Indonesian Journal of Cardiology
Indonesian Journal of Cardiology (IJC) is a peer-reviewed and open-access journal established by Indonesian Heart Association (IHA)/Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI) [www.inaheart.org] on the year 1979. This journal is published to meet the needs of physicians and other health professionals for scientific articles in the cardiovascular field. All articles (research, case report, review article, and others) should be original and has never been published in any magazine/journal. Prior to publication, every manuscript will be subjected to double-blind review by peer-reviewers. We consider articles on all aspects of the cardiovascular system including clinical, translational, epidemiological, and basic studies. Subjects suitable for publication include but are not limited to the following fields: Acute Cardiovascular Care Arrhythmia / Cardiac Electrophysiology Cardiovascular Imaging Cardiovascular Pharmacotherapy Cardiovascular Public Health Policy Cardiovascular Rehabilitation Cardiovascular Research General Cardiology Heart Failure Hypertension Interventional Cardiology Pediatric Cardiology Preventive Cardiology Vascular Medicine
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712 Documents
Perbedaan Rasio Kadar Serum MMP-9/TIMP- 1 pada Kejadian Infark Miokard Akut Elevasi Segmen ST (IMA-EST) dan Sindroma Koroner Akut Non Elevasi Segmen-ST (SKA-NEST)
Basuki Rahmat;
Lucia Kris Dinarti;
Irmalita I;
Budi Yuli Setianto
Jurnal Kardiologi Indonesia Vol. 34, No. 3 Juli - September 2013
Publisher : The Indonesian Heart Association
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DOI: 10.30701/ijc.v34i3.337
Background: Differences between the pathogenesis of ST-Elevation Myocardialinfarction (STEMI) and Non-ST Elevation Acute Coronary Syndrome(NSTE-ACS) had yet unknown. Matrix metalloproteinase-9 (MMP-9) as thematrix degradation enzyme secreted by inflammatory cells play a role in thepathogenesis of plaque rupture. MMP-9 proteolytic activity is inhibited byspecific inhibitors of the Tissue Inhibitor of metalloproteinase-1 (TIMP-1).MMP-9/TIMP-1 ratio describes the actual proteolytic activity of MMP-9.This ratio may distinguish the pathogenesis of STEMI and NSTE-ACS.Objective: To examine the difference serum level ratio MMP-9/TIMP-1 inpatients with STEMI and NSTE-ACS.Methods and subjects: This is a cross-sectional study which recruits patientsconsecutively with ACS admitted to ICCU of Dr. Sardjito General Hospital Yogyakartawithin 24 h onset. Acute infection, chronic inflammation, acute stroke,kidney failure requiring renal replacement therapy, chronic heart failure, liver cirrhosis,acute exacerbation of COPD and pneumonia, thromboembolic disease,malignancy, pregnancy and the use of steroids and steroid anti-inflammatorydrugs are excluded. Serum levels of MMP-9 and TIMP-1 examined using themethod of sandwich enzyme-linked immunosorbent assay (ELISA).Results: The total of 60 subjects with STEMI patients 31 (51.7%) and NSTEACS29 (48.3%). Level of serum MMP-9/TIMP-1 ratio is significantly higher inSTEMI compared to NSTE-ACS (1.106 ± 0.065 vs. 1.046 ± 0.057, p <0.001).MMP-9/TIMP-1 ratio in serum is an independent factor for STEMI (p = 0.003)followed by blood sugar level (p = 0.013) and MMP-9 (p = 0.033). Interestingly,patients with serum MMP-9/TIMP-1 ratio> 1.0639 has a prevalence riskof 1.7 times having STEMI (p = 0.039; KI95% from 1.040 to 8.508). Levels ofserum MMP-9/TIMP-1 ratio significantly higher in STEMI compared to NSTEMIgroup (p = 0.003) and in the STEMI and UAP group (0.026), but did not differsignificantly in NSTEMI and UAP group (p = 0.045).Conclusion: High levels of serum MMP-9/TIMP-1 ratio in patients withSTEMI than NSTEACS may explain the role of serum MMP-9/TIMP-1 ratioin differentiating the pathogenesis of STEMI and NSTE-ACS.(J Kardiol Indones. 2013;34:160-6)
Permanent Pacemaker Implantation Through Persistent Left Superior Vena Cava: Safe for Normal Heart Position and Dextrocardia
Erika Maharani;
Yoga Yuniadi
Jurnal Kardiologi Indonesia Vol. 34, No. 3 Juli - September 2013
Publisher : The Indonesian Heart Association
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DOI: 10.30701/ijc.v34i3.338
Permanent pacemaker implantation in patient with persistent left superior vena cava (LSVC) has been reported in literature. Some authors has also been reported pacemaker implantation in patient with dextrocardia. Both of this situation has a challenging situation in placing the lead in right ventricle and risks of lead dislocation. We report two cases of successful pacemakers implantation,one with mirror image dextrocardia, in patient with persistent LSVC.
