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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,258 Documents

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Modulating Patellofemoral Joint Stress Through Targeted Neuromuscular Training in Runners: A Systematic Review and Meta-Analysis I Gusti Made Baskara Teragnya Mahaputra; Bagus Bayu Pradnyana; Made Dwi Puja Setiawan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1589

Background: Patellofemoral pain syndrome remains a highly prevalent running-related injury, characterized by retropatellar pain exacerbated by knee flexion. While multifactorial, biomechanical imbalances and proximal neuromuscular deficits are primary contributors. This systematic review and meta-analysis evaluated the efficacy of targeted neuromuscular training and gait retraining on pain, functional capacity, and biomechanical parameters in runners with patellofemoral pain syndrome. Methods: A systematic search and analysis were conducted, incorporating nine randomized controlled trials. Inclusion criteria focused on adult runners diagnosed with patellofemoral pain syndrome undergoing neuromuscular exercise or gait retraining compared to control or standard care. Primary outcomes included self-reported pain and functional status. Standardized Mean Differences with 95 percent confidence intervals were calculated using an inverse-variance random-effects model. Results: Nine randomized controlled trials involving robust sample sizes were analyzed. The pooled meta-analysis for pain reduction demonstrated a statistically significant large effect size favoring targeted neuromuscular and gait retraining interventions (Standardized Mean Difference = -1.38, 95 percent confidence interval [-1.85, -0.91], p less than 0.001). Functional outcomes also showed significant improvement in the intervention groups (Standardized Mean Difference = 1.51, 95 percent confidence interval [1.02, 2.00], p less than 0.001). Biomechanical analyses indicated significant modulations in hip kinematics, notably reduced peak hip adduction. Conclusion: Targeted neuromuscular training and gait retraining significantly reduced pain and improved lower extremity function in runners. These interventions successfully modulated patellofemoral joint stress through enhanced proximal control and altered strike mechanics.

Navigating Diagnostic Constraints in Pediatric Herpes Simplex Encephalitis: Successful Empirical Acyclovir Therapy without PCR Confirmation I Kadek Putra Dwipayana; Romy Windiyanto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1596

Background: Herpes simplex encephalitis is an acute or subacute disease associated with focal or global cerebral dysfunction caused by herpes simplex virus type 1 or type 2. Without adequate antiviral administration, the mortality rate reaches 70 percent, with only 9 percent of survivors returning to normal function. While cerebrospinal fluid polymerase chain reaction testing is the gold standard for diagnosis, its availability is severely restricted in resource-limited clinical environments. Case presentation: We report the case of a 4-year-old girl who presented with a profoundly decreased level of consciousness following a five-day history of fluctuating fever. Physical examination revealed a soporific state with a Glasgow Coma Scale of E4V1M1. Initial non-contrast computed tomography of the head was unremarkable. Cerebrospinal fluid analysis demonstrated a mononuclear pleocytosis. Despite the lack of polymerase chain reaction confirmation and the absence of advanced electrophysiological monitoring, the patient was empirically diagnosed with herpes simplex encephalitis based on clinical deterioration and cerebrospinal fluid findings. Immediate management included intravenous acyclovir, dexamethasone, phenobarbital, and supportive care. The patient demonstrated significant clinical improvement and was discharged on day 24 without severe immediate neurological deficits. Conclusion: The absence of molecular diagnostics and advanced neuro-monitoring must not delay the administration of intravenous acyclovir in pediatric patients exhibiting fever and altered mental status. Empirical antiviral intervention remains the most critical determinant of survival and neurological recovery.

