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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 22 Documents
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Search results for , issue "Vol. 30 No. 2 (2024)" : 22 Documents clear
The Role of Effluent Analysis and Culture in Diagnosis and Monitoring of Peritoneal Dialysis-Related Peritonitis Nuri Dyah Indrasari; Najib Ali
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 2 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i2.1900

Abstract

Peritoneal Dialysis (PD) is one of the available renal replacement therapy options for End-Stage Renal Disease (ESRD). One of the most common complications of PD is peritonitis. A 13-year-old boy was admitted to the hospital due to cloudy effluent and abdominal pain four days before admission. He was diagnosed with ESRD in 2015 and has undergone Continuous Ambulatory Peritoneal Dialysis (CAPD) since 2017. The physical examination findings were as follows: the temperature was 36.6 C, the conjunctiva was anemic, the abdomen was tender, and both of the lower extremities were edematous. Peritoneal dialysis effluent analysis showed yellow and turbid effluent with a leukocyte count of 13.346 cells/µL and polymorphonuclear (PMN) cells predominance (69.3%), effluent and serum urea of 221 and 243 mg/dL, effluent and serum creatinine of 16.7 and 18.26 mg/dL, respectively. Effluent Gram stain showed increased leukocytes without bacteria, while effluent culture showed the growth of Methicillin-sensitive Staphylococcus aureus. According to the International Society of Peritoneal Dialysis 2022 guidelines, all criteria for infective peritonitis in this patient were met: clinical features (turbid effluent and abdominal pain), increased cell count (>100 cells/µL) with PMN >50%, and positive effluent culture. The patient was administered intravenous Ampicillin-Sulbactam based on the effluent culture and antimicrobial susceptibility testing. Serial effluent analyses suggested a return-to-normal trend in leukocyte and PMN counts. After 18 days of hospitalization, the patient was allowed to discharge based on clinical and laboratory improvements.
Detection of Partial Central Diabetes Insipidus in Limited Resource Setting Merci M. Pasaribu; Dina Nurul Istiqomah; Dewi Wulandari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 2 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i2.1939

Abstract

Antidiuretic hormone (ADH) is an endogenous prohormone peptide synthesized in the posterior hypothalamus that regulates water excretion by the kidney. Diabetes insipidus is a disorder characterized by the excretion of large amounts of urine (diabetes) that are hypotonic, watery, and tasteless (insipid). The rarity of this case is one of the causes of missed diagnosis. If not diagnosed properly, patients will receive therapy that exacerbates the disease. The Water Deprivation Test (WDT) is one of the dynamic tests that can be done to narrow the diagnosis. A 44-year-old female was admitted to the hospital with chief complaints of polydipsia and polyuria during the previous 9 months. The patient had a history of irregular menstruation, cesarean delivery due to abdominal mass, and breast lump surgery. Diabetes mellitus and thyroid disease were excluded. Her blood pressure during admission was 150/100 mmHg and her body mass index was 31.1. Fluid balance data obtained before the water deprivation test showed that the urine volume (output) was 7.150 mL per 24 hours, and the total water input was 6.290 mL. Water deprivation test results showed that the kidneys were partially respond to the administration of exogenous ADH, suggestive of partial central diabetes insipidus.
Humoral and Cellular Immune Response on COVID-19 Patients and Sinovac Vaccine Participants Brigitte Rina Aninda Sidharta; Mas Aditya Senaputra
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 2 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i2.2061

