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Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)

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Published by Perkumpulan Obstetri dan Ginekologi Indonesia

ISSN : 23386401 EISSN : 23387335 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.

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Articles 24 Documents

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Search results for , issue " Volume. 5, No. 2, April 2017" : 24 Documents clear

Vascular Endothelial Growth FactorC Serum and Endostatin Serum as Predictors of Lympho Vascular Invasion in Early Stage Cervical Cancer Rusmardiani, Andhinna; Rauf, Syahrul; Lukas, Efendi
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the relationship of Vascular Endothelial Growth Factors-C (VEGF-C), endostatin and the ratio of VEGF-C/ endostatin with limfo vascular invasion in patient with early stage cervical cancer. Methods: This study used a cross sectional method. Samples were all patients with early stage cervical cancer who came to the several teaching hospitals of Obstetrics and Gynecology Department Universitas Hasanuddin Medical Faculty that meet the criteria, then we measured the levels of VEGF-C and endostatin. Results: We get 30 women with cervical carcinoma. The results showed that the serum levels of VEGF-C was higher in limfo vascular invasion positive (p = 0.017); the ratio of VEGF-C/ endostatin higher in limfo vascular invasion positive (p = 0.004); whereas serum levels of endostatin did not differ significantly in limfo vascular invasion positive or negative (p = 0.522). Conclusion: The level of VEGF-C and VEGF-C/ endostatin ratio was higher in patients with early stage cervical cancer with positive LVSI than negative LVSI. [Indones J Obstet Gynecol 2017; 5-2: 105-109] Keywords: cervix uteri cancer, endostatin, limfo vascular invasion, VEGF-C

Anti Müllerian Hormone as a Predictor of Metabolic Syndrome in Polycystic Ovary Syndrome Wiweko, Budi; Susanto, Cynthia A.
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate whether Anti Müllerian Hormone (AMH) can be used as a predictor of metabolic syndrome in Polycystic Ovarian Syndrome (PCOS).Methods: This cross-sectional study was conducted in Yasmin Clinic, Dr. Cipto Mangunkusumo General Hospital Jakarta between June and December 2012. Forty-one patients diagnosed with PCOSbased on Rotterdam Criteria were enrolled. Secondary were was taken from medical record..Results: A total of 22 subjects were involved in this study. Mean AMH level in the metabolic syndrome group is compared to the non-metabolic syndrome group (10.72 ± 6.23 ng/ml vs 7.97 ± 4.50ng/ml, p=0.12). AMH was strongly associated with HDL, triglyceride and insulin resistance (r-value of -0.29, 0.23, and 0.21 respectively, p < 0.05).Conclusion: AMH can be used as a predictor of metabolic syndrome in PCOS.[Indones J Obstet Gynecol 2017; 5-2: 83-86]Keywords: anti müllerian hormone, metabolic syndrome, polycystic ovarian syndrome

Evaluation of the Accuracy of Human Kallikrein6, Cancer Antigen125, and Human Epididymis 4 in Predicting Ovarian Cancer Wenas, Yongki; Suwiyoga, Ketut; Sanjaya, I Nyoman H
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate the accuracy of hK6, HE4, and CA125 in predicting the malignancy of ovarian mass. Methods: The design of this study was cross-sectional. This study was conducted in the Obstetrics and Gynecology Clinic, Sanglah Hospital, Denpasar, between the period of September 2014 and August 2016. Samples were all patients with ovarian tumors who underwent surgery at Sanglah Hospital, Denpasar. Data analysis was performed using McNemar and chi square test in SPSS for windows version 17.0. Results: 22 samples were obtained. P > 0.05 value of age and parity variables indicated no differences between the two groups. There is no accuracy differences (sensitivity, specificity, positive predictive value, negative predictive value) of hK6 compared to histopathology examination in diagnosing ovarian cancer (p = 1). There is no accuracy differences (sensitivity, specificity, positive predictive value, negative predictive value) of HE4 compared to histopathology examination in diagnosing ovarian cancer (p = 1). There is no accuracy difference (sensitivity, specificity, positive predictive value, negative predictive value) of CA125 compared to histopathology examination in diagnosing ovarian cancer (p = 0.687). Conclusion: There was no accuracy differences (sensitivity, specificity, positive predictive value, negative predictive value) found between hK6, CA125, HE4 compared to histopathology examination in predicting ovarian cancer. [Indones J Obstet Gynecol 2017; 5-2: 110-113] Keywords: cancer antigen 125, human epididymis-4, human kallikrein 6, ovarian cancer

