International Journal of Cardiovascular Practice
International Journal of Cardiovascular Practice(IJCP) is an international quarterly journal dedicated to a broad spectrum of topics in cardiology. All manuscripts must be prepared in English, and are subject to a rigorous and fair peer-review process. Accepted papers will immediately appear online followed by printed hard copy.
Articles
198 Documents
Coronary Microvascular Dysfunction and Microvascular Angina
Sun Yuhua;
Wang Baoping
International Journal of Cardiovascular Practice Vol. 4 No. 3 (2019)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences
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DOI: 10.29252/ijcp-26713
Many patients present with myocardial ischemic symptoms, but fail to be diagnosed of obstructed coronary artery disease, since the normal coronary arteries or no any atherosclerosis stenosis ≥ 50% at coronary angiography. Myocardial ischemia can be caused by either abnormalities of epicardial coronary arteries or coronary microvascular dysfunction (CMD). Patient with microvascular angina in the absence of coronary artery disease and myocardial diseases, CMD is suggested to be the unique cause of symptoms. The previous clinical and pathogenetic classification of CMD is based on presence or absence of coronary artery disease, myocardial diseases, or other traditional risk factors, which would obscure the importance of the disease primarily provoked by CMD. The role of atherosclerotic plaque rupture in epicardial coronary arteries and the abnormality of hemorheology (especially in perimenopausal women) should be more stressed in the pathogenetic mechanism of CMD. The pathogenetic mechanism of CMD will be classified according to microvascular structure (embolization and stenosis), microvascular function and blood risk factors in this paper. The CMD related diseases including cardiac X syndrome and coronary slow flow would be better uniformly named as microvascular angina. While little data supported therapies for CMD related diseases so far, the blood healthy therapy as a novel method is recommended to treat microvascular angina, especially in the patients with high hematocrit, increased blood viscosity and coronary slow flow.
Correlation of Hematologic Indices with CT-pulmonary Arterial Obstruction Index in Patients with Acute Pulmonary Emboli
Taraneh Faghihi Langhroudi;
Mahtab Borji Esfahani;
Isa Khaheshi;
Mohammadreza Naderian;
Farbod Zahedi Tajrishi;
Mohammad Javad Namazi
International Journal of Cardiovascular Practice Vol. 4 No. 3 (2019)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences
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DOI: 10.29252/ijcp-27078
Introduction: Acute Pulmonary thromboembolism (PTE) is an imperative medical condition with a considerable global impact. Inflammation is deemed to take a notable part in the pathophysiology of this potentially fatal disorder. The aim of the current study was to predict acute PTE severity in helical pulmonary CT-angiography using easily accessible hematological complete blood count (CBC) indices.Methods: After exclusion of inflammatory conditions that may affect CBC parameters, a total of 69 consecutive patients with definite diagnosis of acute PTE according to pulmonary helical CT –angiography were recruited. Laboratory tests, including CBC parameters were performed on admission in the emergency unit, before initiation of any therapy. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and RDW to platelet ratio (RPR) were calculated in each case of acute PTE. Ultimately, CT pulmonary arterial obstruction index (PAOI) was assessed subsequent to pulmonary helical CT-angiography for each patient.Results: We found that NLR is positively correlated with acute PTE severity according to CT pulmonary arterial obstruction index (PAOI) (P < 0.01, r = 0.56); however, PLR, RDW and RPR did not appear to show such correlations (P > 0.05).Conclusions: NLR could be an easily calculated and capable index to predict severity of acute PTE in pulmonary CT-angiography. Consequently, NLR might be used in precise risk stratification when suspicious for acute PTE and in accurately triage of patients who would benefit greatly from urgent diagnostic and therapeutic interventions.
Successful Primary Angioplasty of Anomalous Coronary Artery through Radial Access and Increased Guide Support: A Case Report
Amar Upadhyay;
Barun Kumar
International Journal of Cardiovascular Practice Article in Press
Publisher : Publisher: Shahid Beheshti University of Medical Sciences
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DOI: 10.29252/ijcp-29184
One of the rare abnormalities of coronary artery anatomy is the common origin of all three coronary arteries from the right sinus of Valsalva, which, may associated with myocardial ischemia. Percutaneous coronary intervention of such patients with anomalous coronary arteries is particularly challenging. In such patients femoral route is usually chosen for coronary angioplasty, various studies have proved that the radial access provides better engagement and robust support to the guide catheter. We report a rare case diagnosed with ST-segment elevated myocardial infarction. The patient underwent successful trans-radial primary angioplasty with a buddy wire, parked in the non-culprit artery.
