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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,209 Documents

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Serum Vitamin D Levels Related to Cognitive Function in Chronic Kidney Disease Patients Elsi Rahmadhani Hardi; Yuliarni Syafrita; Syarif Indra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.640

Background: Vitamin D acts as a neuroprotector and modulator in the central nervous system. Hypovitaminosis is a risk factor for cognitive dysfunction. Hypovitaminosis D and impaired cognitive function are common in patients with chronic kidney disease. Impaired cognitive function is comorbid that can increase the morbidity and mortality of patients with chronic kidney disease. This study aims to assess the relationship between serum vitamin D levels and cognitive function in patients with chronic kidney disease. Methods: This research is an observational study with a cross-sectional approach. A total of 60 research subjects participated in this study. Sociodemographic data, cognitive function, and vitamin D levels were analyzed in this study. Data analysis was performed with SPSS 25 to perform univariate and bivariate tests. Results: The impaired cognitive function was found in 56.7% of CKD patients. The median serum vitamin D level of patients with chronic kidney disease with impaired cognitive function was 30.80 ng/mL and without impaired cognitive function 42.98 ng/mL. There was a significant relationship between serum vitamin D levels and impaired cognitive function (OR=4.125, p=0.035). The cut-off point of serum vitamin D levels associated with impaired cognitive function in CKD patients was 34.8 ng/mL (sensitivity 64.7% and specificity 69.2%). Conclusion:There is a significant relationship between serum vitamin D levels and the incidence of cognitive dysfunction in patients with chronic kidney disease. The cut-off point for serum vitamin D levels associated with impaired cognitive function in chronic kidney disease is 34.8 ng/mL.

The Role of Psychological Stress in Psoriasis: A Narrative Literature Review Winda Wijayanti; Annisa Fildza Hashfi; Irene Ardiani Pramudya Wardhani; Muhammad Eko Irawanto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.641

Psoriasis is a chronic, persistent skin disease characterized by characteristic lesions in the form of well-defined erythematous patches covered by thick white, shiny scales resembling wax droplets. Psoriasis has a psychological, social, and emotional impact. Psychological stress has also been shown to influence the disease and course of psoriasis. Therapy in psoriasis patients with psychological stress can be given pharmacologically and psychologically. Patients with moderate to severe psoriasis using the Goeckerman regimen for psoriasis showed significant improvements in anxiety and depression scores. Psychological therapies such as relaxation therapy and meditation are able to control the emotions that trigger stress and reduce the appearance and severity of psoriasis. This literature review aims to describe the impact of psychological stress on psoriasis patients so as to increase awareness to detect psychological stress and provide appropriate treatment.

Diagnosis and Treatment of Multibacillary Leprosy Borderline Lepromatous Type: A Case Report Annisa Fildza Hashfi; Winda Wijayanti; Nurrachmat Mulianto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.642

Background: Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae. This disease has a high transmission ability and can cause physical disability and have an impact on the social life of the sufferer because of the negative stigma about leprosy. This study aims to describe the examinations performed in the diagnosis and treatment of patients with multibacillary leprosy, borderline lepromatous type. Case presentation: A 43-year-old woman with a chief complaint of redness on the arm since 1 year ago. The patches are not itchy, painless, stiff, and numb. Since 3 months ago, the patient complained of red patches increasing and spreading to the trunk and legs. Dermatological examination found in the facial region et truncus anterior et posterior et superior, and inferior extremities bilateral showing multiple erythematous plaques, well-demarcated with scales in several parts. Sensory function examination revealed a decrease in lesions on the face, superior and inferior extremities, and anterior and posterior trunks. Negative AFB examination and biopsy results support the diagnosis of borderline lepromatous type (BL) multibacillary leprosy (MB). Conclusion: Clinical findings in the form of hypopigmented lesions that feel numb is a cardinal signs of leprosy. Asymmetrical distribution of lesions with a number of more than 5 lesions accompanied by impaired nerve function in the form of decreased sensibility is a characteristic of MB leprosy. Histopathological features support the diagnosis of MB type BL leprosy even though the results of the skin slit smear examination were negative.

