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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Published by Perkumpulan Obstetri dan Ginekologi Indonesia
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 1,731 Documents
 108   109   110   111   112 
Efficacy of 600 μg Misoprostol compare to 400 μg Misoprostol orally for expulsion of conception mass on pregnancy failure under twenty two weeks of gestational age Rahmedi Rosa
Indonesian Journal of Obstetrics and Gynecology Volume. 34. No. 2, April 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To evaluate the efficacy and adverse effect of misoprostol in pregnancy termination under 22 weeks of gestation with dosage 400 μg, in comparison to 600 μg. Method: The research was performed in Obstetric and Gynecology Division in Dr. Cipto Mangunkusumo General Hospital to 70 subjects which were chosen with consecutive sampling, divided into two groups with block randomization and double blind. Group A received 400 μg of misoprostol every 6 hours while group B received 600 μg of misoprostol every 6 hours for a maximum of 2 days. Each group was evaluated for the time it took to reach complete abortion and for the adverse effects, consisting of abdominal cramping, bleeding, vomiting, and diarrhea. Result: Success rate for termination with misoprostol 400 μg and 600 μg were 88.5% and 91.4%, with no statistical difference found (p=1.000). There was no difference in the time for reaching complete abortion between two dosages (p=0.701) with a mean of 22 ± 8 hours. Adverse effects were found more frequent and more severe in the group consuming 600 μg of misoprostol compared to the group receiving 400 μg of misoprostol. Conclusion: Four hundred micrograms of misoprostol every six hour is recommended for termination of pregnancy under 22 weeks of gestational age, without statistical difference in efficacy, but with lower adverse effects. [Indones J Obstet Gynecol 2010; 34-2: 59-63] Keywords: misoprostol, pregnancy failure, dosage, efficacy, adverse effect
The Changes of H2O2 Level and Glutathione/Glutathione dioxide Ratio with the Administration of N-Acetylcystein, Vitamin C, and Vitamin E towards in Vitro Eclampsia Human Umbilical Vein Endothelial Cell Model Siti Candra Windu Baktiyani
Indonesian Journal of Obstetrics and Gynecology Volume. 34. No. 2, April 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To identify the optimum dosage to lower H2O2 and to increase the highest ratio of Glutathione/Glutathione dioxide in the media of eclampsia HUVEC’s model with the administration of NAC, Vitamin C, and Vitamin E. Method: We compare the concentration of H2O2 and ratio of glutathione (GSH) glutathione dioxide (GSSG) in eclampsia HUVEC’s model (as control group), and administration of three different dose of N-Acetyl Cystein (NAC), vitamin C, vitamin E and combination of them. Result: The addition of NAC, vitamin C and vitamin E to eclampsia HUVEC’s model can reduce the H2O2 level and increase GSH/GSSG ratio (p < 0.05). The optimal dose for NAC administration is 2 μM, while greater dose hamper the result. Combination of three antioxidants showed the best result compare to single antioxidant. Conclusion: The lowest level of H2O2 and the highest ratio of GSH/GSSG is achieved with the administration of the combination of NAC 2 μM, Vitamin C 100 μM and Vitamin E 100 μM. [Indones J Obstet Gynecol 2010; 34-2: 64-8] Keywords: HUVECs, eclampsia plasma, antioxidant
Objective: There were only few studies about the characteristic of vaginal pH among contraception user in Indonesia. This study aimed to determine the effect of contraception on vaginal pH among Indonesian women. Method: This study is a cross-sectional study. The target population was Indonesian women aged 15 - 50 years. The samples consisted of 492 people. Based on the method of contraception, subjects were grouped into 4 groups, subjects with combination hormonal contraceptives, progestin only Dwiana Ocviyanti
Indonesian Journal of Obstetrics and Gynecology Volume. 34. No. 2, April 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: There were only few studies about the characteristic of vaginal pH among contraception user in Indonesia. This study aimed to determine the effect of contraception on vaginal pH among Indonesian women. Method: This study is a cross-sectional study. The target population was Indonesian women aged 15 - 50 years. The samples consisted of 492 people. Based on the method of contraception, subjects were grouped into 4 groups, subjects with combination hormonal contraceptives, progestin only, condoms/IUDs, and subjects with no contraception or sterile. Vaginal acidity (pH) was examined by Dip- Stick (Merck®). Result: The average age was 30.9 ± 8.27. The methods of contraception the subjects used were combination hormonal contraception (18.0%), progestin-only (29.5%), condom/IUDs (5.1%) and no contraception/sterile (47.4%). Most subjects had vaginal pH
