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Profile of pregnant women with tuberculosis at the tuberculosis policlinic of the eradication of tuberculosis, Tuberculosis Foundation, Baladewa Central Jakarta
Maharani, Laksmi
Indonesian Journal of Obstetrics and Gynecology Volume. 33. No. 4, October 2009
Publisher : Indonesian Socety of Obstetrics and Gynecology
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Objective: To know profile of pregnant women with tuberculosis
at PPTI Baladewa polyclinic Jakarta, to evaluate impacts of tuberculosis
medicinal treatment on pregnancy and to know the obstacles
of pregnant women to look for tuberculosis treatment.
Methods: Subjects were all pregnant women with tuberculosis
and received tuberculosis treatment at polyclinic of PPTI Baladewa
from January 2006 - December 2007. We reviewed medical record
and did home visitation to fill questioners.
Results: All subjects were in reproductive age and most of all
were low socio-economic group. Pulmonary tuberculosis was found
in 88.2% cases and Extrapulmonary tuberculosis in 11.8% cases.
We found 29.4% relapse cases and 11.8% multi-drug resistance.
Sputum examination with a smear positive for acid fast-bacillus was
found in 52.9% cases. There was abnormality for all chest x-rays.
The third most frequently symptoms were cough more than two
weeks (88.2%), weight loss (88.2%) and anorexia (82.4%). Average
time for the patients to look for treatment was 50.71 ± 31.2 days.
The patients need more time because most of the symptoms are also
present in pregnancy, the patients know absolutely nothing about
TB and healthcare provider didnât examine carefully. Treatment for
the patients was given immediately without considering the gestational
age.
Conclusion: No harmful effect was observed for neonates even
if the drugs were given in the first trimester of pregnancy.
[Indones J Obstet Gynecol 2009;33-4:210-5]
Keywords: profile, pregnancy, tuberculosis
Two Designated Pathways of Ovarian Cancer and the Crucial Implications to the Treatment
Putri, Henny M.A. Rachmasari
Indonesian Journal of Obstetrics and Gynecology Volume. 33. No. 4, October 2009
Publisher : Indonesian Socety of Obstetrics and Gynecology
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Objective: To review the two designated pathways of ovarian
cancer and their implications to the management of ovarian cancer.
Method: Literature review
Result: A proposed carcinogenesis of ovarian cancer has been
developed based on a long history of pathological and molecular
genetic findings. It divides ovarian cancer as having designated type
I or type II pathway. Type I pathway involves ovarian carcinomas
with low-grade serous subtype, mucinous, clear cell and endometrioid
subtypes. They grow in a stepwise manner, shows low response
toward platinum-based chemotherapy and mostly relate to
MAPK pathway mutations. High-grade serous ovarian carcinomas
which are often found in rapid-aggressive progression with poorer
prognosis are suggested as type II pathway. Their major mutations
are mainly in TP53. Optimal surgery and adjuvant chemotherapy
are the treatment for both confined and advanced cancers. However,
the optimal cytoreduction in type II pathway is becoming more
important to increase overall survival or disease-free interval. The
strategy of screening type II pathway is proposed to be shifted from
detection of stage I tumors to detection of minimal ovarian carcinomas
probably by biomarkers since the rapid inception is hardly
found. Meanwhile the BRCA1/2 screening and classification should
be improved for the hereditary breast/ovarian cancer screening.
Mutations of KRAS, BRAF, PTEN and CTNNB1 occur majorly in
the type I tumors. Therefore, targeted chemotherapy and inhibitor
treatments which are investigated foremost in type II recurrence of
ovarian malignancies may also be directed to the low response of
type I pathway to platinum-based chemotherapy.
Conclusion: A different strategy based on the tumorigenesis of
ovarian cancer should be considered in term of screening, primary
approach and following chemotherapy since there are some distinctive
patterns in both pathways.
[Indones J Obstet Gynecol 2009;33-4:239-46]
Keywords: ovarian cancer, carcinogenesis, screening, cytoreduction,
chemotherapy
Effectiveness of psychoeducation of postpartum depression (a study in health services in subprovince Nias, North Sumatra)
Nazara, Yafeti
Indonesian Journal of Obstetrics and Gynecology Volume. 33. No. 4, October 2009
Publisher : Indonesian Socety of Obstetrics and Gynecology
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Objective: To evaluate the effectiveness of psycho-education intervention
which is given to postpartum mothers in preventing the
existence of postpartum depression and its relation to age, parity,
occupation, education and family support.