Membedakan Takikardia Ventrikel dan Takikardia Supraventrikular Dengan Aberansi Pada Takikardia Dengan Kompleks QRS Lebar
Andi Haryanto;
Yoga Yuniadi
Jurnal Kardiologi Indonesia Vol. 34, No. 3 Juli - September 2013
Publisher : The Indonesian Heart Association
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DOI: 10.30701/ijc.v34i3.340
Wide complex tachycardia is a quite common rhythm found in ECG. Basicly there are 3 arrhytmia that can cause wide QRS complex tachycardia, which are: Ventricle tachycardia (VT) which is the most common (80%), Supraventricular tachycardia (SVT) with abberancy (15-20%), and Atrioventriculare Reentrant Tacycardia (AVRT) with antidromic conduction (1–6 %). Correct diagnosis in differentiating SVT with aberancy and VT is important, due to the different patophysiology and different mechanism they present. Thus the therapy and management will be different, and miss treatment proven to be fatal. Since ECG is still the main modality to provide the diagnosis in wide QRS complex tachycardia, many effort were done including the creation of algorhythms to help establish the diagnosis for wide complex tachycardia. The oldest and most widely used algorhythm is the Brugada algorhythm with respectable sensitivity and specificity. In 2007 Vereckei et al proposed a new algorhythm for differentiating VT and SVT with abberancy, and in 2008 Vereckei renew his previous algorhythm into only using single aVR lead to differentiate VT and SVT with abberancy, which was made solely based on the differences in the direction and velocity of the impulse. The latest method was again proposed by Brugada in 2010 which was called the ultrasimple Brugada criterion evethough there still haven’t many research that discuss the accuracy of such criteria.
Sindroma Pre Eksitasi Asimtomatik: Ablasi Versus Konservatif
Dian Andina Munawar;
Yoga Yuniadi
Jurnal Kardiologi Indonesia Vol. 34, No. 3 Juli - September 2013
Publisher : The Indonesian Heart Association
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DOI: 10.30701/ijc.v34i3.341
Wolff-Parkinson-White (WPW) is a sporadic and familial abnormality. Epidemiologicaldata indicate that 0.1% to 0.3% of the general populationhave ECG findings suggesting that during sinus rhythm. The risk of suddencardiac death is around 0.25%. Patients with WPW syndrome is oftensymptomatic because of cardiac arrhythmias. Sometimes the arrhythmiacan be life-threatening, and leads to sudden cardiac death. However, thereis still controversy in management of individuals with asymptomatic WPWpattern. Despite radiofrequency catheter ablation remains the first linetherapy of the WPW syndrome, the risk of complications of this procedureis almost the same as the risk of sudden cardiac death in asymptomaticWPW. Therefore, an algorithm to determine the appropriate managementof asymptomatic WPW patients is needed.
