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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 25 Documents
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Search results for , issue "Vol. 26 No. 1 (2019)" : 25 Documents clear
Correlation between Lactic Acid Concentration and The Severity of Neonatal Sepsis Agustin Iskandar; Nada Putri Pranidya; Eko Sulistijono; Aryati Aryati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1370

Abstract

Neonatal sepsis remains a major cause of high infant mortality rate in Indonesia, and served as one of risk factor for early neonatal mortality. This study aims to determine the relationship between lactate levels andthe severity of sepsis and prognostic value of lactic acid as a predictor of severity in neonatal sepsis. This research is analytic observational research using cross sectional method. The subjects were patients of neonatal sepsis treated in the Perinatology Room of Saiful Anwar Hospital Malang from February to June 2015. Lactic acid concentration in plasma was measured by using enzymatic colorimetric  method The results showed a positive and significant correlation (p = 0.023; r= 0.414) between lactate concentration and severity of sepsis, where every increase of sepsis degree increased lactate level of 0.151 mmol / L. Whereas by using  cut off ≥ 2.5 mmol / L, the prognostic test showed  66.7% of sensitivity and 76.2% of specificity. The chi square test of lactate> 2 mmol / L and <2 mmol / L showed Odd Ratio (OR) of 1,3 whereas at lactate level > 5 mmol / L and <5 mmol / L showed OR of 4.8 indicated that although there was no difference but the mortality outcomes of neonatal sepsis 4.8 times greater those of life. Thus lactate levelsof > 5 mmol / L can determine mortality outcome of neonatal sepsis. The higher the lactic acid level the more severe of neonatal sepsis. Lactate levels greater than 5 mmol / L was predictor for determining mortality outcome in neonatal sepsis.
Vitamin D, Calcium and Phosphor in Patients with β-Thalassemia Major Ade Hariza Harahap; Bidasari Lubis; Herman Hariman
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1384

Abstract

There has been many reports that patients with β-thalassemia major have bone problems such as thinning of the bone, bone fragility and pathological fractures. For so many years it was believed that the bone problems is mainly caused by marrow expansion due to compenstation of the bone marrow to handle the chronic anaemia and hiypoxia in β-thalassemia major. Recently, there is evidence to suggest that in β-thalassemia major there is hypocalcemia and hypovitaminosis D. So, this study is to clarify if hypovitaminosis D is trully the cause of bone problem in thalassemia. Forty five subjects were recruited in this study, 35 were β-thalassemia major patients and 10 normal subjects as controls. Ten mL of venous blood were taken from median vein for investigations of total vitamin D [25(OH) vitamin D], total calcium and phosphor using the Enzyme-Linked Fluorescent Assay (ELFA), metallochromic dye (Arsenazo III) and chemical reaction of inorganic phosphate with amonium mollybdate respectily. Mean ± SD of vitamin D in β-thalassemia major is 21.28 ± 6.36 ng/ml and in control 34.85 ± 3.50 ng/ml (p<0.05); total calcium in β-thalassemia major is 8.58 ± 0.68 mg/dl and in control 9.22 ± 0.35 mg/dl (p<0.05); and phosphor in β-thalassemia major 3.98 ± 0.53 mg/dl and control  3.89 ± 0.49 mg/dl (p>0.1). There was no significant correlation (r = 0.17, p>0.05), when vitamin D was analysed against calcium for the correlation study,. This study demostrates that there was state of hypovitaminosis D and hypocalcemia in β-thalassemia major but hypovitaminosis D is not the only causative factor of the calcium levels. There should be another factor responsible for the calcium levels in β-thalassemia major and marrow expansion may remain the factors responsible for bone abnomarlities.
Detection of Bacteria Causes Ventilator Associated Pneumonia with Bronchoalveolar Lavage Culture and Endotracheal Aspirate Culture Hairiah Asty; Loesnihari R; Syarani F
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1394

