Garuda - Garba Rujukan Digital

Analisis Kaitan Jumlah Trombosit dengan Mortalitas Pasien Infark Miokard Akut selama Perawatan Kurniawan, Liong Boy; Bahrun, Uleng; Arif, Mansyur; ER, Darmawaty
Cermin Dunia Kedokteran Vol 41, No 9 (2014): Diabetes Mellitus
Publisher : PT. Kalbe Farma Tbk.

Latar belakang Trombosit berperan dalam aterotrombosis dengan menghasilkan enzim yang dapat mendegradasi matriks sehingga plak aterosklerosis mudah ruptur. Ruptur plak akan menyebabkan adhesi, aktivasi dan agregasi trombosit sehingga membentuk trombus yang dapat mematikan sel otot jantung. Jumlah trombosit diduga berkaitan dengan mortalitas pasien infark miokard akut. Tujuan Untuk mengetahui jumlah trombosit pasien infark miokard akut saat masuk rumah sakit dan menilai kaitannya dengan mortalitas pasien selama perawatan di rumah sakit. Metode Penelitian ini merupakan studi retrospektif dengan analisis potong silang, menggunakan data sekunder rekam medik 81 pasien infark miokard akut yang dirawat di Unit Perawatan Jantung Intensif Rumah Sakit dr. Wahidin Sudirohusodo, Makassar periode Juli 2010 hingga Juni 2011. Jumlah trombosit yang diteliti adalah jumlah trombosit saat pasien masuk rumah sakit. Uji statistik dengan Uji T dan Mann Whitney. Hasil Rerata jumlah trombosit penderita infark miokard akut yang survive dan meninggal selama perawatan adalah 245,02+69,58/ÂµL dan 259,18+111,17/ÂµL (p=0,543). Tidak ditemukan hubungan antara tingkat mortalitas dengan jumlah trombosit secara keseluruhan (p=0,433). Pasien dengan trombositosis memiliki risiko mortalitas 4,27 kali dibandingkan dengan jumlah trombosit normal (p=0,256, 95%IK 0,368-49,676) sedangkan pasien dengan trombositopenia memiliki risiko mortalitas 1,71 kali dibandingkan dengan pasien dengan jumlah trombosit normal (p=0,471, 95%IK 0,418-6,993). Simpulan Tidak ditemukan perbedaan bermakna jumlah trombosit pasien yang survive dan yang meninggal selama perawatan, tetapi ditemukan kecenderungan peningkatan mortalitas pada pasien infark miokard akut dengan trombositosis dan trombositopenia dibandingkan dengan pasien dengan jumlah trombosit normal.Background Platelet has important role in atherothrombosis by producing enzymes which may degrade matrix leading to plaque rupture. Rupture of plaques induces platelet adhesion, activation and aggregation forming thrombus which can cause myocardial infarction. Platelet counts are thought to correlate with mortality of acute myocardial infarction patients. Objective To observe platelet counts at admission among acute myocardial patients and to evaluate its influence to in-hospital mortality. Method A retrospective study with cross sectional approach was performed using secondary data from 81 acute myocardial infarction patients hospitalized in Intensive Cardiac Care Unit of dr. Wahidin Sudirohusodo Hospital Makassar from June 2010 to July 2011. Platelet counts at admission were analyzed and statistical analysis was performed using T and Mann Whitney Tests. Results The mean platelet counts at admission in the in-hospital survived and non survived acute myocardial infarction patients were 245.02+69.58/ÂµL and 259.18+111.17/ÂµL respectively (p=0,543). No correlation found between mortality rate and overall platelet count (p=0.433). Patients with thrombocytemia had 4.27 times mortality rate compared to normal platelet counts patients (p=0.256, 95% CI =0.368-49.676) while thrombocytopenia patients had 1.71 times mortality rate compared to those with normal platelet counts (p=0.471, 95% CI =0.418-6.993). Conclusion No significant difference of platelet counts at admission in the in-hospital survived and non survived acute myocardial infarction patients; patients with thrombocytemia and thrombocytopenia had tendency of higher mortality compared to patients with normal platelet counts.Â