Methods: This research used a quasi experimental with post test
only design. Research was implemented at public hospital of
Gunung Sitoli and five community health centres in Sub-Province of
Nias taken by random on since May - July 2006. There were 85
mothers with normal childbirth as samples. They were accompanied
by their husband, condition of mothers and their babies were
healthy without any complication. This research used an Edinburg
Pascasalin Depression Scale questionnaire as instrument and psycho-
education intervention was given with a booklet as media.
Results: 85 subjects were included, 40 were intervention group
and 45 control group. This research showed that psycho-education
intervention was effective significantly (p= 0,001), Odds Ratio
(OR): 5,924 (95 % CI : 2,081-16,868) to prevent the postpartum depression
occurrence. The most dominant variable in effectiveness of
psycho-education intervention is family support variable with pvalue
is p = 0,001, OR : 80 (95 % CI : 6,069-1054,570).
Conclusion: Psycho-education intervention is very effective for
preventing the postpartum depression occurrence after controlled
by family support factor.
[Indones J Obstet Gynecol 2009;33-4:216-23]
Keyword: psycho-education, postpartum depression, family support.
Serum Anti Mullerian Hormone level as ovarium response predictor at women received ovarium stimulation invitro
Soebijanto, Soegiharto
Indonesian Journal of Obstetrics and Gynecology Volume. 33. No. 4, October 2009
Publisher : Indonesian Socety of Obstetrics and Gynecology
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Objective: To evaluate clinical value of basal anti-Mullerian
Hormone level as predictor of ovarian response to stimulation in
women following in vitro fertilization program; compared with Follicle
Stimulating Hormone (FSH), estradiol and basal antral follicle.
Method: Research was conducted in Yasmin Clinic Cipto Mangunkusumo
Hospital as tertiary referral center for reproductive
health and in vitro fertilization. Infertile patients which going to undergo
controlled ovarian hyper stimulation cycle for in vitro fertilization
were checked for basal FSH level, estradiol level, AMH level
and amount of basal antral follicle. We were divided the sample into
two categories; poor responders and good responders. Statistical
analysis using ANOVA was done to evaluate demographic data and
Receiver Operator Characteristic area under curve (ROCAUC), and to
analyze whether AMH was more superior than the other 3 predictors
and to get the cut off point for AMH level.
Result: We have collected 22 patients data; 14 were categorized
as good responders and 8 were bad responders. Mean AMH value
in the good responders group was 4.46±1,01 and in the poor responders
group was 1,35±0,96, with p 0,000. According to ROCAUC,
AMH is a good predictor for good ovarian response in patient who
are a good responders (AUC 0,821), compared to the other three
predictors (FSH, E2 and basal antral follicle). Anti Mullerian Hormone
cut-off point level is 3, which means value
The effect of letrozole and clomiphen citrate in mature follicle count, ovulation and endometrial thickness in unovulated cycle women
Maryati, Sri
Indonesian Journal of Obstetrics and Gynecology Volume. 33. No. 4, October 2009
Publisher : Indonesian Socety of Obstetrics and Gynecology
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Objective: To know the efficacy of letrozole and clomiphene citrate
for ovulation induction in anovulation women.
Method: During the period of January-October 2007, 44 women
who met criteria for an ovulation age 18-35 years old, were done
anamnesis, physical examination, USG, and hormonal analysis
(FSH, LH, E2, Progesterone and Prolactin). All participants were
divided into letrozole and clomiphene citrate group. For the letrozole
group received 2,5 mg letrozole daily on 3th until 7th day menstrual
cycle. The clomiphene citrate group received 50 mg twice a
day, on 3th until 5th day menstrual cycle. On 12th menstrual cycle the
ultrasound examination was perfomed to measure number of mature
follicle and endometrial thickness. On the 18th day of menstrual cycle,
ultrasound was perfomed to evaluate ovulation.