Abstract

Ventilator associated pneumonia (VAP) is the most common hospital infection in ICU. Proper and prompt diagnosis and treatment with adequate antibiotics can reduce the high mortality rate, and prevent complications and antibiotic resistance. Invasive methods, such as bronchoalveolar lavage can make a more accurate diagnosis and help with the choice of antibiotics, but require lung experts. While non-invasive methods, such as endotracheal aspirate can be done faster with less complications. The aim of the study was to determine the pattern of bacterial and bacterial sensitivity to bronchoalveolar lavage and endotracheal fluid. This was an observational study with cross-sectional approaches performed at the Intensive Care Unit of RSUP H. Adam Malik Medan, in August 2017 - February 2018. The sample of  23 patients  who met the criteria and was suspected with VAP was carried out by taking endotracheal aspirate and bronchoalveolar lavage. The samples obtained were culture and sensitivity test using BD Phoenix. There was bacteria pattern had compatibility at moderate levels and there was sensitivity and antibiotic resistance were not significantly different from bronchoalveolar cultures and endotracheal aspirate cultures. Endotracheal aspirate culture has a sensitivity of 78.9% and a specificity of  75% for diagnose VAP. Information on the identification of bacteria and sensitivity testing in patients with suspected VAP is required using appropriate sampling techniques. There were no significant differences between bronchoalveolar lavage culture and endotracheal aspirate culture to diagnosing VAP. Endotracheal aspirate culture is a non invasive diagnostic tool that can be used as an alternative diagnostic tool in patients with suspected VAP.
Increased Insulin Like Growth Factor-1 and Antropometri in Premature Infants with Breast Milk I Dewa Ayu Agung Sridharaswari; Mira Irmawati; Ahmad Suryawan; Irwanto idris; Endang Retnowati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1399

Abstract

Massage stimulation has consistently led to greater anthropometric in preterm infant by increasing IGF-1 in which plays an important role in promoting growth by stimulating cell growth, multiplication and inhibiting apoptosis. This research to analyze the effect of massage stimulation on IGF-1 and anthropometric in breastfeeding preterm infant. A randomized control trial was conducted on preterm infant with gestational age less than 37 weeks between February – May 2018 in nursery Dr. Soetomo Hospital. Fifty infants in nursery was randomly assigned to massage stimulation or control group. Massage stimulation consisted for three, 15 minutes periods per day for 10 days. Insulin Growth Factor -1 serum was examined on day 1 and 10. Data were analyzed by statistical software using t-test and spearman correlation. The average increase of IGF -1  in massage group was 4.8 (SD 4.41) and 3.1 (SD 3.57) in control group. The average increase of body weight was 252.2 (SD 208.55) in massage group, and 137.9 (SD 69.78) in control group. The average increase of body length was 2 (0.68) in massage group, and 1.1 (0.33) in control group. The average increase of head circumference was 1.5 (SD 0.82) in massage group, and 0.9 (0.28) in control group. The positive correlation between the mean increase of IGF-1 and body length was 0.347. The conclusion was IGF-1 and anthropometric  increase in both groups, but the massage group has a significantly higher mean. An increase in IGF-1 correlates with increase in body length.
Non-Genetic Risk Factors for The Formation of Factor VIII Inhibitors in Hemophilia A Patients in RSUD Dr. Soetomo Intani Dewi Syahti Fauzi; Maria C Shanty Larasati; I Dewa Gede Ugrasena
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1400

Abstract

Neutralizing alloantibodies (inhibitors) is one of the complications that affect the morbidity and quality of life of hemophilia patient and can be caused by multifactorials. Genetic and inhibitors examination are not routine and expensive. Therefore, identification of non-genetic factors is important to predict the formation of inhibitors. To analyze non-genetic risk factors for the formation of factor VIII inhibitors in children with Hemophilia A.  A cross-sectional study of hemophilia children aged 1-18 years at the pediatric hematology oncology outpatient clinic of Dr. Soetomo hospital in March-April 2018. Factors analyzed included the severity of hemophilia, early age of diagnosis, initial age of therapy, type of replacement therapy, frequency of factor VIII administration, and severity of bleeding by bleeding score. Statistical analysis using Chi square, Fisher, ANOVA and logistic regression analysis. A total of 29 children were evaluated, 7/29 mild, 15/29  moderate, and 7/29  severe hemophilia. Inhibitors were found in 11/29 subjects, 7/11 low (1-5 BU) and 4/11 high titer (> 5 BU). The initial age of diagnosis ≤ 1 year is associated with the formation of factor VIII inhibitors (OR 8.75; 95% CI = 1.5-50.2; p = 0.015). Severity of hemophilia, early age of therapy, type of replacement therapy, frequency of therapy, and bleeding score was not significantly associated with the formation of factor VIII inhibitors. The initial age of diagnosis less than 1 year is a significant risk factor for the formation of factor VIII inhibitors.
Correlation between Serum Ferritin and Heart Function in Children with Major Thalassemia at Dr. Soetomo Hospital Evisina Hanafiati Frans; Mahrus A Rahman; Teddy Ontoseno; I Dewa Gede Ugrasena; R Fatchul Wahabe
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1401