Nilai Prediktif Mri Kardiak Pasca Stemi Peran Late Enhancement
Irnizarifka I;
Sony Hilal Wicaksono;
Ario Soeryo Kuncoro;
Manoefris Kasim
Jurnal Kardiologi Indonesia Vol. 34, No. 3 Juli - September 2013
Publisher : The Indonesian Heart Association
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DOI: 10.30701/ijc.v34i3.342
Forum Pencitraan Kardiovaskular edisi sebelumnya membahas tentang peran Magnetic Resonancec Imaging (MRI) kardiak pada kasus Penyakit Jantung Koroner dalam kondisi akut maupun kronik. Dalam forum kali ini, kami sajikan contoh kasus penggunaan MRI kardiak pada pasien pasca Infark Miokard Akut Elevasi ST (IMAEST) yang dilakukan pemeriksaan MRI kardiak saat perawatan sebagai stratifikasi risiko pasien pasca IMAEST. Penyakit kardiovaskular masih menjadi penyebab morbiditas dan mortalitas tertinggi di dunia, dengan penyakit arteri koroner (PAK) sebagai manifestasi utamanya.1 Dengan semakin berkembangnya manajemen serangan jantung akut, setidaknya 70% pasien yang dirawat di rumah sakit dengan infark miokard akut (IMA) berhasil melewati fase akutnya. Namun, konsekuensi jangka panjang pasca serangan akut tetap dapat terjadi meskipun intervensi fase akut telah dilakukan. Dengan demikian, ketepatan waktu dalam mendiagnosis IMAEST menjadi sangat penting.
Tips Dan Trik: Mengenali Tamponade
Rina Ariani;
Amiliana M Soesanto
Jurnal Kardiologi Indonesia Vol. 34, No. 3 Juli - September 2013
Publisher : The Indonesian Heart Association
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DOI: 10.30701/ijc.v34i3.343
Tamponade merupakan kondisi klinis mengancam jiwa dimana fungsi jantung terganggu oleh penekanan dari ruang pericardium, baik oleh cairan, massa, bekuan darah, ataupun kombinasi antara ketiganya. Fisiologi tamponade terjadi akibat terganggunya hemodinamik akibat peningkatan tekanan intra pericardium sehingga mengganggu pengisian ruang jantung. Tamponade dapat terjadi akibat adanya volume efusi yang cukup besar atau terbentuknya efusi dalam waktu yang singkat. Perlu diingat bahwa efusi yang besar dapat tidak menimbulkan tamponade bila terakumulasi bertahap sehingga memungkinkan rongga perikard meregang dan beradaptasi. Harus pula digaris bawahi diagnosis tamponade merupakan diagnosis berdasarkan klinis namun ekokardiografi seringkali dapat mengenali adanya tamponade dengan lebih dini.
Torsades de Pointes pada pasien Hipokalemia: Peranan Afterdepolarization pada mekanisme Takiaritmia
Alexander Tondas;
Yoga Yuniadi
Jurnal Kardiologi Indonesia Vol. 34, No. 3 Juli - September 2013
Publisher : The Indonesian Heart Association
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DOI: 10.30701/ijc.v34i3.344
KasusSeorang wanita usia 56 tahun, dengan riwayat gagaljantung dalam pengobatan dengan obat diuretik furosemid, mengalami muntaber selama 3 hari terakhir. Saat tiba di UGD, EKG dengan irama sinus tiba-tiba mengalami degenerasi menjadi takikardia QRS lebar polimorfik saat perekaman. Presentasi hemodinamik pasien menjadi tidak stabil sehingga diputuskan untuk dilakukan kardioversi elektrik. Setelah defibrilasi, irama jantung kembali menjadi irama sinus dan hasil laboratorium menujukkan hipokalemia berat (2,4 meq/L). Setelah koreksi potassium dan perawatan, pasien membaik kemudian dipulangkan. Apa mekanisme tercetusnya torsades de pointes pada pasien ini?