Concomitant Erythema Nodosum Leprosum and Bullous Dapsone Hypersensitivity Syndrome in Relapsed Multibacillary Leprosy: Pathophysiological Insights and Therapeutic Strategy Nurrachmat Mulianto; Ivani; Pratiwi Prasetya Primisawitri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1588

Background: Multibacillary leprosy management is frequently complicated by severe immunological reactions and adverse drug events. Erythema nodosum leprosum is an immune-complex-mediated complication, while dapsone hypersensitivity syndrome is an idiosyncratic, potentially life-threatening drug reaction. The concomitant presentation of these distinct entities, especially with bullous eruptions, creates a profound diagnostic and therapeutic dilemma. Case presentation: A 42-year-old male with a history of relapsed borderline lepromatous leprosy and rheumatoid arthritis presented with exquisitely painful erythematous nodules, high-grade fever, and bullous eruptions exactly 72 hours after the re-initiation of multidrug therapy. Physical examination recorded a Visual Analog Scale pain score of 9. Expanded histopathological evaluation confirmed a dual pathology: extensive dermal neutrophilic infiltration characteristic of Erythema Nodosum Leprosum, occurring alongside pronounced subepidermal blistering and marked eosinophilic exocytosis indicative of a dapsone-induced bullous eruption. Standard multidrug therapy was immediately discontinued. A modified regimen comprising rifampicin, clarithromycin, and carefully titrated immunosuppressants (methylprednisolone and azathioprine) was initiated. Conclusion: The substitution of dapsone with clarithromycin facilitated rapid clinical resolution of both the bullous eruptions and recurrent immune reactions. This case underscores the critical need for precise temporal tracking, individualized therapeutic modifications, and comprehensive histopathological evaluation in leprosy patients demonstrating complex, overlapping hypersensitivity syndromes.

Metabolic and Hematologic Synergism in Idiopathic Intracranial Hypertension: Reversal of Bilateral Papilledema via Multidisciplinary Gynecological and Systemic Interventions Anak Agung Putri Satwika; Anak Agung Mas Putrawati Triningrat; Made Widhi Asih
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1590

Background: Idiopathic Intracranial Hypertension (IIH) conventionally presents with elevated intracranial pressure without structural etiologies, heavily associating with central adiposity. Emerging clinical frameworks recognize the intersecting roles of hematologic and metabolic abnormalities, notably iron deficiency anemia and hypovitaminosis D. Case presentation: A 41-year-old obese female (Body Mass Index 30.04 kg/m2) presented with progressive, painless bilateral visual blurring. Initial evaluation revealed a right eye visual acuity of 6/7.5 and a severely reduced left eye visual acuity of 1/60, alongside prominent bilateral papilledema and flame-shaped hemorrhages. The patient was incorrectly diagnosed with optic neuritis externally. Upon referral, rigorous evaluation successfully dismantled the misdiagnosis; intact pupillary reflexes, absence of a relative afferent pupillary defect, and an enlarged blind spot pointed definitively to papilledema. A lumbar puncture confirmed an elevated opening pressure of 340 mmH2O with normal cerebrospinal fluid composition. Targeted systemic profiling uncovered severe iron deficiency anemia (Hemoglobin 7.90 g/dL) driven by chronic menorrhagia from a uterine myoma, compounded by marked hypovitaminosis D. A tailored multidisciplinary intervention was initiated. A conservative acetazolamide dosage (500 mg/day) was utilized to minimize systemic stress, combined with cholecalciferol supplementation, ferrous sulfate, and a laparotomic myomectomy. One month post-operatively, hemoglobin normalized to 11.70 g/dL, visual acuity was fully restored to 6/6 bilaterally, and papilledema completely resolved. Conclusion: IIH is a multifactorial systemic syndrome. Prompt identification and aggressive correction of hematologic and metabolic drivers, including surgical eradication of hemorrhagic etiologies, are imperative for reversing intracranial hypertension and preventing permanent optic neuropathy.

Renal and Cardiovascular Outcomes of SGLT2 Inhibitors versus ARNI in Cardiorenal Syndrome: A Network Meta-Analysis of Randomized Controlled Trials Gladian Yanuriska; Taufik Rizkian Asir; Wahyudi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1591