Postlaparoscopic GnRHagonist Therapy does not Improve Spontaneous Conception Rates of Women with Endometriosis Tjandraprawira, Kevin D; Djuwantono, Tono
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To investigate the reproductive benefits of combining laparoscopic surgery with GnRH-agonist hormonal therapy in treating women with endometriosis. Methods: This is a non-randomized prospective analytic study of patients with endometriosis conducted in a private hospital in Bandung during the period of January 2014 to December 2015, whom were later followed up after 12-24 months for assessment of post-surgical reproductive performance. A total of 121 patients were enrolled, 60 of which received post-surgical GnRH-agonist hormonal therapy. Results: We discovered that 56 women (46.3%) eventually achieved spontaneous conception after surgery but upon further analysis, it was discovered that GnRH-agonist played no significantly meaningful role in improving the spontaneous pregnancy rates of these patients (OR 1.539; 95% CI 0.750-3.159; p-value 0.239). Furthermore, even though there was a wide range as to when they achieved conception, those untreated with hormonal therapy tended to conceive far more quickly than those who were (5.91 ± 6.28; 8.56 ± 4.24; p-value: 0.011). Conclusion: Post-laparoscopic GnRH-agonist administration to women with endometriosis does not significantly improve their chances of spontaneous conception. In fact, such administration seems to delay it. [Indones J Obstet Gynecol 2017; 5-2: 87-93] Keywords: endometriosis, GnRH-agonist, laparoscopy

Human Papilloma Virus Selftesting as an Alternative Method for Cervical Cancer Screening Chandra, Richard; Rauf, Syahrul; Malinta, Umar
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the level of acceptance of self Human Papilloma Virus (HPV) examination and to compare the level of sensitivity and specificity of self HPV examination with Fluid Based Cytology on precancerous cervical lesion and cervical cancer. Methods: The analytical method used in this research was cross sectional with purposive sampling. This study is conducted at Wahidin Sudirohusodo Hospital and its affiliation from October 2014 to May 2015 with 101 subjects. The data measurement used self HPV examination tool and fluid based cytology kit. The data collected through questionnaires before and after the examination. The laboratory examination was carried out using the way of HPV Genotyping primary system (MY09/11) method Wl LTS-06, which is able to detect 35 types of HPV viruses. Results: A total of 101 subjects were involved in this study. The subjects were divided into two groups: the abnormal and normal group (n - 50/51). The acceptance level of self HPV examination was 62.37% (n = 63/101). Majority of subjects (88.21%) were ready to repeat the same examination in the future. The level of sensitivity and specificity for self HPV were (56% (95%CI (41.25 - 70.01%)) vs 98% (95%CI (89.55 - 99.95%)), p=<0.000001, while the level of sensitivity and specificity for fluid based cytology were (40% (95%CI (26.41 - 54.82%)) vs 98% (95%CI (89.35 - 99.95%)), p=0.000002. Conclusion: HPV self-testing is very potential to be used as an alternative method for cervical cancer screening. [Indones J Obstet Gynecol 2017; 5-2: 114-119] Keywords: cervical cancer, cervical cancer screening, human papilloma virus, sensitivity, specificity

