skin microbiota also play vital roles in the pathogenesis of AV. Understanding the skin microbiota and its disruption in patients with AV is paramount in treating patients with AV.Methods: Samples were obtained from 36 subjects to evaluate the proportion of Cutibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus in lesions of AV by means of bacterial culture.Results: There were 69 specimens collected from the 36 subjects with AV. The most abundant type of bacteria that was successfully isolated in the cultured AV lesions was Staphylococcus epidermidis(46.4%), followed by Cutibacterium acnes(14.5%), and Staphylococcus aureus(2.9%).Conclusion: Staphylococcus epidermidis,the major species of human skin flora, is the most abundant microorganism found in AV. The development of AV is not necessarily associated with the high proportion of Cutibacterium acnes. More pathogenic bacteria, such as Staphylococcus aureusis also not always found in the AV lesions. These findings may provide the basis for the clinicians to determine which types of antibiotics to prescribe for the treatment of AV. Keywords: acne vulgaris, Cutibacterium, skin microbiome
Impact of scabies on Indonesian public boarding school students’ quality of life: A mixed-method analysis Sri Linuwih Menaldi; Melani Marissa; Danny Surya; Valensia Vivian The
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 5, No 2 (2021): June 2021
Publisher : Universitas Indonesia

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Background: Scabies is a neglected tropical disease in which people affected primarily presents with intense pruritus. The disease is often recurrent, especially in people living in close contacts, such as in a community; thus, it negatively impacts their quality of life (QoL).This study analyzes the impact of pruritus in scabies on the QoL of patients living in a public boarding school (PBS) in West Java, Indonesia. Methods: This study is a mixed-method study conducted on 39 subjects. TheQoL was examined using the Indonesian version of the dermatology life quality index (DLQI) questionnaire and in-depth interviews.Results: Most subjects were female, grade 9 students, had a duration of symptoms between six months to one year, had been infected more than twice, and with no family member affected by the same symptoms. We found that sex, duration of symptoms, disease frequency, and affected family members did not significantly affect subjects’ QoL. In-depth interviews revealed that pruritus affected social relationships, quality of learning, and sleeping.Conclusion: Holistic and comprehensive community management is needed to treat and prevent scabies transmission, as its symptoms negatively impact the QoL of students in PBS. Keywords: pruritus, boarding school, QoL, scabies
Multisystem Langerhans Cell Histiocytosis in high-risk group: A case series of two infants Anggun Putri Yuniaswan; Putri Rachma Safitri; Diah Prabawati Retnani
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 5, No 2 (2021): June 2021
Publisher : Universitas Indonesia

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Background: Langerhans Cell Histiocytosis (LCH) has diverse manifestations, from asymptomatic to aggressive, which involves many organs. Histopathological examination playsa crucialrole as a basic diagnostic standard for LCH. Writing Group of the Histiocyte Society proposes a guideline for diagnosing LCH, divided into presumptive, designated, and definitive diagnosis. Case Illustration:Two cases of a 14 month-old girl and an 18 month-old girl presented similar clinical manifestation and multi-organ involvement. Dermatological examination revealed red papules and plaques covered by brownish scales and crusts on the scalp and body, erosion in some folds of the body. Histopathological examination of the first case revealed an early purpuric phase. S100 immunostaining just revealed hyperplasia of Langerhans cell but still could not support the diagnosis of LCH. Fine Needle Aspiration Biopsy of the enlarged submandibular lymph node after two months ofobservation suggested LCH. In the second case, histopathological examination revealed proliferation of round-oval nucleated cells, pleomorphic, some reniform nuclei, with amphophilic cytoplasm. S100 and CD1a immunostaining revealed a positive reaction in the proliferative cells.Discussion:Patients aged 14 and 18 monthsoldindicatedalmost similar clinical manifestations leading to LCH diagnosis, with different histopathological pictures. The first patient was presumptively diagnosedas high-risk multisystem LCH, but theinitial histopathology results did not support LCH diagnosis. On the other hand, the second patient was definitively diagnosed with high-risk multisystem LCH. Conclusion:Patientswith clinically suspected LCH without histopathological confirmation should be observed at least six months to reassess the necessity of a follow-up biopsy. Keywords: Langerhans Cell Histiocytosis, multisystem organ, histopathology, S100
Childhood-onset borderline tuberculoid leprosy with reversal reaction Ramona D. Lubis; Mila Darmi; Rudi Chandra
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 5, No 2 (2021): June 2021
Publisher : Universitas Indonesia

