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Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)

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Published by Perkumpulan Obstetri dan Ginekologi Indonesia

ISSN : 23386401 EISSN : 23387335 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.

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Articles 35 Documents

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Search results for , issue "Volume. 2, No. 1, January 2014" : 35 Documents clear

HER2/Neu Expression was Different between Benign, Borderline and Malignant Epithelial Ovarian Tumors Hadisubroto, Yona S.; Suwiyoga, Ketut
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the difference of HER2/neu expression in benign, borderline and malignant epithelial ovarian tumor. Method: An analytic cross-sectional study was performed on 49 samples of epithelial ovarian cases which were divided into three groups: twelve cases of benign epithelial ovarian tumor, 9 cases of borderline epithelial ovarian tumor and 28 cases of malignant epithelial ovarian tumor. Paraffin embedded tissue samples was cut, stained with HER2/neu imunohistochemistry and examined in Pathology Laboratory at Sanglah Hospital. The other data was collected from medical record samples. The data was analysed using One Way Anova test and Chi-square test with level of confidence α = 0.05. Result: There were 13 cases (46.43%) of the HER2/neu over expression in malignant epithelial ovarian tumors, 2 cases (22.22%) of the HER2/neu over expression in borderline epithelial ovarian tumors and 1 case (9.09%) of the HER2/neu over expression in benign epithelial ovarian tumors. With p = 0.048 (p < 0.05), there are differentiation of HER2/neu expression in benign, borderline and malignant epithelial ovarian tumors. Conclusion: In this study HER2/neu expression was different between benign, borderline and malignant epithelial ovarian tumors. Keywords: benign epithelial ovarian tumor, borderline epithelial ovarian tumor, HER2/neu, malignant epithelial ovarian tumor, ovarian cancer.

Risk of Malignancy Index is not accurate as a Triage Tool for Ovarian Cancer Tanamas, Gregorius; Iskandar, Jasmine; Utami, Tofan W; Anggraeni, Tricia D; Nuryanto, Kartiwa H
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate Risk of Malignancy Index (RMI) as a triage tool for ovarian cancer in Dr. Cipto Mangunkusumo Hospital. Method: This is a retrospective study conducted from January 2008-December 2012 in patients diagnosed with ovarian mass. Patients admitted for surgery due to ovarian masses were included to this study. RMI 3 score was calculated based on ultrasonography examination in Dr. Cipto Mangunkusumo Hospital, CA-125 test and menopausal status. Patients without final pathological report and incomplete data were excluded from study. Data were analysed using SPSS 20 to evaluate RMI result and final pathlogical report in benign and malignant case. Result: From 882 patients identified with ovarian masses from cancer registry, only 99 patients aged 17-70 y.o were included in this study. Most of the patients were nully-parity (28.3%), non-menopausal women (60.6%), normal body mass index (40.4%), and with stage IIIC ovarian cancer (33.3%). Ultrasonography examination showed that most of patients had solid mass and ascites (19.2%). Meanwhile, CA-125 showed that patients with <35 U/ml were 10.1% and ≥ 35 U/ml were 89.9%. Patients with RMI scores <200 (benign cases) were 19 cases (19.2%) and ≥ 200 (malignant cases) were 80 cases (80.8%). Meanwhile, patients with benign final pathological report were 23 cases (23.2%) and malignant cases were 76 cases (76.8%). There was no statistical difference in RMI between benign and malignant cases based on final pathological report. Conclusion: Our study showed that RMI was not accurate as triage tool for ovarian cancer in our hospital. Further investigation and more patients are needed to confirm this study. Keywords: CA-125, menopausal status, ovarian cancer, risk of malignancy index (RMI), ultrasonography.

Prevention of Recurrent Urinary Tract Infections in Postmenopausal Women Fernando, Darrell; Santoso, Budi I
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the most effective and applicable methods to reduce recurrence of urinary tract infections in postmenopausal women. Method: A search was conducted on Pubmed, NEJM, BMJ, and Google. After screening and selection, six articles were considered useful; comprising of two original research articles, one systematic review, and three society guidelines. Result: Society guidelines recommended continuous antimicrobial prophylaxis, with postcoital antimicrobial prophylaxis as an alternative. The first research article found similar results in continous antimicrobial prophylaxis group and intermittent antimicrobial prophylaxis group. The second research article found no significant difference in cranberry and trimethoprim group. The systematic review revealed vaginal estrogens are effective in preventing recurrent UTI, but the type of estrogen is less clear. Oral estrogens are not effective. Conclusion: Prevention of recurrent urinary tract infections in postmenopausal women include risk factor identification, non-antimicrobial prophylaxis with cranberry and vaginal estrogen preparations, and antimicrobial prophylaxis (continuous or intermittent). Keywords: postmenopausal, prevention, recurrent urinary tract infection.