The Impact of Educational Intervention of HighRisk Pregnancy and HighRisk Childbirth on Knowledge, Attitude, and Behavior in Recognizing Danger Signs in Pregnancy: A Single Blind Clinical Trial Adjie, JM Seno; Malik, Devi M
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To assess the impact of additional educational interventions given to pregnant women in identifying high-risk pregnancy and high-risk childbirth by measuring changes in knowledge, attitudes and behaviors in the pregnancy and after childbirth. Methods: This study was a single blind clinical trial conducted at obstetrics out-patient clinic of Dr. Cipto Mangunkusumo Hospital, Jakarta. Total sample were 52 responders, for the 26 responders to the control group and 26 responders to the intervention group. The research instrument was a questionnaire form, which include knowledge, attitude and behaviour of a number of 48 questions. Analysis was performed using SPSS 20 with bivariate analysis. Results: We did not found significant differences in a range of age (30.65  29.38 with 1.20  0.75), education (both groups showed a high level of education) and employment for both groups. We found significant differences on knowledge, behaviour (p = 0.001 and = 0.042, respectively) on the first antenatal care compared with after childbirth. Conclusion: The educational intervention gives significant impact in attitude and behaviour. [Indones J Obstet Gynecol 2017; 5-2: 69-72] Keywords: attitude, behaviour, educational intervention, knowledge

The Efficacy of Monoplant® and Indoplant® as Contraceptive Methods: A Comparative Study Gunardi, Eka R; Ballo, Frista
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the effectiveness, safety, and time of insertion between Monoplant® with Indoplant® to prevent pregnancy. Methods: Data were collected from November 2015 until May 2016 in Raden Saleh Clinic. A total of 153 patients met the inclusion and exclusion criteria for the study and were divided into 77 patients who received Monoplant® and 76 patients received Indoplant®. The study period was 6 months. Results: The data obtained showed no significant difference in the effectiveness of both contraceptive methods. In addition, side effects such as menstrual disorders and weight gain did not differ significantly in those study groups. However, the time of insertion between Monoplant® and Indoplant® was siginificantly different (162.91 + 197.04 + 49.81 seconds versus 44.96 seconds, p<0.001). For complications such as skin irritation, inflammation, there are no differences between Monoplant® (0.0%) and Indoplant® users (0.0%). Conclusion: There are no significant differences in efficacy and side effects using Monoplant® and Indoplant® during the 6-month follow-up. However, the insertion time of Monoplant® is shorter compared to Indoplant®’s. Monoplant® can be considered for use as contraception with the effectiveness and side effects are almost the same, but with shorter time of insertion compared to Indoplant ®. [Indones J Obstet Gynecol 2017; 5-2: 94-98] Keywords: contraception, implant, indoplant®, monoplant®

Human Papilloma Virus L1 Gene Methylation as a Potential Biomarker for Precancerous Cervical Lesion: a Preliminary Report Mongan, Suzanna P; Andrijono, Andrijono; Tjahadi, Hartono
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine whether HPV L1 gene methylation can be used in triage of precancerous cervical lesions. The main objective is to determine the genotype of HPV in cervical precancerous lesions and to determine the percentage, the sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratio of DNA HPV L1 methylation in precancerous cervical lesions. Methods: A number of 57 samples of paraffin blocks (FFPE) from precancerous lesions and cervical cancer biopsies in the Department of Pathology Faculty of Medicine-Cipto Mangunkusumo General Hospital that had been re-evaluated by the pathologist, underwent extraction of HPV DNA. The genotypes of HPV DNA were examined using primers GP5 / 6 and specific HPV 16, HPV 18 and HPV 52 probes and analyzed by real time PCR. Sequencing was performed on samples with unknown HPV DNA type that were detected using the specific probes to determine the type of HPV. Bisulfite conversion procedure was then performed for the samples that met the inclusion criteria. Results: There were 30 samples (52.6%) with CIN 1, 12 samples (21.1%) CIN 2, 9 samples (15.8%) CIN 3 and 6 samples (10.5%) of cervical cancer. Most of the samples were 36-45 years (35.1%). Of the total 57 samples, 55 samples were successfully extracted and determined the DNA genotyping of HPV (96.5%). HPV 16 infections both in the form of single or multiple was found to be 76.36%. The samples were mostly dominated by co-infection of HPV16 and 18 (49.1%) followed by HPV 16 (24.6%) and HPV 18 (14.0%). Based on the sequencing results there were other types of high risk HPV infection found: HPV 33, HPV 35, HPV 58 and also undeterminate risk HPV 53 and low risk HPV 54. After several procedures of optimization for methylation examination of HPV DNA L1 there was thin band found in electrophoresis procedure in 8 of 42 samples (19%) of HPV 16 after bisulfite conversion but once it was purified there weren’t any band found so we can not proceed to the stage sequencing. Until now we are still in the stage of optimizing the methylation procedure. Conclusion: HPV 16 infection were most commonly found in the form of single or multiple. Co-infection of HPV 16 and 18 were found in the majority of the samples. There were no significant correlation between HPV type and the severity of cervical lesions. Until now, the examination of DNA methylation HPV L1 already obtained eight samples of HPV 16 with a thin band on electrophoresis but the result could not be concluded because it is still in the process of optimization. [Indones J Obstet Gynecol 2017; 5-2: 120-126] Keywords: HPV DNA genotype, L1 gene methylation, precancerous cervical lesions