Effect of clomiphene citrate on the quality of cervical mucus in infertile women Elizabeth Catherine Jusuf
Indonesian Journal of Obstetrics and Gynecology Volume. 34. No. 2, April 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To describe the effect of clomiphene citrate on the quality of cervical mucus in infertile women. Method: This study is a non-randomized clinical trial. The study was carried out at several education hospitals in Makassar from March 2008 to April 2009. The subjects of the study were infertile women who fulfilled the inclusion criteria with intervention study. The statistical analysis was performed using Wilcoxon Sign-ed Rank Test with α 5%. Result: There were 36 cases found, and most were in the range of 26 - 30 years old (38.9%), university level education (50%), civil servant (47.2%), normal nutritionals status (55.5%), regular menstruation cycle (94.4%), marriage length 1 - 5 years (52.8%), and previously treated (61.1%). There was a significant difference of the cervical mucus quality in the infertile women before and after the administration of clomiphene citrate which tend to become worse (p = 0.012). At previously CC-treated group, it was found that after the administration of clomiphene citrate, the quality of cervical mucus tend to be worse (100%). Conclusion: The administration of clomiphene citrate tends to have declining effect on cervical-mucus quality of infertile women. [Indones J Obstet Gynecol 2010; 34-2: 73-6] Keywords: clomiphene citrate, quality of cervical mucus, infertile women
Patient’s assessment on quality of Obstetrics and Gynecology service at Dr. Cipto Mangunkusumo Hospital Erni Nurrahmi Suprihatin Priatna
Indonesian Journal of Obstetrics and Gynecology Volume. 34. No. 2, April 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To evaluate patient’s assessment on service quality of Obstetrics and Gynecology at Dr. Cipto Mangunkusumo Hospital, the importance of each service quality dimension, and the relation between quality assessment and several factors. Method: The research was performed to 112 patients who were hospitalized in the Obstetrics and Gynecology ward in August 2009. We used a questionnaire which was developed from SERVQUAL instrument. This questionnaire consists of 26 questions about patient expectation and perception on the service they received. It covered 5 service quality dimensions (reliability, responsiveness, assurance, empathy, and tangibility). Patients were asked to state the answer in Likert scale from 1 to 7. The gap between perception and expectation score was then calculated. If the gap was zero or positive it means the quality was good and if negative it means the quality was not good. Result: Among 112 respondents, 82 respondents (73.2%) assess that the service quality was not good, only 26.8% considered it good. Reliability dimension had the highest expectation score followed by assurance, responsiveness, empathy, and tangibility with the proportion of 21%, 20%, 20%, 20%, and 19% respectively. The sequence of the gap from the biggest to the smallest was empathy, responsiveness, reliability, assurance, and tangibility. There was a significant relationship between patients’ educational background and assessment of service quality (p=0.036). Conclusion: Obstetrics and Gynecology Deparment’s service quality at Dr. Cipto Mangunkusumo Hospital has not fulfilled patients’ expectation. Improvements of the service quality need to be addressed on 4 factors, which are empathy, reliability, responsiveness, and assurance. [Indones J Obstet Gynecol 2010; 34-2: 77-83] Keywords: patient expectation, patient perception, Obstetrics and Gynecology service quality
Correlation between level of serum estrogen, c-telopeptide, and interleukin-6 in determining bone density in perimenopausal women Eddy Suparman
