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Nur Samsu
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INDONESIA
Indonesian Journal of Kidney and Hypertension
Published by Indonesian Society of Nephrology (InaSN)
ISSN : 30470765     EISSN : 26544253     DOI : https://doi.org/10.32867/inakidney
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
The primary mission of this journal is to serve as a conduit for the dissemination of both clinical and foundational research pertinent to the expansive domains of nephrology and hypertension. Spanning a diverse array of topics, the journal delves into multifaceted areas including but not limited to chronic kidney disease, electrolyte and pH imbalances, hyperparathyroidism, CKD-MBD (chronic kidney disease-mineral and bone disorder), anemia, acute kidney injury, renal replacement therapy encompassing both dialysis and transplantation modalities, hypertension, onconephrology, nephrotic and nephritic syndromes, as well as glomerulonephritis and various other glomerulopathies. Through comprehensive coverage of these multifaceted subjects, the journal aims to offer a holistic understanding of the intricate dynamics within the realms of nephrology and hypertension, thereby fostering advancements in clinical practice, research methodologies, and therapeutic interventions.
Arjuna Subject : Kedokteran - Nephrology
Articles 42 Documents
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Should All Patients with Nephrotic Syndrome Undergo a Renal Biopsy? Nur Samsu
Indonesian Journal of Kidney and Hypertension Vol 1 No 3 (2024): Volume 1 No. 3, December 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i3.160

Abstract

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Ethanol 50% as Antidote in Propylene Glycol Due to Antifreeze Ingestion in General Hospital, Bali, Indonesia: Case Report Morris Lintong Barimbing; I Gde Raka Widiana
Indonesian Journal of Kidney and Hypertension Vol 2 No 1 (2025): Volume 2 No. 1, April 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i1.150

Abstract

Propylene glycol intoxication is a medical emergency requiring immediate intervention. It is metabolized by alcohol dehydrogenase into toxic metabolites, such as lactate and pyruvate, which can lead to metabolic acidosis and organ failure. The primary antidote strategy involves inhibiting alcohol dehydrogenase to prevent the formation of these harmful metabolites. This case report highlights a 53-year-old man who accidentally ingested a propylene glycol radiator coolant. He presented with symptoms of nausea, vomiting, and metabolic acidosis, confirmed through laboratory tests. With no fomepizole available—the preferred antidote—the patient was administered ethanol (gin) at a concentration of 50% over 10 minutes until intoxication occurred. Ethanol competes with propylene glycol for alcohol dehydrogenase, thereby preventing the formation of toxic lactate metabolites. The patient recovered without complications after two days of being given oral ethanol and was discharged. Although ethanol use as an antidote for propylene glycol poisoning is limited, this case underscores its potential effectiveness in reducing morbidity and mortality when fomepizole is unavailable. This approach demonstrates the importance of timely intervention in cases of toxic alcohol exposure.
Characteristics of Chronic Kidney Disease Patient Undergoing Regular Hemodialysis with Tunneled Cuffed Catheter Dialysis Access Noel Matthew Imaniku Sihombing; Bayu Rusfandi Nasution
Indonesian Journal of Kidney and Hypertension Vol 2 No 1 (2025): Volume 2 No. 1, April 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i1.162

