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Current Research on Biosciences and Biotechnology
Published by Institut Teknologi Bandung
ISSN : -     EISSN : 26861623     DOI : https://doi.org/10.5614/crbb
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Materials Science & Nanotechnology Medicine & Pharmacology
The Current Research on Biosciences and Biotechnology (CRBB) encourages researchers to publish works related to the use of the biosciences and biotechnology in understanding the world around us. From Health and Medicine to Advanced Materials, these state-of-the-art research offer novel insights in a multidisciplinary environment. We encourage scientists to submit papers focusing on the following broad topics: Health and Medicine Pharmaceutical Sciences Pharmacology and Toxicology Food Microbiology and Biotechnology Biotechnology Agriculture Bio-Energy Marine Sciences Advanced Materials Environmental Sciences
Arjuna Subject : Umum - Umum
Articles 2 Documents
 1 
Search results for , issue "Vol. 7 No. 2 (2026)" : 2 Documents clear
Secondary metabolites, antioxidant activity, and acute toxicity of ethanol extract of Artocarpus elasticus leaves Yafandi, Muchlis; Sabandar, Carla Wulandari; Dwidayati, Ari; Agusriyadin; Yulyana
Current Research on Biosciences and Biotechnology Vol. 7 No. 2 (2026)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2026.7.2/48NN15AB

Abstract

Artocarpus elasticus belongs to Moraceae; a family best known for their fruits that support human life. Along with its nutritive components, different parts of A. elasticus are traditionally used to treat fever, hypertension, digestive problems, infections, and female fertility. However, scientific data of this plant, especially its leaves, are still limited, requiring further research. The present study investigated secondary metabolites, antioxidant, and acute toxicity of its leaves using methods on ethanolic maceration, phytochemical screening, determination of phenolics and flavonoids content, qualitative and quantitative DPPH radical scavenging activity, and brine shrimp lethality test. The yield of ethanolic extract of A. elasticus leaves was 6.52 gram extract per 100 gram of dried leaves. The study found the presence of alkaloids, flavonoids, tannins, terpenoids, steroids, and saponins in the extract. The TPC (28.29 ± 1.46 mg GAE/g of extract) and TFC (7.72 ± 0.34 mg QE/g of extract) found high in diluted extract at 10 and 100 µg/mL, respectively. The extract showed moderate free radical scavenging activity with an SC50 value of 8.04 µg/mL and an AAI of 0.99. The extract also displayed toxicity towards A. salina nauplii with an LC50 of 116.24 µg/mL. The study concludes that leaves of A. elasticus could be further explored for antioxidant and cytotoxic agents.
Prospecting laccase-producing wood-decaying fungi from the UPR peat swamp forest, Central Kalimantan Lumbantoruan, Lidia Amelia; Arum, Diah Panjar; Charles, Adrian; Togatorop, Hanna Esrani; Suni, Muhammad Ikhwan; Rahayu, Putri; Krissilvio, Eka Jhonatan; Haryono, Agus; Agnestisia, Retno
Current Research on Biosciences and Biotechnology Vol. 7 No. 2 (2026)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2026.7.2/Z7TNZK3U

Abstract

Tropical peat forests of Kalimantan harbor diverse wood-decaying fungi with strong ligninolytic potential, yet their functional enzymatic characteristics remain poorly documented. This study prospectively examined the physiological expression of laccase production in native fungi isolated from the Universitas Palangka Raya peat swamp forest, Central Kalimantan. Three stable pure cultures were obtained: MIPA 2 (Ganoderma sp.), MIPA 4 (Trametes sp. 1), and MIPA 8 (Trametes sp. 3). All isolates produced extracellular laccase but showed clear differences in growth and enzyme productivity. Growth analysis revealed distinct radial expansion rates, with MIPA 2 exhibiting the fastest mycelial growth (13.64 mm/day). The faster radial growth of MIPA 2 suggests higher metabolic activity and biomass formation, which may contribute to its superior laccase production compared to the other isolates. Qualitative screening on syringaldazine-amended PDA also confirmed extracellular laccase activity in all isolates, with activity levels ranging from weak (+) to strong (+++). Quantitative assays in potato dextrose broth and modified glucose–peptone medium revealed strong nutrient-dependent regulation of laccase biosynthesis, with MIPA 2 reaching 93.71 U/L on day 21. The pronounced stimulation by organic nitrogen indicates ecological adaptation to acidic, nutrient-limited peat environments and distinguishes these isolates from many previously reported Ganoderma and Trametes strains that typically require external inducers for high activity. These findings demonstrate that peat swamp ecosystems represent not only a geographic source but also a reservoir of fungi with distinct ligninolytic expression profiles and potential biotechnological relevance.

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