Abstract

Cardiac hemosiderosis in major thalassemia has a high mortality rate. Serum ferritin levels are routinely performed to measure body iron deposit Early detection of cardiac dysfunction by routine echocardiography is very important to prevent complications due to hemosiderosis. To analyze correlation between serum ferritin levels and heart function in thalassemia major children. A cross-sectional study involving children of thalassemia major less than 18 years in the pediatric hematology oncology outpatient clinic at Dr. Soetomo Hospital. The subjects were children diagnosed with thalassemia major who had received more than 10 transfusions and had ferritin levels above 500 µg / L. All subjects were taken through consecutive sampling and performed echocardiography to measure right ventricular systolic function, left ventricular systolic function, and diastolic function. The factors analyzed included serum ferritin levels, TAPSE index, ejection fraction, and E / A ratio. Statistical analysis using Chi-Square. A total of 82 children were taken as the study sample that met the inclusion and exclusion criteria, 1 sample was dropped out due to pneumonia. Serum ferritin was not correlated to right ventricular systolic function (Cramer's phi constant 0.14, p = 0.209). Serum ferritin was not correlated with left heart systolic function (Cramer's phi constant 0.187, p = 0.09). Serum ferritin was not related to diastolic function (Cramer's phi constant 0.124, p = 0.264). Serum ferritin level in major thalassemia was not correlated with cardiac function.
The Compatibility Analysis of Serum Ascites Albumin Gradient and Ascitic Fluid Evaluation to Clinical Diagnosis of the Patient Ivonne Desiana Thioritz; Yuyun Widaningsih; Fitriani Mangarengi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1405

Abstract

Ascites is a condition of abnormal fluid accumulation in the peritoneal cavity that can be caused by many underlying diseases. Some studies conclude that ascitic fluid evaluation with transudate-exudate concept has been replaced by greater indicator, known as Serum Ascites Albumin Gradient (SAAG). This study aims to analyze the compatibility of SAAG and ascitic fluid evaluation to the clinical diagnosis of patients in Dr. Wahidin Sudirohusodo Hospital Makassar. The retrospective cross-sectional study was conducted by taking data from all patients with ascites condition examining both ascitic fluid and serum albumin simultaneously or within 3 days at the Dr. Wahidin Sudirohusodo Hospital Makassar from January – August 2018. The statistical analysis was performed for frequency distribution and Kappa statistical test to assess the compatibility of SAAG and ascitic fluid evaluation to clinical diagnosis of the patient. The study was conducted on 68 subjects and found that both ascitic fluid examination and SAAG were significantly compatible to the clinical diagnosis, 25.8% (p <0.05), 42.5% (p <0.001), respectively. SAAG and ascitic fluid evaluation were significantly in accordance with the clinical diagnosis of the patient. The compatibility value of SAAG is greater than ascitic fluid evaluation so that SAAG is more recommended for ascites examination.
Differences of Vitamin D Levels in Controlled and Uncontrolled Type 2 Diabetes Mellitus Patients Adhisti Azlin; Ratna Akbari Ganie; Santi Syafril
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1407

