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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,274 Documents

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In-House Virtual Surgical Planning Using 3D Slicer: Outcomes of Free Fibular Flap Mandibular Reconstruction Redo Alif Iszar; Mulyadi; Ozi Rahmat Firdaus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1618

Background: Mandibular reconstruction following tumor resection remains a significant surgical challenge requiring precise restoration of facial symmetry and function. Virtual surgical planning has emerged as a transformative approach, yet its adoption remains limited by the high costs of commercial platforms and proprietary cutting guides. Methods: This proof-of-concept case series evaluated the operative outcomes and cost-effectiveness of an in-house virtual surgical planning workflow using 3D Slicer, a free open-source software platform, for mandibular reconstruction with free fibular flap without fibular cutting guides. Results: Four consecutive patients (three males, one female; mean age 39.0 years; standard deviation 13.1; range 28-58) who underwent mandibular reconstruction between July and December 2024 were included. Three patients presented with ameloblastoma and one with squamous cell carcinoma. Preoperative computed tomography data were processed using 3D Slicer version 5.6.2 to generate three-dimensional mandibular models through thresholding segmentation, followed by mirroring technique reconstruction and polylactic acid three-dimensional printing. The mean ischemic time was 51.0 minutes (standard deviation 10.7; 95% confidence interval 34.0-68.0), representing a 70.4% reduction compared with conventional approaches in published literature. The mean total operative time was 455.0 minutes (standard deviation 136.5; 95% confidence interval 237.8-672.2). Model printing costs of IDR 50,000-100,000 (approximately USD 3-7) represented a 99% reduction compared with commercial cutting guides. Conclusion: All flaps survived without complications. These preliminary findings suggest that simplified in-house virtual surgical planning using free open-source software provides a potentially cost-effective and efficient alternative for mandibular reconstruction, warranting validation in larger prospective studies.

Successful Management of Culture-Negative Fungal Keratitis with Epithelial Keratectomy and Intracameral Fluconazole Injection: A Case Report Kristian Dernitra; I Gusti Ayu Made Juliari; Ida Ayu Ary Pramita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1619

Background: Fungal keratitis is a major cause of corneal blindness in tropical regions. Microbiological culture often yields negative results in up to 40% of clinically suspected cases, creating diagnostic and therapeutic challenges. This report describes successful management of culture-negative suspected fungal keratitis using epithelial keratectomy combined with intracameral fluconazole injection. Case presentation: A 58-year-old male presented with progressive visual loss in the left eye following mud exposure and irrigation with river water. Examination revealed a 3×3 mm paracentral corneal ulcer with stromal infiltration exceeding one-third depth, satellite lesions, and 1.5 mm hypopyon. Gram stain, potassium hydroxide preparation, and culture were all negative. Based on clinical suspicion of fungal etiology, the patient underwent epithelial keratectomy with intracameral fluconazole injection, supplemented by intensive topical and systemic antifungal therapy. Progressive improvement was observed, with complete hypopyon resolution by day 26 and visual acuity improving from 1/300 to 6/30 over four months. Conclusion: This case demonstrates that timely invasive antifungal intervention guided by clinical judgment can achieve favorable outcomes in culture-negative suspected fungal keratitis. The preservation of useful vision without corneal transplantation is particularly significant in resource-limited settings, underscoring the critical role of clinical decision-making when laboratory confirmation is unavailable.