Abstract

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 is a new SARS-CoV virus. A person who is infected with this virus will induce both humoral and cellular immune responses. Herd immunity can be achieved through vaccination. The purpose of vaccination is the formation of antibodies capable of neutralizing coronavirus against the receptor binding domain. This study aimed to determine the differences between humoral and cellular immune responses between confirmed COVID-19 patients and Sinovac vaccine participants. This observational analytic study with a prospective cohort approach was conducted between March to October 2021. Fifty subjects (25 officers who had received vaccinations for COVID-19 patients and 25 COVID-19 patients treated at the Dr. Moewardi General Hospital) and met the inclusion and exclusion criteria were enrolled. Different tests were carried out to see the difference between the levels of CD8+ T cells and anti-SARS-CoV-2 antibodies in the vaccine group and the COVID-19 patient group. There was no significant difference in humoral immune response (anti-SARS-CoV-2) between the vaccine group and COVID-19 patient group [33.93 (0.4–196.6) U/L vs. 101.28±158.59 U/L; p=0.409], but there was a significant difference in cellular immune response (CD8+) between the vaccine group and COVID-19 patient group [878.52±47368 cells/µL vs. 270.16±213.64 cells/µL; p=0.001]. CD8 assay can be used as a parameter to differentiate the cellular immune response between COVID-19 patients and COVID-19 vaccine recipients.
Analysis of NLR, PLR, and Carcinoembryonic Antigen in Colorectal Cancer Patients Parabang, Budi; Esa, Tenri; Bahrun, Uleng
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 2 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i2.2063

Abstract

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. The development and prognosis of CRC are affected by the tumor's appearance and the host's inflammatory response. A combination of several parameters, including the Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR), has been used as a cancer prognostic marker. Research needs to be performed to analyze its role in CRC. This study aimed to determine the differences in the NLR, PLR, and CEA values with the severity and site of CRC. Medical record data were collected from 246 CRC patients from January 2021 to June 2022 at Dr. Wahidin Sudirohusodo Hospital were used and grouped by severity (metastatic and non-metastatic) and site (left colon, right colon, rectum). This study collected the data on NLR, PLR, and CEA levels. The Mann-Whitney, Spearman Rho, and Kruskal-Wallis tests were used for statistical analysis by the research objectives (significant if p<0.05). There were differences in median PLR (194.47 vs. 201.18; p=0.045) and CEA (3.3 ng/mL vs. 11.95 ng/mL; p<0.001) between the metastatic and non-metastatic groups, whereas there was no significant difference of median NLR between the two groups (2.77 vs. 2.79; p=0.438). No correlation was found between the NLR, PLR, and CEA level values with the location of CRC (p-values 0.978, 0.511,  0.419, respectively). PLR and CEA values were higher in metastatic CRC than in non-metastatic CRC, while NLR value was not significantly different. There was no correlation between the NLR, PLR, and CEA level values with the CRC site.  
CD64 and I/T Ratio as a Diagnostic Test on Neonatal Sepsis in Banjarmasin Dewi Indah Noviana Pratiwi; Pandji Winata Nurikhwan; Muhammad Naufal Firdaus
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 2 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i2.2077

Abstract

Neonatal sepsis remains a major problem in the service and care of neonates. The clinical features of neonatal sepsis are non-specific, which makes it difficult to diagnose. The primary objective of this study was to assess the clinical use of cluster of differentiation 64 as a diagnostic marker of neonatal infection. This research used an analytical observational study. The research subjects consisted of 43 samples of neonates at Ulin Hospital, Banjarmasin who had met the inclusion criteria. The results of the study concluded that there was no significant difference between the I/T ratio and cluster of differentiation 64 values in patients with suspected neonatal sepsis with the gold standard procalcitonin and/or blood culture at Ulin Hospital with p=0.874 for the I/T ratio and p=0.285 for cluster of differentiation 64. The diagnostic test for the I/T ratio with a cut-off of 0.2 showed a sensitivity of 23.8%, specificity of 72.7%, positive predictive value of 45.5%, negative predictive value of 50%, mean of 0.16, and median of 0.11. The results of the cluster of differentiation 64 diagnostic test with a cut-off of 2025 showed a sensitivity of 42.9%, specificity of 72.7%, positive predictive value of 81.8%, negative predictive value of 50%, mean of 2487.93, and median of 1671. There was no significant difference between the I/T ratio and cluster of differentiation 64 values in patients with suspected neonatal sepsis with the gold standard procalcitonin and/or blood culture at Ulin Hospital, Banjarmasin.  
Differences in Hemoglobin Levels 6 Hours and 24 Hours After Packed Red Cells Transfusion Surawijaya Bakhtiar Kaslam; Usi Sukorini; Teguh Triyono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 2 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i2.2093