Pengaruh Jumlah Leukosit terhadap Mortalitas Pasien Infark Miokard Akut selama Perawatan Kurniawan, Liong Boy; Bahrun, Uleng; Arif, Mansyur; ER, Darmawaty
Cermin Dunia Kedokteran Vol 42, No 10 (2015): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Latar belakang: Patogenesis infark miokard akut melibatkan proses inflamasi sistemik, intraplak, ataupun miokardium. Neutrofil menginfiltrasi plak koroner dan miokardium yang mengalami infark serta memediasi terjadinya kerusakan jaringan melalui pelepasan enzim pendegradasi matriks dan spesies oksigen reaktif. Leukosit yang berperan dalam patogenesis infark miokard diduga berkaitan dengan mortalitas pasien infark miokard akut. Tujuan: Mengetahui kaitan jumlah leukosit, persentase neutrofil, limfosit, dan rasio neutrofil limfosit terhadap mortalitas pasien selama perawatan di rumah sakit. Metode: Studi retrospektif dengan menggunakan data sekunder dari rekam medik 64 pasien infark miokard akut yang dirawat di Unit Perawatan Jantung Intensif Rumah Sakit Dr. Wahidin Sudirohusodo, Makassar, periode Juli 2010 hingga Juni 2011. Dilakukan analisis pada jumlah leukosit, neutrofil, limfosit, dan rasio neutrofil limfosit yang diperoleh dari data hasil tes laboratorium saat pasien masuk rumah sakit. Uji statistik dilakukan dengan uji T, Mann Whitney, dan chi square. Hasil: Rerata jumlah leukosit, persentase neutrofil, limfosit, dan rasio neutrofil limfosit pada penderita infark miokard akut yang survive dan meninggal selama perawatan berturut-turut adalah 11.920+3.610/ÂµL vs 14.410+3.090/ÂµL (p=0,009), 73,98+11,16 vs 76,04+9,74 (p=0,647), 17,29+9,03 vs 15,00+7,00 (p=0,379), dan 5,97+3,90 vs 6,80+4,72 (p=0,403). Pasien dengan leukositosis memiliki risiko mortalitas 10,71 kali dibandingkan dengan jumlah leukosit normal (p=0,009; 95% interval kepercayaan (IK) 1,307 s/d 87,846). Simpulan: Rerata jumlah leukosit pada pasien infark miokard akut yang meninggal selama perawatan lebih tinggi dibandingkan dengan pasien yang survive. Pasien dengan leukositosis memiliki risiko mortalitas selama perawatan lebih tinggi dibandingkan pasien dengan jumlah leukosit normal.Background: Pathogenesis of acute myocardial infarction involves systemic, intraplaque, and myocardial inflammatory processes. Neutrophils infiltrated coronary plaque and infarcted myocardium, also mediate tissue damage through release of matrix degradation enzymes and reactive oxygen species. Leukocyte is suspected to be related to mortality in acute myocardial infarction patients. Objective: To investigate the relationship of leukocyte count, neutrophils and lymphocyte percentages, also neutrophils and lymphocyte ratio with in-hospital mortality of acute myocardial infarction patients. Method: A retrospective study with using secondary data from medical record of 64 acute myocardial infarction patients hospitalized in Intensive Cardiac Care Unit of Dr. Wahidin Sudirohusodo Hospital, Makassar, from June 2010 to July 2011. Admission leukocyte count, percentages of neutrophils and lymphocyte, and neutrophils lymphocyte ratio were analyzed statistically using T, Mann Whitney, and chi square tests. Results: The mean of leukocyte count at-admission, percentages of neutrophils and lymphocyte, and neutrophil : lymphocyte ratio in survived and non survived acute myocardial infarction patients were 11920+3610/ÂµL vs 14410+3090/ÂµL (p=0.009), 73.98+11.16 vs 76.04+9.74 (p=0.647), 17.29+9.03 vs 15.00+7.00 (p=0.379), and 5.97+3.90 vs 6.80+4.72 (p=0.403) respectively. Patients with leukocytosis had 10.71 times mortality rate compared to patients with normal counts (p=0.009; 95% CI =1.307-87.846). Conclusion: Leukocyte count in non-survivors was significantly higher than in survivors. Patients with leukocytosis had higher mortality risk compared with normal count patients.

Penanda Tumor untuk Diagnosis Karsinoma Kaput Pankreas -, Irmayanti; Bahrun, Uleng; Parewangi, A.M. Luthfi; Samad, Ibrahim Abd.
Cermin Dunia Kedokteran Vol 45, No 3 (2018): Muskuloskeletal
Publisher : PT. Kalbe Farma Tbk.

Pendahuluan. Karsinoma kaput pankreas cenderung terjadi pada usia lanjut dan merupakan penyebab kematian keempat akibat keganasan. Diagnosis karsinoma kaput pankreas ditegakkan berdasarkan anamnesis, pemeriksaan fisik, pemeriksaan penunjang laboratorium dan radiologi. Kasus. Karsinoma kaput pankreas pada pasien ini menyebabkan obstruksi aliran empedu, sehingga terjadi kolestasis disertai peningkatan CEA dan CA 19-9 yang sangat tinggi.

