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Molekul: Jurnal Ilmiah Kimia
Published by Universitas Jenderal Soedirman
ISSN : 19079761     EISSN : 25030310     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.
Arjuna Subject : -
Articles 15 Documents
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Search results for , issue "Vol 11, No 1 (2016)" : 15 Documents clear
Quantitative Structure-Activity Relationship Analysis of Xanthone Derivates as Cytotoxic Agents in Liver Cancer Cell Line HepG2 Isnatin Miladiyah; Iqmal Tahir; Jumina Jumina; Sofia Mubarika; Mustofa Mustofa
Molekul Vol 11, No 1 (2016)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (614.538 KB) | DOI: 10.20884/1.jm.2016.11.1.203

Abstract

The study of xanthone derivatives as cytotoxic agents in cancer is increasing. This study was conducted to explore the Quantitative Structure-Activity Relationship (QSAR) of xanthones as cytotoxic agents in HepG2 cells, to find compounds with better potency. The data set were taken from the previous study, involving 26 xanthone derivates and their cytotoxic activities in Inhibitory Concentration 50% (IC50). The parameters (descriptors) were obtained from quantum mechanics calculation using semiempirical AM1 method and QSAR models determined with principle component regression, with log (1/IC50) as a dependent variable and five latent variables as independent variables. From the 26 main descriptors, PCR reduced them to five latent variables (1st– 5th LV). The QSAR analysis gave the best model as follows: log (1/IC50) = 4.592 – 0.204 LV1 + 0.295 LV2 + 0.028 LV3 (n = 26, r = 0.571, SE = 0.234, Fcount/Ftable ratio = 1.165, PRESS value = 3.766). The study concluded that the descriptors contributed to anticancer activity were volume, mass, surface area, log P, dipole moment, HOMO energy, LUMO energy, and atomic net charge of some atoms. Modifications of substitution that would contribute to cytotoxic activity can be performed at phenyl ring A and C, but not at B.
Antioxidant Potential Of Lansium Domesticum Corr. Seed Extract In White Male Rat (Rattus Novergicus) Induced By Alcohol Subandrate Subandrate; Sadakata Sinulingga; Sri Wahyuni; M Fakhri Altiyan; Fatmawati Fatmawati
Molekul Vol 11, No 1 (2016)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (369.353 KB) | DOI: 10.20884/1.jm.2016.11.1.189

Abstract

Lansium domesticum Corr. is a typical plant of Indonesia. The seeds have a lot of useful compounds, such as flavonoids. Flavonoids are a natural compound that can act as antioxidants. The aim of this study was to determine the antioxidant potential of Lansiumdomesticum Corr. seed extract. This study was an experimental research with posttest control group design. The subjects were 32 white male rats. Rats were randomly divided into 4 groups: negative control group was given suspension of Na CMC 1%, dose group I, II and III were given Lansium domesticum Corr. seed extract with each dose of 100mg/kg, 200 mg/kg, and 300 mg/kg. Observation of the subject's response was done by measuring the levels of glutathione (GSH) and malondialdehyde (MDA). Analysis ANOVA test showed that there was a group that had an average difference both GSH levels (p=0.00) and MDA levels (p=0.00). Post hoc test analysis for GSH levels and MDA levels showed that only a dose of 100 mg/kg which have significant differences (p=0.00). Thus, Lansiumdomesticum Corr. seed extract has antioxidant potential and optimum dose of 100 mg/kg.
Identification of Secondary Metabolites Compounds and Antibacterial Activities on The Extract of Soursop Leaf Dian Riana Ningsih; Zusfahair Zusfahair; Dwi Kartika
Molekul Vol 11, No 1 (2016)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (445.261 KB) | DOI: 10.20884/1.jm.2016.11.1.199