The Role of Hospitals in Cervical Cancer Prevention Susie Susilawati; Dwiana Ocviyanti
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate the role of hospitals in DKI Jakarta on primary and secondary cervical cancer prevention. Method: This was a survey conducted to 25 hospitals, chosen with simple random sampling from 109 hospitals in DKI Jakarta. Questionnaire used for interview contained statements regarding knowledge, attitude and behavior of 117 health care professionals along with identification of facility preparedness for cervical cancer prevention within those 25 hospitals. Result: The assessment of knowledge shows that all health care professionals (100%) knew that HPV vaccination is used as a primary prevention for cervical cancer. About 98.3% respondent knew HPV vaccine injected intramuscularly. As much as 91.5% of the respondent knew HPV vaccine is given three times either at month 0, 1, 6 or at month 0, 2, 6. About 71.8% respondent knew deltoid as site for vaccine injection. Most of health care professionals (99.1%) knew VIA (visual inspection with acetic acid) can be used for early detection of cervical cancer. About 76.9% respondent knew how to interpret positive VIA results and 60.7% respondent knew how to do VIA test. As much as 93.2% health care professional knew the purpose of Pap test and about 82.1% knew how to do it. From attitude aspect, most of health care professionals (96.6%) agreed in giving HPV vaccination. About 94% of them agreed to do VIA test and about 98.3% agreed in conducting Pap test. From behavioral aspect, most of the respondent (76.9%) offered HPV vaccination to their clients/patients and 62.4% respondent did HPV vaccination. VIA test was offered and conducted by 52.1% and 30.8% of them, respectively. About 86.3% respondent offered Pap test and 71.8% did the Pap test. As many as 75% of female health care professionals who meet the qualification already had a Pap test for themselves, but only 32.5% ever been vaccinated for HPV. From facility aspect, twenty hospitals (80%) in DKI Jakarta offered HPV vaccination with Pap test can be done in all of them. VIA test and colposcopy were only available in eleven (44%) and ten (40%) hospitals respectively. Conclusion: Most hospitals in DKI Jakarta have health care professionals with good knowledge and attitude in cervical cancer prevention. However, not many have shown expected behavior in the primary prevention. Most hospitals in DKI Jakarta provide facilities for HPV vaccination and Pap test, but only few have VIA facilities and colposcopy. Keywords: cervical cancer prevention, health care professional, hospital

Complication on Teenage Pregnancy and Related Factors Omo A Madjid; Nanda I S Roesman
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate related factors, which contribute to complication of teenage pregnancy. Method: A cross-sectional research by consecutive sampling method was held upon teenager who was having her first pregnancy or had just been having her first child. This research took place at dr. Zainoel Abidin Public Hospital, Banda Aceh, in period of June until November 2012. Result: By demographic characteristic, we obtained that the majority of complication of teenage pregnancy occur in the age range of 17-19 years old and most are within Sex maturation Rate grade 5. The most common complications are caesarean section, premature rupture of membranes and cephalo-pelvic disproportion. There is a significant relation between antenatal visit conducted in accordance with WHO criteria and economic level with the incidence of complication. Conclusion: We found significant relation between antenatal visit conducted in accordance with WHO criteria and economic level with the incidence of complication. Keywords: complications, teenage pregnancy.

Intracervical Lidocaine Block is more Effective for Pain Management of Curettage in Incomplete Abortion Oktovianus Saranga; Eddy Hartono; Isharyah Sunarno
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To compare the effects of Intra cervical and paracervical block with 1% lidocaine for pain management in curettage of incomplete abortion. Method: This study is a prospective study with Randomized Control Trial approach. The samples were 52 pregnant women with gestational age of less than 20 weeks, which diagnosed as having an incomplete abortion and a procedure using any local anesthetic technique. T test was used to calculate the mean VAS score and standard deviation for each group. Fisher Exact test was used to assess the relationship between variable characteristics and the local anesthetic technique. Result: The use of local anesthesia using intra cervical block technique for pain management in incomplete abortion with curettage proved to be more effective in lowering degree of pain than paracervical block techniques. Conclusion: Intracervical block technique as a local anesthetic technique is simpler and relatively safer than paracervical block. This technique can be used extensively in Department of Obstetrics and Gynecology Medical Faculty, Hasanuddin University for pain management in curettage. Keywords: pain, Intracervical anesthesia, paracervical anesthesia, Visual Analogue Scale (VAS)