Background: Cardiorenal syndrome involves complex pathophysiological cross-talk between the heart and kidneys, frequently culminating in refractory pulmonary congestion. Two primary pharmacological pillars, Sodium-Glucose Cotransporter-2 inhibitors and Angiotensin Receptor-Neprilysin Inhibitors, independently provide profound cardiovascular and renal benefits. However, direct comparative efficacy remains unquantified, creating clinical dilemmas in therapeutic sequencing. Methods: A systematic review and network meta-analysis were conducted utilizing nine pivotal randomized controlled trials. A frequentist network meta-analysis approach utilizing random-effects models was employed. Time-to-event and continuous outcomes were harmonized and pooled utilizing Standardized Mean Differences to allow for indirect head-to-head comparisons between the two drug classes. Results: The network comprised 43,450 patients. Both therapies significantly reduced cardiovascular events compared to standard care. In indirect comparisons, Angiotensin Receptor-Neprilysin Inhibitors demonstrated a superior reduction in the risk of urgent heart failure hospitalizations (Standardized Mean Difference -0.14; 95 percent Confidence Interval, -0.27 to -0.01) compared to Sodium-Glucose Cotransporter-2 inhibitors. Conversely, regarding the primary composite renal outcome (estimated glomerular filtration rate decline, end-stage renal disease, or renal death), Sodium-Glucose Cotransporter-2 inhibitors exhibited overwhelming statistical superiority over Angiotensin Receptor-Neprilysin Inhibitors (Indirect Standardized Mean Difference -0.35; 95 percent Confidence Interval, -0.50 to -0.20; p<0.001). Conclusion: Both drug classes are indispensable for managing cardiorenal syndrome. Angiotensin Receptor-Neprilysin Inhibitors provide superior acute cardiovascular hemodynamic relief, whereas Sodium-Glucose Cotransporter-2 inhibitors offer unparalleled long-term structural protection of renal function. Tailored therapeutic sequencing must leverage these distinct physiological advantages.

Intravenous Iron Therapy Reverses Myocardial Iron Deficiency and Improves Functional Capacity in Non-Anemic Heart Failure: A Meta-Analysis of Randomized Controlled Trials Siswanto; Rudy Afriant
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1592

Background: Iron deficiency is a profound metabolic comorbidity in chronic heart failure, driving deleterious consequences on patient prognosis and functional independence. Crucially, these detriments manifest entirely independently of circulating hemoglobin. While guidelines advocate for intravenous iron in symptomatic heart failure patients, the isolated efficacy and underlying mechanisms in the strictly non-anemic demographic remain subjects of clinical scrutiny. Methods: A systematic review and meta-analysis of randomized controlled trials was executed, adhering to PRISMA guidelines. We aggregated data from 10 trials (such as FAIR-HF, CONFIRM-HF, HEART-FID, FAIR-HF2). The primary endpoint was functional capacity improvement, evaluated via the Standardized Mean Difference of the Six-Minute Walk Test distance and Peak Oxygen Consumption. Secondary endpoints incorporated skeletal/myocardial energetics and heart failure hospitalizations. Data from non-anemic subgroups were extracted. Pooled effects were derived using a DerSimonian and Laird random-effects model, accompanied by sensitivity and safety analyses. Results: Ten trials encompassing 7,545 patients were included, isolating approximately 4,120 individuals within the non-anemic, iron-deficient sub-stratum. Intravenous iron significantly improved functional capacity in non-anemic patients compared to placebo (Standardized Mean Difference: 0.42, 95% Confidence Interval: 0.28 to 0.56, p < 0.001). Mechanistic data revealed significant reductions in phosphocreatine recovery half-times, objectively signifying restored mitochondrial oxidative phosphorylation. Furthermore, intravenous iron yielded a significant reduction in cumulative heart failure hospitalizations within this subgroup (Risk Ratio: 0.81, 95% Confidence Interval: 0.72 to 0.91, p = 0.003). Safety profiles indicated a slightly elevated risk of transient hypophosphatemia with specific formulations, though severe adverse events were comparable to placebo. Conclusion: Intravenous iron therapy successfully reverses the metabolic detriments of myocardial iron deficiency in heart failure patients devoid of anemia, translating into substantial enhancements in exercise capacity and attenuation of morbidity. Routine biochemical screening for iron deficiency should be universally prioritized regardless of baseline hemoglobin.