Abstract

Background: Chronic kidney disease (CKD) is one of the leading contributors to morbidity and mortality rates worldwide, where end-stage patients require dialysis. Dialysis requires access, and tunneled cuffed catheters (TCCs) are considered a viable option. Objective: This study aims to describe the characteristics of the CKD patients with TCCs dialysis access at Rasyida Kidney Hospital. Methods: This descriptive study with a cross-sectional design was conducted based on patients' medical records. Total sampling was used as the sampling technique. Results: A total of 96 patients with TCC dialysis access were identified at Rasyida Kidney Hospital from January 2021 to 2024. Most patients were aged 61-75 years (39.6%), female (63.7%), and had hypertension as a comorbidity (53.8%). Additionally, 67% had a history of non-tunneled cuffed catheter access, 70.3% had the right internal jugular vein as the insertion site, and 53.8% had the indication of failed AV fistula. The duration of TCC use was more than 12 months for 65.9% of patients, and catheter thrombosis occurred in 13.2% of cases. Conclusion: The characteristics of CKD patients with TCC dialysis access at Rasyida Kidney Hospital in Medan include individuals aged 61-75 years, female, with a history of hypertension and non-tunneled cuffed catheter access, an insertion site at the right internal jugular vein, failed AV fistula as the primary indication, catheter usage for more than 12 months, and the most occurred complication is catheter thrombosis.
Association Between Intradialysis Hypotension and Interdialytic Weight Gain in Deceased Hemodialysis Patients at Banyumas Regional General Hospital Gigih Rahmandanu Poernomo; Dwi Lestari Partiningrum; Lestariningsih Lestariningsih; Ayudyah Nurani; Arwedi Arwanto; Shofa Chasani; Haidar Alatas
Indonesian Journal of Kidney and Hypertension Vol 2 No 1 (2025): Volume 2 No. 1, April 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i1.178

Abstract

Background: Intradialytic hypotension (IDH) occurs in 5-40 percent of chronic kidney disease (CKD) with hemodialysis patients, it is associated with increased cardiovascular events and mortality. High Interdialytic Weight Gain (IDWG) requires higher ultrafiltration, increases the incidence of IDH, associated with a worse prognosis, patients with a history of diabetes are at higher risk. Objective: This study aimed to assess the association between IDWG and the occurrence of IDH in deceased patients undergoing hemodialysis, with a particular focus on the differences between diabetic and non-diabetic patients Methods: A retrospective study was conducted for one year at Banyumas Regional General Hospital, involving deceased hemodialysis patients. IDWG was calculated as the average of the last three hemodialysis sessions. Patients were further categorized based on their history of diabetes. Results: Among 37 deceased hemodialysis patients, 56.8% experienced IDH, including 50% of those with diabetes mellitus. IDWG was normally distributed (p = 0.283) and showed a weak but statistically significant correlation with IDH (r = 0.333, p = 0.044). Logistic regression indicated that each 1% increase in IDWG was associated with an 8% increase in the predicted probability of IDH. Diabetic status did not significantly modify this association (p = 0.772). Conclusion: Higher IDWG was associated with increased incidence of IDH in deceased hemodialysis patients, independent of diabetic status.
Prevalence and Factors Associated with Sarcopenia in Chronic Kidney Disease Patients Undergoing Dialysis: A Single Center, Cross-sectional Study Fauliza Rakhima; Ria Bandiara; Rudi Supriyadi; Lazuardhi Dwipa
Indonesian Journal of Kidney and Hypertension Vol 2 No 1 (2025): Volume 2 No. 1, April 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i1.180

Abstract

Background: Sarcopenia is associated with worse outcomes in stage 5 Chronic Kidney Disease on dialysis (CKD 5D) patients, influenced by various diagnostic criteria and patient characteristics. Nonetheless, the factors contributing to sarcopenia in CKD 5D remain underexplored. Objective: To investigate the prevalence and factors associated with sarcopenia in the CKD 5D population. Methods: An observational cross-sectional study was conducted on 132 CKD 5D patients (≥18 years old, dialysis ≥ 3 months) at Hasan Sadikin Hospital from July to August 2024. Descriptive statistics, bivariate analysis, and logistic regression were utilized to determine the prevalence of sarcopenia and its association with the Simplify Creatinine Index (SCI), physical activity, nutritional status, phosphate, and calcium serum levels. Hand Grip Strength (HGS) assessed muscle strength, Bioelectrical Impedance Spectroscopy (BIS) measured muscle mass, the 6-meter walk test evaluated physical performance, and the Asian Working Group for Sarcopenia (AWGS) 2019 criteria were employed for diagnosing sarcopenia. Results: Sarcopenia prevalence was 15.9%. Bivariate analysis revealed significant correlations with underweight (p=0.014), malnutrition (p=0.041), phosphate serum level (p=0.047), and calcium serum level (p=0.043). Logistic regression indicated that higher serum levels of calcium and phosphate and healthy nutritional status, served as protective factors against sarcopenia, with odds ratios of 0.677 (OR 0.677; CI 95% 0.493-0.93 and OR 0.313; CI 95% 0.130-0.755). Conclusion: Sarcopenia prevalence was 15.9%. Phosphate and calcium serum levels, underweight, and malnutrition were significantly correlated with sarcopenia. Higher serum phosphate and calcium levels, higher body weight, and good nutrition status were protective factors against sarcopenia in CKD 5D patients.
Patterns of Kidney Diseases in Native Biopsies: A Single-Center Experience Regina Anjani Budi Pratiwi; Shintia Christina; Dina Nilasari
Indonesian Journal of Kidney and Hypertension Vol 2 No 1 (2025): Volume 2 No. 1, April 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i1.181