Abstract

The hemoglobin examination instructed by Dr. Sardjito General Hospital attending doctors was 6 hours after the PRC transfusion. It is recommended that a hemoglobin examination be carried out 24 hours after transfusion to determine the patient's hemoglobin after complete equilibrium occurs. This study aimed to determine the mean increase in Hb levels 6 hours and 24 hours after PRC transfusion and to examine the difference in Hb levels 6 hours and 24 hours after PRC transfusion, respectively, compared with baseline Hb levels in non-hematological malignancy patients. This prospective analytic observational study examined hemoglobin at 6 hours and 24 hours after PRC transfusion. The differential test between delta Hb levels 6 hours after PRC transfusion compared to baseline Hb levels and delta Hb levels 24 hours after PRC transfusion compared to baseline Hb levels were analyzed using paired T-test. There was a statistically significant difference between baseline Hb levels and Hb levels 6 hours after PRC transfusion (p<0.0001) and a statistically significant difference between baseline Hb levels and Hb levels 24 hours after PRC transfusion (p<0.0001). The differential test between delta Hb levels 6 hours after PRC transfusion compared to baseline Hb levels and delta Hb levels 24 hours after PRC transfusion compared to baseline Hb levels obtained a statistically significant difference (p=0.0024). The mean increase in hemoglobin was 1.76+0.78 g/dL 6 hours after PRC transfusion and 1.9+0.78 g/dL 24 hours after PRC transfusion. There were differences in delta Hb levels 6 hours and 24 hours after PRC transfusion, respectively, compared with baseline Hb levels in non-hematological malignancy patients, which were statistically significant but not clinically significant.
Modified HEART Score Analysis in Patients with NSTEMI and STEMI Widya Pratiwi; Sulina Yanti Wibawa; Amaliyah T. Lopa; Darmawati Rauf
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 2 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i2.2095

Abstract

Cardiovascular disease is one of the leading causes of death. The utility of the risk score in the emergency department is for the initial examination of patients with chest pain suspected of acute coronary syndrome. HEART score was developed in the Netherlands and utilized to stratify chest pain patients and classify the risk of the patients as well as to identify the possibility of Major Adverse Cardiac Event (MACE) occurrences in 6 weeks. This study aimed to compare STEMI and NSTEMI using the modified HEART score in chest pain patients at the Integrated Heart Center (PJT) Dr. Wahidin Sudirohusodo Government Hospital, Makassar. This study used a cross-sectional approach from January 1 to March 31, 2022. The sample was drawn from patients with chest pain clinically diagnosed NSTEMI or STEMI based on the medical records containing the procedure of initial examination and HEART score risk stratification of each patient. The HEART score was found to be statistically significantly higher in STEMI (7.0 and 7.3) than in NSTEMI (6.0 and 5.6) (p<0,001). AUC 0.809 (p<0.001). The cut-off value of the HEART score can be used as a predictor of STEMI/NSTEMI. A cut-off value of 5.5 and 6.5 (alternative) were obtained from the ROC curve and can provide optimal sensitivity and specificity. The higher the score appeared on the HEART score (high risk), the higher the number of STEMI diagnoses compared to NSTEMI diagnoses. This is characterized by a significant increase of Troponin-I. Hence, the HEART score can be used as a scoring measure to predict whether the patient will be diagnosed with NSTEMI or STEMI.
Comparison of Two SARS-CoV-2 Rapid Antigen Test Stefany Boroh; Irda Handayani; Nursin Abdul Kadir; Uleng Bahrun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 2 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i2.2098

