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ISM (Intisari Sains Medis) : Jurnal Kedokteran

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Published by Universitas Udayana

ISSN : 25033638 EISSN : - DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.

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Articles 1,063 Documents

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High dose and long-term use of spironolactone induce gynecomastia in an elderly man with chronic heart failure: a case report Putu Giani Anabella Bestari Putri; Nurfitriani Nurfitriani; I Gusti Ayu Suryawati
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Introduction: Gynecomastia is caused by an imbalance of estrogen and androgen in the male breast tissue. It can be divided into three causes, physiological, drug-induced, and idiopathic. Spironolactone is a potassium-sparing diuretic that has known to pose an antiandrogen effect and can cause gynecomastia.Case Description: A 75 years old man came for a regular cardiac examination at the hospital. He complained of tenderness and pain at his right breast for the last six months and only getting worse since the previous two weeks. He had a regular appointment with a cardiologist after diagnosed with Chronic Heart Failure Functional Class III, Suspected as Coronary Artery Disease, Hypertensive Heart Disease since January 2017. The patient regularly takes Furosemide 40 mg once a day, Clopidogrel 75 mg once a day, Valsartan 10 mg once a day, Bisoprolol 1.25 mg once a day, and Spironolactone 100 mg once a day. On physical examination, tenderness was felt on the right breast. Fine-needle aspiration cytology examination of the right breast was conducted, the finding was compatible with gynecomastia.Conclusion: Gynecomastia is a breast enlargement in men that occurred due to hormonal imbalance and most often caused by the side effect of a high-dose and long-term use of Spironolactone. Discontinuation of the spironolactone treatment or switching to other therapy is recommended. However, gynecomastia should not be used as a reason for not prescribing Spironolactone to patients with severe heart failure.

Anomalies of the sigmoid colon during laparotomy exploration: a case report of a redundant colon in the sigmoid and transverse colon Made Bagus Sastrapramaya Bharata; Made Dwi Yoga Bharata; I Gusti Ayu Agung Bella Jayaningrum
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Introduction: The redundant colon is rare, often resulting in a late diagnosis because it is often asymptomatic and eventually leads to complications. The average person has a large intestine/colon 120-150 cm long in his abdominal cavity. The large intestine organ does not extend to the side but is tortuous to occupy the abdominal cavity. An abnormal condition can be found in the intestine length is beyond normal, known as “redundant colon”. The redundant colon may have additional loops or turns, which cause it to become longer. In people who experience the redundant colon, the process of removing feces in the body tends to be longer, so it often experiences constipation.Case description: In this case, A 40-year-old patient of female gender reportedly came to the BIMC Hospital and complaints of her abdominal pain, unable to defecate for 3 weeks ago, and did not improve with enemas. The patient had a history of total hysterectomy 13 years ago. The abdomen's physical examination is distended while inspected, there is no tenderness during palpation, and has normal auscultation. CT-Scan investigation found redundant transverse colon, low ileocecal junction location, and many intraluminal (colonic) stools, as well as plain abdominal images with obstruction of the large intestine. In patients, an exploratory laparotomy has been performed.Conclusion: Ileus obstruction was found due to momentum adhesion which tangled the sigmoid colon and was redundant in the transverse colon during the surgery. With proper management of this case, we hope this surgery can attain this case back to normal.

Fistulectomy in a 9-years old boy with pre-auricular fistula Komang Soniananda Pradnyana Putri; Luh Witari Indrayani
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Introduction: Preauricular fistule is a congenital malformation of the six auditory hillocks during the development of auricle. It mostly appears like a small pit close to the first ascending portion of the helix's anterior margin. The sebaceous glands secreted fluid through the opening of the fistule. Surgery is needed if the discharge is prolonged or if there was a repeated infection. It must be completely removed to prevent a recurrence. Accuracy is required in performing fistulectomy and aesthetics because the operation is in the area around the face.Case description: Male patient, 9 years old, complained of itching in the right ear. Since birth, the patient has an abnormal hole (fistule) in front of his right ear, anterior of the medial supra auricle helix, round and the size of a tip of the pencil. The mother has the same history. There is an abscess near that hole that secretes yellow pus. That occurred twice this year and it has greatly disturbed the patient's activities at school. The patient was diagnosed with a preauricular fistula with an abscess in the right ear. An abscess drainage incision was performed and an antibiotic was given. Fistulectomy is performed after the acute infection subsides under general anesthesia. The patient underwent a simple fistulectomy surgery. The whole track and sinus were removed, the defect was undermined and sutured.Conclusion: A simple fistulectomy is a good option as a standard procedure for preauricular fistula excision. It is especially useful as an alternative in cases where the other approaches are difficult to be performed.