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Background: Leprosy is a chronic granulomatous infection caused by Mycobacterium lepraethat predominantly affects the skin and peripheral nerves. Leprosy among children is still common in endemic countries. Case Illustration:A 12-year-old girl complained about a hypopigmented anesthetic patch on her face for 11 years, which became larger and spread slowly to her arms and legs. She had a history of close contact with her aunt, who was diagnosed with multibacillary leprosy. On slit-skin-smear test, acid-fast-bacilli (bacteriologic index +1) were found. She was diagnosed with multibacillary leprosy and treated with children’s multidrug therapy-multibacillary (MDT-MB) regimen. After 2 months of MDT-MB treatment, she complained that the hypopigmented patches became reddish and swollen with enlarged peripheral nerves. She underwent a reversal reaction (RR) and was treated with 40 mg prednisone daily and continued the MDT regimen.Discussion: RR is found less frequently in children than the adult.Accurate diagnosis is vital because of its psychosocial impact on the family. One of the most prominent features of borderline tuberculoid leprosy is its susceptibility to RR. It is characterized by rapid changes from existing plaques to edematous lesions with or without abrupt neuritis.Conclusion: We reported a girl with borderline tuberculoid leprosy with developed RR after taking MDT-MB for 2 months. The risk factors for developing RR were being diagnosed with borderline tuberculoid leprosy, female, multiple and disseminated patches involving larger body areas and multiple nerve involvement, large facial patches, and starting treatment. These risk factors were found in our patient. Keywords: borderline tuberculoid, leprosy, reversal reaction
Dermoscopy-guided carbon dioxide laser destruction for nevus sebaceous: two case reports Larisa Paramitha Wibawa; Kuniaki Ohara
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 5, No 2 (2021): June 2021
Publisher : Universitas Indonesia

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Background:Nevus sebaceous (NS) is a common hamartoma of the cutaneous adnexal structure, clinically appear as a well demarcated yellow-orange plaque, sometimes with verrucous surface. Dermoscopy may aid the diagnosis of NS and also guide carbon dioxide (CO2) laser therapy.Case Illustration: Two cases of brown and yellowish plaque on the face, with clinical appearance, dermoscopic, and histopathological findings consistent with NS. The patients consented to undergo serial CO­2laser destruction, aimed to reduce recurrences and shorten the duration of the downtime. Dermoscopy aided in locating the area and the depth of each treatment.Discussion: The dermoscopy finding of NS were already reported as milia-like structure and multiple whitish structures (dots) varying in size, with orange background. The dermoscopy findings of these two cases were in accordance with previous reports. CO2laser destruction was reported to produce satisfying results, but with known recurrences. With the knowledge of dermoscopy appearance, we could determine the area and depth of the lesion to prevent reoccurrence. After two years of follow-up, the area where the deep ablation was performed had not reoccurred. Conclusion: Dermoscopy may aid the diagnosis and therapeutic confirmation of NS. Keywords: dermoscopy, sebaceous nevus, serial CO2laser
Basal cell carcinoma in a 14-year-old: A rare case of a common skin cancer Danang Tri Wahyudi; Firman Parrol; Aida Sofiati Hoemardani; Agassi Suseno Sutarjo
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 5, No 2 (2021): June 2021
Publisher : Universitas Indonesia

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Abstract

Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. It usually arises in sun-exposed areas of the body, with the face and neck being the most common sites for BCC. BCC is typically found in older individuals, but it is becoming more prevalent in people younger than 50. However, such cases in children under 15 are rarely encountered. Pigmented BCC is a common presentation in people of color, while such presentation is relatively unusual in Caucasians. Pediatric cases could be idiopathic, but it is more commonly associated with a genetic defect, such as basal cell nevus syndrome, xeroderma pigmentosum, Bazex syndrome, and albinism. Those cases could also arise from a congenital lesion, e.g., nevus sebaceous, radiotherapy-related, or solid organ transplant. Case Illustration:We present the case of a 14-year-old boy with a chief complaint of growing tumor on the left cheek since he was 8 years old. He was diagnosed with childhood-onset BCC based on the findings of dermoscopy and skin biopsy. The patient underwent surgical excision of the lesion with 3 mm margins and a full-thickness skin graft obtained from the left retroauricular area. Discussion:Removal of the tumor with clear margins remains the gold standard for BCC treatment. This case presentation showed the best practice for BCC cases in the childhood population. Conclusion:The diagnosis of BCC should not be neglected in the childhood population. Keywords: idiopathic BCC, childhood, excision
Alternative modality in the treatment of acne vulgaris: Low level laser therapy Rudi Chandra; Nelva Karmila Jusuf
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 5, No 2 (2021): June 2021
Publisher : Universitas Indonesia

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Abstract

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit with polymorphic manifestations. The four key elements leading to the formation of acne lesions are alteration of follicular keratinization that leads to comedones, increased and altered sebum production under androgen control, follicular colonization by Propionibacterium acnes, and complex inflammatory mechanisms that involve both innate and acquired immunity. Phototherapy (light, lasers, and photodynamic therapy) has been proposed as an alternative therapeutic modality to treat acne vulgaris and is proposed to have less side effects compared to other treatment options. Recently, low-level laser (light) therapy (LLLT) which refers to the use of red-beam or near-infrared laser with a wave-length between 600 and 1000 nanometers and power from 5 to 500 milliwatts, starts to be used in the treatment of acne. Mechanism of action of LLLT for acne is through photochemical reaction that produces reactive free radicals and singlet oxygen species which in turn lead to bacterial destruction by blue light. Meanwhile, red light can affect the sebum secretion of sebaceous glands, change keratinocytes behavior, and modulate cytokines from macrophages and other cells that reduce inflammation. LLLT is proposed to be effective as an alternative modality for inflammatory type lesions in acne vulgaris. Keywords: acne vulgaris, blue light, low level laser therapy, red light.
Noninvasive diagnostic modality for skin cancer Remenda Siregar; Raja Nurhayati; Widyaningsih Oentari; Ari Karmila Sari
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 5, No 2 (2021): June 2021
Publisher : Universitas Indonesia

