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Indonesian Journal of Chemistry

ijc
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Published by Universitas Gadjah Mada

ISSN : 14119420 EISSN : 24601578 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).

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Articles 31 Documents

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Search results for , issue "Vol 9, No 2 (2009)" : 31 Documents clear

MOLECULAR DOCKING OF D6-ANHYDROERYTHROMYCIN TO rRNA 23S Deinococcus radiodurans AND THE PREDICTION OF ITS ANTIBIOTIC POTENCY Winarto Haryadi; Umar Anggara Jenie; Retno Sunarminingsih Sudibyo; Harno Dwi Pranowo; Fajar Rakhman Wibowo
Indonesian Journal of Chemistry Vol 9, No 2 (2009)
Publisher : Universitas Gadjah Mada

D6-anhidroeritromisin-A is a new derivative of erythromycin which is synthesized through biosynthetic engineering technique. The molecular docking in rRNA 23S Deinoccocus radiodurans are accomplished to determine the model and strength of binding to the target macromolecule. The molecular docking of erythromycin-A and 6-deoksieritromisin-A to the same macromolecule is used as a control. The docking result of the D6-anhidroeritromisin-A shows that it occupies the same cavity as of the experimental erythromycin-A in the same macromolecule. The binding position of D6-anhidroeritromisin-A is not exactly same as erythromycin-A and 6-deoksieritromisin-A due to the presence of D6 unsaturated double bond. However the hydroxyl group(OH) at C-6 does not have an apparent effect on the binding model to rRNA23S D. radiodurans.

PREPARATION AND CATALYTIC ACTIVITY FOR ISOPROPYL BENZENE CRACKING OF Co, Mo AND Co/Mo-Al2O3-PILLARED MONTMORILLONITE CATALYSTS Hasanudin Hasanudin; Karna Wijaya; Budi Santoso
Indonesian Journal of Chemistry Vol 9, No 2 (2009)
Publisher : Universitas Gadjah Mada

It has been prepared Co, Mo and Co/Mo-Al2O3-pillared montmorillonite catalysts using montmorillonite clay as raw material. The structure and porosity of the catalysts were determined using N2 adsorption-desorption and FT-IR spectroscopy analysis methods. Isopropyl benzene cracking using these catalysts were used to test the catalytic activity and performance of Co, Mo and Co/Mo-Al2O3-pillared montmorillonites. Characterization results showed that pillarization resulted in the increase of the total pore volume and specific surface area of the clay. Meanwhile, transition metals (Co, Mo and Co/Mo) loaded on Al2O3-pillared monmorillonites could increase the catalytic activity of the catalysts for isopropyl benzene cracking significantly.

DISTRIBUTION OF URANIUM IN WATER OF GRESIK COASTAL WATERS June Mellawati
Indonesian Journal of Chemistry Vol 9, No 2 (2009)
Publisher : Universitas Gadjah Mada

Determination of uranium in water sample at Gresik coastal waters around Gresik industrial area have been carrid out. The purpose of research is to find the distribution of uranium at the coastal where the phosphate industry standing and potencially to contribute uranium pollutant to the waters. The measurement of uranium was pasive of Gamma Spectrometry, and uranium was measured as 234Th (uranium daughters) on 92.80 and 1001.03 keV gamma energies. Sea water sample was taken up by water pump sampler as a vertical mixing. The sample was sampling on the highest tide and lowest ebb, at the east season (March-August) west season (September-February). The concentration of 238U on higher tide of the west season are range between 0.0016-0.0128 Bq/l, while on lowest ebb of the east season are 0,0013-0,0877 Bq/l. There was significantly different (α= 5%) of uranium concentration in water between two seasons (east and west) in tide and ebb respectively. According to Quality Standard from Dirjen BATAN No.293/Dj/VII/1995 (radioactivity on environment), the concentration of 238U in water obtained from coastal around phosphate industry are still lower than that of recomended values (10.000 Bq/l).

COMPUTATIONAL INVESTIGATION ON THE STRUCTURE AND NMR CHEMICAL SHIFTS OF ENDO-CONE [CS2(p-METHYLCALIX[4]ARENE)] COMPLEX Hanggara Sudrajat; Muhammad S. Saefullah; Danis Sriwijaya; Mirta A. Putri; Ria Armunanto
Indonesian Journal of Chemistry Vol 9, No 2 (2009)
Publisher : Universitas Gadjah Mada

The structure and NMR chemical shifts of endo-cone [CS2(p-methylcalix[4]arene)] complex have been computationally investigated using BIO+ force fields, semi-empirical (PM3) and ab initio (RHF/6-311G++(d,p)) calculations. The first comparison of ab initio NMR chemical shift calculations for a calix[4]arene inclusion complex with solid-state 13C NMR chemical shifts based on the 1:1 complex of p-methylcalix[4]arenes with carbon disulfide in endo-cone complexation mode has been reported. The results showed that ab initio (RHF/6-311G++(d,p)) NMR calculations of the host-guest [CS2(p-methylcalix[4]arene)] complex are in good agreement with experimental solid-state NMR data.