Low dose radiation exposure and cardiovascular diseases: a review
Ling Gao;
Chun-Yan Ding
International Journal of Cardiovascular Practice Vol. 2 No. 4 (2017)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences
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DOI: 10.21859/ijcp-030103
ICRP stated that particular attention should be paid to radiation effects in the cardiovascular system because of recent published observations of radiation effects in this systems occurring after much lower doses than reported previously (ICRP, 2007 and 2012). The review was based on scientific articles available in the open literature, major reviews by other organizations, in particular International Commission on Radiation Protection (ICRP, 118). In this review, we describe low-dose ionizing radiation effect, causes of cardiovascular diseases, relationship between low-dose ionizing radiation and cardiovascular diseases, as well as the importance and urgent of elucidate the relationship between low dose ionizing radiation and cardiovascular disease.
Dilated Cardiomyopathy in Behcet's Disease in a Young Male Patient
Hamid Khederlou;
Samin Taheri;
Alireza Sadeghi;
Amirhossein Moghtader Mojdehi
International Journal of Cardiovascular Practice Vol. 2 No. 4 (2017)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences
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DOI: 10.21859/ijcp-030102
Behcet’s disease is a multisystemic, inflammatory and chronic disorder characterized by recurrent oral aphthous ulcers and genital ulcers, uveitis and other manifestations, including systemic organ involvement. Cardiac involvement in Behcet’s disease is rarely however, it plays an important role in prognosis and increases mortality. We hereby have reported a case of Behcet's disease with dilated cardiomyopathy. He was presented with constitutional symptoms and also oral and genital aphthous ulcers, pseudofolliculitis, tachycardia, arthritis, splenomegaly, ESR (erythrocyte sedimentation rate) and CRP (C-reactive protein) elevation and LV systolic dysfunction with LVEF=45% were found in evaluation. He was started on Azathioprine and Prednisolone.
The Assessment of left ventricular Function in MRI using the detection of myocardial borders and optical flow approaches: A Review
Narjes Benameur;
Tarek Kraim;
Younes Arous;
Najemeddine Benabdallah
International Journal of Cardiovascular Practice Vol. 2 No. 4 (2017)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences
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DOI: 10.21859/ijcp-030101
The evaluation of left ventricular wall motion in Magnetic Resonance Imaging (MRI) clinical practice is based on a visual assessment of cine-MRI sequences. In fact, clinical interpreters (radiologists) proceed with a global visual evaluation of multiple cine-MRI sequences acquired in the three standard views. In addition, some functional parameters are quantified following a manual or a semi-automatic contouring of the myocardial borders. Although these parameters give information about the functional state of the left ventricle, they are not able to provide the location and the extent of wall motion abnormalities, which are associated with many cardiovascular diseases. In the past years, several approaches were developed to overcome the limitations of the classical evaluation techniques of left ventricular function. The aim of this article is to present an overview of the different methods and to summarize the relevant techniques based on myocardial contour detection and optical flow for regional assessment of left ventricular abnormalities.
A Mysterious Case of ST-Elevation Myocardial Infarction; an Old Man with Weight Loss and Dyspepsia
Morteza Safi;
Isa Khaheshi;
Mehdi Memaryan;
Mohammadreza Naderian
International Journal of Cardiovascular Practice Vol. 2 No. 4 (2017)
Publisher : Publisher: Shahid Beheshti University of Medical Sciences
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We present a 65-year-old man who developed retrosternal compressive chest pain. A 12-lead electrocardiography demonstrated ST-segment elevation in leads II, III and aVF. Emergent coronary angiography showed significant thrombus in the distal portion of the left main coronary artery. Abdomino-pelvic computed tomography scan, which was performed the next day, confirmed a pancreatic mass with peritoneal seedings, compatible with peritoneal carcinomatosis. This case underscores the importance of malignancies that may lead to a catastrophic ST-elevation myocardial infarction due to a hypercoagulable state and following thrombosis in the left main coronary artery.
RARE COR TRIATRIUM COMPLICATIONS : CASES REPORTS AND LITERATURE REVIEW
Rihab Machtache;
abdenasser drighil;
sara chibane;
amal moukhliss;
leila azzouzi;
rachida habbal
International Journal of Cardiovascular Practice Article in Press
Publisher : Publisher: Shahid Beheshti University of Medical Sciences
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Cor triatriatum, est une anomalie cardiaque congénitale impliquant une membrane fibromusculaire qui divise même l'oreillette gauche ou la droite en 2 chambres.Cette anomalie n'a été rapportée que chez 0,1% à 0,4% des patients atteints de cardiopathie congénitale. La plupart des patients sont diagnostiqués avec la condition dans la petite enfance ou l'enfance; les cas adultes sont rares.Nous décrivons trois complications rares du cor triatriatum. Le premier cas concerne une embolie pulmonaire compliquant un cor triatrium dextrum chez un homme de 44 ans, ce qui n'a jamais été rapporté, du moins à notre connaissance. Il a subi une résection corrective de la membrane et a été asymptomatique par la suite.Le deuxième cas concerne la mort subite d'un nourrisson de 9 mois cor triatrium sinistrumLe dernier est un patient de 45 ans environ admis pour fibrillation auriculaire révélant un triatrium cornéen.