Result: There was significant difference between letrozole group
and clomiphene citrate group (p=0.04) with the number if follicles
in letrozole group is 1.08 (±0.27), in clomiphene citrate group 1.40
(±0.51). There was no significant different in mean of follicle size
(p=0.32). Ovulation in both groups was not significantly different
(p=0.53), 59% in letrozole group and 68% in clomiphene citrate
group. There was significant difference in endometrial thickness,
mean of endometrial thickness in letrozole group is 8.77 mm (±2.32
mm) and in clomiphene citrate group 6,66 mm (±2.34 mm)
(p
Hubungan pengetahuan dan sikap bidan tentang rujukan kasus obstetri dengan ketepatan rujukan: suatu studi analisis verifikatif di Kabupaten Bantul, Yogyakarta
Wahyuningsih, Heni Puji
Indonesian Journal of Obstetrics and Gynecology Volume. 33. No. 4, October 2009
Publisher : Indonesian Socety of Obstetrics and Gynecology
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Tujuan: Memperoleh informasi mengenai ketepatan rujukan
kasus obstetri oleh bidan di Kabupaten Bantul, Yogyakarta.
Metode: Rancangan penelitian ini menggunakan metode survei
eksplanatoris terhadap pengetahuan dan sikap bidan tentang rujukan
kasus obstetri dengan ketepatan rujukannya. Data dikumpulkan secara
potong silang, dengan rancangan retrospektif (kasus-kontrol).
Subjek penelitian 109 responden. Analisis data menggunakan prosedur
analisis uji t, Mann-Whitney, uji Chi-Kuadrat, uji korelasi VCramer
dan analisis regresi logistik ganda.
Hasil: Pada penelitian ini didapatkan bahwa terdapat perbedaan
skor pengetahuan berdasarkan rujukan tepat vs tidak tepat (81,2 vs
63,6; p
Cytology of uterine cervix after one year use of Depo Provera and Cyclofem
Kambu, Jan Pieter
Indonesian Journal of Obstetrics and Gynecology Volume. 33. No. 4, October 2009
Publisher : Indonesian Socety of Obstetrics and Gynecology
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Objective: The objective was to examine cervical cytology findings
from conventional Pap smear examination in Depo-Provera®
and Cyclofem® acceptor in one-year period.
Method: The study design is descriptive observational involving
35 Depo-Provera® and 35 Cyclofem® acceptor. We follow up their
cytology findings prospectively. This study was conduct in FER
and gynecology clinics at Dr. Kariadi Hospital Semarang also at
Halmahera and Ngesrep public health service.
The subjects were women, aged 20 - 40 years old who chosen
Depo-Provera® and Cyclofem® as their contraceptive methods. This
study began on December 2006, all subjects who met inclusion criteria
underwent initial cytology screening. On December 2007, and
there were 70 subjects. They underwent cytology examination at
month sixth (simultaneously with third Depo-Provera® injection and
seventh Cyclofem® injection) and at month twelve (simultaneously
with fifth Depo-Provera® injection and thirteenth Cyclofem® injection).
Distribution frequency was analyzed using univariate analysis
and data shown as mean and standard deviation whereas bivariate
analysis was conduct with X2 and t-test. Cytology examination was
conduct in anatomy pathology laboratory at Medicine Faculty,
Diponegoro University/Dr. Kariadi Hospital, Semarang.
Result: Inflammation rates tend to increase on Depo-Provera®
group compare to Cyclofem® group. At first cytology result there is
no difference between two groups, it suggest that both groups had
same baseline characteristic. Thereafter, at second and third examination,
Depo-Provera® group significantly showed higher inflammation
and dysplasia rates compare to Cyclofem® group.
Conclusion: After one-year period, there was difference on cervical
cytology results that is inflammation rates which higher on
Depo- Provera® acceptor compare to Cyclofem®.