Hasil Positif Palsu Tes Morfin pada Skrining Urin Narkoba Diduga Akibat Rifampisin Kurniawan, Liong Boy; Widaningsih, Yuyun; Sennang, Nurhayana; Bahrun, Uleng; Arif, Mansyur
Cermin Dunia Kedokteran Vol 42, No 1 (2015): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Hasil positif palsu pada tes skrining urin narkoba dengan metode imunologi jarang terjadi. Pemastian hasil memerlukan anamnesis yang baik mengenai konsumsi obat dan konfirmasi dengan tes yang lebih spesifik, biasanya dengan metode kromatografi gas/spektrometri massa. Beberapa substansi dilaporkan dapat menyebabkan hasil positif palsu. Dilaporkan satu kasus laki-laki 18 tahun dengan hasil positif morfin (tes urin narkoba) menggunakan metode imunologi kompetitif. Setelah anamnesis ketat diketahui bahwa pasien tersebut dalam pengobatan rifampisin selama 6 bulan karena tuberkulosis dan tidak pernah mengkonsumsi narkoba. Sampel urin berwarna kemerahan (hasil ekskresi metabolit rifampisin melalui urin). Diperlukan konfirmasi pasti dengan metode lebih spesifik dengan kromatografi gas/spektrometri massa (standar baku emas).False positive reports on urine drug screening using immunoassay method are rare. Confirmation should be done through detailed anamneses on consumed drugs that may interfere result and perform test with more specific method such as gas chromatography/mass spectrometry (GC-MS). Some substances have been reported as the causes of false positive test. A case reported to have positive on morphine urine drug test using competitive immunoassay from an 18 year-old male. The patient was on 6-month rifampicin treatment for tuberculosis and had no history of substance abuse. The urine sample was reddish due to rifampicin metabolite excretion. Confirmation with gas chromatography/mass spectrometry method should be performed as gold standard.

Hubungan Rasio APO-B/APOA-I dengan Index Massa Tubuh Megawati, Megawati; Kurniawan, Liong Boy; Bahrun, Uleng
Jurnal Kesehatan Vol 13 No 1 (2022): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v13i1.2686

Body Mass Index (BMI) is a simple way to monitor weight. Overweight as a result of excessive body fat accumulation which is characterized by a decrease in HDL (High-Density Lipoprotein), namely the atherogenic side represented by levels of Apolipoprotein AI (ApoA-I), increased triglycerides (TG), VLDL (Very Low-Density Lipoprotein). ), LDL (Low-Density Lipoprotein), and Total Cholesterol which is the anti-atherogenic side represented by the levels of Apolipoprotein B (Apo-B). If we measure both Apo-B and ApoA-I and express them as the Apo-B/ApoA-I ratio, we get a strong marker of cardiovascular risk. By combining the two markers in the ratio, we get synergies and increase predictive power. This study aims to analyze the levels of Apo-B, ApoA-I, and the ratio of Apo-B/ApoA-I to BMI. An experimental study with a cross-sectional design using 72 subjects during April 2021. Apo-B and ApoA-I were examined using the Cobas c311/501 instrument with the immunoturbidimetric test method. The results of this study showed a significant relationship between Apo-B levels and BMI, while ApoA-I levels and Apo-B/ApoA-I ratios did not have a significant relationship. In conclusion, there is no relationship between BMI and the ApoB/ApoA-I ratio in male and female subjects.

Analysis of NLR, PLR, and Carcinoembryonic Antigen in Colorectal Cancer Patients Parabang, Budi; Esa, Tenri; Bahrun, Uleng
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 2 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i2.2063

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. The development and prognosis of CRC are affected by the tumor's appearance and the host's inflammatory response. A combination of several parameters, including the Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR), has been used as a cancer prognostic marker. Research needs to be performed to analyze its role in CRC. This study aimed to determine the differences in the NLR, PLR, and CEA values with the severity and site of CRC. Medical record data were collected from 246 CRC patients from January 2021 to June 2022 at Dr. Wahidin Sudirohusodo Hospital were used and grouped by severity (metastatic and non-metastatic) and site (left colon, right colon, rectum). This study collected the data on NLR, PLR, and CEA levels. The Mann-Whitney, Spearman Rho, and Kruskal-Wallis tests were used for statistical analysis by the research objectives (significant if p<0.05). There were differences in median PLR (194.47 vs. 201.18; p=0.045) and CEA (3.3 ng/mL vs. 11.95 ng/mL; p<0.001) between the metastatic and non-metastatic groups, whereas there was no significant difference of median NLR between the two groups (2.77 vs. 2.79; p=0.438). No correlation was found between the NLR, PLR, and CEA level values with the location of CRC (p-values 0.978, 0.511, 0.419, respectively). PLR and CEA values were higher in metastatic CRC than in non-metastatic CRC, while NLR value was not significantly different. There was no correlation between the NLR, PLR, and CEA level values with the CRC site.