Efficacy of Anti-IgE Therapy on Concurrent Upper and Lower Airway Outcomes in United Airway Disease: A Systematic Review and Meta-Analysis Rinda; Dewi Wijaya
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1593

Background: United Airway Disease represents a paradigm wherein the upper and lower respiratory tracts function as a continuous immunological unit. Inflammatory conditions like allergic rhinitis, chronic rhinosinusitis with nasal polyps, and allergic asthma frequently co-occur, driven systemically by Type 2 inflammation and Immunoglobulin E. This study aimed to evaluate the concurrent efficacy of systemic anti-IgE therapy (omalizumab) on upper and lower airway outcomes in patients with United Airway Disease, addressing varying phenotypes and study designs. Methods: A systematic review and meta-analysis were conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The protocol was prospectively registered in PROSPERO. Data were extracted from nine primary studies. Standardized mean differences and risk ratios were pooled using a DerSimonian-Laird random-effects model with inverse variance weighting. To address methodological heterogeneity, a priori subgroup analyses stratified the data by study design (randomized controlled trials versus observational cohorts) and upper airway phenotype (allergic rhinitis versus chronic rhinosinusitis with nasal polyps). Publication bias was assessed via Egger’s regression test. Results: Nine studies comprising 1900 patients were included. Omalizumab significantly improved lower airway outcomes, with a pooled standardized mean difference of 1.45 (95% Confidence Interval: 1.12 to 1.78). Subgroup analysis revealed robust effects in both randomized trials and observational cohorts. Upper airway outcomes demonstrated profound symptom resolution (Standardized Mean Difference 1.32). Phenotypic stratification showed significant improvements in both allergic rhinitis and chronic rhinosinusitis with nasal polyps subgroups, though effect sizes varied slightly by local tissue remodeling profiles. The annualized rate of severe asthma exacerbations was reduced by a risk ratio of 0.48. Egger’s test indicated no significant publication bias (P = 0.15). Conclusion: Systemic anti-IgE therapy concurrently ameliorates upper and lower respiratory tract pathologies in United Airway Disease. These findings support the systemic use of biologics in patients who remain refractory to optimized standard-of-care topical therapies, aligning with stepwise clinical guidelines for severe disease management.

The Double Inflammatory Burden: Red Cell Distribution Width as an Exploratory Biomarker for Functional Outcome in Ischemic Stroke with Comorbid Systemic Lupus Erythematosus Resita Indah Sukraputri; Endang Kustiowati; Hexanto Muhartomo; Dodik Tugasworo; Aris Catur Bintoro; Elta Diah Pasmanasari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1594

Background: Ischemic stroke in patients with systemic lupus erythematosus (SLE) presents a highly unique clinical phenotype characterized by amplified systemic inflammation, profound endothelial dysfunction, and a pervasive prothrombotic state. The combined, synergistic effect of this double inflammatory burden exacerbates acute neuronal injury and leads to significantly poorer clinical recovery. This study evaluated Red Cell Distribution Width (RDW), a widely available surrogate marker of systemic inflammation, oxidative stress, and impaired erythrocyte deformability, as a prognostic biomarker for functional outcomes in this specific, high-risk inflammatory phenotype. Methods: In this retrospective analytical pilot study, 34 adult patients diagnosed with acute ischemic stroke and comorbid SLE were analyzed. Admission RDW values, National Institutes of Health Stroke Scale (NIHSS) scores, and 90-day Modified Rankin Scale (mRS) scores were collected. A poor functional outcome was rigorously defined as an mRS score of 3–6. Statistical evaluation included Mann-Whitney U tests, Spearman rank correlation, receiver operating characteristic (ROC) curve analysis, and multivariable logistic regression to adjust for baseline neurological severity. Results: RDW demonstrated a statistically significant positive correlation with initial stroke severity (NIHSS; r = 0.397; p = 0.020) and 90-day functional disability (mRS; r = 0.711; p < 0.001). The median RDW was significantly higher in patients with poor outcomes compared to those with good outcomes (15.6% versus 13.4%, p < 0.001). ROC analysis yielded an excellent Area Under the Curve of 0.89 (p < 0.001) with an optimal predictive cut-off established at 13.75%. In multivariable analysis adjusting for baseline stroke severity, an admission RDW of 13.75% or higher remained a strongly associated factor for severe long-term disability (adjusted Odds Ratio: 14.82, 95% Confidence Interval: 1.95–112.45, p = 0.009). Conclusion: RDW is a promising, inexpensive, and universally available prognostic biomarker that demonstrates a strong association with severe functional disability in ischemic stroke patients with comorbid SLE, accurately reflecting the profound neurotoxic impact of the double inflammatory burden.