Abstract

Background: Kidney biopsy is the definitive diagnostic method for kidney disease, providing essential histopathological information for prognosis and treatment. However, in Indonesia, comprehensive data on kidney biopsy patterns remain limited, making it difficult to assess disease prevalence and epidemiological trends. Objective: To analyze the epidemiology of biopsy-confirmed kidney diseases in a single-center cohort and evaluate the distribution of clinical and histopathological diagnoses. Methods: A retrospective descriptive analysis was performed on patients who underwent a kidney biopsy at Siloam Hospital Kebon Jeruk between January 2021 and August 2024. Data on demographics, clinical manifestations, biopsy indications, histopathological findings, and immunofluorescence results were analyzed using descriptive statistics. Results: A total of 45 kidney biopsies were conducted, resulting in a biopsy rate of 5.24 per 1,000 individuals, higher among young adults (15–44 years). The median patient age was 43 years, with a nearly equal male-to-female ratio. Nephrotic syndrome was the leading clinical presentation (35.9%), followed by nephritic syndrome (33.3%). Hematuria and proteinuria (35.6%) were the most frequent biopsy indications. Glomerular diseases represented as majority of histopathological diagnoses, with focal segmental glomerulosclerosis (FSGS) being the most common finding (37.8%), followed by lupus nephritis and IgA nephropathy. A rare case of monoclonal gammopathy of renal significance was also identified. Conclusion: This study provided insight into biopsy-confirmed kidney disease patterns in Indonesia. The predominance of glomerular diseases, particularly FSGS, aligns with global trends. The low biopsy rate underscores the need for expanded nephrology services and further multicenter studies to develop a comprehensive national kidney disease registry.
The Role of Vitamin C in Management of Hypertension: A systematic review Rivani Sintia Suratman; Harnavi Harun; Drajad Priyono; Deka Viotra
Indonesian Journal of Kidney and Hypertension Vol 2 No 1 (2025): Volume 2 No. 1, April 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i1.184

Abstract

Background: Vitamin C is an antioxidant that can reduce oxidative stress. Oxidative stress has been thought to play an important role in the pathophysiology of hypertension. Studies have looked at Vitamin C as a supplement to treat hypertension. Vitamin C’s use as a complementary treatment for hypertension remains controversial, nevertheless. This study aims to evaluate vitamin C’s contribution to the treatment of hypertension. Objective: To conduct a literature review that examines how vitamin C (VC) supplements affect hypertension. Methods: This research uses a systematic literature review (SLR) approach with sources obtained from various online databases, including PubMed, Cochrane Library, EBSCO, and Elsevier, using the keywords "vitamin C" and "Hypertension". The selected articles were in accordance with the inclusion and exclusion criteria and discussed the role of vitamin C in lowering blood pressure in hypertension. Results: All the articles displayed fair methodological quality and reported significant positive effects of vitamin C for lowering blood pressure. Conclusions: Vitamin C can help decrease blood pressure as a complementary treatment.
Intradialytic Hypotension: Is Reducing Extracorporeal Blood Flow Rate an Appropriate Intervention? Nur Samsu
Indonesian Journal of Kidney and Hypertension Vol 2 No 1 (2025): Volume 2 No. 1, April 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i1.185

