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Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)

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Published by Perkumpulan Obstetri dan Ginekologi Indonesia

ISSN : 23386401 EISSN : 23387335 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.

Arjuna Subject : -

Articles 1,731 Documents

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Electroacustimulation is as Effective as B6 for Reducing Nausea and Vomiting in the First Trimester of Pregnancy Novan S. Pamungkas
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the benefit of electroacustimulation in reducing nausea and vomiting in the first trimester of pregnancy. Methods: This study is an experimental study. The subject were 40 pregnant women divided into 2 groups randomly. The control group was given vitamin B6 3x30 mg per day and the case given the electroacustimulation device. The degree of severity of nausea and vomiting of patients assessed before and 3 days after treatment using Pregnancy Unique Quantification of Emesis and Nausea (PUQE) questionnaire. Result: There were no differences between groups in gestational age at entry and PUQE score pre-treatment. After 3 days therapy, there were significant decrease in PUQE score in group receiving B6 (p=0.004) and also in electroacustimulation group (p=0.000). However, the change in PUQE score was not significantly different between the two groups (p=0.286). Conclusion: From the results of this study concluded that electroacustimulation is effective for reducing nausea and vomiting in the first trimester of pregnancy. There is no difference in effectiveness between electroacustimulation and vitamin B6 to treat nausea and vomiting in the first trimester of pregnancy. [Indones J Obstet Gynecol 2013; 37-2: 71-6] Keywords: electroacustimulation, nausea and vomiting in pregnancy, P6 or neiguan point, pregnancy unique quantification of emesis and nausea (PUQE)

Ferritin Level Decreased between the Second and Third Trimester of Pregnancy Hermie MM. Tendean
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To know the change in ferritin level in second and third trimester of pregnancy. Methods: This study was a cohort study. The level of ferritin was estimated in the second trimester of pregnancy and examined again in the third trimester of pregnancy. Data processed and analyzed by statistically. Result: The number of sample in this study was 30 patients. From this study, we found that the Ferritin level in second to third trimester of pregnancy was decreased in 28 patients (93.3%) and increased in 2 patients (6.7%). This result showed that ferritin serum level in second and third trimester would significant difference (p < 0.001). This different can be showed in media ferritin serum level in second trimester higher than third trimester (31.10 ng/ml > 22.20 ng/ml). Conclusion: There was a significant decrease in the level of ferritin from the second to third trimester. This could be caused by the occurence of hemodilution reaching its peak at 28-32 weeks of pregnancy, increasing the need of iron intake. This could also be caused by an imbalanced diet of the mother. [Indones J Obstet Gynecol 2013; 37-2: 77-81] Keywords: ferritin, pregnancy

The Number of Vaginal Epithellial and Neutrophil Strongly Correlates with the Occurrence of Premature Delivery Alia Sandra
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To investigate the relationship of the amount of vagina epithelia and neutrophil with premature delivery. The study was carried out in several hospitals at Obstetrics and Gynecology Department of the Faculty of Medicine Hasanuddin University, from September 2011 to January 2012. Methods: The study was cross-sectional study involving two groups of sample: premature delivery group fulfilling inclusive criteria and a control group of normal delivery. The total samples are 48 persons, comprising of 16 premature deliveries, and 32 normal pregnancy. Result: The study revealed that there was a significant correlation between â‰¥1 parity and premature delivery (p<0.05). The average vagina epithelia in the premature delivery were 6.81 per field of view and in the normal pregnancy were 1.59 per field of view (p<0.001). The average vagina neutrophil in the premature delivery was 10.6 per field of view and in the normal pregnancy was 1.91 (p<0.001). Spearman correlation test showed that the vagina epithelia and neutrophil have a significant correlation with premature delivery as reflected by the coefficient correlation values of 0.907 and 0.770 with p=0.000. Conclusion: The number of ephitelia and vagina neutrophil in the premature delivery is higher than normal pregnancy, thus there is a strong correlation between number of ephitelia and vagina neutrophil and premature delivery. [Indones J Obstet Gynecol 2013; 37-2: 82-5] Keywords: epithelia, neutrophil, premature delivery

Women in the Rural Areas Experience more Severe Menopause Symptoms Mono Yohanis
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: The aim of this study is to compare the severity of menopausal symptoms between menopause women who lived in urban area with those who lived in rural area. Methods: The study is conducted by comparing the scores of Menopause Rating Scale (MRS) and World Health Organization Quality of Life (WHOQOL) questionnaires of menopause women who lived in the City of Makassar with those who lived in rural areas of Selayar. Results: The results of the study revealed that menopausal symptoms are more severe on menopause women who lived in rural areas than those who lived in urban area. Less educated menopause women have more severe menopausal symptoms than those who have more education. Their Quality of Life show no significant difference. There is a correlation between the severity of menopausal symptoms with the quality of life of menopause women, the more severe the symptoms, the less the quality of life are. Conclusion: Menopausal symptoms are more severe on menopause women who lived in rural areas than those who lived in urban area. [Indones J Obstet Gynecol 2013; 37-2: 86-91] Keywords: menopausal symptoms, rural area, urban area