[Indones J Obstet Gynecol 2009; 33-4: 233-8]
Keywords: pap smear, Depo-Provera®, Cyclofem®, Pap smear
on hormonal contraception
Hubungan pengetahuan dan sikap bidan tentang rujukan kasus obstetri dengan ketepatan rujukan: suatu studi analisis verifikatif di Kabupaten Bantul, Yogyakarta
Heni Puji Wahyuningsih
Indonesian Journal of Obstetrics and Gynecology Volume. 33. No. 4, October 2009
Publisher : Indonesian Socety of Obstetrics and Gynecology
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Full PDF (36.658 KB)
Tujuan: Memperoleh informasi mengenai ketepatan rujukan kasus obstetri oleh bidan di Kabupaten Bantul, Yogyakarta. Metode: Rancangan penelitian ini menggunakan metode survei eksplanatoris terhadap pengetahuan dan sikap bidan tentang rujukan kasus obstetri dengan ketepatan rujukannya. Data dikumpulkan secara potong silang, dengan rancangan retrospektif (kasus-kontrol). Subjek penelitian 109 responden. Analisis data menggunakan prosedur analisis uji t, Mann-Whitney, uji Chi-Kuadrat, uji korelasi VCramer dan analisis regresi logistik ganda. Hasil: Pada penelitian ini didapatkan bahwa terdapat perbedaan skor pengetahuan berdasarkan rujukan tepat vs tidak tepat (81,2 vs 63,6; p
Profile of pregnant women with tuberculosis at the tuberculosis policlinic of the eradication of tuberculosis, Tuberculosis Foundation, Baladewa Central Jakarta
Laksmi Maharani
Indonesian Journal of Obstetrics and Gynecology Volume. 33. No. 4, October 2009
Publisher : Indonesian Socety of Obstetrics and Gynecology
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Objective: To know profile of pregnant women with tuberculosis at PPTI Baladewa polyclinic Jakarta, to evaluate impacts of tuberculosis medicinal treatment on pregnancy and to know the obstacles of pregnant women to look for tuberculosis treatment. Methods: Subjects were all pregnant women with tuberculosis and received tuberculosis treatment at polyclinic of PPTI Baladewa from January 2006 - December 2007. We reviewed medical record and did home visitation to fill questioners. Results: All subjects were in reproductive age and most of all were low socio-economic group. Pulmonary tuberculosis was found in 88.2% cases and Extrapulmonary tuberculosis in 11.8% cases. We found 29.4% relapse cases and 11.8% multi-drug resistance. Sputum examination with a smear positive for acid fast-bacillus was found in 52.9% cases. There was abnormality for all chest x-rays. The third most frequently symptoms were cough more than two weeks (88.2%), weight loss (88.2%) and anorexia (82.4%). Average time for the patients to look for treatment was 50.71 ± 31.2 days. The patients need more time because most of the symptoms are also present in pregnancy, the patients know absolutely nothing about TB and healthcare provider didn’t examine carefully. Treatment for the patients was given immediately without considering the gestational age. Conclusion: No harmful effect was observed for neonates even if the drugs were given in the first trimester of pregnancy. [Indones J Obstet Gynecol 2009;33-4:210-5] Keywords: profile, pregnancy, tuberculosis
Effectiveness of psychoeducation of postpartum depression (a study in health services in subprovince Nias, North Sumatra)
Yafeti Nazara
Indonesian Journal of Obstetrics and Gynecology Volume. 33. No. 4, October 2009
Publisher : Indonesian Socety of Obstetrics and Gynecology
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Objective: To evaluate the effectiveness of psycho-education intervention which is given to postpartum mothers in preventing the existence of postpartum depression and its relation to age, parity, occupation, education and family support. Methods: This research used a quasi experimental with post test only design. Research was implemented at public hospital of Gunung Sitoli and five community health centres in Sub-Province of Nias taken by random on since May - July 2006. There were 85 mothers with normal childbirth as samples. They were accompanied by their husband, condition of mothers and their babies were healthy without any complication. This research used an Edinburg Pascasalin Depression Scale questionnaire as instrument and psycho- education intervention was given with a booklet as media. Results: 85 subjects were included, 40 were intervention group and 45 control group. This research showed that psycho-education intervention was effective significantly (p= 0,001), Odds Ratio (OR): 5,924 (95 % CI : 2,081-16,868) to prevent the postpartum depression occurrence. The most dominant variable in effectiveness of psycho-education intervention is family support variable with pvalue is p = 0,001, OR : 80 (95 % CI : 6,069-1054,570). Conclusion: Psycho-education intervention is very effective for preventing the postpartum depression occurrence after controlled by family support factor. [Indones J Obstet Gynecol 2009;33-4:216-23] Keyword: psycho-education, postpartum depression, family support.