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Pharmacology and Clinical Pharmacy Research
Published by Universitas Padjadjaran
ISSN : 25277332     EISSN : 26140020     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.
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Articles 8 Documents
 1 
Search results for , issue "Vol 8, No 1 (2023)" : 8 Documents clear
Correlation of Polypharmacy and Comorbidity with NIHSS Status in Ischemic Stroke Patient Wardhani, Firdha A.
Pharmacology and Clinical Pharmacy Research Vol 8, No 1 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i1.38919

Abstract

Drug-related problems are a common problem among stroke patients due to comorbidities resulting from the complex management of stroke treatment leading to polypharmacy management. Studies show that 90% of stroke patients have drug-related problems (DRPs). However, there is limited information on the impact of comorbidities as risk factors for DRP prevalence and unfavorable prognosis in patients with ischemic stroke. This study aimed to determine the risk factors for DRP and clinical outcomes as modifiable comorbidities in ischemic stroke patients admitted to a tertiary hospital between January 2020 and October 2021 were indeed significant influences. The study was conducted retrospectively using a cross-sectional analysis of patient’s medical records. The study found no significant association between the presence of comorbidities and polypharmacy in patients with the incidence of DRP, although we found that the DRPs occurrence was found more in a patient with comorbidities and polypharmacy. Diabetes mellitus was found to have a significant association with no improvement in NIHSS scores in ischemic stroke patients. We found that diabetes mellitus patient had an increased risk of non-improvement NIHSS score 2,987 times compared to patients without diabetes mellitus. The second increased risk was the presence of comorbid hypertension (OR 1.352), the third was the occurrence of polypharmacy (OR 1,175), and the fourth was dyslipidemia (OR 1.138).
Benefits of probiotics in Autism Spectrum Disorders : A meta-analysis of RCTs Sharanabasayyaswamy B. Hiremath; Srinivas L. Devendrappa
Pharmacology and Clinical Pharmacy Research Vol 8, No 1 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i1.40063

Abstract

Using probiotics as a pharmaceutical intervention is based on the fact that dysbiosis affects many people with autism spectrum disorders (ASD). This study aimed to quantify various probiotics’ overall and individualized benefits in treating ASD. Randomized or cross-over trials comparing the efficacy of placebo or active control vs. probiotics in patients of any age diagnosed with ASD based on DSM IV/V criteria were considered under inclusion criteria.  An electronic database search in PUBMED and Cochrane Library was conducted using MeSH search terms “probiotics” AND “Autism.”  Mean change in the total score of clinical parameters used to assess ASD symptom severity was the primary outcome measure analyzed. All the outcome measures were estimated by calculating the Standardized Mean Difference (SMD) values and their 95% Confidence Intervals (CI), considering the different clinical parameters used to assess the change in ASD symptoms in identified clinical trials. An insignificant decrease in the total score value of primary outcome measure by -0.14 (SMD: 0.14, 95% CI:-0.45 to 0.17) in patients treated with probiotics was observed. The quantity of decrease remained insignificant in subgroup analyses also. Observed insignificant clinical benefits of probiotics in ASD patients could be due to the presence of gastrointestinal symptoms as co-morbidity. We hypothesize that intolerance to dietary components is responsible for gastrointestinal symptoms and inflammation. Perhaps probiotics are still beneficial in ASD patients without gastrointestinal symptoms, while their combination with prebiotics is effective in patients with gastrointestinal symptoms. 
Evaluating the Knowledge, Attitude, and Perception of Medical Interns regarding Contraception in a Tertiary Care Centre Usha NS; Sabari Anandh J V; Afzal Khan A K; Swapna R Nayaka
Pharmacology and Clinical Pharmacy Research Vol 8, No 1 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i1.39227

