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JURNAL KIMIA SAINS DAN APLIKASI
Published by Universitas Diponegoro
ISSN : 14108917     EISSN : 25979914     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering
urnal Kimia Sains dan Aplikasi (p-ISSN: 1410-8917) and e-ISSN: 2597-9914) is published by Department of Chemistry, Diponegoro University. This journal is published four times per year and publishes research, review and short communication in field of Chemistry.
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Articles 7 Documents
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Search results for , issue "Vol 27, No 6 (2024): Volume 27 Issue 6 Year 2024" : 7 Documents clear
Study on the Upgrading Citronella (Cymbopogon nardus L.) Oil Isolation Using Microwave Assisted Hydro-distillation Method Diana Diana; Venitalitya Alethea Sari Augustia; Arif Hidayat; Kiki Adi Kurnia
Jurnal Kimia Sains dan Aplikasi Vol 27, No 6 (2024): Volume 27 Issue 6 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.6.293-299

Abstract

Isolation of essential oil using microwave-assisted hydro-distillation (MAHD) method could enhance the yield compared to steam-distillation or conventional hydro-distillation methods. This study explored the isolation of essential oil from Citronella (Cymbopogon nardus L.) using the MAHD method with several parameters, such as solid-to-liquid ratio, power of the microwave, and extraction time. The essential oils produced were evaluated based on yield, density, refractive index, and composition. The result showed that the density of the essential oil product was in the range of 0.866–0.902 g/mL, while the refractive index was in the range of 1.470–1.475, which met the ISO standard. Chemical compounds were identified using Gas Chromatography-Mass Spectrometry (GC-MS) analysis. It was found that the total amount of citronellal, citronellol, and geraniol in the product obtained by MAHD is higher than the one from conventional methods. This study aims to identify the most efficient operating conditions to maximize yield while analyzing energy consumption to determine the most cost-effective conditions.
Synthesis, Characterization and Molecular Docking of Bis-(1-(2,4-dichlorobenzoyl)-3-methylthiourea) Iron (III) Complex as Anticancer Candidate Ruswanto Ruswanto; Feri Sandria; Winda Trisna Wulandari; Richa Mardianingrum
Jurnal Kimia Sains dan Aplikasi Vol 27, No 6 (2024): Volume 27 Issue 6 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.6.258-264

Abstract

The Bis-(1-(2,4-dichlorobenzoyl)-3-methylthiourea) iron (III) complex has been synthesized from the reaction between 1-(2,4-dichlorobenzoyl)-3-methylthiourea and Fe (III) metal ion by reflux method with ethanol solvent at a temperature of 75°C for 7 hours. It was characterized by a hot stage microscope (HSM), UV-Vis, FT-IR, and mass spectroscopy. The % yield of the synthesis result was 97.58%. From the docking study on the ribonucleotide reductase enzyme, the binding affinity value was -7.76 kcal/mol, and the inhibition constant was 2.11 mM. The Bis-(1-(2,4-dichlorobenzoyl)-3 methylthiourea) iron (III) complex compounds can be synthesized and predicted as anticancer candidates.
Effect of Precursors Concentration on The Optical and Photoelectrochemical Properties of Bi₂S₃/TiO₂ Nanotubes Arrays Photoanode Synthesized by the SILAR Technique Eko Martin Sinaga; Muhammad Iqbal Syauqi; Jarnuzi Gunlazuardi
Jurnal Kimia Sains dan Aplikasi Vol 27, No 6 (2024): Volume 27 Issue 6 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.6.265-270

Abstract

The use of robust solar energy-driven photocatalysis materials to address the global energy and environmental crisis has gained significant attention in recent years. However, the wide band gaps in many robust semiconductor photocatalysts hinder their absorption of visible light from the solar spectrum. To address this issue, the modification of the large band gap semiconductor with the lower band gap material using the Successive Ionic Layers Adsorption and Reaction (SILAR) technique has emerged as an economical, accessible, and reproducible method for depositing nanoscale materials onto semiconductor substrates. This research aims to know how the concentration variation of cation and anion precursors in the SILAR technique affects the optical and photoelectrochemical properties of the resulting composite materials. Bi₂S₃ serves as a modifier for TiO₂ nanotube arrays (NTAs). The result shows that the cation-anion concentration ratio of 1:1.5 mM with five SILAR cycles gives the best photoelectrochemical performance, with a stable current density of 0.12 mA/cm², compared to pristine TiO₂ NTAs the current density of Bi₂S₃/TiO₂ NTAs is 15-fold. In addition, at each variation, the concentration ratio of cation and anion precursors decreases bandgap energy with each increase in the SILAR cycle.
Synthesis of Bromo Eugenol Derivatives with Molecular Bromine Verucha Fauzia Putri; Purwantiningsih Sugita; Budi Arifin
Jurnal Kimia Sains dan Aplikasi Vol 27, No 6 (2024): Volume 27 Issue 6 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.6.271-277