Indonesian Journal of Obstetrics and Gynecology Volume. 34. No. 2, April 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To evaluate the role of estrogen as a menopausal biochemical marker to c-telopeptide (CTx) and IL-6 as a biochemical marker of mineral bone density in perimenopausal women. Method: This is an observational, cross-sectional study in perimenopausal women between 45 - 51 years old, who matched the inclusion and exclusion criteria such as no contraception was taken before, no specific disease that could affect the laboratory findings. Samples were taken from outpatients clinic of Prof Dr. R.D. Kandou hospital. The patients were gathered for blood samples collection. Blood samples were tested in laboratory. All data were collected and being processed statistically using Pearson correlation coefficient (SPSS version 16). Result: From 60 perimenopausal women (45 - 51 years old) sample, mean age was 47.98 ± 2.26 SD. Estrogen (estradiol) level: < 10 pg/ml, maximum 358 pg/ml, and mean 77.11 ± 86.2 SD. IL-6 level: minimum is 1.645 pg/ml, maximum 7.771 pg/ml, and mean 4.317 ± 2.112 SD. We found significant correlation between age and estrogen level (correlation level < 0.05) and CTx level (in level < 0.01). From regression curve, age has no significant correlation with IL-6 concentration. However, we found significant correlation between estradiol and CTx and IL-6 with respective correlation coefficient value of < 0.01. Likewise the correlation between CTx and IL- 6 showed significant statistically with the value of the correlation coefficient < 0,01. Conclusion: There is a significant correlation between estrogen, Il-6 and CTx. These variables play an important role in the occurrence of the physiological changes in the perimenopausal women. This study also showed the occurrence of a bone reabsorption process that was marked by the increase of CTx level in accordance with the increase in the age and the increase in the level of CTx together with the decline in the level of oestrogen. Therefore, prevention therapy of osteoporosis should begin in earlier age, before the further bone reabsorption take place. [Indones J Obstet Gynecol 2010; 34-2: 84-8] Keywords: c-telopeptide, bone mineral density, estrogen, interleukin- 6, perimenopause women
Characteristics of Patients with Hypertension in Pregnancy at Sanglah Hospital Hendrik Sutopo
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 3, July 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To report the profile of patients with Hypertension in Pregnancy (HIP) at Sanglah Hospital Denpasar from 2009 to 2010. Method: A retrospective descriptive study from all HIP patients at Sanglah Hospital Denpasar, Bali during January 2009 to December 2010. Result: The prevalence of HIP at Sanglah Hospital was 9.32%, which consisted of 1.82% gestational hypertension, 0.19% chronic hypertension, 1.36% mild preeclampsia, 4.70% severe preeclampsia, 0.43% superimposed preeclampsia, and 0.82% eclampsia. From all of HIP cases, we found that the majority were nulliparous (47.23%), primipaternal (53.1%), and had hypertension at term (51.9%). Most of the cases were found at maternal age > 35 years (14.62%), followed by age < 20 years (13.47%). Most of them also had Ante Natal Care (ANC) frequency ≥ 4 times (69.09%), and had their ANC done by a midwife (52.76%) and followed with an obstetrician (40.81%). The majority of the cases were referral cases (62.39%) mostly by midwives (22.45%). From all of the cases, we found that total preterm labor was 35.14%, perinatal mortality was 9.32% and maternal mortality was 1.16%. Conclusion: The prevalence of HIP at Sanglah Hospital was higher than previous years. Most of them had already had ANC done by health care providers, who were mostly midwives and obstetricians. Therefor, the quality of ANC seems to need an improvement by having an earlier referral system, so cases can be treated earlier. [Indones J Obstet Gynecol 2011; 35-3: 97-9] Keywords: hypertension in pregnancy, preeclampsia and eclampsia, descriptive
Antioxidant Milk Supplementation in Pregnancy: A Study of Retinol Binding Protein and Angiogenic Factors in Preeclampsia Martina Hutabarat
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 3, July 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objectives: To assess the role of retinol supplementation in the process of angiogenesis in preeclampsia. Methods: The research was a double blind randomized clinical trial conducted Dr. Cipto Mangunkusumo Hospital outpatient clinic since January 2009 - December 2010. Samples were analyzed in Prodia Laboratory and Showa University in Tokyo, Japan. Subjects were tested in trimester 1, 2 and 2 weeks after delivery. During pregnancy subjects were given pregnancy milk supplements available on the market which had and that has been retinol fortified. Bivariate and multivariate analysis were performed of which retinol milk feeding, retinol binding protein (RBP) level, and level of angiogenic factors as independent variables and preeclampsia acted as the dependent one. Results: One hundred four study subjects were divided into a control group of 55 and treatment of 49. Incidence of preeclampsia in this study was is 8.7% from which 8 persons (14.5%) came from the control group and 1 person (2%) from the treatment