Prevalensi kejadian perdarahan uterus abnormal di Rumah Sakit Umum Daerah Wangaya Denpasar periode Januari – Desember 2020 Ida Bagus Aditya Mayanda; I Gede Deni Surasandi
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Introduction: Abnormal uterine bleeding (AUB) is the most common gynecological disorder experienced by women of reproductive age. The Federation of Gynecology and Obstetrics (FIGO) classifies AUB according to its etiology into PALM-COEIN. This study aims to determine the prevalence of AUB incidence according to the FIGO classification and AUB patients' characteristics based on age group, parity, BMI, and educational level at Wangaya Hospital Denpasar.Method: The study design is descriptive retrospective. Samples were collected by total sampling. Data was taken from medical records of patients diagnosed with AUB in Obstetrics-Gynaecology Polyclinic and Obstetrics-Neonatal Comprehensive Emergency Services at Wangaya Hospital Denpasar period January-December 2020.Result: The results showed 68 cases of AUB (15.8%) from 437 gynecologic cases. AUB due to structural abnormalities is 45 people (66.2%) with the most cases being AUB-L are 26 people (38.2%). In comparison, AUB was not due to structural abnormalities are 23 people (33.8%) with the most cases AUB-O, namely 18 people (26.4%). The AUB incidence most occurred in the age group ?41 years which is 25 people (36.8%). Parity ?2 times had the most AUB incidence, namely 26 people (57.8%). The most AUB incidence in normal BMI (18.5-24.9), namely 53 people (77.8%), and 37 people (54.4%) at the nongraduated.Conclusion: Prevalence of AUB incidents at Wangaya Hospital Denpasar period January-December 2020 almost one-fifth of all gynecological cases. The AUB incidence most prevalent in the age group ?41 years, parity ? 2 times, normal BMI, and non-graduated. Latar Belakang: Perdarahan uterus abnormal (PUA) merupakan kelainan di bidang ginekologi yang paling sering dialami oleh perempuan usia produktif. Federation of Gynecology and Obstetrics (FIGO) mengklasifikasikan PUA menurut etiologinya menjadi PALM-COEIN. Penelitian ini bertujuan untuk mengetahui prevalensi kejadian PUA sesuai klasifikasi FIGO dan mengetahui karakteristik pasien PUA berdasarkan kelompok usia, paritas, IMT, dan tingkat pendidikan di RSUD Wangaya Denpasar.Metode: Rancangan penelitian yang digunakan adalah deskriptif retrospektif. Teknik penentuan sampel yang digunakan adalah total sampling. Data penelitian didapatkan dari rekam medis pasien di Poliklinik Kebidanan-Kandungan dan Pelayanan Obstetri Neonatal Emergensi Komprehensif (PONEK) Rumah Sakit Umum Daerah (RSUD) Wangaya Denpasar periode Januari – Desember 2020.Hasil: Dari hasil penelitian didapatkan 68 kasus PUA (15,8%) dari 437 kasus di ginekologi. PUA karena kelainan struktural sebanyak 45 orang (66,2%) dengan kasus terbanyak adalah PUA-L 26 orang (38,2%), sedangkan PUA bukan karena kelainan struktural sebanyak 23 orang (33.8%) dengan kasus terbanyak PUA-O yaitu 18 orang (26,4%). Kejadian PUA paling banyak terjadi pada kelompok usia ?41 tahun sebanyak 25 orang (36,8%). Paritas ?2 kali paling banyak mengalami kejadian PUA yaitu 26 orang (57,8%). Kejadian PUA paling banyak pada IMT Normal (18,5-24,9) yaitu 53 orang (77,8%), dan tingkat pendidikan bukan Sarjana/D3 sebanyak 37 orang (54,4%).Simpulan: Prevalensi Kejadian PUA di RSUD Wangaya Denpasar periode Januari – Desember 2020 hampir seperlima dari seluruh kasus ginekologi. Kejadian PUA paling banyak terjadi pada kelompok usia ?41 tahun, paritas ?2 kali, IMT normal, dan tingkat pendidikan bukan Sarjana/D3.