Abstract

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The Effect of Hemodialysis Adequacy on Inflammatory Status in Stage 5 Chronic Kidney Disease Patients Dedi Winarto; Dwi Lestari Partiningrum; Lestariningsih Lestariningsih; Ayudyah Nurani; Arwedi Arwanto; Shofa Chasani
Indonesian Journal of Kidney and Hypertension Vol 2 No 2 (2025): Volume 2 No. 2, August 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i2.183

Abstract

Background: Chronic Kidney Disease (CKD) is a critical global health issue, particularly Stage 5 CKD, where kidney function is severely impaired. Hemodialysis, essential for managing such patients, aims to remove waste and excess fluids. Chronic inflammation, common among CKD5-HD patients, heightens cardiovascular risks and worsens quality of life. Hemodialysis adequacy, measured by the Kt/V ratio, plays a vital role in outcomes, yet its relationship with inflammatory markers, such as Hs-CRP, albumin, and TIBC, remains unclear. Objective: This study aimed to evaluate the relationship between hemodialysis adequacy, as reflected by Kt/V values, and inflammatory markers such as c-reactive protein (CRP), albumin, and total iron binding capacity (TIBC) in CKD stage 5 patients undergoing hemodialysis, providing insights into optimizing dialysis protocols to mitigate inflammation. Methods: A cross-sectional study of 45 CKD5-HD patients assessed Kt/V values and inflammatory markers (Hs-CRP, albumin, TIBC). Data were analyzed using Shapiro-Wilk, Independent t-tests, or Mann-Whitney U tests based on data distribution. Results: The mean Kt/V value was 1.31 ± 0.21. Lower Kt/V values were significantly associated with elevated Hs-CRP levels (p = 0.018). No significant differences in Kt/V values were observed concerning albumin (p = 0.546) or TIBC (p = 0.523). Correlations between Hs-CRP and albumin or TIBC were non-significant (p = 1.000). Conclusion: Adequate hemodialysis, reflected in optimal Kt/V values, is crucial for reducing systemic inflammation marked by Hs-CRP. Albumin and TIBC levels showed no significant association, underscoring the multifactorial nature of inflammation in CKD5 patients.
Automated Peritoneal Dialysis Versus Continuous Ambulatory Peritoneal Dialysis For People With Kidney Failure: A Review Komang Satvika Yogiswara; Putu Raka Widhiarta; Yenny Kandarini; Metalia Puspitasari; Nyoman Kertia
Indonesian Journal of Kidney and Hypertension Vol 2 No 2 (2025): Volume 2 No. 2, August 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i2.186

Abstract

Background: Peritoneal dialysis is a well-established renal replacement therapy for patients with end-stage kidney disease, offering two primary modalities: Automated Peritoneal Dialysis (APD) and Continuous Ambulatory Peritoneal Dialysis (CAPD). Both methods provide effective solute and fluid removal, cost-effectiveness, accessibility, and impact on patient lifestyle that vary significantly, particularly in resource-limited settings such as Indonesia. Objective: This review compares APD and CAPD in terms of efficacy, convenience, cost-effectiveness, and accessibility, with a focus on their implications for patient care in Indonesia. Methods: A systematic review of relevant literature was conducted to evaluate the benefits and limitations of both dialysis modalities. Factors such as treatment outcomes, cost, infection risk, insurance coverage, and availability were analyzed to determine the most suitable option for different patient populations. Results: APD offers greater convenience, improved quality of life, and a lower risk of peritonitis due to fewer disconnections. However, its higher cost, dependency on electricity, and limited insurance coverage reduce its accessibility. Conversely, CAPD is more cost-effective, widely available, and covered by BPJS Kesehatan, making it the preferred option for many patients. Despite its affordability, CAPD requires greater patient commitment, increases peritonitis risk, and may interfere with daily activities. Conclusions: Both APD and CAPD are effective dialysis options, but CAPD remains the more accessible and cost-effective choice in Indonesia. APD may benefit select populations if economic and infrastructural challenges are addressed. Expanding insurance coverage, reducing equipment costs, and improving infrastructure are crucial to increasing APD accessibility and optimizing dialysis care in Indonesia.

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