CHEMICAL TRANSFORMATION OF EUGENOL ISOLATED FROM CLOVE OIL TO 4-ALLYL-2-METHOXY-6-SULFONICPHENOL AND 4-ALLYL-2-METHOXY-6-AMINOPHENOL I Made Sudarma; Maria Ulfa; Sarkono Sarkono
Indonesian Journal of Chemistry Vol 9, No 2 (2009)
Publisher : Universitas Gadjah Mada

The overall objective of this research was to develop new compounds with potential biological activity from readily accessed natural products, in particular eugenol. Eugenol has been reported to posses antioxidant and anticancer properties. In an attempt to enhance intrinsic activity of this natural compound, some derivatives were possible to synthesize. The main aim of this preliminary research was to isolate eugenol from clove oil and made its sulfonic and amine derivatives through chemical transformation. Clove oil was extracted from clove buds with dichloromethane and followed by isolation of eugenol using column chromatography to afford eugenol (73%). Eugenol has been reported to posses antioxidant and anticancer properties. In an attempt to enhance intrinsic activity of this natural compound, some derivatives were possible to synthesize. Eugenol was transformed to its sulfonic derivative in moderate yield by treatment with chlorosulfonic acid and to its amine by reduction of its nitro derivative. This transformation was rapidly confirmed by GC-MS analysis which showed significance molecular ion at m/z 244 corresponding to molecular formula C10H12SO5. and at m/z 179 corresponding to molecular formula C10H11O2NH2.

FTIR AND NMR STUDIES OF ADSORBED TRITON X-114 IN MCM-41 MATERIALS Paulina Taba
Indonesian Journal of Chemistry Vol 9, No 2 (2009)
Publisher : Universitas Gadjah Mada

One source of water pollutions is caused by the high use of surface-active agents (surfactants) by industries and households. As a consequence, it is required to remove such substances from the environment One of the important and widely used methods for removal of substances from solution is adsorption. In this research, MCM-41 and its modification MCM41-TMCS were used to adsorb nonionic surfactant, Triton X-114. FTIR and NMR methods were used to study the interaction between the surfactants and the adsorbents. MCM-41 was synthesized hydrothermally at 100 oC and its modification was conducted by silylation of MCM-41 with trimethylchloro silane (MCM41-TMCS). Both unmodified and modified MCM-41 can adsorb the surfactant. The amount adsorbed in the unmodified material is higher than that in the modified one. The interaction of Triton X-114 with MCM-41 was hydrogen bonding between the silanol groups in MCM-41 and hydroxyl groups of Triton X-114. For modified samples, Triton X-114 interacted with alkylsilyl groups mostly through hydrophobic interaction. It is more likely that the interaction was through C12, C13, C26 and C27 of Triton X-114.

THE VALIDITY OF FNAA AND AAS METHOD FOR ANALYSIS OF Cu AND Fe ELEMENTS IN BIOTA SAMPLES Sunardi Sunardi; Samin Samin; C. Supriyanto
Indonesian Journal of Chemistry Vol 9, No 2 (2009)
Publisher : Universitas Gadjah Mada

The validity test of Fast Neutron Activation Analysis (FNAA) and Atomic Absorption Spectrometry (AAS) method for analysis of Cu and Fe elements in biota samples has been done. The validity test was represented by the validation test, homogenous test, Z-score test, t test and F test for both methods. The respective validity test results for Cu and Fe elements show that the FNAA precision test were 2.28% and 2.96% while the accuracy were 98.07% and 98.55%, and the precision of AAS validation test results were 1.72% and 2.29% and the accuracy were 98.50% and 98.35%. The uncertainty results for Cu and Fe by FNAA were 2.74% and 3.42%, while AAS were 2.98% and 3.73%. The limit of detection for both methods of Cu and Fe were 1.05 µg/g and 1.35 µg/g, while AAS were 0.05 µg/g and 0.904 µg/g, and the value of Z-score in the range ≥-2 and ≤+2 for both methods. In this case the precision, accuracy, uncertainty, limit of detection and value Z-score on both methods are valid or property to be applied for element analysis. After FNAA and AAS methods were validated then were applied for determining of element contents in biota samples. From the homogenous test result was found that the samples of biota is homogeny, while t test shows that there is no significant difference in average concentration, F test of both methods shows that there is no difference in accuracy.