Tonsillectomy indication in adult with chronic tonsillitis: a case report Komang Soniananda Pradnyana Putri
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Introduction: Tonsils are the body's defense against viruses or bacterial antigens that enter the tonsils. These pathogens can cause inflammation and formed focal infection. Either persistent or recurrent infection of the palatine tonsils occurs in chronic tonsillitis. Tonsillectomy is surgical procedure that removed the entire palatine tonsils. It is performed if conservative and medical management failed to relieve symptoms and if indicated by the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) consensus published 1995.Case description: A 30 years old male, complained a lump in his throat for about a year and had worsened for the previous 1.5 months. The patient also had difficulty in breathing, especially during sleep and snored. The patient had received treatment and got better. However, some complaints such as fever, cough, runny nose, difficulty and painful swallowing appear more than three times a year. The patient was alert, vital signs and general examination are within normal limits. Throat examination revealed T2 - T3 tonsils, hyperemic + / +, dilated crypts + / +, detritus - / -, midline uvula with hyperemic mucosa. The patient was diagnosed with chronic tonsillitis and undergone Tonsillectomy.Conclusion: Tonsillectomy is indicated in patients with enlarged tonsils that cause upper airway obstruction and recurrent episode of tonsil infections more than three times per year despite adequate medical therapy.

Problem diagnostik seorang penderita endokarditis infektif dengan komplikasi perdarahan intrakranial: Sebuah laporan kasus Franky Simarmata; Ida Bagus Aditya Nugraha; I Wayan Wita; Dwijo Anargha Sindhughosa
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Introduction: Infective Endocarditis (IE) is a disease frequently affecting heart valves. The diagnosis is relatively simple, however it could be difficult in unspecific symptoms. Intracranial complications of patients with IE rarely happen.Case: The case was a 64 years-old male with sudden decrease of consciousness 12 hours prior to admission and diagnosed as a hemorrhagic stroke. He had a history of heavy smoking for about 10 years. Infective Endocarditis (IE) was diagnosed by Duke Criteria, and from this patient we found the vegetation at mitral valve with diameter 1.09 x 0.73 cm. Treatment for the patient is antibiotic according to sensitivity test of blood culture. The patient was discharged with improvement of condition. However, in approximately three months after discharge, the patient got hospitalized again due to the same condition and passed away.Conclusion: Infective endocarditis is a relatively rare disease. In our case we had a definite IE patient with a spectrum of neurological events complicating this disease. The presence of cerebral hemorrhage complications makes the patient's prognosis worse. Pendahuluan: Endokarditis Infektif (IE) merupakan penyakit yang umumnya menyerang katup jantung. Diagnosis pada umumnya relatif sederhana, namun dapat menjadi sulit gejala yang ditemukan tidak spesifik. Komplikasi intrakranial pasien dengan IE jarang terjadi.Laporan Kasus: Seorang laki-laki 64 tahun dengan penurunan kesadaran mendadak 12 jam sebelum masuk rumah sakit (MRS) dan didiagnosis sebagai stroke hemoragik. Pasien memiliki riwayat perokok berat selama kurang lebih 10 tahun. Endokarditis infektif (IE) di diagnosis dengan kriteria Duke, dan dari pasien ini ditemukan vegetasi pada katup mitral dengan diameter 1,09 x 0,73 cm. Pengobatan untuk pasien adalah antibiotik berdasarkan uji sensitivitas kultur darah. Pasien dipulangkan dengan kondisi perbaikan. Namun, sekitar tiga bulan setelah keluar, pasien kembali dirawat di rumah sakit karena kondisi yang sama dan meninggal dunia.Simpulan: Endokarditis infektif merupakan penyakit yang relatif jarang. Dalam laporan kasus ini, pasien dengan spektrum kejadian neurologis yang menyulitkan penyakit IE. Adanya komplikasi perdarahan otak membuat prognosis pasien semakin buruk.