Effectiveness Test of Green Betel Leaf Extract (Piper betle L.) on the Growth of Staphylococcus aureus Riris Grace Aprilia; Yohania Premita; Boyke Marthin Simbolon; Riyani Susan Bt. Hasan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.644

Background: Diseases due to infection where one of the causes is Staphylococcus aureus is one of the biggest problems faced today. Treatment using penicillin antibiotics tends to cause resistance and side effects, so people prefer to overcome them by means of self-medication or the use of traditional ingredients such as betel leaf. The purpose of the study was to examine the effect of green betel leaf extract (Piper betle L.) on the growth of Staphylococcus aureus on the antibacterial activity. Methods: This study is experimental research in vitro using a well diffusion method. The betel leaf was extracted using the maceration method and made into concentrations of 5%, 10%, 15%, and 20%. Results: The average diameter of the inhibition zones was 9.82 mm, 9.11 mm, 9.28 mm, and 9.01 mm at concentrations of 5%, 10%, 15%, and 20%, sequentially. Conclusion: The antibacterial activity of betel leaf extract in the overall concentration and the most optimal concentration was 5% at 9.82 mm.

Effectiveness Test of Green Betel Leaf Extract (Piper betle L.) on the Growth of Candida albicans Yohania Premita; Riris Grace Aprilia; Boyke Marthin Simbolon; Riyani Susan Bt. Hasan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.645

Background: Candida albicans is a fungus that often results in opportunistic infections in humans, called candidiasis. People generally practice self-medication to treat candidiasis with azole antifungals. However, this causes resistance due to inappropriate drug or dose selection. Betel leaf extract, which contains active compounds with antifungal properties such as phenols, tannins, and flavonoids, can be used as alternative medicine. The purpose of this study was to determine whether there was an effect of green betel leaf extract (Piper betle L.) on the growth of Candida albicans. Methods: This study is an experimental study and uses the disc diffusion method. The betel leaf was extracted using the maceration method and made into concentrations of 40%, 60%, 80%, and 100%. Results: The mean inhibition zone diameters were 9.12 mm, 8.79 mm, 8.18 mm, and 8.55 mm at concentrations of 40%, 60%, 80%, and 100%, sequentially. Conclusion: Betel leaf extract has an antifungal effect, with the most effective concentration being 40%.

Psychosomatic Aspect of the COVID-19 Pandemic Rahmy Nurdin; Arina Widya Murni
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.650

A pandemic is an epidemic of an infectious disease that spreads over a wider area, multiple continents, or the entire world at the same time. Since COVID-19 was declared a pandemic on March 11th, 2020, the world has entered a global emergency phase. The COVID-19 pandemic has changed the way of life and become a stressor in this century. Various factors become stressors during a pandemic. Many people experience negative emotions, such as fear, anxiety, and depression, during the COVID-19 pandemic. When negative emotions are no longer controlled, they will have a negative effect on the autonomic nervous system and cerebral cortex, causing psychosomatic and somatic symptoms. Many studies have shown a significant relationship between perceived stress and psychosomatic complaints. Research has also shown that stress during the COVID-19 pandemic is associated with an increase in psychosomatic symptoms. In the future, negative emotions during a pandemic, if not managed properly, can lead to post-traumatic stress disorder (PTSD). Peoples who are vulnerable to mental disorders due to COVID-19 include people with chronic diseases. Stressors during a pandemic can exacerbate anxiety, depression, and chronic stress in people with chronic diseases, causing exacerbations of chronic diseases, increasing somatic symptoms, and decreasing immune responses, resulting in increased infection and mortality risk.

Palpebral Basal Cell Carcinoma Profile at Dr. M. Djamil General Hospital Padang, Indonesia Rikha Erina; Ardizal Rahman; Mardijas Efendi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.652

Background: Basal cell carcinoma (BCC) or basalioma is the world's most common type of non-melanoma skin cancer. 80% of BCC occurs in the head and neck area, and 20% occurs in the palpebrals. BCC contributes to 90-95% of malignancies that occur in the palpebrals, is more common in males, and the incidence is higher in those over 60 years of age. BCC grows slowly (slow-growing) and rarely metastasizes but can cause local destruction of surrounding structures. This study aims to explore the profile of palpebral basal cell carcinoma at Dr. M. Djamil General Hospital Padang, Indonesia. Methods: This study is a descriptive observational study. A total of 36 research subjects participated in this study. Data analysis was performed using SPSS univariately. Results: Palpebral basal cell carcinoma most often occurs in the age group of 61-70 years. Gender predilection is more common in men than women and generally occurs unilaterally. More people work outdoors than indoors. The inferior palpebral is the predilection for most tumor sites, and tumor invasion is found in the orbital area in 30.56% of cases. Wide excision and palpebral reconstruction are the most common treatment options. Conclusion: Basal cell carcinoma of the lids most often occurs in the age group of 61-70 years, gender of male, unilateral, more working outdoors, the most predilection in the inferior palpebral and tumor invasion is found in the orbital area in 30.56% of cases, The most common treatments are wide excision and palpebral reconstruction.