Pemasangan Stent pada Pasien dengan Myocardial Bridging Simtomatik
Johan Winata;
Eben Reppi;
Bambang Budiono;
Reggy L Lefrandt
Jurnal Kardiologi Indonesia Vol. 34, No. 3 Juli - September 2013
Publisher : The Indonesian Heart Association
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DOI: 10.30701/ijc.v34i3.345
Background : Myocardial bridging is a congenital coronary anomaly withmostly benign course throughout life. However, several pathological clinicalmanifestations may accompany myocardial bridging, such as arrhythmia,angina, depressed left ventricular function, myocardial stunning, myocardialinfarction, and sudden death. Symptomatic management with anti anginalagents should be adequate in most cases. Stenting, surgical resection ofthe bridge (myotomy), and coronary bypass surgery are only reserved forthe rare patient with severe symptoms.Case Report : A 44 year old man was admitted to the hospital because ofthe recurrent episodes of palpitations, syncope and chest pain. ECG showedsinus rhythm with bigeminy ventricular extra systoles. Echocardiographyshowed no regional wall motion abnormalities with normal ejection fraction.Coronary angiography showed myocardial bridging in mid LAD withno associated atherosclerotic coronary disease.Recurrent episodes of angina and non-sustained VT were detected duringobservation in ICCU, despite anti-arrhytmic drug treatment and Kaliumcorrection. Decision was made to perform PCI to cover bridging segmentusing drug eluting stent (DES). Post stent angiography showed no subsequentmilking effect of systole with improvement in the occurrence ofarrhythmia. Holter monitoring which was done 1 week after PCI showedno ventricular extrasystole found. Clinical evaluation and treadmill test at3 months after the procedure demonstrated good clinical condition andthe patient remained free of symptoms.Conclusion : A successful coronary stenting to mid LAD due to myocardialbridging with persistent symptoms despite medial therapy. A thorough followup should be done to identify the possibility of luminal narrowing causedby intimal proliferation or stent fracture due to external compression.
The Need for National Registry
Yoga Yuniadi
Jurnal Kardiologi Indonesia Vol. 35, No. 1 Januari - Maret 2014
Publisher : The Indonesian Heart Association
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DOI: 10.30701/ijc.v35i1.368
Currently medical outcomes research has generally been conducted with 3 sources of data: randomized clinical trials, administrative claims databases, and data registries. Each of these data sources has a unique set of applications, data quality issues, and requirements.1 In United State, clinical trials is part of the pharmaceutical and device pre-approval process thus it has highly regulated requirements for source document verification.2 In contrast, quality control of administrative data is primarily limited to fields directly related to claims adjudication. Thus, administrative claims data are significantly limited for the purposes of performing healthcare research.3 Like administrative claims data, registries are nonrandomized, observational datasets that can be generalized to real-world practice, depending on the representativeness of participants and the completeness of enrollment.4 However, as with the data collected in randomized clinical trials, registries include detailed clinical data using standardized data definitions.
Akurasi fibrinogen dan hs-crp sebagai biomarker pada sindrom koroner akut (SKA)
Djanggan Sargowo
Jurnal Kardiologi Indonesia Vol. 35, No. 1 Januari - Maret 2014
Publisher : The Indonesian Heart Association
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DOI: 10.30701/ijc.v35i1.369
Background: acute coronary syndrome (ACS) refers to any group of clinical symptom compatible with acute myocardial infarction (AMI). AMI is a major cause of death and disability worldwide with the greates risk of death within the first hours of AMI onset. Thus, the identification of novel biomarkers that improve current strategies and/or accurately identify subjects who are at risk of developing acute and chronic manifestation of cardiovascuar disease are desperately needed.Obsjective: this study was aimed to determine the accuracy diagnostic value of Fibrinogen and High Sensitivity C-Reactive Protein as a biomarker for Acute Coronary SyndromeSubjects and methods: an observational study with cross sectional approach, was conducted from February to July 2011 involving 76 male and female patients aged 35 to 80 years old for cases all well as controls. The biomarker measured were level of Fibrinogen and Hs-CRP. We used Receiver Operating Curve to determine the cut off test. We calculated of sensitivity, specificity, likelihood ratio, negative predictive value, and postive predictive value for biomarkers in combination and single.Results : the mean age in both groups was 57.5 year old. Level of the Fibrinogen in cases (5.8±1.56) was significantly different than control (3.78±1.78). concentration Hs-CRP in cases (4.04±1.94) was significantly different than control (1.98±1.25). both these biomarkers can be used as a diagnostic tool for Acute Coronary Syndrome in combination or single.Conclusion : the combination of Fibrinogen and Hs-CRP has the better diagnostic value that when used single.