Abstract

Vitamin D as an immunomodulator, plays an important role in controlling glycemic levels and decreasing diabetes complications. HbA1c is a marker of glycemic control which is known to have association with vitamin D. This study aims to see the differences in vitamin D serum levels and glycemic index in patients with type 2 DM.The design of this study is cross-sectional study and it was performed in RSUP HAM in December 2017 until March 2018. DM type 2 patients were classified based on HbA1c <7% controlled and ≥ 7% uncontrolled. Vitamin D serum levels were examined using the Enzyme-Linked Fluourescent Assay (ELFA) method., differences in vitamin D levels among controlled and uncontrolled type 2 diabetes mellitus were assessed by using independent t-test, and the differences of HbA1c level were assessed using Mann-Whitney-U test.45 patients with type 2 DM were divided into controlled (HbA1c <7%) and uncontrolled patients (HbA1c ≥ 7%). There was no difference in vitamin D serum levels between controlled and uncontrolled DM Type 2 patients (p = 0,310).
Analysis Platelet Indices in Patient Type 2 Diabetes Mellitus with Vascular Complication Nelly Tolla Taggara; Suci Aprianti; Darmawaty ER
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1411

Abstract

Type 2 Diabetes Mellitus(T2DM) is an endocrin disease that is marked by hyperglycemic condition due to a decrease increase in insulin secretion and insulin resistance or both. Indonesia is the 7th country with the highest incidence of diabetes mellitus in the world. Progression of the disease is slow and cause vascular endothelial damage. The increase  of platelet indices is suspected to be an indications   of vascular complications. To evaluate the  platelet indices in diabetics patients with complication and correlate these indices with GDP and HbA1c. Analyzed platelet indices and biochemical data of patients seen in outpatients by clinicans of  wahidin soedirohusodo hospitals. 120 patients with type 2 diabetes mellitus were included with 64 patients vascular complication and 56 patients without complication. Observed an increase in mean platelet volume (MPV): 9,96 + 1.99vs 8.87 + 1.35(p-value: 0,001); in platelet distribution width (PDW): 15.29 + 3.45 vs 12.36 + 2.819(p-value: 0,000; without increase plateletcrit (PCT); 0.28 + 0.14 vs 0.25 + 0.12 (p-value: 0.168). we observed  a correlation between FBG with PDW (P=0.044). The study findings point to the significant differences in platelet indices (MPV and PDW) in patients with T2DM with complication and without complication, suggesting the presence of platelet in diabetics type 2 patients more reactive and aggregatable  in this group of individuals. These suggest that platelet evaluation may be useful in the early detection of long term complication in diabetics patients.        
Comparison of Lipid Fractions of Icteric Sample by Using Three Devices Ummul Khair; Asvin Nurulita; Darwati Muhadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1412

Abstract

Lipid fraction assessment in laboratory includes cholesterol, HDL, LDL, Triglycerides. The icteric sample is characterized by elevated levels of bilirubin and darkness yellow sample color. This research was to determine the comparison of lipid fraction of icteric sample by using three devices. Cross-sectional study at Clinical Pathology Laboratory of Dr. Wahidin Sudirohusodo of Makassar. Comparison of lipid fraction of icteric samples against 3 (three) devices (Pentra, Biomajesty, Conelab) in period April - June 2018. Statistical analysis using SPSS program. Total sample of 50 indicated that cholesterol level by Biomajesty was lower than Pentra400 (p < 0.001), while the cholesterol level by Conelab was significantly lower than Pentra400 (p > 0.001), but not significantly different with Biomajesty (p < 0.05). HDL level by Biomajesty did not differ significantly with Pentra400 (p > 0.05). HDL level by Conelab were significantly lower than Pentra400 (p < 0.001) and Biomajesty (p < 0.01). HDL level by Biomajesty was smallest than Pentra and Conelab. LDL level by Biomajesty did not differ significantly with Pentra400 (p > 0.05) while LDL level by Conelab was significantly lower than Pentra400 (p < 0.001) and Biomajesty (p < 0.001). It can be seen that the range of TG by Biomajesty is smallest (more accurate) than Pentra400 and Conelab. TG level by Biomajesty was significantly lower than Pentra400 (p < 0.01) while TG level by Conelab was not significantly different than Pentra400 (p > 0.05), but it was significantly higher than Biomajesty (p < 0.001). The research shows that Biomajesty is an accurate device for the measurements of HDL, LDL, and TG of icteric samples, whereas Conelab is an accurate device for cholesterol measurement of icteric samples.  

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