Iron Deficiency Anemia, Cystitis, and Bacterial Vaginosis Increase the Risk for Developing Preterm Labor Sumampouw, Janet; Suwiyoga, I Ketut; Negara, Ketut S.
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To prove the association of iron deficiency anemia, cystitis, and bacterial vaginosis as risk factors for preterm labor.Methods: This study was an observational case-control study conducted at the Polyclinic and IRD of Obstetrics and Gynecology Sanglah Denpasar General Hospital Center between September and December 2015. The sample selection was done by consecutive sampling with total sample as many as 35 case samples (women with preterm pregnancy) and 35 control samples (women with aterm pregnancy).Results: Pregnant mothers with iron deficiency anemia had 4 fold increased risk of developing preterm labor (OR = 4.04, 95% CI = 1.15 to 14.16, p = 0.023) compared to those without iron deficiency anemia. Pregnant mothers with cystitis had 4 fold increased risk of preterm labor (OR = 4.00, 95% CI = 1.25 to 12.80, p = 0.016) compared to those without cystitis. Pregnant mothers with bacterial vaginosis had 3 fold increased risk of preterm frequency (OR = 3.24, 95% CI = 1.22 to 8.63, p = 0.017) compared to those without bacterial vaginosis.Conclusion: Iron deficiency anemia, cystitis, and bacterial vaginosis increase the risk for developing preterm labor.[Indones J Obstet Gynecol 2017; 5-2: 73-76]Keywords: bacterial vaginosis, cystitis, iron deficiency anemia, preterm labor

The Impacts of Pelvic Floor Dysfunction Counseling to Knowledge Level and Attitude of Pregnant Women with Gestational Age above Thirty Six Weeks in the Selection of Delivery Method Hakim, Surahman; Ekaputra, Fajar
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the level of knowledge about pelvic floor dysfunction before and after counseling in term pregnant women and knowing whether a difference a change of attitude in the selection method of delivery before and after counseling. Methods: This study design using pre - post test. At the beginning of our study provide some sort of written test to determine the initial knowledge of participants prior to the extension and the selection of the desired method of delivery. Having obtained the results of the test, followed by education about pelvic floor dysfunction. Then do the post-test to determine the level of knowledge of the subject and mode of delivery that would be pursued. The study took place between February and May 2016 in 5 Public Health Center (PHC) in Jakarta that PHC Warakas (North Jakarta), PHC Tanah Abang (Central Jakarta), PHC Cengkareng (West Jakarta), PHC Jatinegara (East Jakarta) and PHC Jagakarsa (South Jakarta). Results: A total of 102 study subjects who began the study gave the results of the pretest mean 71  10.49 (p<0.0001) and post test results of 80.725  7.7 (p<0.0001). Of the 102 subjects who began the study, there were two people who had previously chose method of delivery by caesarean section turned into vaginal. Conclusion: There is a change scores better in knowledge about pelvic floor dysfunction after counseling. There was no significant difference between selecting the desired method of delivery before the after counseling. [Indones J Obstet Gynecol 2017; 5-2: 99-104] Keywords: fecal incontinence, pelvic floor dysfunction, sexual dysfunction, stress urinary incontinence, uterine prolapse

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eko subaktiansyah

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