The Level of 8-OHdG Serum was Higher in Women with Blighted Ovum I Made Mahadinata Putra; I Gede P Surya
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the difference of 8-hydroxy-2-deoxyguanocyne (8-OHdG) serum level in women experiencing blighted ovum and women with normal pregnancy. Method: This was a cross sectional study with 82 samples, divided into two groups. Thirty two cases of blighted ovum and 51 cases of normal pregnancies, with 7-12 weeks gestational age. The examination of 8-OHdG serum level, was performed with the venous blood taken from the cubiti veins, and its 8-OHdG serum quantities were than examined at the Pathology Lab. at Sanglah General Hospital. Data was analyzed with the Shapiro Wilk Test and the t independent test with alpha 0.05. Result: The average 8-OHdG serum level in women with blighted ovum and normal pregnancies were 0.177 (SD 0.06) ng/ml and 0.111 (SD 0.01)ng/ml, and significantly different (p<0.05). The cut off value of 8-OHdG serum level was 0.138 ng/ml with sensitivity of 96.1% and specificity of 80.6%. Conclusion: The level of 8-OHdG serum was higher in women with blighted ovum than in women with normal pregnancies. Keywords: 8-OHdG serum level, blighted ovum, and normal pregnancy.

Maternal Cystatin C Serum is Higher in Women with Severe Preeclampsia Kurnia M. Isasari; Wim T Pangemanan; Iskandar Zulqarnain; Kemas Rahadiyanto
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the comparison between maternal cystatin C serum in severe preeclampsia and normal pregnancy. Method: This was an observational study with cross sectional analytic approach. The subjects are sixty women with severe preeclampsia and normal pregnancy who met inclusion criteria. The maternal serum level of cystatin C was automatically measured with Particle Enhanced Nephelometric Assay (PENIA). Result: Mean serum level of cystatin C in severe preeclampsia was 1.169 Â± 0.311 mg/l. Mean serum level of cystatin C in normal pregnancy was 0.929 Â± 0.166. There was a significant differences between maternal serum levels of cystatin C in women with severe preeclampsia compared with women with normal pregnancy. Conclusion: There was a significant differences between maternal serum levels of cystatin C in severe preeclampsia compared with normal pregnancy. Keywords: cystatin C, endotheliosis glomerulus, severe preeclamp

The Level of Heat Shock Protein 70 is Lower in Postterm Pregnancy Soetrisno Soetrisno
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To analyze whether there are differences between the levels of HSP70 of Postterm pregnancy and aterm pregnancy in Dr. Moewardi Hospital, Surakarta, Central Java. Method: This was a cross-sectional study. The independent variable was the level of Heat Shock Protein 70 (HSP70), and the dependent variable was the incidence of postterm pregnancy. The data was then analyzed by t test. Result: The subjects were 45 women, who were divided into 2 groups of women with postterm pregnancies (15 women) and aterm pregnancies (30 women). The mean levels of HSP70 in the serum of women with postterm pregnancy is lower (0.40 ng/ml) compared to the level of the normal pregnant group (3.94 ng/ml) and this difference was statistically significant (p<0.001). Conclusion: The mean level of HSP70 in postterm pregnancy is lower than in normal full-term pregnancy. Keywords: Heat Shock Protein 70, Maternal Stress, postterm pregnancy

Expression of B-Cell Lymphoma Protein-2 (Bcl-2) and Caspase-3 are Related with Ovarian Cancer I Nyoman G. Budiana
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the expression of Bcl-2 and caspase-3 and their relationship with ovarian cancer. Method: This study was a cross-sectional study. Speciment was tissue sample from ovarian cancer patients collected from parafinblock to determine the Bcl-2 and caspase-3 expression and demographic data obtained secondary from patients medical records. Expression of Bcl-2 and caspase-3 was examined by immunohistochemistry under light microscope with 400x light power field. The result was recorded as negative when the protein was expressed in 10% or less of cells and as a positive when the protein was expressed in more than 10% of cells. Result: A total of 45 samples was included as research subjects. 31 of 45 subjects showed the expression of Bcl-2 positive (68.9%), while the positive expression of caspase-3 was presented in 20 subjects (44.4%). There was a relationship between the expression of Bcl-2 with the expression of caspase-3 in ovarian cancer patients (p=0.002; Lambda=0.4). There was also a negative relationship, where the subjects with positive expression of Bcl-2 showed negative expression of caspase-3. In contrast, subjects with negative expression of Bcl-2 showed positive expression of caspase-3. Conclusion: There was a significance relationship between the expression of Bcl-2 with the expression of caspase-3 in ovarian cancer patients. Keywords: Bcl-2 expression, caspase-3 expression, ovarian cancer

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Contact Name
eko subaktiansyah

Contact Email
eko.subaktiansyah@gmail.com

Phone
-

Journal Mail Official
support@inajog.com

Editorial Address
-

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA