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<![CDATA[Analisis Persistensi Penggunaan Obat Antihipertensi Terhadap Pencapaian Tekanan Darah Optimal pada Pasien di Puskesmas ]]>
<![CDATA[Serli Andini]]>;
<![CDATA[Nurmainah Nurmainah]]>;
<![CDATA[Mohammad Andrie]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v4i3.15370
<![CDATA[Persistence of the use of antihypertensive drugs in hypertensive patients is very necessary considering the main outcome of hypertension therapy is to prevent cardiovascular disease events such as myocardial infarction and stroke which can lead to death. This study aims to analyze the relationship between characteristic factors and drug use factors with the persistence of antihypertensive drug use and to determine the average blood pressure of outpatient hypertension patients at Sungai Raya Dalam Public Health. This study uses a retrospective cohort study design and uses secondary data sources for outpatient hypertension patients at Sungai Raya Dalam Public Health Center, Kubu Raya Regency. Persistence measurement method is the gaps between refill method with a grace period of 14 days for taking the drug. Data were analyzed using chi square test. The number of subjects who took part in this study were 402 hypertensive patients who used antihypertensive drugs (diagnostic index date 1 June 2020 to 30 June 2021). The results showed that the majority of the characteristics of hypertensive patients who visited the Sungai Raya Dalam Public Health Center tended to be 45 years old (57.7%), female (58.7%), patients with monotherapy therapy regimens (73.9%), and patients with CCB therapy (66.9%). Only (36.3%) patients had persistent use of antihypertensive drugs. Chi square analysis showed that there was no significant relationship between age (p=0.715) and gender (p=0.786), statistically there was a statistically significant relationship between therapy regimen (p=0.000) and type of therapy (p=0.029). The conclusion from the research is that the persistence of drug use is influenced by the regimen and type of hypertension therapy.]]>
<![CDATA[Analisis Persistensi Penggunaan Obat Antidiabetik Terhadap Pencapaian Gula Darah Optimal Pada Pasien di Puskesmas ]]>
<![CDATA[Shinta Bella]]>;
<![CDATA[Nurmainah Nurmainah]]>;
<![CDATA[Mohammad Andrie]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v4i3.15371
<![CDATA[DM sufferers in Indonesia lack awareness of using drugs regularly and continuously or in clinical terms known as persistence. The persistence of using antidiabetic drugs for 1 year is known to be low (65%). This study aims to analyze the relationship between patient characteristics, patient therapy factors and drug factors used by patients that can affect the persistence of antidiabetic drug use in outpatient type 2 diabetes mellitus patients at Sungai Raya Dalam Public Health Center, Kubu Raya Regency. This study uses a retrospective cohort study design and uses secondary data sources for outpatient type 2 diabetes mellitus patients at Sungai Raya Dalam Public Health Center, Kubu Raya Regency. The persistence measurement method used is the gaps between refill method with a grace period of 14 days for taking the drug. Data were analyzed using chi square test. The number of subjects used were 206 patients with type 2 diabetes mellitus who used antidiabetic drugs (June 2020-June 2021). The results showed that the majority of the characteristics of patients with type 2 diabetes mellitus who visited the Sungai Raya Dalam Public Health Center tended to be 40-60 years old (68.4%), female (54.9%), patients with monotherapy therapy regimen (76.7%). %), patients with metformin (72.3%) and patients with uncontrolled blood sugar (67.5%). Only (43.2%) of patients persistently used antidiabetic drugs. Chi square analysis showed that there was a significant difference between the age factor (p = 0.036), there was no significant difference between gender (p = 0.425), treatment regimen (p = 0.452) and type of therapy (P = 0.121). The conclusion of this study is that the persistence of drug use is influenced by the therapeutic regimen and the type of antidiabetic drug given.]]>
<![CDATA[Swamedikasi : Pengaruh Perilaku Terhadap Tingkat Pengetahuan Common Cold Pada Mahasiswa Baru Farmasi ]]>
<![CDATA[Syifa Nafisa Musyafak]]>;
<![CDATA[Muhammad Akib Yuswar]]>;
<![CDATA[Nera Umilia Purrwanti]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v4i3.15374
<![CDATA[Self-medication is a person's attempt to treat himself, usually to overcome a mild disease, one of which is the common cold . Self-medication will have a negative impact if self-medication is carried out incorrectly due to lack of knowledge about drug information. The purpose of this study was to determine the relationship between knowledge level and common cold self-medication behavior in Pharmacy students batch 2021 at the Faculty of Medicine, Tanjungpura University. The method used is cross sectional and the total sampling method with of samples used in this study was 60 samples. The instrument used in this research is a questionnaire that has been tested for validity and reliability. Data analysis was carried out by using the Spearman rank test using SPSS. There is a strong relationship with the P value = 0.000 and positive (+) with a correlation coefficient of 0.556 between knowledge level and self-medication behavior Common cold on Pharmacy students batch 2021, Faculty of Medicine, UNTAN .]]>
<![CDATA[Uji Aktivitas Antioksidan Sediaan Salep Ikan Gabus (Channa Striata) Kombinasi Vitamin C dan Madu Kelulut (Heterotrigona Itama) ]]>
<![CDATA[Risma Dwi Anugerah]]>;
<![CDATA[Wintari Taurina]]>;
<![CDATA[Mohamad Andrie]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v4i3.15271
<![CDATA[Based on the results of research, snakehead fish extract and kelulut honey have properties to make wounds heal faster. Ointment with an active formulation of snakehead fish extract and extract of kelulut honey showed an oxidation process that could make the preparation rancid. The addition of BHA and Vitamin C is expected to prevent the oxidation process so that the preparation does not become rancid. This study aims to determine the effect of adding Antioxidant BHA and Vitamin C in preventing the oxidation process of the ointment in the aqueous phase of extracts of snakehead fish (Channa Striata)and of kelulut honey (Heterotrigona Itama) at 28 days storage. Stability was accelerated at a temperature of 40 ± 20ºC and a RH of 75 ± 5%. Variations in the concentration ofiBHA and Vitamin C used were BHA.0.02. : Vitamin C 0.1, BHA 0.02 : Vitamin C 0.01, BHA 0.005 : Vitamin C 0.01, and BHA 0.005 : Vitamin C 0.1 then tested the physical properties of the ointment, namely through organoleptic test, homogeneity test, spreadability test, adhesion test, protection test and acid number test which were then analyzed by SPSS. Based on the analysis of the scattering power showed a significant difference between F0, F1, and F3. The results of the adhesion analysis showed that there were significant differences in each formula. Furthermore, the results of the stability test showed that all formulas had good physical stability. Conclusion: F1 is a very good formula to prevent oxidation in the preparation as evidenced by a decreased acid number, which is 9.62 mg KOH/g.]]>
<![CDATA[Formulasi Salep Ekstrak Ikan Gabus (Channa striata) dan Madu Kelulut (Heterotrigona itama) sebagai Antioksidan ]]>
<![CDATA[Ely lisnawati]]>;
<![CDATA[Wintari Taurina]]>;
<![CDATA[Mohamad Andrie]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v4i3.15270
<![CDATA[Kelulut honey and snakehead fish extract have been demonstrated to improve wound healing, hence the two active components are combined in ointment formulations. Adeps lanae is a base that is included in the oil phase that undergo an oxidation process that causes rancidity in the ointment preparation, so in this study BHA and BHT antioxidants were added to suppress the oxidation process. The ointment was made with 5 concentrations consisting of 1 control group and 4 treatment groups which were given variations of BHA and BHT antioxidants. Organoleptic testing, homogeneity, adhesion, dispersion, protection, and acid numbers were all evaluated. SPSS 24 is used to test data related to adhesion, and dispersion. Results: The addition of antioxidants BHA and BHT based on acid number tests revealed that the higher the combination of antioxidants employed, the less the increase in acid numbers on day 28. The organoleptic test, homogeneity, protection, and adhesion on the preparation fulfilled the test criteria, whereas the adhesion test revealed significant differences in F1, F2, and F4 when compared to the control group. The optimum formula is F4, which fits the test parameters and has the minimum rise in acid number (9.22 mg KOH/g).]]>
<![CDATA[Rasionalitas Penggunaan Obat Pada Pasien GERD di Instalasi Rawat Jalan Rumah Sakit ]]>
<![CDATA[Nurul Aisiyah]]>;
<![CDATA[Muhammad Akib Yuswar]]>;
<![CDATA[Nera Umilia Purwanti]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v4i3.15364
<![CDATA[The prevalence of Gastroesophageal Reflux Disease (GERD) is increasing every year. Inaccuracy of indication, drug, dose, route of administration, and time interval of administration can lead to failure of therapy. The purpose of this study was to evaluate the rationality of drug use in GERD patients in the outpatient installation of RSUD dr. Soedarso Pontianak. This research method is descriptive observational with cross sectional design. Data collection was carried out retrospectively by looking at the medical records and prescriptions of GERD patients for the period 2020-2021. The samples used in the study were 60 samples that met the inclusion criteria. The results showed that the percentage of rationality in patients without comorbidities was based on 100% correct indication, 93,33% correct drug, 100% correct dose, 100% correct route of administration, and 100% right time interval for administration and with comorbidities based on correct indication 100%, 40% right drug, 100% right dose, 100% right route of administration, and 100% right time interval for administration.]]>
<![CDATA[Pola Penggunaan Obat Diare Akut Pada Balita di Rumah Sakit ]]>
<![CDATA[Sofia Futria Wulandari]]>;
<![CDATA[Muhammad Akib Yuswar]]>;
<![CDATA[Nera Umilia Purwanti]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v4i3.15445
<![CDATA[The prevalence of diarrhea in Indonesia based on the diagnosis of health workers reached 6.8% in 2018. Generally attacks toddlers under the age of 5 years because the toddler's immune system is still in the weak category, making them more susceptible to exposure to bacteria that cause diarrhea. The most cases of diarrhea in Indonesia are cases of acute diarrhea. This study aims to determine the pattern of use of acute diarrhea medication in toddlers at Sultan Syarif Mohamad Alkadrie Hospital Pontianak in 2020. This study used a descriptive observational method with a cross-sectional research design. Retrospective data collection using purposive sampling method. The results showed that the characteristics of patients by gender who suffered the most from acute diarrhea were women (55%), the most age group was 0-1 year (30%), the type of diarrhea that most suffered was acute diarrhea without dehydration (51, 25%) and the most felt clinical symptoms were liquid defecation and fever (44.20% and 20.99%). The most widely prescribed drug to treat acute watery diarrhea was zinc (27.97%). The conclusion in this study is that the most widely prescribed drug to treat acute diarrheal disease in toddlers is zinc.]]>
<![CDATA[Pola Penggunaan Obat Antihipertensi Pada Pasien Hipertensi di Instalasi Rawat Jalan Rumah Sakit ]]>
<![CDATA[Umi Khairiyah]]>;
<![CDATA[Muhammad Akib Yuswar]]>;
<![CDATA[Nera Umilia Purwanti]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v4i3.15446