Demographics, Clinical Features, Laboratory Results Characteristic of COVID-19 Patients at Dr. Wahidin Sudirohusodo Hospital Lolongan, Calvarica Lun; Esa, Tenri; Bahrun, Uleng
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2320

Coronavirus Disease 2019 (COVID-19) has spread throughout the world since 2020. WHO declared COVID-19 as a pandemic. Pandemic status has now ended, but the rapid spread of COVID-19 can be a concern to anticipate a new spike. Various studies and results regarding characteristics of COVID-19 patients such as age, gender, clinical symptoms, and laboratory examination results have been carried out to provide an overview of various factors that can support COVID-19 infection. Based on this, authors are interested in identifying characteristics of COVID-19 patients based on age, gender, origin, education, occupation, dominant symptoms, severity, COVID-19 biomarkers (NLR, CRP, procalcitonin, D-dimer, ferritin), and CT value at Dr. Wahidin Sudirohusodo Hospital as COVID-19 referral center in Eastern Indonesia. This study aimed to determine the characteristics of COVID-19 patients at Dr. Wahidin Sudirohusodo Hospital, Makassar. A descriptive cross-sectional study on 650 COVID-19 patients was performed at Dr. Wahidin Sudirohusodo Hospital, from January 2020–July 2022. The data were described based on age, gender, regional origin, education, occupation, severity (asymptomatic, mild, moderate, severe, and critical), dominant symptoms, laboratory biomarker (NLR, CRP, procalcitonin, D-dimer, ferritin) and CT value. There were more males than females (52.8% vs. 47.2%), age range 26-35 years (20.3%), from South Sulawesi (91.3%), non-PNS (37.1%), and senior high school education was the largest (29.2%). Dominant symptoms were respiratory distress (26.9%) and mild severity (41.7%). Based on the results of COVID-19 biomarker research, it is known that the range of COVID-19 biomarkers differs between mild and critical degrees. In mild degrees, the range of COVID-19 biomarkers is lower than critical degrees. It is known that the range of each biomarker in mild degree NLR 1.02-7.14, CRP 0.20-35.20 mg/l, procalcitonin 0.05-0.75 ng/mL, D-dimer 0.11-1.04 µg/mL, and ferritin 16.15-402,40 ng/mL. Higher COVID-19 susceptibility among males and certain occupational groups. Symptoms vary widely, with some cases showing no symptoms. Disease severity ranges from mild to asymptomatic, with biomarkers indicating progression.

ANALYSIS OF NEUTROPHIL-TO-LYMPHOCYTE RATIO, PLATELET-TO-LYMPHOCYTE RATIO, AND VITAMIN D LEVELS IN COVID-19 PATIENTS BASED ON DISEASE SEVERITY TOLLA, NELLY; BAHRUN, ULENG; FAIDAH, NUR; ANGGERAINI, SALSA; HANUM P, PUDYA; ARAS, DARA UGI; LESTARI, AYU
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol. 8 No. 2 (2025): Al-Iqra Medical Journal: Jurnal Berkala Ilmiah Kedokteran
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/knypj818

Background: Patients with COVID-19 experience a range of clinical symptoms, from asymptomatic to multi-organ failure. It is believed that factors including age, gender, systemic disease, and the inflammatory response that takes place have a significant impact in rising morbidity and mortality.3,4 Dysregulation of proinflammatory cytokines might result from the inflammatory response brought on by innate immunity.5 The prognosis of COVID-19 patients is characterized by an elevation in the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), which are regarded to be inflammatory marker parameters.3 Because vitamin D is known as an immunomodulator that is essential for addressing the cytokine storm mechanism as disease development in COVID-19 patients, vitamin D deficiency has lately been believed to play a significant role in the success of therapy.6Methods: A cross-sectional descriptive analytic research approach was applied in this study, which included 88 COVID-19 patients from the Hasanuddin Teaching Hospital divided into two groups.Results: The results showed a significant difference between the NLR (2.82 + 1.86 ; 8.09 + 5.40) and PLR (11.35 + 6.98 ; 34.35 + 16.52) in both groups with higher NLR and PLR levels in patients with severe grades. Although vitamin D levels in both groups were within normal limits, vitamin D levels were lower in patients with severe COVID-19 compared to mild-moderate levels with a mean value (19.62 + 7.89 ; 16.62 + 6.28).Conclusion: Vitamin D insufficiency can be considered when evaluating the therapeutic response and NLR and PLR levels can be employed as markers in measuring the inflammatory response.