Hubungan durasi ketuban pecah dini dengan asfiksia neonatorum di RSUD Negara tahun 2020 I Gde Ketut Fendy Indrapermana; Vidya Saraswati Putri Duarsa; Iswara Somadina Duarsa
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Introduction: Premature rupture of membranes (PROM) was still a significant cause of maternal or neonatal morbidity. Prolonged PROM caused asphyxia due to oligohydramnios that exert pressure to the placenta and causing vasoconstriction of blood vessels. This study aimed to understand the association between duration of PROM and the presence of asphyxia among neonates delivered in RSUD Negara in 2020.Methods: This was a cross-sectional study involving woman who was diagnosed with PROM and delivered in RSUD Negara during January - December 2020, included by total sampling. The duration of PROM, neonatal asphyxia, parity, maternal age and mode of delivery data were collected from medical records. The data were analyzed by the Chi-square test. The p-value <0.05 was considered significant.Results: This study included 220 mothers with PROM. The incidence of asphyxia neonatorum in this study was 17.7%. The majority of the patients were 20-35 years old (75.5%), had parity <2 or> 3 (79.1%), had assisted-delivery (63.6%) and duration of PROM was 6-12 hours (59.5%). The duration of PROM was significantly associated with the incidence of neonatal asphyxia (p<0.05).Conclusion: The longer duration of PROM was associated with a higher incidence of neonatal asphyxia. Effective management of PROM is important to minimize the risk of neonatal asphyxia. Latar belakang: Ketuban pecah dini (KPD) masih menjadi penyebab morbiditas maternal maupun neonatus. KPD berkepanjangan berpotensi menyebabkan asfiksia karena terjadinya oligohidramnion yang menekan plasenta sehingga menimbulkan vasokonstriksi pembuluh darah. Penelitian ini bertujuan untuk mengetahui hubungan antara durasi KPD dengan asfiksia neonatorum di RSUD Negara pada tahun 2020.Metode: Rancangan penelitian ini adalah analitik observasional potong lintang. Sampel penelitian adalah wanita yang terdiagnosis dengan KPD dan menjalani persalinan di RSUD Negara pada periode Januari – Desember 2020 yang dikumpulkan secara total sampling. Data durasi KPD, kejadian asfiksia neonatorum, paritas, usia maternal dan cara persalinan dikumpulkan dari rekam medis. Data kemudian dianalisis secara bivariat dengan uji Chi-square. Hubungan dikatakan signifikan bila diperoleh nilai p<0,05.Hasil: Penelitian ini menginklusi sebanyak 220 ibu dengan KPD. Kejadian asfiksia neonatorum pada penelitian ini sebanyak 17,7%. Mayoritas pasien berusia 20-35 tahun (75,5%), memiliki paritas <2 atau >3 (79,1%), melakukan persalinan dengan tindakan (63,6%) dan memiliki durasi KPD 6-12 jam (59,5%). Durasi KPD berhubungan signifikan dengan kejadian asfiksia neonatorum (p<0,05).Simpulan: Durasi KPD yang lebih lama berhubungan dengan kejadian asfiksia neonatorum yang lebih tinggi. Pemilihan penatalaksanaan KPD yang efektif penting untuk meminimalisasi risiko asfiksia neonatorum.

Surgical excision with paramedian forehead flap reconstruction in recurrent basal cell carcinoma of the nose Nathan Aditya Willyanto; Samsul Huda
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Background: Basal cell carcinoma (BCC) is the most common malignancy worldwide, especially in fair-skinned people. Along with squamous cell carcinoma (SCC), these malignancies are grouped as non-melanoma skin cancer (NMSC). The nose is a common site for BCC because it is exposed to the sun. The rates of recurrence are variable in the literature, between 10% and 67%. The ideal surgical treatment for BCC is complete tumor removal with safety margins. Wide excision of the BCC will leave the nose with a soft tissue defect and sometimes part of cartilage or skeleton, which requires nasal reconstruction.Case presentation: An 80-year-old female was admitted to the General Surgery Department of Soebandi General Hospital Jember presenting with ulceration on the right side of her nose 4 months before admission. The patient had a previous history of surgical excision on the nose 15 years ago on the nose's left side.Conclusion: Recurrent cases of BCC are still the main issue in treating BCC. Wide excision of the BCC will leave the nose with a soft tissue defect, which requires nasal reconstruction. The paramedian forehead flap is recommended for defect closure in nasal reconstruction.