Emergency Bedside Transvenous Pacing Without Fluoroscopic Guidance for Refractory Symptomatic Bradycardia Following Cardiac Arrest in Acute Inferior ST-Elevation Myocardial Infarction: A Case Report Philipus Wiranata; Michael Sebastian Kawilarang
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1620

Background: Symptomatic bradycardia is a recognized complication of acute inferior myocardial infarction due to atrioventricular node ischemia. Temporary transvenous pacemaker insertion traditionally requires fluoroscopic guidance, which may be unavailable in emergency departments. Alternative non-fluoroscopic approaches are essential in time-critical, resource-limited settings. Case presentation: A 62-year-old male with uncontrolled diabetes mellitus presented to the emergency department with respiratory and cardiac arrest. Following cardiopulmonary resuscitation, return of spontaneous circulation was achieved. Electrocardiography revealed inferior ST-elevation myocardial infarction with second-degree atrioventricular block type II. Despite administration of atropine sulfate (cumulative dose 1.25 mg intravenously) and vasopressor support, the patient developed refractory symptomatic bradycardia with heart rate declining to 25-30 beats per minute, culminating in a second cardiac arrest. After achieving return of spontaneous circulation for the second time, a temporary transvenous pacemaker was inserted at the bedside in the emergency department via the femoral vein using a blind technique with electrocardiographic monitoring as the sole guide for successful placement. The pacemaker was set to VVI mode at 70 beats per minute. Subsequent fluoroscopic confirmation in the catheterization laboratory revealed the catheter tip in the right ventricular outflow tract, which was repositioned to the right ventricular apex. Percutaneous coronary intervention was subsequently performed. Conclusion: Bedside blind temporary transvenous pacemaker insertion using electrocardiographic monitoring is a feasible and effective approach in emergency settings where fluoroscopic guidance is unavailable.

Emergency Splenectomy for Blunt Splenic Rupture Complicated by Post-Traumatic Acute Kidney Injury and Multiple Organ Dysfunction Syndrome: A Case Report Syifa Firza Aziza; Satrio Teguh Krisyuantoro; Pandu Anggoro; Dia Irawati; Fitria Nurul Hidayah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1622

Background: Multiple organ dysfunction syndrome is a leading cause of mortality after major blunt trauma. The spleen is the most frequently injured intra-abdominal solid organ, and when rupture occurs, it may precipitate haemorrhagic shock, systemic inflammatory response, and cascading failure of the kidneys, lungs, and coagulation system. Early recognition, rapid haemorrhage control, and coordinated multidisciplinary support are essential to limit progression and improve survival. Case presentation: A 30-year-old male motorcyclist presented to the emergency department after a high-velocity road traffic accident without helmet protection. On arrival, he was hypotensive (72/57 mmHg), tachycardic (140 bpm), apathetic with a Glasgow Coma Scale of 12, and had left upper quadrant tenderness with muscular defence. Focused assessment with sonography for trauma demonstrated free intraperitoneal fluid consistent with splenic rupture. Haemoglobin fell from 12.8 to 5.9 g/dL within hours and leukocytes rose to 37.8 ×10³/µL. An emergency splenectomy was performed for haemostasis. During the five-day intensive care course, he developed progressive oliguric acute kidney injury (peak creatinine 5.6 mg/dL, urea 114 mg/dL) requiring intermittent haemodialysis, hypercapnic respiratory failure (pH 6.969; pCO₂ 124.6 mmHg) requiring mechanical ventilation, stress hyperglycaemia (441 mg/dL) managed with insulin, and transient thrombocytopenia. Multidisciplinary care by trauma surgery, critical care, nephrology, and internal medicine resulted in haemodynamic stabilisation, recovery of renal function, and successful weaning from ventilation. Conclusion: Prompt haemorrhage control through emergency splenectomy, goal-directed resuscitation, early initiation of renal replacement therapy, metabolic support, and coordinated multidisciplinary intervention were decisive in mitigating trauma-induced multiple organ dysfunction syndrome in this patient and are proposed as pillars of management in similar presentations.

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Location Kab. ogan ilir, Sumatera selatan INDONESIA

Abstract

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Contact Name
Rachmat Hidayat

Contact Email
dr.rachmat.hidayat@gmail.com

Phone
-

Journal Mail Official
dr.rachmat.hidayat@gmail.com

Editorial Address
-

Location
Kab. ogan ilir,

Sumatera selatan

INDONESIA