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Journal of Nutraceuticals and Herbal Medicine
Published by Universitas Muhammadiyah Surakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Journal of Nutraceuticals and Herbal Medicine contains peer-reviewed article and research dedicated to advancing the scientific knowledge base of health, especially health nutrition, nutraceuticals, nutrition formula for human essential and functional food. This journal includes original research concerning the herbal medicine phytochemical, phytopharmacy, phytopharmacology, phytotheraphy.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 3, No 2 (2020): JNHM 2020" : 5 Documents clear
Anti Inflammatory Activity Test of Ethanol Extract of Fennel Leaves and Fruits (Foeniculum Vulgare Mill.) In Wistar Rats Ahwan Abdul
Journal of Nutraceuticals and Herbal Medicine Vol 3, No 2 (2020): JNHM 2020
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v3i2.12847

Abstract

Fennel plant has various kinds of benefits such as anti-inflammatory. Fennel plants contain alkaloid compounds, flavonoids, saponins, polyphenols, tannins, anthraquinones, and steroids. The research objective was to determine the anti-inflammatory activity of the ethanol extract from fennel leaves and fruit. The research method belongs to experimental research with edema formation on rats' feet induced by 1% carrageenan. The animals' tests were randomly divided into eight treatment groups and measured the volume of their feet. Each group was given CMC Na 1% (negative control), diclofenac sodium 4.5mg/Kg weight rats (positive control), and ethanol extract of fennel leaves and fruit at a dose of 87.5 mg/Kg rat body weight, 175 mg/ Kg rat body weight, 350 mg/Kg rat body weight. Moreover, the animals' tests were induced with carrageenan 1% while the edema volume of rat leg was measured at the hours of 0.25; 0.5; 0.75; 1; 1.25; 1.5;1.75; 2.00 after induction of carrageenan. The results of the study were edema volume data and AUC value for each treatment. The data were analyzed using the Kolmogorov-Smirnov (normality test), Levene test (homogeneity test), and One-Way Anova (effectiveness test). The normality and homogeneity test results show that there is no significant difference (P0.05). In contrast, the effectiveness test between CMC Na 1% (negative control) and Diclofenac sodium 4,5 mg / Kg weight (positive control) shows the significant result (P0.05), CMC Na (negative control) and all extract treatment shows the insignificant result (P0.05), Diclofenac Natrium 4,5 mg/ Kg weight (positive control) with all treatments indicates the significant result (P0.05).
Antioxidant Activity Using DPPH & Frap Method and Their Correlation with The Levels of Phenolic and Flavonoid Compounds from Nemba Plants (Azadirachta Indica A. Juss) Haryoto Saroyo; Ismi Aziz Nur Arifah
Journal of Nutraceuticals and Herbal Medicine Vol 3, No 2 (2020): JNHM 2020
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v3i2.15658

Abstract

One of the herbal plants, namely neem (Azadirachtaindica A. Juss) can generally be used as an ingredient for traditional medicine. Neem is known to have the potential to produce antioxidants, where it can play an important role in counteracting free radicals. As a result of the increasing number of free radicals, the number of antioxidants and free radicals becomes unbalanced. If this continues, it can cause problems, namely the emergence of various kinds of serious diseases. The purpose of this literature review is to present articles related to the potential for antioxidant activity; content of phenolic compounds and flavonoids; knowing whether there is a relationship between phenolic compounds and flavonoids on antioxidant activity; as well as providing information related to other potentials of neem (Azadirachta indica A. Juss) plants. Several studies have stated that the neem plant has antioxidant activity. The strongest antioxidant activity was found in the neem root. The secondary metabolites produced are alkaloids, flavonoids, steroids, polyphenols, glycosides, phenols, tannins, essential oils, carotenoids, fatty acids, and saponins. Another study also stated that neem has the potential for other pharmacological activities such as antibacterial, immunomodulatory, antidiarrheal, and antifungal activities. polyphenols, glycosides, phenols, tannins, essential oils, carotenoids, fatty acids, and saponins. Another study also stated that neem has the potential for other pharmacological activities such as antibacterial, immunomodulatory, antidiarrheal, and antifungal activities. polyphenols, glycosides, phenols, tannins, essential oils, carotenoids, fatty acids, and saponins. Another study also stated that neem has the potential for other pharmacological activities such as antibacterial, immunomodulatory, antidiarrheal, and antifungal activities.
Literature Review: Study of Antibacterial Activity of Sunflower (Helianthus Annuus L.) Extract and Its Phytochemical Profiles Rifka Amirul
Journal of Nutraceuticals and Herbal Medicine Vol 3, No 2 (2020): JNHM 2020
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v3i2.15644