Abstract

The bromination of eugenol using molecular bromine (Br2) has been widely reported. However, the outcomes have been inconsistent, and as a result, the specific steps of the bromination process have not been definitively established. This research aims to synthesize various derivatives of bromo eugenol, incorporating bromine atoms either in the alkene group, the aromatic ring, or both. The synthetic approaches employed include: (1) direct bromination of eugenol using 1.2, 2.4, and 3.6 equivalents (equiv) of Br2 in chloroform, (2) bromination of eugenyl benzoate with 2.4 equiv of Br2 in chloroform, and (3) debromination of the 1,2-dibromide functionality in selected bromination products using an excess of zinc in ethanol. The bromination steps of eugenol were then proposed based on the composition of the products obtained. Alkene bromination of eugenol predominated with 1.2 equiv of Br2, followed by aromatic bromination with excess Br2 (2.4 and 3.6 equiv). Aromatic substitution primarily occurred at position 6 (ortho to the hydroxyl group) and subsequently at position 5 (para to the methoxy group). Based on these results, we propose that the bromination of eugenol with Br2 proceeds initially through electrophilic addition to the alkene group, followed by electrophilic substitution on the aromatic ring. Protection of the phenol as a benzoyl ester shifted the regioselectivity of the first aromatic bromination from position 6 to 5. Furthermore, the 1,2-dibromide group has been successfully removed by zinc, resulting in derivatives containing bromine atoms only at the aromatic ring. This is by far the first comprehensive report on the bromination of eugenol with Br2 and the first one reporting the bromination of alkene as the main route of bromination with a nearly equimolar amount of Br2.
Antibacterial Properties of Bacterial Cellulose-Quercetin Composite Membrane Riza Apriani; Asman Sadino; Astri Senania; Zahara Oetari; Gania Ningsih Noer Fajrianti
Jurnal Kimia Sains dan Aplikasi Vol 27, No 6 (2024): Volume 27 Issue 6 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.6.278-283

Abstract

Bacterial cellulose has been thoroughly explored as a biomaterial for various applications due to its intrinsic mechanical, physical, and biological features. Its structural characteristics provide ideal conditions for developing composite, expanding its range of applications even further. The current study aims to synthesize quercetin-loaded bacterial cellulose composite as a potential wound dressing by utilizing the antibacterial activity of quercetin and the unique characteristics of bacterial cellulose. The produced bacterial cellulose was ex-situ modified with quercetin. The composite was characterized for its functional group by FTIR, its morphology by FE-SEM, and its antibacterial activity was evaluated against Gram-positive S. aureus and Gram-negative E. coli through the disc diffusion method. Characterization analyses confirmed the successful impregnation of quercetin into the BC matrix. The antibacterial activity of BC-Quercetin showed moderate activity, both against S. aureus and E. coli. Determining the loading dose of quercetin into bacterial cellulose is a gap for conducting future research. However, this study indicates that combining bacterial cellulose with quercetin could provide a base for developing promising alternatives for the conventional dressing system in wound healing.
Synthesis and Characterization of Silica-Biochar Composite as Rhodamine B Dye Adsorbent Lisa Sari; Anis Shofiyani; Ajuk Sapar
Jurnal Kimia Sains dan Aplikasi Vol 27, No 6 (2024): Volume 27 Issue 6 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.6.284-292

Abstract

Composites are synthesized by combining different materials, resulting in properties suitable for use as adsorbents due to the combination of pores and functional groups within the constituent materials. This study developed a silica-biochar composite to serve as an adsorbent for rhodamine B dye, utilizing silica derived from red mud and biochar obtained from oil palm empty fruit bunches (OPEFB). This research focused on analyzing the characteristics and effectiveness of the composite as an adsorbent by varying its composition. Silica from red mud exhibited a purity of 80.05% and possessed silanol (Si-OH) and siloxane (Si-O-Si) functional groups on its surface, whereas biochar from OPEFB had a carbon content of 95.91% and included functional groups such as -OH, C=O, C=C, C-H, and C-O. The combination of silica and biochar yielded a composite surface consisting of -OH, C=O, C=C, C-O, C-H, and Si-O-Si functional groups. The silica-biochar composite demonstrated a greater surface area than its individual components, with silica at 69.824 m²/g and biochar at 95.452 m²/g. The composite with a 1:2 (% w/w) ratio exhibited the largest surface area at 102.371 m²/g, achieving a maximum adsorption capacity of 1.550 mg/g and an efficiency of 88.463%. The adsorption process encompasses physical interactions via pore diffusion and chemical interactions through functional groups.
In Silico Analysis for Exploring the Potential Inhibitors Against Breast Cancer (MCF7) Using Curcumin Analogue Compounds Neni Frimayanti; Adel Zamri; Yum Eryanti
Jurnal Kimia Sains dan Aplikasi Vol 27, No 6 (2024): Volume 27 Issue 6 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.6.250-257

Abstract

Breast cancer is one of the most problematic diseases in the world. Currently, there are no potential vaccines for the treatment of this disease. Therefore, finding effective compounds, such as curcumin analogs, is crucial to inhibit breast cancer. Forty-five synthesized curcumin analogs were tested on the MCF7 cell line using the MTT assay. It was shown that nine curcumin compounds, Cpd 5, Cpd 9, Cpd 17, Cpd 18, Cpd 21, Cpd 25, Cpd 28, Cpd 32, and Cpd 45, had better inhibitory activities against breast cancer. Furthermore, in silico analysis was developed using 2D and 3D QSAR models with high predictive ability, with an r2 value of 0.834. In addition, based on molecular docking, molecular dynamics, and pharmacophore results, it was shown that these nine compounds had the lowest binding free energy and were also stable during the simulation. The presence of methoxy groups, hydrogen bond donors, and aromatic ring features are the main factors that enhance the biological activity of curcumin analogs. Therefore, these compounds could serve as references for the next stage of drug design.

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