Abstract

Treatment of bacterial infectious diseases using semi-synthetic antibiotics can lead to resistance, so as to overcome it necessary to search for natural ingredients from plant extracts that has potential as an antibacterial, one of which is the leaf extract of soursop (Annona muricata L.). This study aims to determine the antibacterial activity of soursop leaf against E. coli and identify groups most active chemical compounds from the extracts. Soursop leaves extracted by maceration using n-hexane, chloroform and methanol. The extracts were tested for antibacterial activity using the diffusion method. Extract with the highest activity determined the minimum inhibitory concentrations grow (MIC) and tested the content of secondary metabolites with phytochemical test, subsequently identified using IR spectrophotometer. Soursop leaves with extraction solvent n-hexane, chloroform and methanol to produce n-hexane extract (E1), the chloroform extract (E2), and the methanol extract (E3) with a yield respectively 0.82%; 5.21%; 8.2% and produce antibacterial activity with consecutive inhibition zone of 3.52 mm; 8.34 mm; 3.00 mm. MIC of soursop leaf chloroform extract of the E. coli bacteria that is at a concentration of 1 ppm with inhibition zone of 3.23 mm. Based on the test results phytochemical soursop leaf chloroform extract showed the presence of compounds alkaloids, steroids, saponins and tannins. IR spectrophotometer identification results showed that the chloroform extract of the leaves of the soursop has functional groups OH, aliphatic C-H, C = O, C = C aromatic, CH3, C-O ether and C-H outside the field.
Physical Damages of Wood Fiber in Acacia Mangium due to Biopulping Treatment Ridwan Yahya; Mucharromah Mucharromah; Devi Silsia; Septiana Septiana
Molekul Vol 11, No 1 (2016)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (452.767 KB) | DOI: 10.20884/1.jm.2016.11.1.198

Abstract

Biopulping is fungal pretreatment of wood chips to reduce unused chemical composition of material in pulping. Preliminary study showed that pretreatment of Phanerochaetachrysosporium to Acacia mangium Willd can reduce lignin and improve holocellulose and cellulose content of the material. Fiber dimension recognized as other important factor for paper properties. The question is how the integrity and dimensions of the wood fiber that has been pretreated with the fungus. The objectives of present study were to know effect of pretreatment of P. chrysosporium to the integrity and dimensions of the fiber. The P. chrysosporium was cultured for 14 days in growth medium, and inoculated to wood chips 5% (w/v) and incubated for 0, 15 and 30 days. The inoculated wood chips were chipped into 1 mm x 1 mm x 20 mm and macerated using franklin solution at 60 oC for 48 hours. Forty fibers from each incubated time were analized their physical damages using a light microscope at a 400 magnification. The inoculated fibers were measured theirs dimensions. The physical damage percentage of fibers pretreated using P. chrysosporium was 0%. Length and wall thickness of the pretreated fibers were can be categorized as middle class and thin fibers, respectively.
Fractionation And Environmental Risk Of Trace Metals In Surface Sediment Of The East China Sea By Modified BCR Sequential Extraction Method Roy Andreas; Jing Zhang
Molekul Vol 11, No 1 (2016)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (838.1 KB) | DOI: 10.20884/1.jm.2016.11.1.193

Abstract

Geochemical fractionation of Cadmium (Cd), Lead (Pb), Cobalt (Co), Zink (Zn), Iron (Fe) and Manganese (Mn) in sediment of the East China Sea were determined using four-stages of modified BCR sequential extraction method combination with ICP-MS. The total concentration of trace metals in sediment samples were in the following order: Fe >Mn>Pb> Zn > Co > Cd. Cd is present mainly in acid soluble fraction. Pb and Mn are in the group with presenting of easy reducible fraction and acid soluble fraction. Fe and Co were found in a group with mainly in residual fraction, while Zn was distributed in all four fractions. The highest contamination factors were found for Cd and Mn while the lowest were found for Fe and Co in almost station. The result showed low risk for Fe and Co in all station, Pb (except S2 and S3), Zn at S3,S6 and S7, and Mn at S1. A medium risk is indicated for Pb at S2 and S3, Zn at S1 and S5, and Mn at S2 and S6. A high risk showed for Zn at S2 and S4, and Mn at S4 and S5, while Cd at almost station (except S4) was very high risk.

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