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Contact Name
Nur Samsu
Contact Email
inakidney.journal@gmail.com
Phone
+62895808539500
Journal Mail Official
inakidney.journal@gmail.com
Editorial Address
Jl. Salemba Raya no. 22. RT.006/06, Kenari - Senen Jakarta Pusat, Jakarta 10430 - Indonesia
Location
Unknown,
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INDONESIA
Indonesian Journal of Kidney and Hypertension
ISSN : 30470765     EISSN : 26544253     DOI : https://doi.org/10.32867/inakidney
Core Subject : Health, Science,
The primary mission of this journal is to serve as a conduit for the dissemination of both clinical and foundational research pertinent to the expansive domains of nephrology and hypertension. Spanning a diverse array of topics, the journal delves into multifaceted areas including but not limited to chronic kidney disease, electrolyte and pH imbalances, hyperparathyroidism, CKD-MBD (chronic kidney disease-mineral and bone disorder), anemia, acute kidney injury, renal replacement therapy encompassing both dialysis and transplantation modalities, hypertension, onconephrology, nephrotic and nephritic syndromes, as well as glomerulonephritis and various other glomerulopathies. Through comprehensive coverage of these multifaceted subjects, the journal aims to offer a holistic understanding of the intricate dynamics within the realms of nephrology and hypertension, thereby fostering advancements in clinical practice, research methodologies, and therapeutic interventions.
Arjuna Subject : Kedokteran - Nephrology
Articles 42 Documents
Finerenone in Diabetic-Kidney Disease, Renal and Cardiovascular Outcome: A Meta-Analysis of Independent Trial Registries Felicita Gracia; Arya Marganda Simanjuntak; Samira Amanda; Linda Ida Mustika; Juwanto Juwanto; Ligat Pribadi Sembiring; Jazil Karimi; Sari Harahap; Rosmaliana Rosmaliana
Indonesian Journal of Kidney and Hypertension Vol 2 No 3 (2025): Volume 2 No. 3, December 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i3.224

Abstract

Background: Diabetic kidney disease (DKD) remains a frequent complication of type 2 diabetes, which significantly increases cardiovascular risk. Despite existing treatments, a substantial risk of disease progression still remains, leading to further exploration in Finerenone, a selective nonsteroidal mineralocorticoid receptor antagonist. Objective: This meta-analysis evaluates finerenone’s effects on the improvement of cardiorenal outcomes in DKD. Methods: A Systematic Review and Meta-Analysis (PROSPERO CRD420251122382) followed PRISMA guidelines. PubMed, ScienceDirect, and Epistemonikos utilized and used keywords “Finerenone AND Diabetes AND Chronic Kidney Disease AND Outcomes.” RCTs comparing finerenone to placebo in DKD, reporting renal or cardiovascular outcomes, were included. Data extraction covered study characteristics and outcomes. RevMan 5.4 analyzed data using a random-effects model. Risk of bias (RoB2) and certainty of evidence (GRADE-PRO) were assessed. Results: Three RCTs (19,027 participants) were included for renal outcomes, and two RCTs (13,026 participants) for cardiovascular outcomes. Finerenone significantly reduced the odds of sustained eGFR decline ≥40% (OR 0.83, p=0.0003) and≥57% (OR 0.86, p=0.0001), as well as the major composite kidney outcome (OR 0.76, p<0.0001). ESKD odds reduction (21%) was not statistically significant. For cardiovascular outcomes, finerenone significantly reduced hospitalization for heart failure (OR 0.78, p=0.0001). Trends towards reduced cardiovascular death (OR 0.88, p=0.09) were noted. Studies had low bias risk, and most outcomes showed moderate evidence certainty. Conclusions: Finerenone is associated with significant renoprotection and significantly reduces heart failure hospitalizations in DKD. Finerenone as an effective nonsteroidal mineralocorticoid receptor antagonist for comprehensive management, improving cardiorenal outcomes in this high-risk group.
The Impact of Icodextrin on Mortality of Peritoneal Dialysis Patients Nur Samsu
Indonesian Journal of Kidney and Hypertension Vol 2 No 3 (2025): Volume 2 No. 3, December 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i3.225

Abstract

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