Personalized Periodontal Regeneration: Integrating 3D Bioprinting with Autologous Activated Growth Factor (AGF) for Enhanced Alveolar Bone Defect Healing Zelka Dapala; Rachmat Hidayat; Muhammad Ashraf
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 12 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i12.1605

Background: The complete structural restoration of alveolar bone defects remains a critical challenge in reconstructive periodontology. Conventional grafting methods often fail to replicate the complex microarchitecture of periodontal tissues. This study integrated three-dimensional bioprinting technology with Autologous Activated Growth Factor to construct personalized scaffolds for treating severe infrabony periodontal defects. Methods: A randomized controlled clinical study was conducted at a private hospital in Palembang, South Sumatera, involving patients with Stage III periodontitis exhibiting vertical alveolar bone defects. Cone-beam computed tomography data guided the precise three-dimensional bioprinting of polycaprolactone and beta-tricalcium phosphate scaffolds. These constructs were functionalized operatively with Autologous Activated Growth Factor prepared from peripheral blood. The control group received conventional deproteinized bovine bone mineral with a collagen membrane. Clinical attachment level, probing depth, and radiographic bone fill were evaluated over six months. Results: The three-dimensional bioprinted scaffolds functionalized with Autologous Activated Growth Factor demonstrated superior clinical outcomes. At six months, the experimental group showed a mean probing depth reduction of 4.82 mm and a clinical attachment level gain of 4.15 mm. Radiographic analysis revealed a mean bone fill of 82.4% in the experimental group compared to 64.1% in the control. Inflammatory biomarkers were significantly modulated, indicating a highly favorable regenerative microenvironment. Conclusion: The synergistic integration of personalized three-dimensional bioprinted scaffolds with the potent osteoinductive and angiogenic properties of Autologous Activated Growth Factor significantly enhanced alveolar bone defect healing, providing a highly predictable alternative for complex periodontal regeneration.

VAT Dyes as Primary Sensitizers in Occupational Contact Dermatitis: Clinical and Patch Test Profiles in the Traditional Sasirangan Textile Industry Medisiana Sukses Soenoe; Muslimin; Radityastuti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1595

Background: Occupational contact dermatitis (OCD) significantly impacts workers in the informal textile sector. While disperse dyes are well-documented sensitizers, the allergenic potential of VAT dyes in traditional manufacturing, such as the Indonesian Sasirangan batik industry, remains under-evaluated. Methods: An analytical observational cross-sectional study was conducted on 40 Sasirangan artisans (20 wet workers, 20 dry workers). Clinical diagnoses were established using the Mathias criteria and NOSQ-2002. Epicutaneous patch testing was performed using a baseline series and specific synthetic dyes (1% in petrolatum), read at 48, 72, and 96 hours per ICDRG criteria. Multivariable logistic regression complemented the primary statistical analysis to assess predictive risk factors. Results: The prevalence of positive patch tests was 62.5% (25/40). The primary sensitizers were VAT dye willanthrene brill rose 4R (42.5%) and VAT dye willanthrene green B (37.5%). A significant correlation was found between a clinical history of OCD and positive patch test outcomes (p=0.014, OR=5.6). Surprisingly, job type (wet vs. dry), handwashing frequency, and PPE use did not significantly correlate with patch test positivity (p>0.05), highlighting the pervasive nature of dye allergens across the workspace. Conclusion: VAT dyes are potent primary sensitizers in the traditional Sasirangan textile industry. A clinical history of OCD is a strong predictor of patch test positivity, emphasizing the need for targeted allergen identification and barrier protection.

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Rachmat Hidayat

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Kab. ogan ilir,

Sumatera selatan

INDONESIA