Abstract

The Coronavirus Disease 2019 (COVID-19) pandemic continues to spread worldwide. A quick, simple, and accurate test to diagnose COVID-19 is essential for this situation. This study aims to evaluate and compare the rapid antigen examination of SARS-CoV-2 with Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) in detecting SARS-CoV-2. A retrospective study with a cross-sectional approach using medical record data from suspected, controlled, and confirmed COVID-19 patients whose samples were taken simultaneously for rapid antigen examination of SARS-CoV-2 (SD-Biosensor and Lungene) and RT-PCR at Labuang Baji Hospital, Makassar from September 2020-September 2021. Each instrument's sensitivity, specificity, negative predictive value, and positive predictive value were analyzed with the Receiver Operating Characteristics (ROC) curve method. This study obtained data from 312 rapid antigen tests for SARS-CoV-2, divided into two categories, 98 using Lungene and 214 using SD-Biosensor. Rapid antigen Lungene had a sensitivity of 71.4%, specificity of 71.4%, an accuracy of 71.4%, and a 31 reactive result in CT value. The SD-Biosensor Rapid antigen had a sensitivity of 62.6%, a specificity of 99.1%, an accuracy of 82.2%, and a 26 reactive result in CT value. In summary, the sensitivity of rapid antigen Lungene is higher than SD-Biosensor. Specificity and accuracy of rapid antigen SD-Biosensor higher than Lungene. Rapid test antigen SARS-CoV-2 has the potential to be a screening test for COVID-19 as long as the sampling time is right.
Detecting Iron Deficiency Anemia in Type C Hospital: Role of RDW and MCV Parameters Marina Ludong; Ninik Sukartini; Nuri Dyah Indrasari; Dewi Wulandari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 2 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i2.2100

Abstract

Iron deficiency anemia remains a global health problem, which is also a prominent cause of morbidity and mortality of all range of ages. There are three stages of anemia development, and there are some parameters to detect bodily iron status. Transferrin saturation is one of the reliable parameters. Among all hematology parameters, Red Cell Distribution Width (RDW) and Mean Corpuscular Volume (MCV) are two of the most often studied. MCV and RDW are relatively affordable and accessible, most importantly for rural areas with lower socioeconomic status. This was an analytical observational study with a cross-sectional design aimed to determine the correlation between RDW and MCV values with iron deficiency anemia, which was measured by transferrin saturation. A significant correlation was found between RDW, MCV values, and iron deficiency anemia in patients of Mitra Keluarga Cikarang Hospital and Permata Keluarga Hospital, Jakarta with a p-value of <0.05. Sensitivity and specificity for MCV were 75% and 100%, for RDW were 55.45% and 80%, respectively. In conclusion, RDW and MCV parameters can be used as screening instruments for iron deficiency anemia.
Procoagulant Phospholipid Activity and MPV Values in Acute Ischemic Stroke Cynthia Cynthia; Suzanna Immanuel; Rahajuningsih Dharma Setiabudhy
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 2 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i2.2103

Abstract

Ischemic stroke can be caused by atherothrombosis or embolism. Atherothrombosis occurs due to the rupture of an atherosclerotic plaque causing platelet activation. There are several markers of platelet activation, including platelet microparticles. The levels of platelet microparticles can be measured by examining procoagulant phospholipid (PPL) activity. It is not yet known exactly what activates thrombopoiesis, which can be assessed by an increase in Mean Platelet Volume (MPV). This study aimed to know whether there is an increase in PPL activity and MPV values in acute ischemic stroke, whether platelet activation is influenced by differences in ischemic stroke subtypes, and whether there is a relationship between PPL activity and MPV values in acute ischemic stroke. The study design was cross-sectional and involved 60 subjects. PPL activity in acute ischemic stroke (65.14±13.35 seconds) tends to be higher (shorter clotting time) than in healthy individuals (68.59±8.56 seconds), however, this difference was not statistically and clinically significant. The MPV value in acute ischemic stroke (9.83±0.72 fL) compared to healthy individuals (9.65±0.86 fL) however this difference was not statistically significant. PPL activity in the SAO subtype (61.66±1.31 seconds) tends to be higher than LAA (68.62±14.57 seconds), however, this difference was also not statistically significant. There was a weak correlation between PPL activity (seconds) and MPV value (fL) in acute ischemic stroke (r =0.34, p-value=0.03).        

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