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Histopathological examination is the gold standard for the diagnosis of nonmelanoma and melanoma skin cancer, but it is an invasive procedure that consumes time and requires large costs. The average cure rate for skin cancer is high with early detection and appropriate treatment. This is an article review that was made through findings from several scientific articles. There are several noninvasive imaging modality choices that can be used for screening at low cost, high quality, and faster result, which includes dermoscopy, optical coherence tomography, reflectance confocal microscopy, electrical impedance spectroscopy, multispectral imaging, and SIAscopy®. These imaging modalities can assist in the detection of skin cancer using a combination of high-quality computer science, mathematics, and optics. This can improve the efficiency of diagnosis and management, reduce treatment costs, and increase patient satisfaction while utilizing teledermatology.Keywords:noninvasive, imaging modality, teledermatology, skin cancer
Dermoscopic features of uncomplicated tinea versus steroid-modified tinea: An observational study in Indian patients Mithila Ninad Gadekar
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 5, No 3 (2021): December 2021
Publisher : Universitas Indonesia

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Background: Tinea is one of the most common superficial fungal skin infections. Steroid-modified tinea infections may present with atypical morphology. This study aims to observe the difference between dermoscopic features of uncomplicated dermatophytosis and steroid-modified dermatophytosis.Methods: This observational study was conducted in 60 patients with tinea cruris, tinea corporis and tinea faciei in the outpatient dermatology department of a tertiary care center. Patients were divided into group A and group B. Group A included 30 patients with no history of steroid use in the past three months. Group B included 30 patients with a history of steroid usage in the past three months. Dermoscopy was performed in both groups using a USB 2.0 dermoscope (Dino-Lite Premier AM3113T®, Magnification – 20x to 50x and 200x) to study the characteristic features in tinea infections. Chi-square test and Fisher’s exact test were applied as applicable.Results: Out of 60 cases of dermatophytosis, 20 cases were of tinea corporis, 28 cases of tinea cruris, and 12 cases of tinea faciei. Dermoscopic features of hair follicular involvement (perifollicular scale, follicular micropustules, the involvement of vellus hair, yellow hair, morse code hair, and transparent hair) were significantly more common in group B than in group A (P = 0.004, P = 0.039, P = 0.0001, P = 0.01, P = 0.03, P = 0.002, respectively for each feature).Conclusions: All dermatophytosis patients with a history of steroid use showed characteristic signs on dermoscopic examination irrespective of their morphologic appearance. Thus, dermoscopy can be used as a rapid diagnostic method for steroid-modified cases of tinea. Keywords: dermoscopy, morse code hair, steroid-modified tinea, yellow hair
Low-calorie diet improves PASI score in psoriasis patients with obesity: An evidence-based case report Kristian Kurniawan; Alessa Fahira; Edwin Ti Ramadan; Windy Keumala Budianti
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 5, No 3 (2021): December 2021
Publisher : Universitas Indonesia

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Background: The association between psoriasis and metabolic syndrome is appealing as the two may share a similar cross-linking systemic inflammation process. The inflammation processes occurring in obesity and psoriasis may aggravate one another. This raised the question of whether a low-calorie diet would possibly reverse the aforementioned process. This study aims to determine whether calorie restriction reduces psoriasis area and severity index (PASI) in obese patients with moderate-to-severe psoriasis receiving conventional treatment compared to no calorie restriction. Methods: We searched Pubmed/Pubmed Central, ScienceDirect, Cochrane library, EBSCOhost, and Scopus databases using keywords derived from our clinical question. The inclusion criteria were randomized clinical trial (RCT) or systematic review, published in English, and available in full-text. Results: We obtained 2 systematic reviews with meta-analyses by Ko et al. and Upala et al. Ko et al. included 6 RCTs which found that the inclusion of a low-calorie diet shows significant improvement in PASI 75 compared to standard therapy (RR 1.66; 95%CI 1.07, 2.58). Upala et al. also found significant improvement in PASI 75 in a meta-analysis of 7 RCTs (Pooled OR 2.92; 95%CI 1.39, 6.13), but shows moderately high heterogeneity between studies. Other secondary outcomes have also shown significant improvements, such as quality of life and metabolic parameters. Conclusion: The intervention of a low-calorie diet may significantly reduce PASI, improve quality of life and reduce comorbidities in obese patients with moderate-to-severe psoriasis, and thus can be recommended in psoriasis management. Keywords: low-calorie diet, obesity, PASI, psoriasis

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