Abstract

Sunflower is one type of plant that grows in Indonesia. Sunflower plants contain secondary metabolites that have antibacterial activity. This study was conducted using a literature review approach to determine the antibacterial activity of sunflowers. The steps taken in this literature review are to collect, identify, evaluate, and interpret the antibacterial activity of sunflowers. Search results from keywords “Sunflower”, “antibacterial”, and “phytochemical profile” obtained as many as 1,834 articles, from several articles search results were then reviewed and obtained 8 articles that matched the inclusion and exclusion criteria. Various antibacterial activities of sunflower are effective against Escherichia coli, Pseudomonas aeruginosa, Micrococcus luteus, Staphylococcus aureus, Bacillus subtilis, Propionibacterium acnes, Streptococcus uberis, and Aspergillus brasiliensis. The results of phytochemical screening of sunflower leaves revealed the presence of terpenoids, sesquiterpenoids, triterpenoids, and steroids. The bioactive components found in sunflower leaves include Heliannuol M, Heliannuol D, helivypolides K, helivypolides L, helieudesmanolide, tambulin, pinoresinol and sesquiterpene 10-oxo-isodauc-3-en-15-al. Factors that affect antibacterial activity include ozonation conditions, acidity value, and oil concentration. Overall it can be concluded that sunflower extract can inhibit bacterial growth.
Inhibition Activity of Leaves, Flower and Root Extracts of Ruellia tuberosa L on α-Glucosidase Enzymes Andi Suhendi; Agus Salim Maulana
Journal of Nutraceuticals and Herbal Medicine Vol 3, No 2 (2020): JNHM 2020
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v3i2.15646

Abstract

Previous study stated that the herba of Ruellia tuberosa L has inhibition activity on α-glucosidase enzymes. The leaves, flowers, and roots of Ruellia tuberosa L contain flavonoids but have different activities. This study aims to determine the inhibitory activity by the leaves, flowers and roots of Ruellia tuberosa on the α-glucosidase enzyme. Extraction was performed by maceration method using ethanol 96% as solvent. Inhibition activity was measured based on the formation of a yellow solution of p-nitrophenol compound as a result of the reaction between p-nitrophenyl-α-D-glucopyranoside (as substrate) and α-glucosidase enzyme at a wavelength of 405 nm. The system reaction of inhibition study is divided into two reactions, namely S0 (contains substrates without enzyme) and S1 (contain substrate and enzyme). The results showed that inhibition activities of leaves, flower and root extract were 9.97 ± 4.97 % at 7.8125 µg/mL concentration of extract; 13.98 ± 5.18 % at 7.8125 µg/mL concentration of extract; 99.08 ± 0.12 % at 31.25 µg/mL concentration of extract, respectively. Based on data, the extract of leaves, flowers and roots of Ruellia tuberosa L. has the potential as an inhibitor of the enzyme α-glucosidase.
Testing Antioxidant Activity of Plumeria Alba and Plumeria Rubra Ethanolic Extracts Using DPPH and Frap Methods and Determining Their Total Flavonoid and Phenolic Levels Muhtadi Muhtadi; Aulia Ayu Fatkhurrohmah Wiyono
Journal of Nutraceuticals and Herbal Medicine Vol 3, No 2 (2020): JNHM 2020
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v3i2.15643

Abstract

Plumeria sp. or Frangipani with local name; Kamboja plants have been reported to have antimicrobial, anticancer, and antioxidant activities spread in every part of the plant. Previous studies that have been carried out only reported antioxidant activity in certain parts with certain methods. This study compared the most potent antioxidant activity in several parts of the plant with different methods with statistically significantly different results. This study aims to determine the antioxidant activity of Plumeria alba L. and Plumeria rubra L. by DPPH and FRAP methods and to determine the total flavonoid and phenolic levels. The methods used are two different methods, namely the DPPH and FRAP methods. Antioxidant activity test using the DPPH method showed that the highest antioxidant activity was found in P. rubra flowers with an IC50 value of 150, 20 ppm while in the FRAP method the highest activity was in P. rubra leaves with an antioxidant activity value of 79.75 mg AAE / g extract. The highest flavonoid content was found in the sample extract of P. rubra leaves with 117.83 mg quercetin equivalent/g extract, while the highest total phenolic content was found in P. rubra flowers with 108.85 mg gallic acid equivalent/g extract. The results showed that the highest antioxidant activity using the method DPPH correlated with phenolic content while the FRAP method correlated with flavonoid content. Antioxidant activity in P. rubra leaves comes from flavonoid compounds while in P. rubra flowers come from phenolic compounds. So that each plant sample can have a source of antioxidant activity from different compounds.

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