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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 23 Documents
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Search results for , issue "Vol 26, No 2 (2020)" : 23 Documents clear
Correlation of Serum Interleukin-6, TNF-α, Procalcitonin and Leukocyte Count in Patients with Suspected Sepsis Erfina Lim; Jusak Nugraha
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 2 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i2.1463

Abstract

Sepsis is a cause of non-cardiac death in the hospital. Early and rapid diagnosis of septic patients is a challenge toincrease the expectancy of life. IL-6 and TNF-α are groups of pro inflammatory cytokines that initiate an initial inflammatoryresponse. Procalcitonin is a specific marker of bacterial infection. This study aimed to analyze the correlation of serumcytokine IL-6, TNF-α, procalcitonin and leukocyte count in suspected sepsis patients. This was a cross-sectionalobservational study consisting of 45 patients with suspected sepsis with procalcitonin level > 0.5 ng/mL. Procalcitonin levelwas measured with Enzyme-Linked Fluorescent Assay (ELFA) (VIDAS), IL-6 and TNF-α levels were measured with theU-CyTech Human Elisa kit (Bioscience, INC) and leukocyte counts were measured with SYSMEX-XN 1000. It was found in thisstudy that IL-6 levels ranged in 0 pg/mL – 73.29 ng/mL (mean 29.43 ng/mL), TNF-α levels were 0 pg/mL – 390.5 pg/mL (mean27.62 pg/mL), and the mean value of leukocytes was 20,139/μL. There was no correlation between leukocyte counts with IL-6(p=0.798 and r=0.040), TNF-α (p=0.304 and r = -0.160), and procalcitonin (p=0.323 and r = 0.154). There was no correlationbetween IL-6 levels with TNF-α levels (p=0.871 and r = -0.025), and procalcitonin levels (p = 0.466 and r = 0.112). There wasa weak negative correlation between TNF-α level and procalcitonin levels (p=0.006 and r = -0.403) and there was a weaknegative correlation between procalcitonin and TNF-α levels in suspected sepsis patients.
Comparison of Hepcidin Levels in Children with and without Soil-Transmitted Helminths Infection Dewi Saputri; Yunilda Andriyani; Almaycano Ginting
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 2 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i2.1471

Abstract

Helminths infection is one of the diseases that still occur insociety. The helminth infection caused by theSoil-Transmitted Helminths (STHs) group, which is Ascaris lumbricoides, Trichuris trichiura, and hookworm in human cancause chronic bleeding resulting in decreasir on storage in the body and increased level of hepcidin. Hepcidin is a liverhormone which regulates iron metabolism and can function as marker of inflammation and iron deficiency. This study aimedto compare the hepcidin levels in STH-infected and non-infected children. A cross-sectional study was conducted betweenMay and October 2018 on 28 STH infected and 140 non-infected subjects. The collected stool samples were analyzed usingthe Kato-Katz method to determine the presence of STH infection and the degree of infection. Urine samples wereprocessed, and their hepcidin levels were measured using a Sandwich-ELISA method. Measurement was made using aSpectrophotometer. The difference of numeric variables was analyzed using Wilcoxon test. The prevalence of STH infectionwas 16.66%. The prevalence of Trichuris trichiura 10.71%, Ascaris lumbricoides 4.76% and hookworm 2.97%. The prevalenceof a single infection was 14.88% and mixed infection 1.78%. Based on the intensity of infection, 15.48% of subjects were mildinfection, 0.59% moderate infection, and 0.59% severe infection. Hepcidin levels in the infected and uninfected group didnot differ significantly (p=0.978). There were no different hepcidin levels in children with and without soil-transmittedhelminths infection.
Analysis of D-dimer Levels in Deep Vein Thrombosis Patients Anton Triyadi; Rachmawati A. Muhiddin; Agus Alim Abdullah
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 2 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i2.1531

Abstract

It is reported the incidence of DVT is approximately 84 cases per 100,000 each year, with 30-50% of untreated DVT are atrisk for pulmonary embolism, causing a 12% increase in mortality rate. An accurate and rapid diagnosis of DVT is needed tominimize the risk of complications and prevent unnecessary anticoagulant therapy without waiting for the results of adiagnostic examination using ultrasound. This study aimed to determine the diagnostic value of plasma D-dimer levels onDoppler ultrasound for DVT diagnosis to help clinicians to select a rapid and accurate diagnostic test for DVT diagnosis. Thisresearch was a retrospective study using data from medical records and performed at the Medical Record Installation of Dr.Wahidin Sudirohusodo Hospital, Makassar, by taking data on patients with DVT along with the results of D-dimer andDoppler ultrasound from January to December 2018. D-dimer levels were measured using an immunoturbidimetric methodwith a reference value of<0.5 μg/mL. A total of 33 samples were obtained with a mean of D-dimer value was higher inpositive Doppler (5.29) compared to negative (2.31), although not statistically significant (p> 0.05). Also, the mean of Wellsscore was higher in positive Doppler (4.74) compared to negative (4.17), although not statistically significant (p> 0.05). Thediagnostic values of D-dimer were as follows: sensitivity of 92.6%, specificity of 33.3%, positive predictive value of 86.2%,negative predictive value of 50.0%, and accuracy of 81.8%. D-dimer test can be used both for screening and diagnostic testswith cut-off value ≥ 2 μg/mL.

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