Homocysteine Level in the Blood and Follicular Fluid is Higher in Infertile Women with Endometriosis Muharam Natadisastra
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To compare and determine the differences in the level of homocysteine in the blood and follicular fluid in infertile women with and without endometriosis, then analyze the effect of homocysteine levels to oocyte quality. Methods: This study was cross-sectional study. Fifty-nine subjects following the in-vitro fertilization program are included in the admission criteria were divided into two equal groups, ie groups of endometriosis and without endometriosis consecutively (consecutive sampling). Each subject taken from the blood and follicular fluid then measured the levels of homocystein levels with immuoassay method. The mean of each group was statistically tested with an independent t test. Result: The mean levels of homocysteine in the blood is higher in the endometriosis group than without endometriosis group and it was statistically significance (8.34 Â± 2.68 vs 6.71 Â± 1.56, p=0.007; 95% CI: 0.02417-0.14657). Similarly, the levels of homocysteine in follicular fluid , the endometriosis group is higher and statistically significance (6.19 Â± 1.67 vs 3.46 Â± 1.03; p= 0.000; 95% CI: 0.19310-0.32353). All oocytes are in good quality in both groups, maturation grade 3. There is a correlation between the levels of homocysteine in the blood and follicular fluid in the endometriosis group and assessed with Pearson test, and it found significant (p = 0.002) and the correlation value 0.553 (moderate correlation strength) and direction of a positive correlation. Conclusion: The mean levels of homocysteine in the blood and follicular fluid in infertile women with endometriosis is higher than without endometriosis and were statistically significantly different. These homocysteine levels does not affect the quality of oocytes. There is a positive correlation between the levels of homocysteine in the blood and follicular fluid in endometriosis group. [Indones J Obstet Gynecol 2013; 37-2: 92-8] Keywords: endometriosis, homocysteine, infertility, oocyte quality

Calcium Level is Lower in Women with Premenstrual Syndrome Maria F.J. Pambudi
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To know the relationship of calcium serum levels with the incidence of Premenstrual Syndrome (PMS). Methods: Study subject that fulfil inclusion criteria were asked to fill questionnaires and venous blood sample was taken to measure calcium serum levels. The data is processed and analyzed statistically. Result: The study was conducted on 45 women aged 20-35 years old. Groups of women with PMS found calcium levels between 8.50 to 9.40 mg/dl. Cut off point levels of calcium for PMS incidence was 9.40 mg/dl with 90.9% sensitivity, 75.0% specificity, and accuracy of 86.7%. Conclusion: Women with PMS have lower calcium levels compared to women without PMS. Calcium levels significantly associated with incidence of PMS. [Indones J Obstet Gynecol 2013; 37-2: 99-102] Keywords: premenstrual syndrome (PMS), calcium serum

The Estrogen Receptor Concentration and Col3A1 Gene Immunoexpression in Uterosacral Ligament is Correlated with Postmenopausal Uterine Prolapse Erick C. Asmara
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To analyze correlation between concentration of estrogen receptor and imunoexpression of Col3A1 gene on uterosacral ligament of postmenopausal uterine prolapse patient. Methods: This is a cross-sectional analytic observational study involving 32 subjects who met inclusion criteria. Samples are taken consecutively in Dr. Hasan Sadikin Hospital in January 1st - December 31st 2012. Statistical analysis was performed with non-parametric Mann-Whitney test and Spearmanâ€™s rho non-parametric correlation test. Result: There is no significant difference of estrogen receptor concentration between postmenopausal women with and without uterine prolapse (p = 0.377), while there is no significant difference of Col3A1 gene immunoexpression between postmenopausal women with and without uterine prolapse (p = 0.119) either. There is a significant positive correlation between the estrogen receptor concentration and Col3A1 gene immunoexpression in uterosacral ligament of postmenopausal uterine prolapse patients (p = 0.002, r= 0.711). Conclusion: There is a positive correlation between the estrogen receptor concentration and Col3A1 gene immunoexpression in uterosacral ligament of postmenopausal uterine prolapse patients. [Indones J Obstet Gynecol 2013; 37-2: 103-6] Keywords: Col3A1 gene, estrogen receptor, menopause, uterine prolapse, uterosacral ligamen