<![CDATA[Hypertension is a condition of a person experiencing an increase in blood pressure above normal, namely systolic blood pressure 140 mmHg and or diastolic blood pressure 90 mmHg. The purpose of this study was to determine the pattern of use of antihypertensive drugs in hypertensive patients in the outpatient installation of RSUD Sultan Syarif Mohamad Alkadrie Pontianak in 2020. The method used was descriptive observational method with a cross sectional design. Data collection was carried out retrospectively through searching medical record data and patient prescription data for the period January-December 2020. The results showed that the characteristics of patients based on age who suffered the most from hypertension were in the age range of 56-65 years, the sex being the most female, and most hypertensive patients suffer from stage 2 hypertension. The most widely used single antihypertensive drug is amlodipine with a percentage of 50%, the most combined antihypertensive drug is a combination of amlodipine and candesartan at 58.06%. The conclusion of this study is that the most widely prescribed antihypertensive drug as a single antihypertensive is amlodipine and as a combination antihypertensive drug, namely amlodipine and candesartan.]]>
<![CDATA[Identifikasi Cemaran Zat Pewarna Berbahaya Rhodamin B Pada Beberapa Produk Lipstik ]]>
<![CDATA[Siti Cholifah]]>;
<![CDATA[Lukky Jayadi]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v4i3.15408
<![CDATA[Rhodamine B is a synthetic dye used in industries such as paper and textile dyes. Rhodamine dye is prohibited from being used in cosmetic preparations because rhodamine is carcinogenic and can cause irritation and cancer in long-term use. This study aims to determine the presence of harmful dyes in lipstick cosmetic preparations. The method used in this research is using concentrated HCl reagent and 10% NaOH, this method is used as a test for the alleged presence of rhodamine in the sample. Positive results of the presence of rhodamine content were indicated by a change in the color of the sample which became dark orange after concentrated HCl was added and turned blue after 10% NaOH was added. Then continued by using the UV-Vis spectrophotometry method to determine the rhodamine levels in the sample. The samples used were 5 red lipsticks, from 5 samples that were tested, 1 sample was indicated which was indicated to contain rhodamine b because it changed color to orange when given concentrated HCl and blue when given 10% NaOH. Positive samples were samples with code C, after measuring with spectrophotometry, the results showed that the levels of Rhodamine in the sample were 0.009% in replication 1; 0.012% at replication 2 and 0.008 at replication 3.]]>
<![CDATA[Gambaran Tingkat Kepatuhan Berobat Antiretroviral Pada Pasien HIV/AIDS ]]>
<![CDATA[Anggie Maulida]]>;
<![CDATA[Muhammad Akib Yuswar]]>;
<![CDATA[Nera Umilia Purwanti]]>
<![CDATA[ Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022 ]]>
Publisher : <![CDATA[State University of Gorontalo ]]>
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DOI: 10.37311/jsscr.v4i3.15444
<![CDATA[Antiretroviral use can reduce the amount of virus in the body and increase the CD4 cell count in people infected with HIV. The success of HIV treatment can be achieved by increasing adherence to taking antiretroviral drugs. The aim of this study was to describe the level of adherence of HIV/AIDS patients undergoing antiretroviral treatment at dr. Agoesdjam Ketapang. The research method used is descriptive research with cross sectional design. Sampling was done by purposive sampling technique with a sample of 45 respondents. Research data were collected through the administration of the Morisky 8-Item Medication Adherence Questionnaire (MMAS-8) questionnaire to HIV/AIDS patients in RSUD dr. Agoesdjam Ketapang. The results showed that the characteristics of HIV/AIDS patients undergoing antiretroviral treatment at VCT Bougenville RSUD dr. Agoesdjam Ketapang is dominated by male patients (78%), patients aged 25-49 years (76%), patients with male HIV transmission factors (38%), patients with high school education (40%), patients who work as private employees (40%), and the majority of HIV/AIDS patients receive artivla therapy (78%). HIV/AIDS patients undergoing antiretroviral treatment at dr. Agoesdjam Ketapang had a high level of treatment adherence (38%), moderate adherence (33%), and low adherence (29%). The conclusion of this study is the level of adherence to treatment of HIV/AIDS patients in RSUD dr. Agoesdjam Ketapang according to high compliance.]]>