Abstract

Maternal mortality is one of the significant burdens requiring appropriate measures including family planning methods to control post-partum morbidity and mortality. The early age of marriage among women is accompanied by early pregnancies also contributes to maternal mortality. Knowledge about contraceptive usage could prevent such incidences.  This study aimed to evaluate the knowledge, attitude, and perception regarding contraceptives among medical interns in our college. This cross-sectional questionnaire study was done on 60 house surgeons (interns), at MVJ Medical College and Research Hospital, Hoskote, using a validated questionnaire that consisted of 22 questions including MCQs and case scenarios to assess their knowledge, perception, and attitude about contraceptive methods. Data were analyzed in the form of percentages. Among 60 interns, 36 were females and the majority of students were from urban backgrounds. About 73.3% of interns had adequate knowledge about various contraceptive methods and their usage. The interns have a perception that illiteracy, lack of awareness and social, and religious values are major hurdles for contraceptive usage and have an attitude that doctors are most suitable to give information regarding contraceptive methods. Considering medical interns as future physicians and their responsible role in counseling about contraceptive usage in effective family planning, they need to have a positive attitude with fair knowledge and perception about the contraceptive methods which can be achieved by educating them early in their academic carrier.    
Prescribing Pattern of Antifungal Drugs in a Tertiary Care Teaching Hospital in Western India Parth B. Patel; Akanksha Prajapati; Sumit Patel; Vipul Chaudhary; Vasu Rathod
Pharmacology and Clinical Pharmacy Research Vol 8, No 1 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i1.39238

Abstract

Fungal infections are prevalent in a tropical country like India. Pharmacotherapy of fungal disease has been revolutionized by the introduction of relatively less toxic oral drugs, com- bination therapy, and new formulations of older agents. However, data regarding antifungal drug usage patterns in India must be more present. Hence, this study was planned to study the prescribing pattern and to compare the cost of antifungal drugs in patients attending a tertiary care teaching hospital. It was a cross-sectional, observational study carried out at GCS Hospital, Ahmedabad, from April 2021 to Sept 2021. Prescriptions of 130 patients were collected and analyzed using Microsoft Excel version 2013. A total of 213 antifungal drugs were prescribed to 130 patients. Most patients, 81 (62.3%) were from the 18-40 age group. Combined antifungal treatment (Oral + Topical) was prescribed in 77(59.2%). The most common class of antifungal drugs was imidazole 107 (50.23%), and clotrimazole was the most familiar drug. The most common indication for antifungal therapy was tinea cruris (45.38%). An average of 3.75 drugs were prescribed per prescription, of which 1.63 were antifungal drugs. Combined treatment of oral and topical antifungal drugs was common in dermatological practice. However, the cost of the treatment can be reduced by prescribing generic drugs.
A Study on the Occurrence of Hand Dermatitis in Healthcare Workers during the COVID-19 Pandemic due to Enhanced Hand Hygiene Abhishree BS; Kavitha R; Geetha A
Pharmacology and Clinical Pharmacy Research Vol 8, No 1 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i1.38851

Abstract

Hand hygiene measures have increased in the general population and amongst the health care workers since the outbreak of the pandemic. However, enhanced hand hygiene can have an adverse effect on the skin barrier leading to the development of hand dermatitis. The aim of the study was to determine the occurrence of occupational-related contact dermatitis among the health care workers. An observational, questionnaire based cross-sectional study was conducted in 2021 amongst HCWs of a tertiary care hospital. The data were analysed using Microsoft Excel for Windows. The frequency of hand washing had increased to > 5 times in 42% of the HCWs while hand sanitizer usage had increased to >5 times in 95% of them during the pandemic. The duration of glove usage had increased from 3% pre-pandemic to 91 % during the pandemic and majority of them used latex gloves. Symptoms of hand dermatitis in HCWs had increased from 3% pre-pandemic to 84% during the pandemic. Less than 10 % of the study participants moisturised their hands after sanitization. The fact that over 84% of the HCWs developing HD during the pandemic can be attributed to preventive measures to reduce the transmission of the virus. Measures such as use of moisturizers should be recommended to prevent the onset of occupational hand eczema. It is thus imperative to raise awareness of HD in India and intensive measures should be provided.
Impact of Antidepressant Treatment on Heart Rate Variability in Patients with Depression - A Cross Sectional Study Raghav M V; Geetha A; Praveen Panchaksharimath; Nivetha Raj
Pharmacology and Clinical Pharmacy Research Vol 8, No 1 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i1.39623