Karakteristik pasien kebidanan dengan infeksi COVID-19 di Ruang Praja RSUD Wangaya Bali periode Mei - Desember 2020 Johan Qalaba; Gede Alit Wardana
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Background: Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the SARS-COV2 virus. Pregnant women are important because pregnant women are more susceptible to viral infections and severe pneumonia due to physiological changes in the immune and cardiopulmonary systems during pregnancy, with manifestations ranging from asymptomatic to very severe. At this time, no research has been conducted on the local population, so that the authors will examine the characteristics of obstetric patients with COVID-19 infection in the Praja room of RSUD WANGAYA Bali. To determine the characteristics of midwifery patients with COVID-19 infection in the Praja room at Wangaya Bali Hospital for the period May 2020 - December 2020.Methods: This study was a retrospective descriptive study using medical records from mothers related to COVID-19. The inclusion criteria were obstetric patients with COVID-19 infection in the Praja room with the results of a reactive Rapid Test or RT-PCR at Wangaya Hospital. The data collected were age, parity, screening rapid test, comorbid, probable case, clinical symptoms, laboratory results, chest x-ray, baby weight and APGAR score, type of delivery, amount of postpartum hemorrhage, confirm case with RT-PCR, length of treatment, the need for ICU rooms and the number of deaths.Results: In this study, there were 67 respondents. Most of them were in the age range of 21-30 years and had given birth more than once. More than half of the respondents had a cesarean section, and most of the respondents tested positive for COVID-19 through the RT-PCR test. APGAR scores and baby weight were mostly normal. There were 62 respondents confirmed as RT-PCR, while with the Rapid reactive results, 66 people. Patients with mild anemia were found and found an increase in the number of CRP and neutrophils. Asymptomatic and non-comorbid patients were the most common, and on the x-ray image, most had pneumonia. There was no postpartum hemorrhage in either method of delivery. Only one person needs an ICU room. Patients infected with COVID-19 require a longer treatment time.Conclusion: Most were found in no comorbid and asymptomatic. Laboratory results were mostly found with mild anemia, leukocytosis with neutrophilia and high NLR, and high CRP. Most pregnant women do not need ICU care. Latar belakang: Penyakit corona virus 2019 (COVID-19) merupakan penyakit yang sangat menular yang disebabkan oleh virus SARS-COV2. Wanita hamil penting untuk diperhatikan karena wanita hamil lebih rentan terhadap infeksi virus dan pneumonia parah akibat adanya perubahan fisiologis pada sistem imun dan cardiopulmonal selama kehamilan, dengan manisfestasi dari tanpa gejala hingga sangat berat. Pada saat ini belum ada penelitian yang di lakukan pada populasi lokal, sehingga penulis akan meneliti karakteristik pasien kebidanan dengan infeksi COVID-19 di ruang Praja RSUD WANGAYA Bali. Untuk mengetahui karakteristik pasien kebidanan dengan infeksi COVID-19 di ruang Praja RSUD Wangaya Bali periode Mei 2020 - Desember 2020.Metode: Penelitian deskriptif retrospektif dengan data catatan medik dari ibu terkait COVID-19. Kriteria inklusi merupakan pasien kebidanan dengan infeksi COVID-19 di ruang Praja dengan hasil Rapid Test atau RT-PCR reaktif di RSUD Wangaya. Data yang dikumpulkan adalah usia, paritas, skrining rapid test, komorbid, probable case, gejala klinis, hasil laboratorium, ronsen thorax, berat badan dan skor APGAR bayi, jenis persalinan, jumlah perdarahan post partum, confirm case dengan RT-PCR, lama perawatan, kebutuhan ruang rawat ICU dan jumlah yang meninggal.Hasil: Pada penelitian ini terdapat 67 responden, sebagian besar berada dalam rentang usia 21-30 tahun dan sudah pernah melahirkan lebih dari satu kali. Lebih dari separuh responden jenis persalinannya merupakan seksio sesaria, dan sebagian besar responden positif COVID-19 melalui tes RT-PCR. Skor APGAR dan berat badan bayi sebagian besar normal. Terdapat 62 responden terkonfirmasi RT-PCR, sedangkan dengan hasil Rapid reaktif, sebanyak 66 orang. Ditemukan pasien dengan keadaan anemia ringan, serta di dapatkan adanya peningkatan jumlah CRP dan Neutrofil. Pasien tanpa gejala dan tanpa komorbid paling banyak dijumpai dan pada gambaran ronsen terbanyak mengalami pneumonia. Tidak terdapatnya perdarahan post partum pada kedua metode persalinan. Hanya 1 orang yang memerlukan ruangan ICU. Pasien terinfeksi COVID-19 memerlukan waktu perawatan yang lebih lama.Kesimpulan: Sebagian besar ditemukan dalam tanpa kmorbid dan tanpa gejala. Hasil laboratorium sebagian besar ditemukan dengan anemia ringan, leukositosis dengan neutrofilia dan NLR tinggi, serta CRP tinggi. Sebagian besar ibu hamil tidak mebutuhkan perawatan ICU.