Clinical profile of patients with prosthetic heart valve thrombosis undergoing fibrinolytic therapy and NYHA class as a predictor of outcome
Sanjeev Bhatia;
Sharad Jain;
Vishal Sharma;
Zeeshan Mansuri;
Krutika Patel;
Pragya Jain;
Mithilesh Kulkarni;
Tanmay Agrawal;
Kamal Sharma
International Journal of Cardiovascular Practice Article in Press
Publisher : Publisher: Shahid Beheshti University of Medical Sciences
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DOI: 10.29252/jcp-29642
Background: Prosthetic heart valve thrombosis (PHVT) is a potentially fatal complication of heart valve replacement with mechanical prostheses mainly due to thrombosis.Aim: The study aimed to evaluate the clinical profile of the patients presenting with PHVT undergoing fibrinolytic therapy and analyzing patients with respect to New York Heart Association (NYHA) functional class on presentation and its association with outcome of fibrinolytic therapy.Settings & design: This was prospective, observational study conducted from June, 2016 to April, 2017. Total 133 patients with prosthetic heart valve thrombosis were included. Materials and methods: Routine blood investigations included complete hemogram, liver and renal function tests. Prothrombin time with INR was done on admission. The diagnosis of PHVT was assessed by fluoroscopy and/or echocardiography (transthoracic/transesophageal). Follow-up at 6 months was scheduled for all patients.Statistical analysis: Parametric values between two groups were performed using the independent sample t-test or chi-square test, as appropriate. Univariate and multivariate logistic regression was used to find out factors associated with outcome.Results: All patients received fibrinolytic therapy in which 108 (81.2%) were treated with streptokinase and 25 (18.8%) were treated with urokinase. On presentation, 48.9% patients were in NYHA class III, 41.4% in NYHA class IV and 9.77% in NYHA class II. Fibrinolytic therapy was successful in 105 patients (78.9%) and it failed in 28 patients (21.1%). Mortality in NYHA class II was 0%, NYHA class III was 4.6% and in NYHA class IV was 23.6%. During 6 months follow up prosthetic heart valve thrombosis recurred in 12 (11.43%) patients.Conclusion: From our single centre experience, fibrinolytic therapy is fairly effective first line therapy for prosthetic heart valve thrombosis and NYHA functional class on presentation can predict the outcome of fibrinolytic therapy.
The Association of Serum Vitamin D Levels and Short Term and 6-month Outcomes among Patients with Acute Coronary Syndrome
Mohsen Asadi Qomi;
Sepehr Gohari;
Hassan Ahangar;
Ahmad Jalilvand;
Seyed Jamal Moosavi;
Koorosh Kamali;
Mohammad Masoud Vakili;
Tara Reshadmanesh
International Journal of Cardiovascular Practice Article in Press
Publisher : Publisher: Shahid Beheshti University of Medical Sciences
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Introduction: vitamin D affects the function of most of the cells in the body, including myocytes and endothelial cells, and also affects platelet function. This study aims to evaluate the relation between vitamin D deficiency and in-hospital and 6-month outcomes of patients with the acute coronary syndrome.Methods: This was a prospective cohort study of patients admitted to Mousavi hospital with the diagnosis of acute coronary syndrome. A venous blood sample obtained from patients at the time of admission and 25-hydroxyvitamin D, lipid profile, and hs-troponin-I levels were measured. After coronary angiography, the severity of the coronary artery stenosis was calculated by the syntax score. Patients also evaluated in-hospital outcomes and even followed up for 6-month results.Results: Totally, 204 patients were included in the study. The mean ± SD of age was 60 ± 11.6-year-old. The overall vitamin D deficiency was 80.9%. There was no association between vitamin D deficiency and in-hospital and 6-month mortality in patients with acute coronary syndrome (P = 0.824). There was a direct and statistically significant association between vitamin D levels and HDL cholesterol (P = 0.011). Twenty-eight percent of patients with negative hs-troponin-I and 14% with positive hs-troponin-I had normal vitamin D levels, which was statistically significant (P = 0.045).Conclusion: This study does not demonstrate an association between vitamin D levels and in-hospital and 6-month outcomes in patients with the acute coronary syndrome.