group. Characteristics of the two groups were equivalent. RBP levels obtained in the treatment group was lower than the control group, while in the subjects with preeclampsia the RBP level was higher than the group without preeclampsia. Correlation between the level of RBP with angiogenic factors showed no significant relationship except for the level of PlGF (p=0.036) which had a weak correlation (r=0.206). The level of angiogenic factors in the treatment group showed lower result than the control group whereas among the subjects with preeclampsia angiogenic factor levels were always higher than without preeclampsia. With multivariate analysis we found that significant factors associated with preeclampsia was sFlt-1 levels (p=0.004) and sFlt-1/PlGF ratio (p=0.017). Conclusions: Providing milk supplements can reduce the levels of retinol (RBP), and antiangiogenic factors, but does not significantly increase proangiogenic factor level. Assuming there is no problem with the process of angiogenesis provision of retinol-fortified milk can reduce the incidence of preeclampsia. However, further research with a larger scale is needed. [Indones J Obstet Gynecol 2011; 35-3:100-4] Keywords: retinol-fortified milk, RBP level, sFlt-1 level, sEng level, PlGF level, preeclampsia
Comparison of administration of estradiol valerat 1 mg and 2 mg to improve squamous epithel maturation of Pap Smear preparation on postmenopausal women Ika Sri Purnamaningsih
Indonesian Journal of Obstetrics and Gynecology Volume. 34. No. 2, April 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To determine the most effective dose of estradiol valerat (daily oral administration of 1 mg or 2 mg for 14 days) to improve squamous epithel maturation of Pap Smear on postmenopausal women. Method: Seventy one postmenopausal women with atrophic Pap Smear were participated in this randomized double blind clinical trial. 35 subjects received estradiol valerat 1 mg and the other 36 subjects received estradiol valerat 2 mg. After daily oral administration of estradiol valerat for 14 days, second Pap Smear were performed to evaluate epithel maturation. The side effects were also evaluated in this study. Result: There were 5 subjects whom lost to follow up due to refused to perform second Pap Smear and 1 subject was drop out due to nausea. 65 subjects were included in final analysis. Estradiol valerat 2 mg was significantly more effective than estradiol valerat 1 mg in improving epithel maturation of Pap Smear preparation on postmenopausal women. There were no complain about nausea and vaginal bleeding. Leukorhea occurred more frequently in the 2 mg group. Conclusion: Daily oral administration of 2 mg estradiol valerat was more effective than estradiol valerat 1 mg in improving squamous epithel maturation of Pap Smear on postmenopausal women with minimal side effect (leukorhea). [Indones J Obstet Gynecol 2010; 34-2: 89-91] Keywords: Pap Smear, postmenopausal women, estradiol valerat, epithel maturation of Pap Smear
Clinical appearance and vaginal cytology of atrophic vaginitis in postmenopausal women Agnes Imelda Immanuel
Indonesian Journal of Obstetrics and Gynecology Volume. 34. No. 2, April 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To find out atrophic vaginitis pattern in postmenopausal women based on clinical appearance and vaginal cytology. Method: Descriptive retrospective study with hypothesis cohort to find out clinical appearance and vaginal cytology of atrophic vaginitis based on distribution of estrogen effect (maturation value/ total maturation index) in post menopausal women in outpatient clinic of tertiary hospital in Manado, North Sulawesi. Result: There were 50 subjects met the inclusion criteria. Most of them are 55 to 59 years old, with length of menopausal period 6 to 20 years, and onset of menopause in 45 to 49 years old. Cytology study showed that atrophic vaginitis present in 66% patients. Clinical symptoms are ranging from vaginal dryness (10%), vaginal discharge (6%), and dyspareunia (20%). From clinical appearance we found 44% women had atrophic vaginitis based on vaginal secretion, 42% based on macroscopic surface/integrity of vaginal epithelium, 54% based on vaginal rugae and elasticity, and 42% based on vaginal color. However, 80% of all participants showed vaginal pH more than 7 and most of them categorized as having atrophic vaginitis. Conclusion: By using clinical appearance, we found 42% to 54% of menopausal women had atrophic vaginitis, while cytology study confirmed 66% having it. [Indones J Obstet Gynecol 2010; 34-2: 92-6] Keywords: clinical appearance, cytology, menopause, atrophic vaginitis

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