Abstract

Heart rate variability (HRV) is a non-invasive index of cardiac autonomic regulation. HRV is reduced in depression, which indicates decreased Autonomic Nervous System flexibility. It is associated with an increase in the frequency of cardiac co-morbidities. Depression medications usually take six months for complete remission, but no data on patients on antidepressants for more than six months. Therefore, it becomes necessary to determine if anti-depressants have a better impact on HRV. The current study focused on analyzing the correction of HRV parameters after six months of antidepressant therapy. A cross-sectional study was conducted from February to September 2021 at the AFT lab inpatients. They were recruited from the Psychiatry department, Victoria Hospital, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India. The sample size was calculated to be 40 (20 Patients and 20 Healthy controls). AFT was done on all participants using Power Lab equipment and analyzed using Lab Chart 8 software. Heart rate variability parameters (AFT results) were analyzed using statistical software. The results with a p-value of >0.05% were considered statistically significant and taken up for the study. 55% of the patients with depression in our study were in the age group of 18-25 years, and the mean Ham-D (Hamilton Depression Rating Scale) score was found to be 9.8.  There is a reduction in autonomic function flexibility among patients who are on antidepressants when compared to healthy controls, even after six months of treatment. No conclusion could arrive on the class of antidepressant which was more beneficial owing to its effect on autonomic functions. Hence, randomized controlled studies comparing various classes of antidepressants to assess efficacy in reducing autonomic complications of depression should be taken up
Analysis of ADRs with Hypokalaemia for Severity, Preventability and Causality in a Tertiary Care Centre in South India Shiva Murthy Nanjundappa; Safeera Alikutty K; Mabel Kuriakose EV; Basalingappa Shivanna
Pharmacology and Clinical Pharmacy Research Vol 8, No 1 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i1.38913

Abstract

Hypokalemia is one of the most frequently seen electrolyte disturbances in clinical practice. Various drugs are known to induce hypokalemia, such as furosemide, thiazides, dicloxacillin, ampicillin, etc. The objective of this study is to assess hypokalemia adverse drug reactions (ADRs) for severity, preventability, and causality in a tertiary care centre in the southern part of India. It is a retrospective, cross-sectional study. Data collected at DMWIMS Medical College, India, as per the ongoing pharmacovigilance program of India from November 1st, 2016 to October 30th, 2017 (12 month period) was included for analysis in this study. The SADR form published by the Government of India under the PVPI program was used for collecting the data. In-patients who were on at least one medication and experienced hypokalemia ADR with or without other symptoms or signs were included. Both primary suspected drugs and concomitantly prescribed drugs were analyzed. For the assessment of ADRs, modified Hartwig and Siegel assessment scales and plasma K+ level criteria were used for severity, Schumock and Thornton criteria for preventability, the WHO-UMC scale, and Naranjo's algorithm for causality, respectively. Sixty hypokalemia ADRs were considered for analysis. Both genders were equally affected, with a mean age of 64.28 ± 3.02 years. Four groups of drugs were suspected to cause hypokalemia viz., anti-asthmatics (36.67 %), diuretics (31.67 %), antibiotics (18.33 %), and antidiabetics (13.33 Polypharmacy was reported in 43.33% of cases, with 4.40 ± 01.689 drugs prescribed on average. To summarize, hypokalemia is a preventable ADR and minor variations in serum K+ levels can have a negative impact on patients' outcomes and mortality. FDC of Levosalbutamol with Ipratropium Bromide was the most common causative agent suspected of causing hypokalemia. Elderly patients receiving one or more drugs that are known to alter K+ levels, need close monitoring, and correction of hypokalemia should be done to improve prognosis. Further studies are required to understand the mechanisms involved in DDIs and DDiIs to derive preventive strategies.
Pharmacogenomic Considerations In Propofol: A Review Ziske Maritska; Tri U. Pratiwi; Muhammad J. Aldwin; Clinton F.M Sitanggang; Ferdy Rahadiyan
Pharmacology and Clinical Pharmacy Research Vol 8, No 1 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i1.38749

Abstract

Pharmacogenomics is one of the pivotal fields of science in the era of precision medicine. It helps provide an understanding of what causes the differences in terms of pharmacokinetics and pharmacodynamics of a particular drug in patients. Hence, this leads to better efficacy. This branch of medicine also applies to sedative drugs in the anesthesia field, one of which is propofol. Changes in propofol pharmacokinetics and pharmacodynamics properties might lead to toxicity and inadequate sedation. This review wishes to better understand how pharmacogenomics is applied in anesthesia, especially in propofol, one of its most commonly used medications.     

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