KRAS and BRAF Mutation in Borderline Epithelial Type Ovarian Tumor Dodi Suardi
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To understand the molecular profile by identifying the mutation of KRAS and BRAF in borderline type ovarian tumor. Method: In the study, we examined paraffin tissue sample from Department of Pathology Anatomy, University of Indonesia/Dr. Cipto Mangunkususmo Hospital, Jakarta, that was diagnosed as borderline epithelial ovarian tumor. Seventeen samples were taken to Sandya Laboratory in Bandung for examination of PCR BRAF exon 15 codon 600, and KRAS in exon 2 codon 12 and 13, as well as exon 3 codon 61. Result: Mutation of KRAS occurred in 94% of subjects (serous borderline 62.5%, mucinous bordeline 37.5%), of which 70.6% mutation happened in exon 2 codon 12 (serous borderline 33.3%, mucinous borderline 66.7%), 52.9% mutation in exon 2 codon 13 (serous borderline 33.3%, mucinous borderline 66.7%), and 76.5% mutation in exon 3 codon 61 (serous borderline 30.8%, mucinous borderline 69.2%). Mutation of BRAF occurred only in 47% of subjects, but the results of Exact Fisher test showed that mutation in BRAF gave significant result, while other variables did not give significant result (p=0.009). Conclusion: Molecular pathology in borderline ovarian tumor related with BRAF mutation is more likely to occur in serous borderline type, while KRAS mutation is more likely to occur in mucinous borderline type. [Indones J Obstet Gynecol 2013; 37-2: 107-12] Keywords: borderline ovarian tumor, BRAF, KRAS

Modified Gatot Score has a better Specificity in Predicting Ovarian Malignancies Compared to Risk Malignancy Index Shirley Mansur
Indonesian Journal of Obstetrics and Gynecology Volume. 37, No. 2, April 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: The study was designed to evaluate the sensitivity and specificity of several methods in detecting ovarian epithelial malignancy by comparing Gatot Score and Risk Malignancy Index, and also proposing the modification of Gatot Score. Methods: Four hundred and one subjects with suspected epithelial ovarian malignancy were subjected to the study and had anamnesis, physical examinations, laboratories studies and ultrasonography performed. From the data, we took the variables according to Gatot Score and Risk Malignancy Index. We performed statistic analysis in term of sensitivity, specificity, ROC and optimal cut-off-point. Result: From 401 observation subjects, revealed that Gatot Score possess the sensitivity of 73.7% and specificity of 45.6% (p = 0.000; LR 28.830), while RMI possess the sensitivity of 72.4% and specificity of 35.94% (p = 0.02, LR 9.588) for RMI 1, and the sensitivity of 76% and specificity of 30.9% (p = 0.05; LR 7.984) for RMI 2. Modification to Gatot Score was performed by re-weighting to its all variables, which resulted in Gatot Score Modification 1 with cut-off point of 28.5, sensitivity of 60.4% and specificity of 35.94% (p= 0.000, LR 44.228) and Gatot Score Modification 2 with cut-off point of 5.75, sensitivity range between 49.3-69.6% and specificity range between 51.6-65.2% (p = 0.000; LR 36.806). Conclusion: Both Gatot Score and RMI gave unsatisfactory output in predicting the malignancy of ovary. By reassigning the weighting of all variables in Gatot Score, the sensitivity and especially the specificity was improved in detecting the malignancy of epithelial type ovary. This measure was directed for patients in reproductive ages, thus increasing the possibility of true malignancy. [Indones J Obstet Gynecol 2013; 37-2: 113-6] Keywords: Ca-125, epithelial ovary tumor, Gatot score, risk malignancy index

Serum Adiponectin Level is Lower in Patients with Endometriotic Cyst Fahdiansyah Fahdiansyah; Ruswana Anwar; setyorini Irianti
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: To analyse the difference of serum adiponectin level between patients with endometriotic cyst and those with non-endometriotic cyst, and its difference between endometriosis stages. Methods: This is a cross-sectional comparative analytical study involving 25 women with endometriotic cyst and 25 women with nonendometriotic cyst, which had undergone laparoscopy or laparotomy surgery. Blood samples were withdrawn and checked for serum adiponectin level in PRODIA laboratory in Jakarta. Serum adiponectin level of both groups were then measured and compared. The study was conducted in Dr. Hasan Sadikin Hospital in September- December 2012. Results: Shows no significant difference in subjectsâ€™ characteristic which are age (p = 0.994) and BMI (p = 0.267). There is a significant difference (p < 0.0001) between serum adiponectin level in endometriosis group (mean = 3.91 Â± 1.976) with level of which in nonendometriosis group (mean = 8.59 Â± 1.977). There is no significant difference (p = 0.384) of serum adiponectin level between stage III endometriosis (mean = 4.24 Â± 1.8168) and stage IV endometriosis (mean = 3.54 Â± 2.1531). Conclusion: Serum adiponectin level in patients with endometriotic cyst is significantly lower compared to level of which in patients with non-endometriotic cyst. There is no significant difference of serum adiponectin level between endometriosis stages. [Indones J Obstet Gynecol 2013; 1-3: 119-23] Keywords: adiponectin, endometriotic cyst, non-endometriotic cyst, endometriosis stage

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eko subaktiansyah

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eko.subaktiansyah@gmail.com

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