Comparison of Subfoveal Choroidal Thickness Values with Severity of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients Sandiyanto; Weni Helvinda; Kemala Sayuti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.653

Background: Changes in choroidal thickness may be associated with increased severity of diabetic retinopathy and may occur simultaneously or even earlier than diabetic retinopathy. This study aims to compare the value of subfoveal choroidal thickness (SCT) with the severity of RD in patients with type 2 DM without RD with NPDR at Dr. M. Djamil General Hospital Padang, Indonesia. Methods: This research is a cross-sectional analytic observational study. The study was conducted on 36 eyes obtained from 29 study subjects. Data analysis was performed with the help of SPSS to determine the ratio of SCT thickness in diabetic retinopathy patients, p<0.05. Results: The thickest mean SCT value was found in the type 2 DM group without RD (328.78 + 14.78 mm) and the thinnest in the severe NPDR group (234,22 + 12,30 mm). Conclusion: The more severe the severity of diabetic retinopathy, the thinner the SCT (subfoveal choroidal thickness).

Histopathological Features of Primary Cutaneous Diffuse Large B-Cell Lymphoma Leg Type: A Case Report Triasari Oktavriana; Ayu Kusuma Dewi; Ambar Mudigdo
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 14 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.654

Background: Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), is a rare and aggressive lymphoma with poor prognostic. It is difficult to diagnose PCDLBCL-LT at an early stage due to its nonspecific manifestations that overlap with other lymphomas. A histopathological examination can be performed to establish the diagnosis. Case Presentation: A 74-year-old female presented with itchy red, swollen patches accompanied by a burning sensation on both her legs. Clinical examination revealed a hard ping pong ball-sized lump palpable on her left inner thigh. Haematoxylin eosin staining demonstrated the proliferation of diffused neoplastic cells, homogenous cells with atypical nuclei, and mitoses. Immunohistochemical examination revealed positive for CD 45 as well as CD 20 and negative for CD3. These findings were consistent with a diagnosis of PCDLBCL-LT. Conclusion: The presented case demonstrates that skin lesions in patients with diagnosed PCDLBCL-LT may have a variable clinical presentation. Histologically is characterized by a diffuse dermal infiltrate mostly consisting of activated B-cell (centroblast) and activated lymphocyte (immunoblast), with high mitotic activity and a minimal T-reactive component. Immunohistochemical analysis is necessary for establishing the diagnosis of PCDLBCL-LT which shows positive markers for CD 45, CD 20, CD79a, Bcl-2, MUM-1, FOX-P1, CD10, IgM, CD 138, Ki-67, CD 30 and MYC.

Comparison of Central Corneal Thickness and Lamina Cribrosa Thickness in Ethnic Indians and Ethnic Malays as Predictors of Glaucomatous Optic Neuropathy Meironi Waimir; Andrini Ariesti; Ardizal Rahman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i13.655

Background: Glaucoma poses a public health problem because it is the second leading cause of blindness after cataracts. A thinner central corneal thickness (CCT) is also a contributor to the development of primary open-angle glaucoma (POAG). Lamina cribrosa (LC) is a structure of the optic nerve head (ONH). LC structural changes such as thinning, posterior displacement, and connective tissue deficiency are associated with the mechanism of retinal nerve fiber layer (RNFL) thickness damage, leading to glaucomatous optic neuropathy. Methods: Cross-sectional analytic observational study. A total of 36 eyes from 36 research subjects participated in this study. Data analysis was carried out using SPSS version 25. Then, univariate and bivariate analyzes were carried out to see the difference in CCT and LC thicknesses. Results: The average CCT in ethnic Indians is 514.33 ± 14,142 μm and in ethnic Malays, 542.06 ± 17,234 μm. In this study, there were differences in the average CCT in Indian ethnicity and Malay ethnicity, which was statistically meaningful with a p-value = 0.000. Conclusion: There are differences in the average central corneal thickness and lamina cribrosa thickness in ethnic Indians compared to ethnic Malays, where the central corneal thickness and lamina cribrosa thickness in ethnic Indians are thinner than ethnic Malays.

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Contact Name Rachmat Hidayat

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Location Kab. ogan ilir, Sumatera selatan INDONESIA

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Contact Name
Rachmat Hidayat

Contact Email
dr.rachmat.hidayat@gmail.com

Phone
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Journal Mail Official
dr.rachmat.hidayat@gmail.com

Editorial Address
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Location
Kab. ogan ilir,

Sumatera selatan

INDONESIA