Hubungan antara rasio neutrofil limfosit dengan derajat klinis COVID-19 pada pasien anak di RSUD Tarakan provinsi Kalimantan Utara Daniel kurniawan Sintoro; Franky Sientoro; Dian Artanti
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Introduction: Coronavirus Disease-19 (COVID-19) is an outbreak that spread in early 2020 caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), this disease has a wide spectrum of symptoms from asymptomatic to severe respiratory symptoms. Neutrophil-lymphocyte ratio (NLR) is widely used as a marker of inflammation against viral infections, including SARS-CoV-2. This study was conducted to determine the relationship between NLR and the clinical degree of COVID-19 in pediatric patients at the Tarakan General Hospital in North Kalimantan Province.Methods: A cross-sectional study was conducted on pediatric patients with COVID-19 infection who were treated in the COVID-19 isolation room at Tarakan Hospital, North Kalimantan for the period March 2020 – February 2021. There were 32 children who met the inclusion and exclusion criteria. Data on age, sex, body weight, neutrophil and lymphocyte counts, as well as the clinical degree of COVID-19 were collected from medical records. The NLR data was then categorized to NLR >3.13 or NLR <3.13 and searched for the relationship with the clinical degree of COVID-19. Spearman correlation test was used for bivariate analysis.Results: The clinical degree of mild COVID-19 was found in 21 children (65.62%). NLR values in mild clinical grade were mostly increased (46.87%) than than which did not increase (21.87%). All children with moderate clinical COVID-19 infection had RNL > 3.13 (18.74%). In asymptomatic infection, no children having an increase in RNL (12.5%). The Spearman correlation test between NLR and the clinical degree of COVID-19 resulted in a correlation coefficient (r) = 0.758 (p < 0.001).Conclusion: There is a strong relationship between the Neutrophil-Lymphocyte ratio and the clinical degree of COVID-19 in pediatric patients at Tarakan Hospital, North Kalimantan Province. Pendahuluan: Coronavirus Disease-19 (COVID-19) adalah wabah yang menyebar pada awal 2020 disebabkan oleh virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), penyakit ini memiliki spektrum gejala yang luas dari asimptomatis hingga gejala respiratori yang berat. Rasio neutrofil-limfosit (RNL) banyak digunakan sebagai penanda inflamasi terhadap infeksi virus, termasuk SARS-CoV-2. Penelitian ini dilakukan untuk mengetahui besar hubungan antara RNL dengan derajat klinis COVID-19 pada pasien anak di Rumah Sakit Umum Daerah (RSUD) Tarakan Provinsi Kalimantan Utara.Metode: Studi potong lintang dilakukan pada pasien anak dengan infeksi COVID-19 yang dirawat di ruang isolasi COVID-19 RSUD Tarakan Kalimantan Utara periode Maret 2020 – Febuari 2021. Terdapat 32 anak yang memenuhi kriteria inklusi dan eksklusi. Data mengenai usia, jenis kelamin, berat badan, jumlah hitung neutrofil dan limfosit, serta derajat klinis COVID-19 dikumpulkan dari rekam medis. Data RNL kemudian dikategorikan berdasarkan adanya peningkatan >3,13 atau tidak adanya peningkatan <3,13 dan dicari hubungan dengan derajat klinis COVID-19. Uji korelasi Spearman digunakan untuk analisis bivariat.Hasil: Derajat klinis COVID-19 ringan ditemukan pada 21 anak (65,62%). Nilai RNL pada derajat klinis ringan sebagian besar meningkat (46,87%) daripada pada derajat klinis ringan dengan RNL yang tidak meningkat (21,87%). Semua anak yang mengalami infeksi COVID-19 dengan derajat klinis sedang memiliki RNL >3,13 (18,74%). Hal ini berbanding terbalik dengan derajat klinis asimtomatik, dengan semua anak tidak mengalami peningkatan RNL (12,5%). Uji korelasi Spearman antara RNL dengan derajat klinis COVID-19 menghasilkan koefisien korelasi (r) = 0,758 (p< 0,001).Kesimpulan: Terdapat hubungan kuat antara rasio Neutrofil-Limfosit dengan derajat klinis COVID-19 pada pasien anak di RSUD Tarakan Provinsi Kalimantan Utara.

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Contact Name
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Contact Email
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Phone
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Journal Mail Official
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Editorial Address
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Location
Kota denpasar,

Bali

INDONESIA