SYNTHESIS OF POLYEUGENYL OXYACETIC ACID AS A CARRIER TO SEPARATE HEAVY METAL ION Fe (III), Cr(III), Cu(II), Ni(II), Co(II), AND Pb(II) THAT USING SOLVENT EXTRACTION METHOD La Harimu; Sabirin Matsjeh; Dwi Siswanta; Sri Juari Santosa
Indonesian Journal of Chemistry Vol 9, No 2 (2009)
Publisher : Universitas Gadjah Mada

Polyeugenyl oxyacetic acid has been synthesized from polyeugenol and chloroacetic acid and applied to separate metal Fe(III), Cr(III), Cu(II), Ni(II), Co(II), and Pb(II) using solvent extraction method. pH effect, polyeugenyl oxyacetic acid ion carrier concentration, extraction time, and metal concentration optimized to gain optimum condition. The result of experiment indicated that polyeugenyl oxyacetic acid resulted the yellowed brown synthesis with melting point 125 °C and yield 68.9%. The Characterization of spectroscopy IR attributed by absorption to the area 1735,8 cm -1 as carbonyl extend vibration (C=O) acid and 1H-NMR that was attributed by chemical shift at 4.6 ppm as carboxy proton (CH2-C=0). The metal separation optimum condition gained pH 3-6 for ion Fe(III), pH 5 for ion Cr(III), Ni(II), and Co(II) and pH 6 for ion Cu(II), and Pb(II). Optimum carrier concentraction 5 mL, 10 mL, and 15 mL for ion Fe(III), and ion Cr(III), Ni(II), Co(II), and ion Cu(II), Pb(II) respectively. Extraction time 2.5 h for ion Fe(III), 20 h for ion Cr(III), and 36 h for ion Cu(II), Pb(II), Ni(II), and Co(II). Metal concentration that would extracted correctly (0.75-5 x 10-4 M) for ion Fe(III), (0.75-2.5 x 10-4 M) for ion Cr(III), Ni(II), and Co(II) and (0.75-1 x 10-4 M) for ion Cu(II) and Pb(II). The best polyeugenil oxyacetic acid response to separate ion Fe(III) than other ions with selectivity order Fe(III)> Cr(III)> Cu(II)> Pb(II)> Ni(II)> Co(II).

QUERCETIN DERIVATIVES DOCKING BASED ON STUDY OF FLAVONOIDS INTERACTION TO CYCLOOXYGENASE-2 Rahmana Emran Kartasasmita; Rina Herowati; Nuraini Harmastuti; Tutus Gusdinar
Indonesian Journal of Chemistry Vol 9, No 2 (2009)
Publisher : Universitas Gadjah Mada

Due to their ability to inhibit cyclooxygenase-2 (COX-2), certain flavonoids show anti-inflammatory effects. Quercetin is a flavonoid suitable to be chosen as the lead compound for development of safe anti-inflammatory agent, because in addition to its anti-inflammatory effect, quercetin shows also protective effect in gastrointestinal track. The objective of this research is to study the binding modes of certain flavonoids and predict the quercetin derivatives inhibiton activity on COX-2 by means of docking method using ArgusLab 4.0.1 software. Some flavonoids (7-hydroxyflavone, apigenin, galangin, kaempferol, quercetin, naringenin and daidzein) and quercetin derivatives were used as ligands for docking study. The COX-2 structure was obtained from Brookhaven protein databank. After assigning hydrogen atoms and charges, computational docking was performed. The docking results were evaluated based on the binding energy and hydrogen bonding of the ligands on binding site of COX-2. A curve constructed by plotting binding energy versus logarithm of IC50 of flavonoids shows a good correlation with a regression equation of log IC50 = 0.8069 ΔGbind + 9.4456(r = 0.9226; P50 values of the quercetin derivatives were calculated. The predicted IC50 values of quercetin-3-O-acetate; 6-chloroquercetin,3-O-acetate; 6,8-dibromoquercetin; 6,8-dichloroquercetin-3-O-acetate and 6,8-dibromoquercetin-3-O-acetate are lower than thats of quercetin. These results show that only substitutions at certain position on quercetin with acetyl group, chlorine and bromine atoms increase the inhibitory activity of quercetin against COX-2.

ISOLATION AND STRUCTURE ELUCIDATIONS OF RESVERATROL OLIGOMERS FROM STEM BARK OF Dryobalanops lanceolata Sahidin Sahidin
Indonesian Journal of Chemistry Vol 9, No 2 (2009)
Publisher : Universitas Gadjah Mada

Five resveratrol oligomers which consist of two resveratrol dimers, balanocarpol (1) and ε-viniferin (2), α resveratrol trimer i.e. α-viniferin (3), and two resveratrol tetramers, vaticanol B (4), and hopeaphenol (5) have been isolated from acetone extract of the stem bark of Dryobalanops lanceolata. These compounds were isolated by vacuum liquid chromatography method. Furthermore, the compound structures were determined based on the spectroscopic evidence, including UV, IR, 1-D and 2D NMR spectra, and comparing with those related data reported previously.

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