Platelet Limphocyte Ratio and Procalcitonin in Survivor and Non-Survivor Sepsis Patients at Dr. Wahidin Sudirohusodo Hospital Makassar Fitriana, Astri Yul; Nurulita, Asvin; Bahrun, Uleng; Arifin Seweng
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2396

Sepsis is a life-threatening organ dysfunction caused by dysregulation in the host's response to infection and is a major cause of global morbidity and mortality.The platelet-to-lymphocyte ratio (PLR) is considered a prognostic marker of sepsis. Another inflammatory marker, procalciton in which is secreted in response to bacterial endotoxin can also serve as a biomarker for diagnosis, prognosis and monitoring of sepsis patients. Analysis of platelet lymphocyte ratio and procalcitonin levels may therefore be useful for predicting survival outcomes in sepsis. This retrospective observational study included 276 patients diagnosed with sepsis, consisting of 128 survivors and 148 non-survivors. Statistical analysis was performed using the Kolmogorov-Smirnov test, Mann-Whitney test, Spearman correlation test, and Friedman test, with significance defined as p <0.05. No significant differences in mean platelet-to lymphocyte ratio between a survivors and non-survivors on day 1 (200.59 vs 233.91, p >0.05), day 3 (191.58 vs 238.74, p >0.05), or day 5 (210.42 vs 208.62, p >0.05). Similarly, no significant difference in mean procalcitonin levels was found on day 1 (20.18 ng/mL vs 16.20 ng/mL, p >0.05). However, mean procalcitonin levels were significantly lower in survivors compared with non-survivors on day 3 (14.04 ng/mL vs 17.48 ng/mL, p <0.05) and day 5 (7.78 ng/mL vs 23.06 ng/mL, p <0.05). In survivors, procalcitonin levels showed a significant decreasing trend across days 1, 3, and 5 (p <0.05). There was no difference in platelet-to-lymphocyte ratio values between survivors and non-survivors. There was a significant difference in procalcitonin levels between survivors and non-survivors on the third and fifth days.

Environmental Exposures, Clinical Allergy Symptoms, and Serum IgE in Young Adults: A Cross-Sectional Study from Makassar, Indonesia Anaam, Andi Khairul; Liong Boy Kurniawan; Rafiah, Sitti; Zainuddin, Andi Alfian; Bahrun, Uleng
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 8 No. 11: NOVEMBER 2025 - Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v8i11.8279

Introduction: The global prevalence of allergic diseases has increased significantly, particularly among young adults. Immunoglobulin E (IgE) plays a central role in the pathophysiology of allergic responses and is considered a crucial biomarker in evaluating allergic sensitivity. However, the influence of environmental exposures and clinical complaints on serum IgE levels in adult populations remains understudied, especially in tropical developing countries. Methods: This study aimed to analyze the relationship between environmental factors and clinical complaints with serum IgE levels in a population of healthy young adults in Makassar, Indonesia. A cross-sectional study was conducted involving 80 healthy adults aged 18–40 years. Environmental exposures and clinical symptoms were analyzed against serum IgE levels. Non-parametric tests (Mann-Whitney U and Kruskal-Wallis) showed no significant associations. However, in the multivariate regression model, humidity was the only environmental factor significantly associated with serum IgE concentration. Results: The mean serum IgE level among participants was 176.8 IU/mL (SD ±196.9), with a wide distribution. No statistically significant associations were found between serum IgE levels and clinical complaints such as asthma, allergic rhinitis, and atopic dermatitis (p > 0.05). Similarly, environmental exposures including cigarette smoke, dust, pet dander, and poor ventilation were not significantly related to IgE levels. Notably, high environmental humidity was negatively associated with serum IgE levels (p = 0.047). Most environmental factors and clinical complaints assessed in this study were not significantly associated with serum IgE concentrations in healthy young adults. Conclusion: The observed inverse association with high humidity suggests a potential modulatory role that warrants further investigation. Future longitudinal studies with larger samples are recommended to confirm these findings and provide stronger evidence to inform public health strategies in allergy prevention.

Title

Found 10 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 10 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 10 Documents
Search